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UniProtKB - Q70EL1 (UBP54_HUMAN)

Entry version 126 (22 Apr 2020)
Sequence version 4 (25 Nov 2008)
Previous versions | rss
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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 54

Gene

USP54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has no peptidase activity.

Caution

Although the active site residues are conserved, it lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Protein family/group databases

MEROPS protease database

More...MEROPSi		C19.080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 54
Alternative name(s):
Inactive ubiquitin-specific peptidase 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP54
Synonyms:C10orf29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23513 USP54

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q70EL1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		159195

Open Targets

More...OpenTargetsi		ENSG00000166348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134959960

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q70EL1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		USP54

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274237

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495301 – 1684Inactive ubiquitin carboxyl-terminal hydrolase 54Add BLAST1684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12Omega-N-methylarginineBy similarity1
Modified residuei481PhosphoserineBy similarity1
Modified residuei603PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei674PhosphoserineBy similarity1
Modified residuei1189PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q70EL1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q70EL1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q70EL1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q70EL1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q70EL1

PeptideAtlas

More...PeptideAtlasi		Q70EL1

PRoteomics IDEntifications database

More...PRIDEi		Q70EL1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68538 [Q70EL1-1]
68539 [Q70EL1-10]
68540 [Q70EL1-4]
68541 [Q70EL1-6]
68542 [Q70EL1-7]
68543 [Q70EL1-8]
68544 [Q70EL1-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q70EL1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q70EL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in a few tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166348 Expressed in corpus callosum and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q70EL1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q70EL1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166348 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 6 [Q70EL1-9]
With#Exp.IntAct
Q96EJ43EBI-11975223,EBI-750454
ANKRD11 [X5D778]3EBI-11975223,EBI-17183751
ANKS1A [Q49AR9]3EBI-11975223,EBI-11954519
ARMC7 [Q9H6L4]3EBI-11975223,EBI-742909
ATXN1 [P54253]3EBI-11975223,EBI-930964
ATXN1L [P0C7T5]3EBI-11975223,EBI-8624731
BFSP2 [Q13515]3EBI-11975223,EBI-10229433
BHLHE40 [O14503]3EBI-11975223,EBI-711810
CARD10 [Q9BWT7]3EBI-11975223,EBI-3866279
CCDC13 [Q8IYE1]3EBI-11975223,EBI-10961312
