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Entry version 110 (16 Jan 2019)
Sequence version 2 (13 Jul 2010)
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Protein

A-kinase anchor protein 9

Gene

Akap9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 2/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 2, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 9
Short name:
AKAP-9
Alternative name(s):
Protein kinase A-anchoring protein 9
Short name:
PRKA9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap9
Synonyms:Kiaa0803
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2178217 Akap9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003954811 – 3797A-kinase anchor protein 9Add BLAST3797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei139PhosphoserineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei3732PhosphoserineBy similarity1
Modified residuei3755PhosphoserineBy similarity1
Modified residuei3787PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q70FJ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q70FJ1

PeptideAtlas

More...
PeptideAtlasi
Q70FJ1

PRoteomics IDEntifications database

More...
PRIDEi
Q70FJ1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70FJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70FJ1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1. Interacts with chloride intracellular channel proteins CLIC1, CLIC4 and CLIC5. CSNK1D binding promotes its centrosomal subcellular location. Interacts with GM130/GOLGA2; leading to recruitment to the Golgi apparatus. Interacts with KCNQ1; targets protein kinase A (PKA) catalytic and regulatory subunits and protein phosphatase 1 (PP1), to the heterodimer KCNQ1-KCNE1. Interacts with PDE4DIP isoform 2; this interaction stabilizes both proteins. In complex with PDE4DIP isoform 2, recruits CAMSAP2 to the Golgi apparatus. Forms a pericentrosomal complex with CDK5RAP2, EB1/MAPRE1 and PDE4DIP isoform 2; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP. Interacts with MAPRE1 and MAPRE3. Interacts (via C-terminus) with CAMSAP2; this interaction is much stronger in the presence of PDE4DIP isoform 2. Interacts with CAMSAP3. Interacts (via C-terminus) with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
221564, 10 interactors

Protein interaction database and analysis system

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IntActi
Q70FJ1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000046129

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q70FJ1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2498 – 2510PKA-RII subunit binding domainBy similarityAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili140 – 607Sequence analysisAdd BLAST468
Coiled coili640 – 976Sequence analysisAdd BLAST337
Coiled coili1808 – 2377Sequence analysisAdd BLAST570
Coiled coili2975 – 3325Sequence analysisAdd BLAST351

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 281Gln-richAdd BLAST62
Compositional biasi3143 – 3337Gln-richAdd BLAST195

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II47 Eukaryota
ENOG41101YB LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169582

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG084047

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70FJ1

KEGG Orthology (KO)

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KOi
K16551

Database of Orthologous Groups

More...
OrthoDBi
8180at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70FJ1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028745 AKAP9/Pericentrin
IPR019528 PACT_domain

