Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 121 (12 Aug 2020)
Sequence version 2 (11 Sep 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sushi, nidogen and EGF-like domain-containing protein 1

Gene

Sned1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi, nidogen and EGF-like domain-containing protein 1
Alternative name(s):
Secreted protein SST-3
Stromal nidogen extracellular matrix protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sned1
Synonyms:Snep
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045960, Sned1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500007210825 – 1403Sushi, nidogen and EGF-like domain-containing protein 1Add BLAST1379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi272 ↔ 284By similarity
Disulfide bondi278 ↔ 297By similarity
Disulfide bondi299 ↔ 308By similarity
Disulfide bondi315 ↔ 326By similarity
Disulfide bondi320 ↔ 335By similarity
Disulfide bondi337 ↔ 346By similarity
Disulfide bondi353 ↔ 364By similarity
Disulfide bondi358 ↔ 373By similarity
Disulfide bondi375 ↔ 384By similarity
Disulfide bondi391 ↔ 402By similarity
Disulfide bondi396 ↔ 411By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi413 ↔ 422By similarity
Disulfide bondi433 ↔ 444By similarity
Disulfide bondi438 ↔ 453By similarity
Disulfide bondi455 ↔ 464By similarity
Disulfide bondi472 ↔ 480By similarity
Disulfide bondi474 ↔ 488By similarity
Disulfide bondi490 ↔ 499By similarity
Disulfide bondi545 ↔ 556By similarity
Disulfide bondi550 ↔ 565By similarity
Disulfide bondi567 ↔ 576By similarity
Disulfide bondi584 ↔ 595By similarity
Disulfide bondi589 ↔ 604By similarity
Disulfide bondi606 ↔ 615By similarity
Disulfide bondi623 ↔ 634By similarity
Disulfide bondi628 ↔ 643By similarity
Disulfide bondi645 ↔ 654By similarity
Disulfide bondi661 ↔ 672By similarity
Disulfide bondi666 ↔ 681By similarity
Disulfide bondi683 ↔ 692By similarity
Disulfide bondi698 ↔ 739By similarity
Glycosylationi712N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi724 ↔ 751By similarity
Disulfide bondi757 ↔ 768By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi779 ↔ 788By similarity
Disulfide bondi795 ↔ 806By similarity
Disulfide bondi800 ↔ 815By similarity
Disulfide bondi817 ↔ 826By similarity
Disulfide bondi833 ↔ 844By similarity
Disulfide bondi838 ↔ 853By similarity
Disulfide bondi855 ↔ 864By similarity
Disulfide bondi871 ↔ 882By similarity
Disulfide bondi876 ↔ 891By similarity
Disulfide bondi893 ↔ 902By similarity
Glycosylationi977N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1310 ↔ 1321By similarity
Disulfide bondi1315 ↔ 1330By similarity
Disulfide bondi1332 ↔ 1341By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q70E20

PRoteomics IDEntifications database

More...
PRIDEi
Q70E20

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q70E20, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70E20

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70E20

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in mesenchymal cells or stromal cell from 10.5 dpc to 17.5 dpc.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000050832

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q70E20, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q70E20

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 258NIDOPROSITE-ProRule annotationAdd BLAST156
Domaini268 – 309EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini311 – 347EGF-like 2PROSITE-ProRule annotationAdd BLAST37
Domaini349 – 385EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini387 – 423EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini429 – 465EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini468 – 500EGF-like 6PROSITE-ProRule annotationAdd BLAST33
Domaini541 – 577EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini580 – 616EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini619 – 655EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini657 – 693EGF-like 10PROSITE-ProRule annotationAdd BLAST37
Domaini696 – 753SushiPROSITE-ProRule annotationAdd BLAST58
Domaini753 – 789EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini791 – 827EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini829 – 865EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini867 – 903EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini908 – 1006Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini1007 – 1105Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini1106 – 1200Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini1306 – 1342EGF-like 15PROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota
KOG4291, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70E20