CCDC24 [Q8N4L8]3EBI-11975223,EBI-1104933
CCNK - isoform 2 [O75909-2]3EBI-11975223,EBI-12010594
CDC23 [Q9UJX2]3EBI-11975223,EBI-396137
CHCHD2 [Q9Y6H1]3EBI-11975223,EBI-2321769
CHERP [Q8IWX8]3EBI-11975223,EBI-2555370
CSTF2 [P33240]3EBI-11975223,EBI-711360
CYSRT1 [A8MQ03]3EBI-11975223,EBI-3867333
DMRT3 [Q9NQL9]3EBI-11975223,EBI-9679045
DOK6 [Q6PKX4]3EBI-11975223,EBI-2880244
DTX2 [Q86UW9]3EBI-11975223,EBI-740376
EPM2AIP1 [Q7L775]3EBI-11975223,EBI-6255981
EXOC8 [Q8IYI6]3EBI-11975223,EBI-742102
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-11975223,EBI-11986315
FBXO17 [Q96EF6]3EBI-11975223,EBI-2510157
FNDC3B - isoform 3 [Q53EP0-3]3EBI-11975223,EBI-10242151
FOXI1 - isoform 2 [Q12951-2]3EBI-11975223,EBI-12018822
GCM2 [O75603]3EBI-11975223,EBI-10188645
HGS [O14964]3EBI-11975223,EBI-740220
HNF1B [P35680]3EBI-11975223,EBI-2798841
HNRNPF [P52597]3EBI-11975223,EBI-352986
HOXC8 [P31273]3EBI-11975223,EBI-1752118
IGFN1 - isoform 5 [Q86VF2-5]3EBI-11975223,EBI-11955401
INSC [Q1MX18]3EBI-11975223,EBI-12081118
KCTD9 [Q7L273]3EBI-11975223,EBI-4397613
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11975223,EBI-11742507
LNX1 [Q8TBB1]3EBI-11975223,EBI-739832
MED25 [Q71SY5]3EBI-11975223,EBI-394558
MID2 - isoform 2 [Q9UJV3-2]3EBI-11975223,EBI-10172526
NUDT22 [Q9BRQ3]3EBI-11975223,EBI-10297093
OIP5 [O43482]3EBI-11975223,EBI-536879
OTX1 [P32242]3EBI-11975223,EBI-740446
PCSK5 - isoform PC6A [Q92824-2]3EBI-11975223,EBI-11956269
PHF1 [O43189]3EBI-11975223,EBI-530034
PLA2G6 [O60733]3EBI-11975223,EBI-12089905
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-11975223,EBI-12014286
POLR1C [O15160]3EBI-11975223,EBI-1055079
PRDM6 [Q9NQX0]3EBI-11975223,EBI-11320284
PRKAB2 [O43741]3EBI-11975223,EBI-1053424
PRR35 [P0CG20]3EBI-11975223,EBI-11986293
QRICH1 [Q2TAL8]3EBI-11975223,EBI-2798044
RACK1 [P63244]3EBI-11975223,EBI-296739
RAMAC [Q9BTL3]3EBI-11975223,EBI-744023
RBPMS2 [Q6ZRY4]3EBI-11975223,EBI-11987469
RHOBTB3 [O94955]3EBI-11975223,EBI-2367123
RNF208 [Q9H0X6]3EBI-11975223,EBI-751555
SEC24A - isoform 2 [O95486-2]3EBI-11975223,EBI-12320085
SHARPIN - isoform 2 [Q9H0F6-2]3EBI-11975223,EBI-9843813
SHC3 [Q92529]3EBI-11975223,EBI-79084
SMARCD1 [Q96GM5]3EBI-11975223,EBI-358489
SMYD1 [Q8NB12]3EBI-11975223,EBI-8463848
SNRPB - isoform SM-B [P14678-2]3EBI-11975223,EBI-372475
SS18L1 - isoform 5 [O75177-5]3EBI-11975223,EBI-12035119
STK16 [O75716]3EBI-11975223,EBI-749295
TBX6 [O95947]3EBI-11975223,EBI-2824328
TCEA2 [Q15560]3EBI-11975223,EBI-710310
TEKT5 [Q96M29]3EBI-11975223,EBI-10239812
TENT5B [Q96A09]3EBI-11975223,EBI-752030
TFAP2D [Q7Z6R9]3EBI-11975223,EBI-11952651
TLE5 - isoform 2 [Q08117-2]3EBI-11975223,EBI-11741437
TNS2 [Q63HR2]3EBI-11975223,EBI-949753
TOLLIP [Q9H0E2]3EBI-11975223,EBI-74615
TSEN15 [Q8WW01]3EBI-11975223,EBI-372432
TSSK3 [Q96PN8]3EBI-11975223,EBI-3918381
TTC19 [Q6DKK2]3EBI-11975223,EBI-948354
USP2 [O75604]3EBI-11975223,EBI-743272
VENTX [O95231]3EBI-11975223,EBI-10191303
ZCCHC14 [Q8WYQ9]3EBI-11975223,EBI-3937908
ZNF148 - isoform 2 [Q9UQR1-2]3EBI-11975223,EBI-11742222
ZNF76 [P36508]3EBI-11975223,EBI-7254550
Q70EL1
With#Exp.IntAct
ATXN1 [P54253]3EBI-946185,EBI-930964
EIF4E2 [O60573]3EBI-946185,EBI-398610
NXT2 [Q9NPJ8]3EBI-946185,EBI-752122

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127739, 57 interactors

Protein interaction database and analysis system

More...IntActi		Q70EL1, 130 interactors

Molecular INTeraction database

More...MINTi		Q70EL1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345216

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q70EL1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 352USPAdd BLAST322

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili736 – 770Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi559 – 570Poly-SerAdd BLAST12
Compositional biasi866 – 869Poly-Gln4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1887 Eukaryota
ENOG410XSNE LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004234_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q70EL1

Identification of Orthologs from Complete Genome Data

More...OMAi		YGAENFH

Database of Orthologous Groups

More...OrthoDBi		101145at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q70EL1

TreeFam database of animal gene trees

More...TreeFami		TF336130

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040142 USP54
IPR028889 USP_dom

The PANTHER Classification System

More...PANTHERi		PTHR22975:SF5 PTHR22975:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70EL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV 
        60         70         80         90        100
LWHLDIFRRS FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR 
       110        120        130        140        150
SALAKTFQDE QRFQLGIMDD AAECFENLLM RIHFHIADET KEDICTAQHC 
       160        170        180        190        200
ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ MVHYISTTSL CNQAICMLER 
       210        220        230        240        250
REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM NAPQIITIGL 
       260        270        280        290        300
VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG 
       310        320        330        340        350
KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA 
       360        370        380        390        400
DPQGTPVSTQ DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY 
       410        420        430        440        450
PYKHSHHESV VSHFSSDSQG TVIYNVENDS MSQSSRDTGH LTDSECNQKH 
       460        470        480        490        500
TSKKGSLIER KRSSGRVRRK GDEPQASGYH SEGETLKEKQ APRNASKPSS 
       510        520        530        540        550
STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP DKKPPRTLPL 
       560        570        580        590        600
HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT 
       610        620        630        640        650
QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ 
       660        670        680        690        700
HPRLIQRMES GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS 
       710        720        730        740        750
WRHIPKSHSS SILEVDSTAS MGGWTKSQPF SGEEISSKSE LDELQEEVAR 
       760        770        780        790        800
RAQEQELRRK REKELEAAKG FNPHPSRFMD LDELQNQGRS DGFERSLQEA 
       810        820        830        840        850
ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS THSRALVDKK 
       860        870        880        890        900
LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ 
       910        920        930        940        950
VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR 
       960        970        980        990       1000
SALKLLTSVE VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ 
      1010       1020       1030       1040       1050
GSRCDNSSCS KLPPQEGRGI AQEQLFQEKK DPANPSPVMP GIATSERGDE 
      1060       1070       1080       1090       1100
HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS SFVLHCPDPV QKTNQCLQGQ 
      1110       1120       1130       1140       1150
SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ GVSMRDSTGF 
      1160       1170       1180       1190       1200
KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE 
      1210       1220       1230       1240       1250
ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS 
      1260       1270       1280       1290       1300
STDLGTSLPL DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN 
      1310       1320       1330       1340       1350
HILLHPHWNQ DTEQETSELE SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT 
      1360       1370       1380       1390       1400
GSADGMGRRL HSAHDPGLSK TSTAEMEHGL HEARTVRTSQ ATPCRGLSRE 
      1410       1420       1430       1440       1450
CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS NVRKPLETGH 
      1460       1470       1480       1490       1500
RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT 
      1510       1520       1530       1540       1550
SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ 
      1560       1570       1580       1590       1600
HIGTRFLTTP GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV 
      1610       1620       1630       1640       1650
HPVYPPSSSL HVPLRSAWNS DPVPGSRTPG PRRVDMPPDD DWRQSSYASH 
      1660       1670       1680 
SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW
Length:1,684
Mass (Da):187,388
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i853D9CFCB35C63C4
GO
Isoform 2 (identifier: Q70EL1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-403: REPSISSDTRTDSSTESYPYK → EQPGSLPLLSPHPMRSNSWDS
     404-1684: Missing.

Show »
Length:403
Mass (Da):45,703
Checksum:i2749CBBCC8AF37A9
GO
Isoform 3 (identifier: Q70EL1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     893-893: S → R
     894-1684: Missing.

Show »
Length:893
Mass (Da):100,476
Checksum:i7D1C84A450FEB447
GO
Isoform 4 (identifier: Q70EL1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-275: Missing.

Show »
Length:1,534
Mass (Da):170,581
Checksum:iB00DC48D0DE75BC3
GO
Isoform 5 (identifier: Q70EL1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.

Show »
Length:772
Mass (Da):84,938
Checksum:iA41B0ACF854B4AF2
GO
Isoform 6 (identifier: Q70EL1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1391-1437: Missing.

Show »
Length:725
Mass (Da):79,771
Checksum:i98EFA86D1005C89F
GO
Isoform 7 (identifier: Q70EL1-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1386-1390: Missing.

Show »
Length:767
Mass (Da):84,366
Checksum:iC622D8C5CE11DDF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RHN7X6RHN7_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1E9H7C1E9_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C296H7C296_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN32R4GN32_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
412Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RH50X6RH50_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGF2X6RGF2_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04393 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG53943 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BX649087 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110 – 111EQ → KE in BX649087 (PubMed:17974005).Curated2
Sequence conflicti191C → S in CAE47747 (PubMed:14715245).Curated1
Sequence conflicti226P → L in BX649087 (PubMed:17974005).Curated1
Sequence conflicti733E → G in BX649087 (PubMed:17974005).Curated1
Sequence conflicti1345H → P in BAC04393 (PubMed:14702039).Curated1
Sequence conflicti1425S → P in BAC86566 (PubMed:14702039).Curated1
Sequence conflicti1438D → H in AAI30634 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036360505L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047258976K → E. Corresponds to variant dbSNP:rs1618542Ensembl.1
Natural variantiVAR_0472591231D → N. Corresponds to variant dbSNP:rs4619071Ensembl.1
Natural variantiVAR_0472601367G → D. Corresponds to variant dbSNP:rs7083344Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0356741 – 912Missing in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST912
Alternative sequenceiVSP_029922126 – 275Missing in isoform 4. CuratedAdd BLAST150
Alternative sequenceiVSP_026525383 – 403REPSI…SYPYK → EQPGSLPLLSPHPMRSNSWD S in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_026526404 – 1684Missing in isoform 2. 1 PublicationAdd BLAST1281
Alternative sequenceiVSP_035675893S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_035676894 – 1684Missing in isoform 3. 1 PublicationAdd BLAST791
Alternative sequenceiVSP_0356771386 – 1390Missing in isoform 7. 1 Publication5
Alternative sequenceiVSP_0356781391 – 1437Missing in isoform 6. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ583820 mRNA Translation: CAE47747.1
AK094637 mRNA Translation: BAC04393.1 Different initiation.
AK123711 mRNA Translation: BAG53943.1 Different initiation.
AK126497 mRNA Translation: BAC86566.1
AK127213 mRNA Translation: BAC86886.1
AK127267 mRNA Translation: BAC86907.1
BX649087 mRNA No translation available.
AC073389 Genomic DNA No translation available.
AL359074 Genomic DNA No translation available.
BC064967 mRNA Translation: AAH64967.1
BC130633 mRNA Translation: AAI30634.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7329.2 [Q70EL1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001307366.1, NM_001320437.1
NP_689799.3, NM_152586.3 [Q70EL1-1]
XP_016871263.1, XM_017015774.1 [Q70EL1-1]
XP_016871264.1, XM_017015775.1 [Q70EL1-1]
XP_016871265.1, XM_017015776.1
XP_016871266.1, XM_017015777.1 [Q70EL1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339859; ENSP00000345216; ENSG00000166348 [Q70EL1-1]
ENST00000422491; ENSP00000407368; ENSG00000166348 [Q70EL1-9]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		159195

