UniProtKB - Q70EX6 (SOAT_RAT)
Protein
Solute carrier family 10 member 6
Gene
Slc10a6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.1 Publication
GO - Molecular functioni
- bile acid:sodium symporter activity Source: GO_Central
- sodium-dependent organic anion transmembrane transporter activity Source: RGD
GO - Biological processi
- bile acid and bile salt transport Source: GO_Central
- sodium-dependent organic anion transport Source: RGD
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
Protein family/group databases
TCDBi | 2.A.28.1.3, the bile acid:na(+) symporter (bass) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 10 member 6Alternative name(s): Sodium-dependent organic anion transporter |
Gene namesi | Name:Slc10a6 Synonyms:Soat |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727800, Slc10a6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 67 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 97 | ExtracellularSequence analysis | 9 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 126 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 159 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 181 – 195 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 224 | ExtracellularSequence analysis | 8 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 265 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 266 – 283 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 284 | ExtracellularSequence analysis | 1 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 306 – 370 | CytoplasmicSequence analysisAdd BLAST | 65 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309217 | 1 – 370 | Solute carrier family 10 member 6Add BLAST | 370 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q70EX6 |
PRIDEi | Q70EX6 |
PTM databases
GlyGeni | Q70EX6, 2 sites |
Expressioni
Tissue specificityi
Highly expressed in heart, lung, spleen and adrenal gland. Moderately expressed in skeletal muscle, testis and small intestine.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000002057, Expressed in esophagus and 20 other tissues |
Genevisiblei | Q70EX6, RN |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | Q70EX6 |
OMAi | MEIGIHN |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q70EX6 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030203, SLC10A6 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF55, PTHR10361:SF55, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q70EX6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSADCEGNST CPANSTEEDP PVGMEGQGSL KLVFTVLSAV MVGLVMFSFG
60 70 80 90 100
CSVESRKLWL HLRRPWGIAV GLLCQFGLMP LTAYLLAIGF GLKPFQAIAV
110 120 130 140 150
LIMGSCPGGT VSNVLTFWVD GDMDLSISMT TCSTVAALGM MPLCLYVYTR
160 170 180 190 200
SWTLPQSLTI PYQSIGITLV SLVVPVASGI YVNYRWPKQA TFILKVGAAV
210 220 230 240 250
GGMLLLVVAV TGVVLAKGWN IDVTLLVISC IFPLVGHVMG FLLAFLTHQS
260 270 280 290 300
WQRCRTISIE TGAQNIQLCI AMMQLSFSAE YLVQLLNFAL AYGLFQVLHG
310 320 330 340 350
LLIVAAYQAY KRRQKSQYRR QHPECQDISS EKQPRETSAF LDKGAEAAVT
360 370
LGLEQHHRTA ELTSHVPSCE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ583503 mRNA Translation: CAE47478.1 |
RefSeqi | NP_932166.1, NM_198049.1 |
Genome annotation databases
Ensembli | ENSRNOT00000002819; ENSRNOP00000002819; ENSRNOG00000002057 ENSRNOT00000088508; ENSRNOP00000072386; ENSRNOG00000002057 |
GeneIDi | 289459 |
KEGGi | rno:289459 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ583503 mRNA Translation: CAE47478.1 |
RefSeqi | NP_932166.1, NM_198049.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002819 |
Protein family/group databases
TCDBi | 2.A.28.1.3, the bile acid:na(+) symporter (bass) family |
PTM databases
GlyGeni | Q70EX6, 2 sites |
Proteomic databases
PaxDbi | Q70EX6 |
PRIDEi | Q70EX6 |
Genome annotation databases
Ensembli | ENSRNOT00000002819; ENSRNOP00000002819; ENSRNOG00000002057 ENSRNOT00000088508; ENSRNOP00000072386; ENSRNOG00000002057 |
GeneIDi | 289459 |
KEGGi | rno:289459 |
Organism-specific databases
CTDi | 345274 |
RGDi | 727800, Slc10a6 |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | Q70EX6 |
OMAi | MEIGIHN |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q70EX6 |
TreeFami | TF315811 |
Enzyme and pathway databases
Reactomei | R-RNO-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
Miscellaneous databases
PROi | PR:Q70EX6 |
Gene expression databases
Bgeei | ENSRNOG00000002057, Expressed in esophagus and 20 other tissues |
Genevisiblei | Q70EX6, RN |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030203, SLC10A6 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF55, PTHR10361:SF55, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOAT_RAT | |
Accessioni | Q70EX6Primary (citable) accession number: Q70EX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families