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70E20

TreeFam database of animal gene trees

More...
TreeFami
TF335195

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit
cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR009030, Growth_fac_rcpt_cys_sf
IPR013783, Ig-like_fold
IPR003886, NIDO_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 13 hits
PF00041, fn3, 3 hits
PF12661, hEGF, 1 hit
PF06119, NIDO, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 1 hit
SM00181, EGF, 15 hits
SM00179, EGF_CA, 14 hits
SM00060, FN3, 3 hits
SM00539, NIDO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF57184, SSF57184, 1 hit
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 15 hits
PS01186, EGF_2, 14 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 3 hits
PS50853, FN3, 3 hits
PS51220, NIDO, 1 hit
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70E20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLGAAWALL LAAALGLGTR GVRAAVALAD FYPFGTKRGD TVTPKQDDGG
60 70 80 90 100
SGLQPLSVPF PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV
110 120 130 140 150
VAAFWADVDN RRAGDVYYRE ATDPAMLNRA TEDIRRYFPE LPDFSATWVF
160 170 180 190 200
VATWYRVTFF GGSSSSPVNT FQTVLITDGR FSFTIFNYES ILWTTGTHAS
210 220 230 240 250
SGGDTDGLGG IAAQAGFNAG DGHRYFNIPG SRTADMAEVE TTTNVGVPGR
260 270 280 290 300
WAFRIDDAQV RVGGCGHTTS VCLVLRPCLN GGKCIDDCVT GNPSYTCSCL
310 320 330 340 350
AGFTGRRCHL DVNECASHPC QNGGTCTHGV NSFSCQCPAG FKGPTCESAQ
360 370 380 390 400
SPCDNKVCQN GGQCQAESSS AVCVCQAGYT GATCETDVDE CSSDPCQNGG
410 420 430 440 450
SCVDLVGNYS CICVEPFEGP QCETGSYLVP SPCLSNPCQN GGTCVDADEG
460 470 480 490 500
YVCECPEGFM GLDCRERILN DCDCRNGGRC LGANTTLCQC PPGFFGLLCE
510 520 530 540 550
FEVTATPCNM NTQCPDGGYC MEYGGSYLCV CHTDHNISHS LPSPCDSDPC
560 570 580 590 600
FNGGSCDAHE DSYTCECPRG FHGRHCEKAR PHLCSSGPCR NGGTCKEMGD
610 620 630 640 650
EYRCTCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS
660 670 680 690 700
GRHCEIAPSP CFRSPCMNGG TCEDLGTDFS CYCQPGYTGH RCQAEVDCGH
710 720 730 740 750
PEEVEHATMR FNGTHVGSVA LYTCEPGFSL SALSHIRVCQ PQGVWSQPPQ
760 770 780 790 800
CIEVDECRSQ PCLHGGSCQD LIADYQCLCS PGYEGVHCEL ETDECQAQPC
810 820 830 840 850
RNGGSCRDLP RAFICQCPEG FVGIHCETEV DACASSPCQH GGRCEDGGGA
860 870 880 890 900
YLCVCPEGFF GYNCETVSDP CFSSPCGSRG YCLASNGSHS CTCKVGYTGK
910 920 930 940 950
DCTKELLPPT ALRVERVEES GVSISWSPPE GTTARQVLDG YAVTYASSDG
960 970 980 990 1000
SSRRTDFVDR SRSSHQLRAL AAGRAYNISV FSVKRNTNNK NDISRPAALL
1010 1020 1030 1040 1050
TRTRPRPIED FEVTNISANA ISVQWALHRI QHATVSRVRV SILYPEASAV
1060 1070 1080 1090 1100
QSTEVDRSVD RLTFGDLLPG RRYTVRLTTL SGPGGAEYPT ESLASAPLNV
1110 1120 1130 1140 1150
WTRPLPPANL TASRVTATSA HMIWDTPAPG ISLEAYVINV TTSQSTKSRY
1160 1170 1180 1190 1200
IPNGKLVSYT VRDLMPGRRY QLSVTAVQST EQGQLHSEPA HLYIITSPRD
1210 1220 1230 1240 1250
GTDRRWHHGG HHSRMLRNRP APVRLPELRL LNDHSAPETP TQSSRFSELV
1260 1270 1280 1290 1300
DGRGRVSARF GGLPSRAVTV RSQPTTPVPL KNTEAPEQVH LALQLPKNSS
1310 1320 1330 1340 1350
KDTESTPGSC SEDACQNGGT CVPGADAHSC DCRPGFKGRH CELACEKVPR
1360 1370 1380 1390 1400
PCTRLFSETK SFPVWEGDIC HHVYKKVYKV HQDVCFKERC QSTSLRKPKQ

ETK
Length:1,403
Mass (Da):151,581
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i869F84724E44D8CE
GO
Isoform 2 (identifier: Q70E20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1403: Missing.

Show »
Length:1,065
Mass (Da):114,252
Checksum:iF2390427F60E2373
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0N0A0A0R4J0N0_MOUSE
Sushi, nidogen and EGF-like domain-...
Sned1
1,403Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V5H4F6V5H4_MOUSE
Sushi, nidogen and EGF-like domain-...
Sned1
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC28030 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti288C → W in CAE48492 (PubMed:15162516).Curated1
Sequence conflicti867V → M in AAO41836 (PubMed:12665856).Curated1
Sequence conflicti1084Missing in BAC28030 (PubMed:16141072).Curated1
Sequence conflicti1123I → V in AAI45887 (PubMed:15489334).Curated1
Sequence conflicti1123I → V in BAC28030 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0277551066 – 1403Missing in isoform 2. 1 PublicationAdd BLAST338

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY169783 mRNA Translation: AAO41836.1
AJ584850 mRNA Translation: CAE48492.1
BC145886 mRNA Translation: AAI45887.1
AK032805 mRNA Translation: BAC28030.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35670.1 [Q70E20-1]

NCBI Reference Sequences

More...
RefSeqi
NP_766051.4, NM_172463.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
208777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:208777

UCSC genome browser

More...
UCSCi
uc007cdm.1, mouse [Q70E20-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169783 mRNA Translation: AAO41836.1
AJ584850 mRNA Translation: CAE48492.1
BC145886 mRNA Translation: AAI45887.1
AK032805 mRNA Translation: BAC28030.1 Different initiation.
CCDSiCCDS35670.1 [Q70E20-1]
RefSeqiNP_766051.4, NM_172463.4

3D structure databases

SMRiQ70E20
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050832

PTM databases

GlyGeniQ70E20, 3 sites
iPTMnetiQ70E20
PhosphoSitePlusiQ70E20

Proteomic databases

PaxDbiQ70E20
PRIDEiQ70E20

Genome annotation databases

GeneIDi208777
KEGGimmu:208777
UCSCiuc007cdm.1, mouse [Q70E20-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25992
MGIiMGI:3045960, Sned1

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
KOG4291, Eukaryota
InParanoidiQ70E20
OrthoDBi7525at2759
PhylomeDBiQ70E20
TreeFamiTF335195

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
208777, 1 hit in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:Q70E20
RNActiQ70E20, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00033, CCP, 1 hit
cd00063, FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR009030, Growth_fac_rcpt_cys_sf
IPR013783, Ig-like_fold
IPR003886, NIDO_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 13 hits
PF00041, fn3, 3 hits
PF12661, hEGF, 1 hit
PF06119, NIDO, 1 hit
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00181, EGF, 15 hits
SM00179, EGF_CA, 14 hits
SM00060, FN3, 3 hits
SM00539, NIDO, 1 hit
SUPFAMiSSF49265, SSF49265, 2 hits
SSF57184, SSF57184, 1 hit
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 15 hits
PS01186, EGF_2, 14 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 3 hits
PS50853, FN3, 3 hits
PS51220, NIDO, 1 hit
PS50923, SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNED1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70E20
Secondary accession number(s): A6H6I3, Q810H2, Q8BMD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: August 12, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again