The PANTHER Classification System

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PANTHERi
PTHR44981 PTHR44981, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10495 PACT_coil_coil, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70FJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDEERQRKL AAGKAKLARF RQRKAQYDGD IPKKQKKKRT SSSKHDSSLH
60 70 80 90 100
TDQQSGELCS ESSQRVDLAG NPDCSGPERK HGQVFSAEPE SEISTTADEC
110 120 130 140 150
SSEINGCNSV MKPRKPTDPL REEEFSLDDS SSEQGAQSSQ TCLQMVEKEL
160 170 180 190 200
AEKQHDIEEL TQELEEMRAS FGTEGLKQLQ EFEAAIKQRD GIITQLTANL
210 220 230 240 250
QQARREKDDT MVEFLELTEQ SQKLQIQFQH LQANETLQNS TLSRTATDLL
260 270 280 290 300
QAKRQIFTQQ QQLQDYQKKE EDLQAQISFL QEKLRAFEME KDRKIENLNA
310 320 330 340 350
KEIQEKQALI DELNTRVVEE EKKTVELKNK VTTADELLGG LHEQLTQRNQ
360 370 380 390 400
EIQSLKLELG NSQQNERKCS EEIKELMRTV EELQKRNLKD SWLETSAVRR
410 420 430 440 450
VEQETQRKLS HLQAELDEMY GKQIVQMKQE LINQHMSQIE ELKSQHKREM
460 470 480 490 500
ENTLKSDTNA AISKEQVNLM NAAINELNVR LQETHAQKEE LKGELGVVLG
510 520 530 540 550
EKSALQSQSN DLLEEVRFLR EQVQKARQTI AEQENRLSEA RKSLSTVEDL
560 570 580 590 600
KAEIVAASES RKELELKHEA EITNYKIKLE MLEKEKNAVL DRMAESQEAE
610 620 630 640 650
LERLRTQPLF SHEEELSKLK EDLEVEHRIN IEKLKDNLGI HYKQQIDGLQ
660 670 680 690 700
NEMNRKMESM QCETDNLITQ QNQLILENSK LRDLQECLVN SKSEEMNLQI
710 720 730 740 750
NELQKEIEIL KQEEKEKGTL EQEVQELQLK TEQLEKQLKE KEDDLQEKCA
760 770 780 790 800
QLDAENNILK EEKRVLEDKL KMYSPSEQEE RSIAVDPSTS KLADSRWQKE
810 820 830 840 850
VAMLRKETED LQQQCLYLNE EIEKQRNTFA FAEKNFEVNY QELQREYTCL
860 870 880 890 900
LKIRDDLEAT QTKQALEYES KLRALEEELL SKRGNPXAPK GKSSGIFPSE
910 920 930 940 950
TLEIGEVVEK DTTELMEKLE VTKREKLELS EKVSGLSEQL KQTHCTINSL
960 970 980 990 1000
SAEXRALKQE KEQLLLRCGE LELLANPSGT ENAAVCPVQM SSYQAGLVMG
1010 1020 1030 1040 1050
KVGDSGGSIS KISKDLAEES KPMIEDKIPF KESGREQLLL PTRAQEPSHA
1060 1070 1080 1090 1100
TVEPCESEKL QQELHALKAE QDDLRLQMEA QRICLFVVYS THADQVRAHM
1110 1120 1130 1140 1150
EKEREEALCS LKDELISAQQ KKIDELHKMH QCQLQNVKIQ ETGDEPLQVL
1160 1170 1180 1190 1200
IERLQKAVSE KCFHISKTLN NVFDECYTPL KCEMNIEEKE NSGVYTSQNQ
1210 1220 1230 1240 1250
SPELQEYRYE VQDFQESMQV LLGKVTEECR KLSGLQTRLG KIHEQQTDGV
1260 1270 1280 1290 1300
ALEFAEQNAA EEEAGLLSGC SQSALQSTDV SLESKVSSLP ASEKNRECER
1310 1320 1330 1340 1350
QVQELQSPVA AGQLQLTETE ASHRAEIECL QQRLEAASEA PVQPSLSIDS
1360 1370 1380 1390 1400
VVFKGSGAQK PVYCGSCLRE YVDGTAKFSD RFEVRQETNM VNLMEKQYQE
1410 1420 1430 1440 1450
RLEEEIAKVI VSMSIAFAQQ TELSRLSEGK ENTIQSEQAH TLCSQNKHQL
1460 1470 1480 1490 1500
NDITSQSQVG LQTFEATDKB FKEEFKPLSK ELGEYRKAVP LSSHDDLDDI
1510 1520 1530 1540 1550
LKSEEHGLAI SEEIFSKDET FIVRKSMHDE VLVSSMDTSR QLILNEQLED
1560 1570 1580 1590 1600
MRQELVRQYE EHQQATEMLR QAHMQQMERQ REDQEQLQEE IKRLNEQLTQ
1610 1620 1630 1640 1650
KSSIDTEHVV SERERVLLEE LEALKQLPLA GRKELCCELR HSSTQTQDGH
1660 1670 1680 1690 1700
DDQEVEEQTL KDKTLERSPE DALLDRNLSN ERYALKKANN RLLKILLEVV
1710 1720 1730 1740 1750
KTTSAAEETI GRHVLGILDR SSKGQTASSL LWRSEADASA TTCAPEDCAR
1760 1770 1780 1790 1800
AMDESIPSYP GTAIATHDSI WSKVTEEGAE LSQRLVRSGF AGPVIDPENE
1810 1820 1830 1840 1850
ELMLNISSRL QAAVEKLLEA ISETNTQLEH AKVTQTELMR ESFRQKQEAT
1860 1870 1880 1890 1900
ESLHCLEELR ERLQEESRAR EQLAEELNKA ESVIDGYSDE KTLFERQIQE