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:159195

UCSC genome browser

More...UCSCi		uc001juo.4 human [Q70EL1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583820 mRNA Translation: CAE47747.1
AK094637 mRNA Translation: BAC04393.1 Different initiation.
AK123711 mRNA Translation: BAG53943.1 Different initiation.
AK126497 mRNA Translation: BAC86566.1
AK127213 mRNA Translation: BAC86886.1
AK127267 mRNA Translation: BAC86907.1
BX649087 mRNA No translation available.
AC073389 Genomic DNA No translation available.
AL359074 Genomic DNA No translation available.
BC064967 mRNA Translation: AAH64967.1
BC130633 mRNA Translation: AAI30634.1
CCDSiCCDS7329.2 [Q70EL1-1]
RefSeqiNP_001307366.1, NM_001320437.1
NP_689799.3, NM_152586.3 [Q70EL1-1]
XP_016871263.1, XM_017015774.1 [Q70EL1-1]
XP_016871264.1, XM_017015775.1 [Q70EL1-1]
XP_016871265.1, XM_017015776.1
XP_016871266.1, XM_017015777.1 [Q70EL1-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi127739, 57 interactors
IntActiQ70EL1, 130 interactors
MINTiQ70EL1
STRINGi9606.ENSP00000345216

Protein family/group databases

MEROPSiC19.080

PTM databases

iPTMnetiQ70EL1
PhosphoSitePlusiQ70EL1

Polymorphism and mutation databases

BioMutaiUSP54
DMDMi215274237

Proteomic databases

EPDiQ70EL1
jPOSTiQ70EL1
MassIVEiQ70EL1
MaxQBiQ70EL1
PaxDbiQ70EL1
PeptideAtlasiQ70EL1
PRIDEiQ70EL1
ProteomicsDBi68538 [Q70EL1-1]
68539 [Q70EL1-10]
68540 [Q70EL1-4]
68541 [Q70EL1-6]
68542 [Q70EL1-7]
68543 [Q70EL1-8]
68544 [Q70EL1-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54962 73 antibodies

Genome annotation databases

EnsembliENST00000339859; ENSP00000345216; ENSG00000166348 [Q70EL1-1]
ENST00000422491; ENSP00000407368; ENSG00000166348 [Q70EL1-9]
GeneIDi159195
KEGGihsa:159195
UCSCiuc001juo.4 human [Q70EL1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		159195
DisGeNETi159195

GeneCards: human genes, protein and diseases

More...GeneCardsi		USP54
HGNCiHGNC:23513 USP54
HPAiENSG00000166348 Tissue enhanced (brain)
neXtProtiNX_Q70EL1
OpenTargetsiENSG00000166348
PharmGKBiPA134959960

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1887 Eukaryota
ENOG410XSNE LUCA
GeneTreeiENSGT00940000155571
HOGENOMiCLU_004234_0_0_1
InParanoidiQ70EL1
OMAiYGAENFH
OrthoDBi101145at2759
PhylomeDBiQ70EL1
TreeFamiTF336130

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		USP54 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		159195
PharosiQ70EL1 Tdark

Protein Ontology

More...PROi		PR:Q70EL1
RNActiQ70EL1 protein

Gene expression databases

BgeeiENSG00000166348 Expressed in corpus callosum and 197 other tissues
ExpressionAtlasiQ70EL1 baseline and differential
GenevisibleiQ70EL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040142 USP54
IPR028889 USP_dom
PANTHERiPTHR22975:SF5 PTHR22975:SF5, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70EL1
Secondary accession number(s): A1L4Q4
, A3KFK3, A3KFK5, A3KFK6, A3KFK7, A6PVS4, A6PVS5, A6PVS6, A6PVS7, B3KVY1, B9ZVM1, Q5F2F4, Q6P1N6, Q6ZSP1, Q6ZSR1, Q6ZTM0, Q8N1X2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 25, 2008
Last modified: April 22, 2020
This is version 126 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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