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Entry version 133 (31 Jul 2019)
Sequence version 2 (04 Nov 2008)
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Protein

Ubiquitin carboxyl-terminal hydrolase 34

Gene

USP34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1903NucleophileCurated1
Active sitei2164Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.067

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 34 (EC:3.4.19.122 Publications)
Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP34
Synonyms:KIAA0570, KIAA0729
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20066 USP34

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615295 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q70CQ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1903C → S: Loss of function. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
9736

Open Targets

More...
OpenTargetsi
ENSG00000115464

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134897042

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP34

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276488

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495191 – 3546Ubiquitin carboxyl-terminal hydrolase 34Add BLAST3546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei352PhosphoserineCombined sources1
Modified residuei486PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei490PhosphoserineBy similarity1
Modified residuei649PhosphoserineCombined sources1
Modified residuei1469PhosphoserineBy similarity1
Modified residuei2488PhosphoserineCombined sources1
Modified residuei3358PhosphoserineCombined sources1
Modified residuei3359PhosphoserineCombined sources1
Modified residuei3381PhosphothreonineCombined sources1
Modified residuei3386PhosphoserineCombined sources1
Modified residuei3406PhosphoserineCombined sources1
Modified residuei3503PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q70CQ2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q70CQ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q70CQ2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q70CQ2

PeptideAtlas

More...
PeptideAtlasi
Q70CQ2

PRoteomics IDEntifications database

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PRIDEi
Q70CQ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68521 [Q70CQ2-1]
68522 [Q70CQ2-2]
68523 [Q70CQ2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70CQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70CQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain at low level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115464 Expressed in 241 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q70CQ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q70CQ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA025815
HPA070764

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AXIN1 and AXIN2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115085, 71 interactors

Protein interaction database and analysis system

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IntActi
Q70CQ2, 8 interactors

Molecular INTeraction database

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MINTi
Q70CQ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381577

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q70CQ2

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1894 – 2239USPAdd BLAST346

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1866 Eukaryota
COG5077 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158659

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70CQ2

KEGG Orthology (KO)

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KOi
K11853

Identification of Orthologs from Complete Genome Data

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OMAi
EGPYIRA

Database of Orthologous Groups

More...
OrthoDBi
625455at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70CQ2

