Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 123 (16 Oct 2019)
Sequence version 4 (25 Nov 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Inactive ubiquitin carboxyl-terminal hydrolase 54

Gene

USP54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has no peptidase activity.

Caution

Although the active site residues are conserved, it lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 54
Alternative name(s):
Inactive ubiquitin-specific peptidase 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP54
Synonyms:C10orf29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23513 USP54

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q70EL1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
159195

Open Targets

More...
OpenTargetsi
ENSG00000166348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134959960

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q70EL1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP54

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274237

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495301 – 1684Inactive ubiquitin carboxyl-terminal hydrolase 54Add BLAST1684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12Omega-N-methylarginineBy similarity1
Modified residuei481PhosphoserineBy similarity1
Modified residuei603PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei674PhosphoserineBy similarity1
Modified residuei1189PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q70EL1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q70EL1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q70EL1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q70EL1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q70EL1

PeptideAtlas

More...
PeptideAtlasi
Q70EL1

PRoteomics IDEntifications database

More...
PRIDEi
Q70EL1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68538 [Q70EL1-1]
68539 [Q70EL1-10]
68540 [Q70EL1-4]
68541 [Q70EL1-6]
68542 [Q70EL1-7]
68543 [Q70EL1-8]
68544 [Q70EL1-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70EL1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70EL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in a few tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166348 Expressed in 198 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q70EL1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q70EL1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047663

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127739, 49 interactors

Protein interaction database and analysis system

More...
IntActi
Q70EL1, 131 interactors

Molecular INTeraction database

More...
MINTi
Q70EL1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345216

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 352USPAdd BLAST322

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili736 – 770Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi559 – 570Poly-SerAdd BLAST12
Compositional biasi866 – 869Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1887 Eukaryota
ENOG410XSNE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155571

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70EL1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YGAENFH

Database of Orthologous Groups

More...
OrthoDBi
101145at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70EL1

TreeFam database of animal gene trees

More...
TreeFami
TF336130

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040142 USP54
IPR028889 USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22975:SF5 PTHR22975:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70EL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV
60 70 80 90 100
LWHLDIFRRS FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR
110 120 130 140 150
SALAKTFQDE QRFQLGIMDD AAECFENLLM RIHFHIADET KEDICTAQHC
160 170 180 190 200
ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ MVHYISTTSL CNQAICMLER
210 220 230 240 250
REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM NAPQIITIGL
260 270 280 290 300
VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG
310 320 330 340 350
KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA
360 370 380 390 400
DPQGTPVSTQ DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY
410 420 430 440 450
PYKHSHHESV VSHFSSDSQG TVIYNVENDS MSQSSRDTGH LTDSECNQKH
460 470 480 490 500
TSKKGSLIER KRSSGRVRRK GDEPQASGYH SEGETLKEKQ APRNASKPSS
510 520 530 540 550
STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP DKKPPRTLPL
560 570 580 590 600
HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT
610 620 630 640 650
QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ
660 670 680 690 700
HPRLIQRMES GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS
710 720 730 740 750
WRHIPKSHSS SILEVDSTAS MGGWTKSQPF SGEEISSKSE LDELQEEVAR
760 770 780 790 800
RAQEQELRRK REKELEAAKG FNPHPSRFMD LDELQNQGRS DGFERSLQEA
810 820 830 840 850
ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS THSRALVDKK
860 870 880 890 900
LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ
910 920 930 940 950
VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR
960 970 980 990 1000
SALKLLTSVE VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ
1010 1020 1030 1040 1050
GSRCDNSSCS KLPPQEGRGI AQEQLFQEKK DPANPSPVMP GIATSERGDE
1060 1070 1080 1090 1100
HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS SFVLHCPDPV QKTNQCLQGQ
1110 1120 1130 1140 1150
SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ GVSMRDSTGF
1160 1170 1180 1190 1200
KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE
1210 1220 1230 1240 1250
ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS
1260 1270 1280 1290 1300
STDLGTSLPL DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN
1310 1320 1330 1340 1350
HILLHPHWNQ DTEQETSELE SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT
1360 1370 1380 1390 1400
GSADGMGRRL HSAHDPGLSK TSTAEMEHGL HEARTVRTSQ ATPCRGLSRE
1410 1420 1430 1440 1450
CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS NVRKPLETGH
1460 1470 1480 1490 1500
RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT
1510 1520 1530 1540 1550
SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ
1560 1570 1580 1590 1600
HIGTRFLTTP GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV
1610 1620 1630 1640 1650
HPVYPPSSSL HVPLRSAWNS DPVPGSRTPG PRRVDMPPDD DWRQSSYASH
1660 1670 1680
SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW
Length:1,684
Mass (Da):187,388
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i853D9CFCB35C63C4
GO
Isoform 2 (identifier: Q70EL1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-403: REPSISSDTRTDSSTESYPYK → EQPGSLPLLSPHPMRSNSWDS
     404-1684: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,703
Checksum:i2749CBBCC8AF37A9
GO
Isoform 3 (identifier: Q70EL1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     893-893: S → R
     894-1684: Missing.

Note: No experimental confirmation available.
Show »
Length:893
Mass (Da):100,476
Checksum:i7D1C84A450FEB447
GO
Isoform 4 (identifier: Q70EL1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-275: Missing.

Note: No experimental confirmation available.
Show »
Length:1,534
Mass (Da):170,581
Checksum:iB00DC48D0DE75BC3
GO
Isoform 5 (identifier: Q70EL1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.

Show »
Length:772
Mass (Da):84,938
Checksum:iA41B0ACF854B4AF2
GO
Isoform 6 (identifier: Q70EL1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1391-1437: Missing.

Show »
Length:725
Mass (Da):79,771
Checksum:i98EFA86D1005C89F
GO
Isoform 7 (identifier: Q70EL1-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1386-1390: Missing.

Show »
Length:767
Mass (Da):84,366
Checksum:iC622D8C5CE11DDF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RHN7X6RHN7_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1E9H7C1E9_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C296H7C296_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN32R4GN32_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
412Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RH50X6RH50_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGF2X6RGF2_HUMAN
Inactive ubiquitin carboxyl-termina...
USP54
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04393 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG53943 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BX649087 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110 – 111EQ → KE in BX649087 (PubMed:17974005).Curated2
Sequence conflicti191C → S in CAE47747 (PubMed:14715245).Curated1
Sequence conflicti226P → L in BX649087 (PubMed:17974005).Curated1
Sequence conflicti733E → G in BX649087 (PubMed:17974005).Curated1
Sequence conflicti1345H → P in BAC04393 (PubMed:14702039).Curated1
Sequence conflicti1425S → P in BAC86566 (PubMed:14702039).Curated1
Sequence conflicti1438D → H in AAI30634 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036360505L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047258976K → E. Corresponds to variant dbSNP:rs1618542Ensembl.1
Natural variantiVAR_0472591231D → N. Corresponds to variant dbSNP:rs4619071Ensembl.1
Natural variantiVAR_0472601367G → D. Corresponds to variant dbSNP:rs7083344Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0356741 – 912Missing in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST912
Alternative sequenceiVSP_029922126 – 275Missing in isoform 4. CuratedAdd BLAST150
Alternative sequenceiVSP_026525383 – 403REPSI…SYPYK → EQPGSLPLLSPHPMRSNSWD S in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_026526404 – 1684Missing in isoform 2. 1 PublicationAdd BLAST1281
Alternative sequenceiVSP_035675893S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_035676894 – 1684Missing in isoform 3. 1 PublicationAdd BLAST791
Alternative sequenceiVSP_0356771386 – 1390Missing in isoform 7. 1 Publication5
Alternative sequenceiVSP_0356781391 – 1437Missing in isoform 6. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ583820 mRNA Translation: CAE47747.1
AK094637 mRNA Translation: BAC04393.1 Different initiation.
AK123711 mRNA Translation: BAG53943.1 Different initiation.
AK126497 mRNA Translation: BAC86566.1
AK127213 mRNA Translation: BAC86886.1
AK127267 mRNA Translation: BAC86907.1
BX649087 mRNA No translation available.
AC073389 Genomic DNA No translation available.
AL359074 Genomic DNA No translation available.
BC064967 mRNA Translation: AAH64967.1
BC130633 mRNA Translation: AAI30634.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7329.2 [Q70EL1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001307366.1, NM_001320437.1
NP_689799.3, NM_152586.3 [Q70EL1-1]
XP_016871263.1, XM_017015774.1 [Q70EL1-1]
XP_016871264.1, XM_017015775.1 [Q70EL1-1]
XP_016871265.1, XM_017015776.1
XP_016871266.1, XM_017015777.1 [Q70EL1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339859; ENSP00000345216; ENSG00000166348 [Q70EL1-1]
ENST00000422491; ENSP00000407368; ENSG00000166348 [Q70EL1-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
159195