1910 1920 1930 1940 1950
KTDIIEHLEQ EVLCMNNRLQ ELESDQRRVE EERQLLCRQR EAMRAEAGPV
1960 1970 1980 1990 2000
EQQFLQETEK LMKEKLEVQC QAEKVRGDLQ KQVKALEIDV EEQVSRFIEL
2010 2020 2030 2040 2050
EQEKNAELTD LRQQSQALEK QLEKMRKFLD EQAIDREHER DVFQQEIQKL
2060 2070 2080 2090 2100
EHQLKAAPRI QPVSEHQARE VEQLTNHLKE KTDRCSELLL SKEQLQRDIQ
2110 2120 2130 2140 2150
ERNEEIEKLE CRVRELEQAL LASAEPFPKV EDQKRSGAVA ADPELSLEVQ
2160 2170 2180 2190 2200
LQAERDATDR KQKEITNLEE QLEQFREELE NKNDEVQELL MQLEIQRKES
2210 2220 2230 2240 2250
TTRLQELQQE NRLFKDEIEK LGFAMKESDS VSTRDQPMLF GKFAQLIQEK
2260 2270 2280 2290 2300
EIEIDRLNEQ FIKLQQQLKL TTDNKVIEEQ KEQIQDLETQ IERLMSEREH
2310 2320 2330 2340 2350
EKKQREEEVE QLTGVVEKLQ QEVVSTEQQR EGARTLPEDE ESFKHQLDKV
2360 2370 2380 2390 2400
TAEKLVLEQQ VETTNQVMTH MNNVLKEINF KMDQITQSLC NLNKECASNE
2410 2420 2430 2440 2450
ELPSLPKESV HMTVHELGSD NLQPEDAPAQ DVTKPLEKQT SLTRLQESPE
2460 2470 2480 2490 2500
ASRTQEIESL ASSVGAKDVE LTQCREQTET IQEQAQSETD RLQKKLTDLQ
2510 2520 2530 2540 2550
RSLEKFAAAL VSQVQMEAAQ EYVPFHQEKQ PVSSAPGSTD IQNANGLTGA
2560 2570 2580 2590 2600
STESLIPTVT LRLAEVESRV AEVHSGTMSE KLVGIVGGNA SETEKRVIEL
2610 2620 2630 2640 2650
QKLLEEAEER PEEGGEQSSR DGEVRESYMT SLQKDLGQVK DPLTEAKEKL
2660 2670 2680 2690 2700
SYSLEKEKRT GEQESREAPI PEPPSVEVGG CSGLTERTDK VSSSGNQTLQ
2710 2720 2730 2740 2750
ILLRDAAIQT DLQSESSQEE VRDTINQLTK KMEHIQELHA AEILDMESRH
2760 2770 2780 2790 2800
ILETESLKKE HYVAIQLLTK ECETLKEMTQ CLRCKEGSSI PELADSVAYQ
2810 2820 2830 2840 2850
SREVYSSDSE SDWGQSQGFD TAIEGREEGE TSADLFPKKI KGLVKAVHSE
2860 2870 2880 2890 2900
GMQVLSLSSP LCDDGEDRSI QQLSESWLKE RQAYLNTISS LKDLISKMQV
2910 2920 2930 2940 2950
RRETEVYDRC HLSDWRGELL LACQRVFIKE RSVLLATFQT ELTSLSTRDV
2960 2970 2980 2990 3000
DGLLNSLEQR IQEQGIEYHT AMDCLQKADR RSLLAEIEDL RAQINGGKMT
3010 3020 3030 3040 3050
LEREQGTEKS SQELLDCSMQ QKQSLEMQLE LSSLRDRAAE LQEQLSSEKM
3060 3070 3080 3090 3100
VVAELKSELA QAKLELGTTL KAQHKRLKEL EAFRSEVKEK TDEIHFLSDT
3110 3120 3130 3140 3150
LAREQKNSLE LQWALEKEKA RSGHHEEREK EELEDLKFSL EDQKRRNTQL
3160 3170 3180 3190 3200
NLLLEQQKQL LNESQQKIES QKMLHDAQLS EEQGRNLGLQ ALLESEQVRI
3210 3220 3230 3240 3250
QEMKSTLDKE RELYAQLQSR EDGGQPPPAL PSEDLLKELQ KQLEEKHSRI
3260 3270 3280 3290 3300
VELLSETEKY KLDSLQTRQQ MEKDRQVHQK TLQTEQEANT QGQKKMQELQ
3310 3320 3330 3340 3350
SKVEELQRQL QEKRQQVYKL DLEGKRLQGL MQEFQKQELE PEEKPGSRGL
3360 3370 3380 3390 3400
VDQNLNEPAT WNFTDDRTRN WVLQQKMGEA KDRNFTKLIE INGGELDHNH
3410 3420 3430 3440 3450
DLEMIRQTLQ HVASKLQHVA QKACSRLQFE TAGDDAFIWI QENIDGIILQ
3460 3470 3480 3490 3500
LQKLTGQPGD EHSLGPPSSS CGSLTESLMR QNTELTRLIN QLTEEKNTLR
3510 3520 3530 3540 3550
SIVIKLEELN RCYWHTGASR DCCSRFSFID PADIEAIIAS EKEVWNREKL
3560 3570 3580 3590 3600
SLQKALKRAE AKVYKLKAEL RNDALLRNLG PDTDHAALQK IYNKYLRASS
3610 3620 3630 3640 3650
FRKALIYQKK YLLLLLGGFQ ECEDVTLGVL ARMGGHLALK DSKTITNHPK
3660 3670 3680 3690 3700
AFSRFRSAVR VSIAISRMKF LVRRWQQVTS TSSININRDG FGLSPGIEKT
3710 3720 3730 3740 3750
DPFYHSPGGL ELYGEPRHTM YRSRFDLDYP RSLLPLQNRY PGTPGDLNSI
3760 3770 3780 3790
SMASSQLHQY NPDKSLTDYV TRLEALRRRL GAIQSGSTTQ FHFGMRR
Length:3,797
Mass (Da):436,214
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA30D11FF5696124
GO
Isoform 2 (identifier: Q70FJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-121: Missing.