TreeFam database of animal gene trees

More...
TreeFami
TF323966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70CQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCENCADLVE VLNEISDVEG GDGLQLRKEH TLKIFTYINS WTQRQCLCCF
60 70 80 90 100
KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ
110 120 130 140 150
AEEPLNIDRE CNEGSTERQK SIEKKSNSTR ICNLTEEESS KSSDPFSLWS
160 170 180 190 200
TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM
210 220 230 240 250
NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL IAHAFITVVS
260 270 280 290 300
NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV
310 320 330 340 350
KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN
360 370 380 390 400
ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA
410 420 430 440 450
EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA
460 470 480 490 500
LEPSVHTEQT LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNIPIGN
510 520 530 540 550
KKEEEELRRT APSPWSPAAS PQSSDNSDTH QSGGSDIEMD EQLINRTKHV
560 570 580 590 600
QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ
610 620 630 640 650
SAGSPGSEVQ SEDIADIEAL KEEDEDDDHG HNPPKSSCGT DLRNRKLESQ
660 670 680 690 700
AGICLGDSQG MSERNGTSSG TGKDLVFNTE SLPSVDNRMR MLDACSHSED
710 720 730 740 750
PEHDISGEMN ATHIAQGSQE SCITRTGDFL GETIGNELFN CRQFIGPQHH
760 770 780 790 800
HHHHHHHHHH DGHMVDDMLS ADDVSCSSSQ VSAKSEKNMA DFDGEESGCE
810 820 830 840 850
EELVQINSHA ELTSHLQQHL PNLASIYHEH LSQGPVVHKH QFNSNAVTDI
860 870 880 890 900
NLDNVCKKGN TLLWDIVQDE DAVNLSEGLI NEAEKLLCSL VCWFTDRQIR
910 920 930 940 950
MRFIEGCLEN LGNNRSVVIS LRLLPKLFGT FQQFGSSYDT HWITMWAEKE
960 970 980 990 1000
LNMMKLFFDN LVYYIQTVRE GRQKHALYSH SAEVQVRLQF LTCVFSTLGS
1010 1020 1030 1040 1050
PDHFRLSLEQ VDILWHCLVE DSECYDDALH WFLNQVRSKD QHAMGMETYK
1060 1070 1080 1090 1100
HLFLEKMPQL KPETISMTGL NLFQHLCNLA RLATSAYDGC SNSELCGMDQ
1110 1120 1130 1140 1150
FWGIALRAQS GDVSRAAIQY INSYYINGKT GLEKEQEFIS KCMESLMIAS
1160 1170 1180 1190 1200
SSLEQESHSS LMVIERGLLM LKTHLEAFRR RFAYHLRQWQ IEGTGISSHL
1210 1220 1230 1240 1250
KALSDKQSLP LRVVCQPAGL PDKMTIEMYP SDQVADLRAE VTHWYENLQK
1260 1270 1280 1290 1300
EQINQQAQLQ EFGQSNRKGE FPGGLMGPVR MISSGHELTT DYDEKALHEL
1310 1320 1330 1340 1350
GFKDMQMVFV SLGAPRRERK GEGVQLPASC LPPPQKDNIP MLLLLQEPHL
1360 1370 1380 1390 1400
TTLFDLLEML ASFKPPSGKV AVDDSESLRC EELHLHAENL SRRVWELLML
1410 1420 1430 1440 1450
LPTCPNMLMA FQNISDEQSN DGFNWKELLK IKSAHKLLYA LEIIEALGKP
1460 1470 1480 1490 1500
NRRIRRESTG SYSDLYPDSD DSSEDQVENS KNSWSCKFVA AGGLQQLLEI
1510 1520 1530 1540 1550
FNSGILEPKE QESWTVWQLD CLACLLKLIC QFAVDPSDLD LAYHDVFAWS
1560 1570 1580 1590 1600
GIAESHRKRT WPGKSRKAAG DHAKGLHIPR LTEVFLVLVQ GTSLIQRLMS
1610 1620 1630 1640 1650
VAYTYDNLAP RVLKAQSDHR SRHEVSHYSM WLLVSWAHCC SLVKSSLADS
1660 1670 1680 1690 1700
DHLQDWLKKL TLLIPETAVR HESCSGLYKL SLSGLDGGDS INRSFLLLAA
1710 1720 1730 1740 1750
STLLKFLPDA QALKPIRIDD YEEEPILKPG CKEYFWLLCK LVDNIHIKDA
1760 1770 1780 1790 1800
SQTTLLDLDA LARHLADCIR SREILDHQDG NVEDDGLTGL LRLATSVVKH