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:159195

UCSC genome browser

More...
UCSCi
uc001juo.4 human [Q70EL1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583820 mRNA Translation: CAE47747.1
AK094637 mRNA Translation: BAC04393.1 Different initiation.
AK123711 mRNA Translation: BAG53943.1 Different initiation.
AK126497 mRNA Translation: BAC86566.1
AK127213 mRNA Translation: BAC86886.1
AK127267 mRNA Translation: BAC86907.1
BX649087 mRNA No translation available.
AC073389 Genomic DNA No translation available.
AL359074 Genomic DNA No translation available.
BC064967 mRNA Translation: AAH64967.1
BC130633 mRNA Translation: AAI30634.1
CCDSiCCDS7329.2 [Q70EL1-1]
RefSeqiNP_001307366.1, NM_001320437.1
NP_689799.3, NM_152586.3 [Q70EL1-1]
XP_016871263.1, XM_017015774.1 [Q70EL1-1]
XP_016871264.1, XM_017015775.1 [Q70EL1-1]
XP_016871265.1, XM_017015776.1
XP_016871266.1, XM_017015777.1 [Q70EL1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127739, 49 interactors
IntActiQ70EL1, 131 interactors
MINTiQ70EL1
STRINGi9606.ENSP00000345216

Protein family/group databases

MEROPSiC19.080

PTM databases

iPTMnetiQ70EL1
PhosphoSitePlusiQ70EL1

Polymorphism and mutation databases

BioMutaiUSP54
DMDMi215274237

Proteomic databases

EPDiQ70EL1
jPOSTiQ70EL1
MassIVEiQ70EL1
MaxQBiQ70EL1
PaxDbiQ70EL1
PeptideAtlasiQ70EL1
PRIDEiQ70EL1
ProteomicsDBi68538 [Q70EL1-1]
68539 [Q70EL1-10]
68540 [Q70EL1-4]
68541 [Q70EL1-6]
68542 [Q70EL1-7]
68543 [Q70EL1-8]
68544 [Q70EL1-9]

Genome annotation databases

EnsembliENST00000339859; ENSP00000345216; ENSG00000166348 [Q70EL1-1]
ENST00000422491; ENSP00000407368; ENSG00000166348 [Q70EL1-9]
GeneIDi159195
KEGGihsa:159195
UCSCiuc001juo.4 human [Q70EL1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
159195
DisGeNETi159195

GeneCards: human genes, protein and diseases

More...
GeneCardsi
USP54
HGNCiHGNC:23513 USP54
HPAiHPA047663
neXtProtiNX_Q70EL1
OpenTargetsiENSG00000166348
PharmGKBiPA134959960

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1887 Eukaryota
ENOG410XSNE LUCA
GeneTreeiENSGT00940000155571
InParanoidiQ70EL1
OMAiYGAENFH
OrthoDBi101145at2759
PhylomeDBiQ70EL1
TreeFamiTF336130

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
USP54 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
159195
PharosiQ70EL1

Protein Ontology

More...
PROi
PR:Q70EL1

Gene expression databases

BgeeiENSG00000166348 Expressed in 198 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ70EL1 baseline and differential
GenevisibleiQ70EL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040142 USP54
IPR028889 USP_dom
PANTHERiPTHR22975:SF5 PTHR22975:SF5, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP54_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70EL1
Secondary accession number(s): A1L4Q4
, A3KFK3, A3KFK5, A3KFK6, A3KFK7, A6PVS4, A6PVS5, A6PVS6, A6PVS7, B3KVY1, B9ZVM1, Q5F2F4, Q6P1N6, Q6ZSP1, Q6ZSR1, Q6ZTM0, Q8N1X2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 25, 2008
Last modified: October 16, 2019
This is version 123 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again