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UniProtKB - Q70DX9 (SED1_ASPFU)
Protein
Tripeptidyl-peptidase sed1
Gene
sed1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
1 PublicationCatalytic activityi
- Release of an N-terminal tripeptide from a polypeptide. EC:3.4.14.10
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
pH dependencei
Optimum pH is about 5.5.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 300 | Charge relay systemBy similarity | 1 | |
Active sitei | 304 | Charge relay systemBy similarity | 1 | |
Active sitei | 561 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 602 | CalciumBy similarity | 1 | |
Metal bindingi | 603 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 621 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 623 | CalciumBy similarity | 1 |
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: InterPro
- tripeptidyl-peptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: AspGD
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Virulence |
Ligand | Calcium, Metal-binding |
Protein family/group databases
MEROPSi | S53.007 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sed1 Synonyms:sedA ORF Names:AFUA_6G10250 |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:Afu6g10250 |
Subcellular locationi
Extracellular region or secreted
- extracellular space By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000390741 | 19 – 196 | Removed in mature form1 PublicationAdd BLAST | 178 | |
ChainiPRO_5000072119 | 197 – 644 | Tripeptidyl-peptidase sed1Add BLAST | 448 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 235 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 326 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 332 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 519 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Glycoprotein, ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 224 – 643 | Peptidase S53Add BLAST | 420 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTN1, Eukaryota |
HOGENOMi | CLU_013783_4_0_1 |
InParanoidi | Q70DX9 |
OMAi | ACREYHV |
OrthoDBi | 1294880at2759 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q70DX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLSHVLLGT AAAAGVLASP TPNDYVVHER RAVLPRSWTE EKRLDKASIL
60 70 80 90 100
PMRIGLTQSN LDRGHDLLME ISDPRSSRYG QHLSVEEVHS LFAPSQETVD
110 120 130 140 150
RVRAWLESEG IAGDRISQSS NEQFLQFDAS AAEVERLLGT EYYLYTHQGS
160 170 180 190 200
GKSHIACREY HVPHSLQRHI DYITPGIKLL EVEGVKKARS IEKRSFRSPL
210 220 230 240 250
PPILERLTLP LSELLGNTLL CDVAITPLCI SALYNITRGS KATKGNELGI
260 270 280 290 300
FEDLGDVYSQ EDLNLFFSTF AQQIPQGTHP ILKAVDGAQA PTSVTNAGPE
310 320 330 340 350
SDLDFQISYP IIWPQNSILF QTDDPNYTAN YNFSGFLNTF LDAIDGSYCS
360 370 380 390 400
EISPLDPPYP NPADGGYKGQ LQCGVYQPPK VLSISYGGAE ADLPIAYQRR
410 420 430 440 450
QCAEWMKLGL QGVSVVVASG DSGVEGRNGD PTPTECLGTE GKVFAPDFPA
460 470 480 490 500
TCPYLTTVGG TYLPLGADPR KDEEVAVTSF PSGGGFSNIY ERADYQQQAV
510 520 530 540 550
EDYFSRADPG YPFYESVDNS SFAENGGIYN RIGRAYPDVA AIADNVVIFN
560 570 580 590 600
KGMPTLIGGT SAAAPVFAAI LTRINEERLA VGKSTVGFVN PVLYAHPEVF
610 620 630 640
NDITQGSNPG CGMQGFSAAT GWDPVTGLGT PNYPALLDLF MSLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ585109 mRNA Translation: CAE51075.1 AAHF01000006 Genomic DNA Translation: EAL88876.1 |
RefSeqi | XP_750914.1, XM_745821.1 |
Genome annotation databases
EnsemblFungii | EAL88876; EAL88876; AFUA_6G10250 |
GeneIDi | 3508219 |
KEGGi | afm:AFUA_6G10250 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ585109 mRNA Translation: CAE51075.1 AAHF01000006 Genomic DNA Translation: EAL88876.1 |
RefSeqi | XP_750914.1, XM_745821.1 |
3D structure databases
SMRi | Q70DX9 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S53.007 |
Genome annotation databases
EnsemblFungii | EAL88876; EAL88876; AFUA_6G10250 |
GeneIDi | 3508219 |
KEGGi | afm:AFUA_6G10250 |
Organism-specific databases
VEuPathDBi | FungiDB:Afu6g10250 |
Phylogenomic databases
eggNOGi | ENOG502QTN1, Eukaryota |
HOGENOMi | CLU_013783_4_0_1 |
InParanoidi | Q70DX9 |
OMAi | ACREYHV |
OrthoDBi | 1294880at2759 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SED1_ASPFU | |
Accessioni | Q70DX9Primary (citable) accession number: Q70DX9 Secondary accession number(s): Q4WMD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 19, 2010 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |