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1 to 25 of 74  Show
  1. 1
    "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 3761 other entries.

  2. 2
    "Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains."
    Kuiper R.P., Schepens M., Thijssen J., Schoenmakers E.F.P.M., Geurts van Kessel A.
    Nucleic Acids Res. 32:2315-2322(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Tissue: Muscle and Spleen.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 6 other entries.

  3. 3
    Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Source: UniProtKB/TrEMBL (unreviewed).
  4. 4
    "Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation."
    Davis I.J., Hsi B.L., Arroyo J.D., Vargas S.O., Yeh Y.A., Motyckova G., Valencia P., Perez-Atayde A.R., Argani P., Ladanyi M., Fletcher J.A., Fisher D.E.
    Proc. Natl. Acad. Sci. U.S.A. 100:6051-6056(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: This gene fuses with an intronless gene in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  5. 5
    "Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR."
    Argani P., Lae M., Hutchinson B., Reuter V.E., Collins M.H., Perentesis J., Tomaszewski J.E., Brooks J.S., Acs G., Bridge J.A., Vargas S.O., Davis I.J., Fisher D.E., Ladanyi M.
    Am. J. Surg. Pathol. 29:230-240(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: TFEB protein is a highly sensitive and specific diagnostic marker for these renal neoplasms.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  6. 6
    "Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient."
    Pecciarini L., Cangi M.G., Lo Cunsolo C., Macri' E., Dal Cin E., Martignoni G., Doglioni C.
    Genes Chromosomes Cancer 46:419-426(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: TFEB in the neoplastic tissue compared to the normal sample supports that the fusion gene does not encode for a chimeric protein but causes an upregulation of the wild-type TFEB.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  7. 7
    "Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas."
    Martignoni G., Pea M., Gobbo S., Brunelli M., Bonetti F., Segala D., Pan C.C., Netto G., Doglioni C., Hes O., Argani P., Chilosi M.
    Mod. Pathol. 22:1016-1022(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: overexpression of TFE3 or TFEB in renal cell carinomas activates the expression of genes normally regulated by microphthalmia transcription factor in other cell types.
    Source: GeneRIF:7942.

    This publication is mapped to 17 other entries.

  8. 8
    Category: Function.
    Annotation: TFEB is identified as a master regulator of lysosomal biogenesis and function.
    Source: GeneRIF:7942.

    This publication is cited by 1 and mapped to 15 other entries.

  9. 9
    Category: Function.
    Annotation: study found that starvation activates a transcriptional program controlling major steps of the autophagic pathway; TFEB a master gene for lysosomal biogenesis coordinated this program by driving expression of autophagy and lysosomal genes.
    Source: GeneRIF:7942.

    This publication is mapped to 24 other entries.

  10. 10
    "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways."
    Palmieri M., Impey S., Kang H., di Ronza A., Pelz C., Sardiello M., Ballabio A.
    Hum. Mol. Genet. 20:3852-3866(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: TFEB coordinates the expression of 471 genes network involved in the early and late steps of lysosomal biogenesis.
    Source: GeneRIF:7942.

    This publication is mapped to 30 other entries.

  11. 11
    Category: Function, Subcellular Location.
    Annotation: TFEB transcriptionally regulates lysosomal exocytosis both by inducing the release of intracellular Ca2+ through its target gene MCOLN1 and by increasing the population of lysosomes ready to fuse with the plasma membrane.
    Source: GeneRIF:7942.

    This publication is mapped to 13 other entries.

  12. 12
    "TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy."
    Pena-Llopis S., Brugarolas J.
    Cell Cycle 10:3987-3988(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: mTORC1 regulates the nuclear localization of TFEB by promoting phosphorylation in the serine-rich motif.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  13. 13
    "A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB."
    Settembre C., Zoncu R., Medina D.L., Vetrini F., Erdin S., Erdin S., Huynh T., Ferron M., Karsenty G., Vellard M.C., Facchinetti V., Sabatini D.M., Ballabio A.
    EMBO J. 31:1095-1108(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: When nutrients are present phosphorylation of TFEB by mTORC1 inhibits TFEB activity.
    Source: GeneRIF:7942.

    This publication is mapped to 64 other entries.

