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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 53

Gene

USP53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).By similarity1 Publication

Caution

Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

GO - Biological processi

Protein family/group databases

MEROPSiC19.081

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 53
Alternative name(s):
Inactive ubiquitin-specific peptidase 53
Gene namesi
Name:USP53Imported
Synonyms:KIAA1350Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145390.11
HGNCiHGNC:29255 USP53
MIMi617431 gene
neXtProtiNX_Q70EK8

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi54532
OpenTargetsiENSG00000145390
PharmGKBiPA134940368

Polymorphism and mutation databases

BioMutaiUSP53
DMDMi88943889

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806811 – 1073Inactive ubiquitin carboxyl-terminal hydrolase 53Add BLAST1073

Proteomic databases

EPDiQ70EK8
MaxQBiQ70EK8
PaxDbiQ70EK8
PeptideAtlasiQ70EK8
PRIDEiQ70EK8
ProteomicsDBi68536

PTM databases

iPTMnetiQ70EK8
PhosphoSitePlusiQ70EK8

Expressioni

Tissue specificityi

Expressed predominantly in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000145390 Expressed in 200 organ(s), highest expression level in oviduct epithelium
CleanExiHS_USP53
ExpressionAtlasiQ70EK8 baseline and differential
GenevisibleiQ70EK8 HS

Organism-specific databases

HPAiHPA035844
HPA035845

Interactioni

Subunit structurei

Interacts (via the C-terminal region) with the heterodimer TJP1:TJP2.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi120020, 27 interactors
IntActiQ70EK8, 27 interactors
STRINGi9606.ENSP00000274030

Structurei

3D structure databases

ProteinModelPortaliQ70EK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 351USPAdd BLAST322

Sequence similaritiesi

Belongs to the peptidase C19 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1887 Eukaryota
ENOG410XSNE LUCA
GeneTreeiENSGT00440000033513
HOGENOMiHOG000236318
HOVERGENiHBG080701
InParanoidiQ70EK8
OMAiCIRCHFQ
OrthoDBiEOG091G00Q6
PhylomeDBiQ70EK8
TreeFamiTF323194

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q70EK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWVKFLRKP GGNLGKVYQP GSMLSLAPTK GLLNEPGQNS CFLNSAVQVL
60 70 80 90 100
WQLDIFRRSL RVLTGHVCQG DACIFCALKT IFAQFQHSRE KALPSDNIRH
110 120 130 140 150
ALAESFKDEQ RFQLGLMDDA AECFENMLER IHFHIVPSRD ADMCTSKSCI
160 170 180 190 200
THQKFAMTLY EQCVCRSCGA SSDPLPFTEF VRYISTTALC NEVERMLERH
210 220 230 240 250
ERFKPEMFAE LLQAANTTDD YRKCPSNCGQ KIKIRRVLMN CPEIVTIGLV
260 270 280 290 300
WDSEHSDLTE AVVRNLATHL YLPGLFYRVT DENAKNSELN LVGMICYTSQ
310 320 330 340 350
HYCAFAFHTK SSKWVFFDDA NVKEIGTRWK DVVSKCIRCH FQPLLLFYAN
360 370 380 390 400
PDGTAVSTED ALRQVISWSH YKSVAENMGC EKPVIHKSDN LKENGFGDQA
410 420 430 440 450
KQRENQKFPT DNISSSNRSH SHTGVGKGPA KLSHIDQREK IKDISRECAL
460 470 480 490 500
KAIEQKNLLS SQRKDLEKGQ RKDLGRHRDL VDEDLSHFQS GSPPAPNGFK
510 520 530 540 550
QHGNPHLYHS QGKGSYKHDR VVPQSRASAQ IISSSKSQIL APGEKITGKV
560 570 580 590 600
KSDNGTGYDT DSSQDSRDRG NSCDSSSKSR NRGWKPMRET LNVDSIFSES
610 620 630 640 650
EKRQHSPRHK PNISNKPKSS KDPSFSNWPK ENPKQKGLMT IYEDEMKQEI
660 670 680 690 700
GSRSSLESNG KGAEKNKGLV EGKVHGDNWQ MQRTESGYES SDHISNGSTN
710 720 730 740 750
LDSPVIDGNG TVMDISGVKE TVCFSDQITT SNLNKERGDC TSLQSQHHLE
760 770 780 790 800
GFRKELRNLE AGYKSHEFHP ESHLQIKNHL IKRSHVHEDN GKLFPSSSLQ
810 820 830 840 850
IPKDHNAREH IHQSDEQKLE KPNECKFSEW LNIENSERTG LPFHVDNSAS
860 870 880 890 900
GKRVNSNEPS SLWSSHLRTV GLKPETAPLI QQQNIMDQCY FENSLSTECI
910 920 930 940 950
IRSASRSDGC QMPKLFCQNL PPPLPPKKYA ITSVPQSEKS ESTPDVKLTE
960 970 980 990 1000
VFKATSHLPK HSLSTASEPS LEVSTHMNDE RHKETFQVRE CFGNTPNCPS
1010 1020 1030 1040 1050
SSSTNDFQAN SGAIDAFCQP ELDSISTCPN ETVSLTTYFS VDSCMTDTYR
1060 1070
LKYHQRPKLS FPESSGFCNN SLS
Length:1,073
Mass (Da):120,806
Last modified:February 7, 2006 - v2
Checksum:i2A5E8B0AB4158878
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF54D6RF54_HUMAN
Inactive ubiquitin carboxyl-termina...
USP53
327Annotation score:
H0Y8Q1H0Y8Q1_HUMAN
Inactive ubiquitin carboxyl-termina...
USP53
64Annotation score:

Sequence cautioni

The sequence AAH17382 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190Missing in CAE47751 (PubMed:14715245).Curated1
Sequence conflicti209A → V in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti276F → FF in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti611P → A in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti869T → G in AAH17382 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051541962S → R1 PublicationCorresponds to variant dbSNP:rs3749591Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583824 mRNA Translation: CAE47751.1
CR749490 mRNA Translation: CAH18315.1
AB037771 mRNA Translation: BAA92588.1
BC017382 mRNA Translation: AAH17382.1 Different initiation.
CCDSiCCDS43265.1
RefSeqiNP_061923.2, NM_019050.2
XP_005263130.1, XM_005263073.3
XP_011530339.1, XM_011532037.2
XP_016863801.1, XM_017008312.1
XP_016863802.1, XM_017008313.1
XP_016863803.1, XM_017008314.1
XP_016863804.1, XM_017008315.1
UniGeneiHs.431081
Hs.595368

Genome annotation databases

EnsembliENST00000274030; ENSP00000274030; ENSG00000145390
ENST00000450251; ENSP00000409906; ENSG00000145390
GeneIDi54532
KEGGihsa:54532
UCSCiuc003icr.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBP53_HUMAN
AccessioniPrimary (citable) accession number: Q70EK8
Secondary accession number(s): Q68DA5, Q8WVQ5, Q9P2J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: September 12, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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