Note: Incomplete sequence.
Show »
Length:3,779
Mass (Da):434,206
Checksum:i52DE20D0FB7DAE3E
GO
Isoform 3 (identifier: Q70FJ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3436-3454: Missing.

Note: Incomplete sequence.
Show »
Length:3,778
Mass (Da):433,976
Checksum:iEC4EB9FA61875834
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QQ10E9QQ10_MOUSE
A-kinase anchor protein 9
Akap9
3,779Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLL7H3BLL7_MOUSE
A-kinase anchor protein 9
Akap9
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8S1A0A140T8S1_MOUSE
A-kinase anchor protein 9
Akap9
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFW0A0A0G2JFW0_MOUSE
A-kinase anchor protein 9
Akap9
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX24G3UX24_MOUSE
A-kinase anchor protein 9
Akap9
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62S → N in CAE46960 (Ref. 1) Curated1
Sequence conflicti2388S → L in CAE46960 (Ref. 1) Curated1
Sequence conflicti2775L → Q in CAE46960 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039481104 – 121Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0394823436 – 3454Missing in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ582913 mRNA Translation: CAE46960.1
AK122374 Transcribed RNA Translation: BAC65656.2
AK168404 mRNA Translation: BAE40324.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS19070.1 [Q70FJ1-2]

NCBI Reference Sequences

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RefSeqi
NP_919444.2, NM_194462.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.46044

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100986

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:100986

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ582913 mRNA Translation: CAE46960.1
AK122374 Transcribed RNA Translation: BAC65656.2
AK168404 mRNA Translation: BAE40324.1
CCDSiCCDS19070.1 [Q70FJ1-2]
RefSeqiNP_919444.2, NM_194462.2
UniGeneiMm.46044

3D structure databases

ProteinModelPortaliQ70FJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221564, 10 interactors
IntActiQ70FJ1, 6 interactors
STRINGi10090.ENSMUSP00000046129

PTM databases

iPTMnetiQ70FJ1
PhosphoSitePlusiQ70FJ1

Proteomic databases

jPOSTiQ70FJ1
PaxDbiQ70FJ1
PeptideAtlasiQ70FJ1
PRIDEiQ70FJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100986
KEGGimmu:100986

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10142
MGIiMGI:2178217 Akap9

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410II47 Eukaryota
ENOG41101YB LUCA
HOGENOMiHOG000169582
HOVERGENiHBG084047
InParanoidiQ70FJ1
KOiK16551
OrthoDBi8180at2759
PhylomeDBiQ70FJ1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Akap9 mouse

Protein Ontology

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PROi
PR:Q70FJ1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR028745 AKAP9/Pericentrin
IPR019528 PACT_domain
PANTHERiPTHR44981 PTHR44981, 2 hits
PfamiView protein in Pfam
PF10495 PACT_coil_coil, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKAP9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70FJ1
Secondary accession number(s): Q3TH74, Q80TR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: January 16, 2019
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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