1810 1820 1830 1840 1850
KPPFKFSREG QEFLRDIFNL LFLLPSLKDR QQPKCKSHSS RAAAYDLLVE
1860 1870 1880 1890 1900
MVKGSVENYR LIHNWVMAQH MQSHAPYKWD YWPHEDVRAE CRFVGLTNLG
1910 1920 1930 1940 1950
ATCYLASTIQ QLYMIPEARQ AVFTAKYSED MKHKTTLLEL QKMFTYLMES
1960 1970 1980 1990 2000
ECKAYNPRPF CKTYTMDKQP LNTGEQKDMT EFFTDLITKI EEMSPELKNT
2010 2020 2030 2040 2050
VKSLFGGVIT NNVVSLDCEH VSQTAEEFYT VRCQVADMKN IYESLDEVTI
2060 2070 2080 2090 2100
KDTLEGDNMY TCSHCGKKVR AEKRACFKKL PRILSFNTMR YTFNMVTMMK
2110 2120 2130 2140 2150
EKVNTHFSFP LRLDMTPYTE DFLMGKSERK EGFKEVSDHS KDSESYEYDL
2160 2170 2180 2190 2200
IGVTVHTGTA DGGHYYSFIR DIVNPHAYKN NKWYLFNDAE VKPFDSAQLA
2210 2220 2230 2240 2250
SECFGGEMTT KTYDSVTDKF MDFSFEKTHS AYMLFYKRME PEEENGREYK
2260 2270 2280 2290 2300
FDVSSELLEW IWHDNMQFLQ DKNIFEHTYF GFMWQLCSCI PSTLPDPKAV
2310 2320 2330 2340 2350
SLMTAKLSTS FVLETFIHSK EKPTMLQWIE LLTKQFNNSQ AACEWFLDRM
2360 2370 2380 2390 2400
ADDDWWPMQI LIKCPNQIVR QMFQRLCIHV IQRLRPVHAH LYLQPGMEDG
2410 2420 2430 2440 2450
SDDMDTSVED IGGRSCVTRF VRTLLLIMEH GVKPHSKHLT EYFAFLYEFA
2460 2470 2480 2490 2500
KMGEEESQFL LSLQAISTMV HFYMGTKGPE NPQVEVLSEE EGEEEEEEED
2510 2520 2530 2540 2550
ILSLAEEKYR PAALEKMIAL VALLVEQSRS ERHLTLSQTD MAALTGGKGF
2560 2570 2580 2590 2600
PFLFQHIRDG INIRQTCNLI FSLCRYNNRL AEHIVSMLFT SIAKLTPEAA
2610 2620 2630 2640 2650
NPFFKLLTML MEFAGGPPGM PPFASYILQR IWEVIEYNPS QCLDWLAVQT
2660 2670 2680 2690 2700
PRNKLAHSWV LQNMENWVER FLLAHNYPRV RTSAAYLLVS LIPSNSFRQM
2710 2720 2730 2740 2750
FRSTRSLHIP TRDLPLSPDT TVVLHQVYNV LLGLLSRAKL YVDAAVHGTT
2760 2770 2780 2790 2800
KLVPYFSFMT YCLISKTEKL MFSTYFMDLW NLFQPKLSEP AIATNHNKQA
2810 2820 2830 2840 2850
LLSFWYNVCA DCPENIRLIV QNPVVTKNIA FNYILADHDD QDVVLFNRGM
2860 2870 2880 2890 2900
LPAYYGILRL CCEQSPAFTR QLASHQNIQW AFKNLTPHAS QYPGAVEELF
2910 2920 2930 2940 2950
NLMQLFIAQR PDMREEELED IKQFKKTTIS CYLRCLDGRS CWTTLISAFR
2960 2970 2980 2990 3000
ILLESDEDRL LVVFNRGLIL MTESFNTLHM MYHEATACHV TGDLVELLSI
3010 3020 3030 3040 3050
FLSVLKSTRP YLQRKDVKQA LIQWQERIEF AHKLLTLLNS YSPPELRNAC
3060 3070 3080 3090 3100
IDVLKELVLL SPHDFLHTLV PFLQHNHCTY HHSNIPMSLG PYFPCRENIK
3110 3120 3130 3140 3150
LIGGKSNIRP PRPELNMCLL PTMVETSKGK DDVYDRMLLD YFFSYHQFIH
3160 3170 3180 3190 3200
LLCRVAINCE KFTETLVKLS VLVAYEGLPL HLALFPKLWT ELCQTQSAMS
3210 3220 3230 3240 3250
KNCIKLLCED PVFAEYIKCI LMDERTFLNN NIVYTFMTHF LLKVQSQVFS
3260 3270 3280 3290 3300
EANCANLIST LITNLISQYQ NLQSDFSNRV EISKASASLN GDLRALALLL
3310 3320 3330 3340 3350
SVHTPKQLNP ALIPTLQELL SKCRTCLQQR NSLQEQEAKE RKTKDDEGAT
3360 3370 3380 3390 3400
PIKRRRVSSD EEHTVDSCIS DMKTETREVL TPTSTSDNET RDSSIIDPGT
3410 3420 3430 3440 3450
EQDLPSPENS SVKEYRMEVP SSFSEDMSNI RSQHAEEQSN NGRYDDCKEF
3460 3470 3480 3490 3500
KDLHCSKDST LAEEESEFPS TSISAVLSDL ADLRSCDGQA LPSQDPEVAL
3510 3520 3530 3540
SLSCGHSRGL FSHMQQHDIL DTLCRTIEST IHVVTRISGK GNQAAS
Length:3,546
Mass (Da):404,233
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA31851911D990044
GO
Isoform 2 (identifier: Q70CQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ

Show »
Length:3,395
Mass (Da):387,154
Checksum:i6171809F72C5EE8E
GO
Isoform 3 (identifier: Q70CQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ
     2936-3018: Missing.

Note: No experimental confirmation available.
Show »
Length:3,312
Mass (Da):377,599
Checksum:i4815E0ED77EC1C03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG73A0A0C4DG73_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP34
810Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C183H7C183_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP34
1,223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C150H7C150_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP34
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ73H7BZ73_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP34
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI07762 differs from that shown. Reason: Frameshift at position 3200.Curated
The sequence BAA25496 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG54261 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047106661M → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs6722430Ensembl.1
Natural variantiVAR_0471071663L → R. Corresponds to variant dbSNP:rs6723818Ensembl.1
Natural variantiVAR_0471082348D → N. Corresponds to variant dbSNP:rs4386306Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0356391 – 139Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST139
Alternative sequenceiVSP_035640140 – 162SKSSD…LLCVA → MRRKNSYYVWQ in isoform 2 and isoform 3. 4 PublicationsAdd BLAST23
Alternative sequenceiVSP_0204632936 – 3018Missing in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ586138 mRNA Translation: CAE51938.1
AB011142 mRNA Translation: BAA25496.2 Different initiation.
AC016747 Genomic DNA No translation available.
AL050092 mRNA Translation: CAB43264.1
AL831918 mRNA Translation: CAD38579.1
AK125898 mRNA Translation: BAG54261.1 Different initiation.
AB018272 mRNA Translation: BAA34449.1
BC022783 mRNA Translation: AAH22783.1
BC062325 mRNA Translation: AAH62325.1
BC107761 mRNA Translation: AAI07762.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42686.1 [Q70CQ2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00338
T13057

NCBI Reference Sequences

More...
RefSeqi
NP_055524.3, NM_014709.3 [Q70CQ2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398571; ENSP00000381577; ENSG00000115464 [Q70CQ2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9736

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9736

UCSC genome browser

More...
UCSCi
uc002sbe.4 human [Q70CQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ586138 mRNA Translation: CAE51938.1
AB011142 mRNA Translation: BAA25496.2 Different initiation.
AC016747 Genomic DNA No translation available.
AL050092 mRNA Translation: CAB43264.1
AL831918 mRNA Translation: CAD38579.1
AK125898 mRNA Translation: BAG54261.1 Different initiation.
AB018272 mRNA Translation: BAA34449.1
BC022783 mRNA Translation: AAH22783.1
BC062325 mRNA Translation: AAH62325.1
BC107761 mRNA Translation: AAI07762.1 Frameshift.
CCDSiCCDS42686.1 [Q70CQ2-1]
PIRiT00338
T13057
RefSeqiNP_055524.3, NM_014709.3 [Q70CQ2-1]

3D structure databases

SMRiQ70CQ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115085, 71 interactors
IntActiQ70CQ2, 8 interactors
MINTiQ70CQ2
STRINGi9606.ENSP00000381577

Protein family/group databases

MEROPSiC19.067

PTM databases

iPTMnetiQ70CQ2
PhosphoSitePlusiQ70CQ2

Polymorphism and mutation databases

BioMutaiUSP34
DMDMi212276488

Proteomic databases

EPDiQ70CQ2
jPOSTiQ70CQ2
MaxQBiQ70CQ2
PaxDbiQ70CQ2
PeptideAtlasiQ70CQ2
PRIDEiQ70CQ2
ProteomicsDBi68521 [Q70CQ2-1]
68522 [Q70CQ2-2]
68523 [Q70CQ2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398571; ENSP00000381577; ENSG00000115464 [Q70CQ2-1]
GeneIDi9736
KEGGihsa:9736
UCSCiuc002sbe.4 human [Q70CQ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9736
DisGeNETi9736

GeneCards: human genes, protein and diseases

More...
GeneCardsi
USP34
HGNCiHGNC:20066 USP34
HPAiHPA025815
HPA070764
MIMi615295 gene
neXtProtiNX_Q70CQ2
OpenTargetsiENSG00000115464
PharmGKBiPA134897042

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1866 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00940000158659
InParanoidiQ70CQ2
KOiK11853
OMAiEGPYIRA
OrthoDBi625455at2759
PhylomeDBiQ70CQ2
TreeFamiTF323966

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
USP34 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
USP34

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9736

Protein Ontology

More...
PROi
PR:Q70CQ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115464 Expressed in 241 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ70CQ2 baseline and differential
GenevisibleiQ70CQ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP34_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70CQ2
Secondary accession number(s): A8MWD0
, B3KWU9, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 4, 2008
Last modified: July 31, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Peptidase families
    Classification of peptidase families and list of entries
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