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Entry version 121 (13 Feb 2019)
Sequence version 2 (07 Feb 2006)
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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 53

Gene

USP53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).By similarity1 Publication

Caution

Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 53
Alternative name(s):
Inactive ubiquitin-specific peptidase 53
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP53Imported
Synonyms:KIAA1350Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145390.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29255 USP53

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617431 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q70EK8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54532

Open Targets

More...
OpenTargetsi
ENSG00000145390

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134940368

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP53

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88943889

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806811 – 1073Inactive ubiquitin carboxyl-terminal hydrolase 53Add BLAST1073

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q70EK8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q70EK8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q70EK8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q70EK8

PeptideAtlas

More...
PeptideAtlasi
Q70EK8

PRoteomics IDEntifications database

More...
PRIDEi
Q70EK8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68536

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70EK8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70EK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145390 Expressed in 200 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q70EK8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q70EK8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035844
HPA035845

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the C-terminal region) with the heterodimer TJP1:TJP2.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120020, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q70EK8, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274030

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q70EK8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 351USPAdd BLAST322

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1887 Eukaryota
ENOG410XSNE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236318

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080701

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70EK8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIRCHFQ

Database of Orthologous Groups

More...
OrthoDBi
101145at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70EK8

TreeFam database of animal gene trees

More...
TreeFami
TF323194

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040143 USP53
IPR028889 USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22975:SF6 PTHR22975:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q70EK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWVKFLRKP GGNLGKVYQP GSMLSLAPTK GLLNEPGQNS CFLNSAVQVL
60 70 80 90 100
WQLDIFRRSL RVLTGHVCQG DACIFCALKT IFAQFQHSRE KALPSDNIRH
110 120 130 140 150
ALAESFKDEQ RFQLGLMDDA AECFENMLER IHFHIVPSRD ADMCTSKSCI
160 170 180 190 200
THQKFAMTLY EQCVCRSCGA SSDPLPFTEF VRYISTTALC NEVERMLERH
210 220 230 240 250
ERFKPEMFAE LLQAANTTDD YRKCPSNCGQ KIKIRRVLMN CPEIVTIGLV
260 270 280 290 300
WDSEHSDLTE AVVRNLATHL YLPGLFYRVT DENAKNSELN LVGMICYTSQ
310 320 330 340 350
HYCAFAFHTK SSKWVFFDDA NVKEIGTRWK DVVSKCIRCH FQPLLLFYAN
360 370 380 390 400
PDGTAVSTED ALRQVISWSH YKSVAENMGC EKPVIHKSDN LKENGFGDQA
410 420 430 440 450
KQRENQKFPT DNISSSNRSH SHTGVGKGPA KLSHIDQREK IKDISRECAL
460 470 480 490 500
KAIEQKNLLS SQRKDLEKGQ RKDLGRHRDL VDEDLSHFQS GSPPAPNGFK
510 520 530 540 550
QHGNPHLYHS QGKGSYKHDR VVPQSRASAQ IISSSKSQIL APGEKITGKV
560 570 580 590 600
KSDNGTGYDT DSSQDSRDRG NSCDSSSKSR NRGWKPMRET LNVDSIFSES
610 620 630 640 650
EKRQHSPRHK PNISNKPKSS KDPSFSNWPK ENPKQKGLMT IYEDEMKQEI
660 670 680 690 700
GSRSSLESNG KGAEKNKGLV EGKVHGDNWQ MQRTESGYES SDHISNGSTN
710 720 730 740 750
LDSPVIDGNG TVMDISGVKE TVCFSDQITT SNLNKERGDC TSLQSQHHLE
760 770 780 790 800
GFRKELRNLE AGYKSHEFHP ESHLQIKNHL IKRSHVHEDN GKLFPSSSLQ
810 820 830 840 850
IPKDHNAREH IHQSDEQKLE KPNECKFSEW LNIENSERTG LPFHVDNSAS
860 870 880 890 900
GKRVNSNEPS SLWSSHLRTV GLKPETAPLI QQQNIMDQCY FENSLSTECI
910 920 930 940 950
IRSASRSDGC QMPKLFCQNL PPPLPPKKYA ITSVPQSEKS ESTPDVKLTE
960 970 980 990 1000
VFKATSHLPK HSLSTASEPS LEVSTHMNDE RHKETFQVRE CFGNTPNCPS
1010 1020 1030 1040 1050
SSSTNDFQAN SGAIDAFCQP ELDSISTCPN ETVSLTTYFS VDSCMTDTYR
1060 1070
LKYHQRPKLS FPESSGFCNN SLS
Length:1,073
Mass (Da):120,806
Last modified:February 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A5E8B0AB4158878
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF54D6RF54_HUMAN
Inactive ubiquitin carboxyl-termina...
USP53
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8Q1H0Y8Q1_HUMAN
Inactive ubiquitin carboxyl-termina...
USP53
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17382 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190Missing in CAE47751 (PubMed:14715245).Curated1
Sequence conflicti209A → V in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti276F → FF in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti611P → A in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti869T → G in AAH17382 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051541962S → R1 PublicationCorresponds to variant dbSNP:rs3749591Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ583824 mRNA Translation: CAE47751.1
CR749490 mRNA Translation: CAH18315.1
AB037771 mRNA Translation: BAA92588.1
BC017382 mRNA Translation: AAH17382.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43265.1

NCBI Reference Sequences

More...
RefSeqi
NP_061923.2, NM_019050.2
XP_005263130.1, XM_005263073.3
XP_011530339.1, XM_011532037.2
XP_016863801.1, XM_017008312.1
XP_016863802.1, XM_017008313.1
XP_016863803.1, XM_017008314.1
XP_016863804.1, XM_017008315.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.431081
Hs.595368

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274030; ENSP00000274030; ENSG00000145390
ENST00000450251; ENSP00000409906; ENSG00000145390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54532

UCSC genome browser

More...
UCSCi
uc003icr.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583824 mRNA Translation: CAE47751.1
CR749490 mRNA Translation: CAH18315.1
AB037771 mRNA Translation: BAA92588.1
BC017382 mRNA Translation: AAH17382.1 Different initiation.
CCDSiCCDS43265.1
RefSeqiNP_061923.2, NM_019050.2
XP_005263130.1, XM_005263073.3
XP_011530339.1, XM_011532037.2
XP_016863801.1, XM_017008312.1
XP_016863802.1, XM_017008313.1
XP_016863803.1, XM_017008314.1
XP_016863804.1, XM_017008315.1
UniGeneiHs.431081
Hs.595368

3D structure databases

ProteinModelPortaliQ70EK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120020, 30 interactors
IntActiQ70EK8, 27 interactors
STRINGi9606.ENSP00000274030

Protein family/group databases

MEROPSiC19.081

PTM databases

iPTMnetiQ70EK8
PhosphoSitePlusiQ70EK8

Polymorphism and mutation databases

BioMutaiUSP53
DMDMi88943889

Proteomic databases

EPDiQ70EK8
jPOSTiQ70EK8
MaxQBiQ70EK8
PaxDbiQ70EK8
PeptideAtlasiQ70EK8
PRIDEiQ70EK8
ProteomicsDBi68536

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54532
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274030; ENSP00000274030; ENSG00000145390
ENST00000450251; ENSP00000409906; ENSG00000145390
GeneIDi54532
KEGGihsa:54532
UCSCiuc003icr.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54532
DisGeNETi54532
EuPathDBiHostDB:ENSG00000145390.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
USP53

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004467
HGNCiHGNC:29255 USP53
HPAiHPA035844
HPA035845
MIMi617431 gene
neXtProtiNX_Q70EK8
OpenTargetsiENSG00000145390
PharmGKBiPA134940368

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1887 Eukaryota
ENOG410XSNE LUCA
GeneTreeiENSGT00940000156337
HOGENOMiHOG000236318
HOVERGENiHBG080701
InParanoidiQ70EK8
OMAiCIRCHFQ
OrthoDBi101145at2759
PhylomeDBiQ70EK8
TreeFamiTF323194

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
USP53 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
USP53

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54532

Protein Ontology

More...
PROi
PR:Q70EK8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145390 Expressed in 200 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ70EK8 baseline and differential
GenevisibleiQ70EK8 HS

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040143 USP53
IPR028889 USP_dom
PANTHERiPTHR22975:SF6 PTHR22975:SF6, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP53_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70EK8
Secondary accession number(s): Q68DA5, Q8WVQ5, Q9P2J7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: February 13, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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