  14. 14
    Category: Expression, Sequences.
    Annotation: Describes the clinical and histopathologic features of TFE3 and TFEB translocation renal cell carcinoma.
    Source: GeneRIF:7942.

    This publication is mapped to 13 other entries.

  15. 15
    "MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB."
    Martina J.A., Chen Y., Gucek M., Puertollano R.
    Autophagy 8:903-914(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Active TFEB also associates with late endosomal/lysosomal membranes through interaction with the LAMTOR/RRAG/MTORC1 complex.
    Source: GeneRIF:7942.

    This publication is mapped to 15 other entries.

  16. 16
    "The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis."
    Roczniak-Ferguson A., Petit C.S., Froehlich F., Qian S., Ky J., Angarola B., Walther T.C., Ferguson S.M.
    Sci Signal 5:ra42-ra42(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  17. 17
    "PGC-1alpha rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function."
    Tsunemi T., Ashe T.D., Morrison B.E., Soriano K.R., Au J., Roque R.A., Lazarowski E.R., Damian V.A., Masliah E., La Spada A.R.
    Sci Transl Med 4:142ra97-142ra97(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease.
    Source: GeneRIF:7942.

    This publication is mapped to 32 other entries.

  18. 18
    "Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency."
    Pastore N., Blomenkamp K., Annunziata F., Piccolo P., Mithbaokar P., Maria Sepe R., Vetrini F., Palmer D., Ng P., Polishchuk E., Iacobacci S., Polishchuk R., Teckman J., Ballabio A., Brunetti-Pierri N.
    EMBO Mol Med 5:397-412(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: TFEB gene transfer is a novel strategy for treatment of liver disease of alpha-1-anti-trypsin deficiency.
    Source: GeneRIF:7942.

    This publication is mapped to 28 other entries.

  19. 19
    Category: Function.
    Annotation: findings identify TFEB as a specific regulator of lysosomal proteostasis and suggest that TFEB may be used as a therapeutic target to rescue enzyme homeostasis in LSDs.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  20. 20
    "TFEB activation promotes the recruitment of lysosomal glycohydrolases beta-hexosaminidase and beta-galactosidase to the plasma membrane."
    Magini A., Polchi A., Urbanelli L., Cesselli D., Beltrami A., Tancini B., Emiliani C.
    Biochem. Biophys. Res. Commun. 440:251-257(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: lysosomal exocytosis induced by TFEB nuclear translocation is required not only for plasma membrane repair and lysosomal content secretion but also for the recruitment of glycohydrolases on the cell surface.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  21. 21
    "2-Hydroxypropyl-beta-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy."
    Song W., Wang F., Lotfi P., Sardiello M., Segatori L.
    J. Biol. Chem. 289:10211-10222(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: HPbetaCD administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  22. 22
    "Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers."
    Kauffman E.C., Ricketts C.J., Rais-Bahrami S., Yang Y., Merino M.J., Bottaro D.P., Srinivasan R., Linehan W.M.
    Nat Rev Urol 11:465-475(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Review of the role of gene fusions involving TFE3 and TFEB in carcinogenesis in sporadic renal cell carcinoma.
    Source: GeneRIF:7942.

    This publication is mapped to 13 other entries.

  23. 23
    "Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA."
    Cortes C.J., Miranda H.C., Frankowski H., Batlevi Y., Young J.E., Le A., Ivanov N., Sopher B.L., Carromeu C., Muotri A.R., Garden G.A., La Spada A.R.
    Nat. Neurosci. 17:1180-1189(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: We examined the transcriptional regulation of autophagy and observed a functionally significant physical interaction between TFEB and AR in spinal and bulbar muscular atrophy.
    Source: GeneRIF:7942.

    This publication is mapped to 44 other entries.

  24. 24
    "Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature."
    Peckova K., Vanecek T., Martinek P., Spagnolo D., Kuroda N., Brunelli M., Vranic S., Djuricic S., Rotterova P., Daum O., Kokoskova B., Vesela P., Pivovarcikova K., Bauleth K., Dubova M., Kalusova K., Hora M., Michal M., Hes O.
    Ann Diagn Pathol 18:351-357(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Results showed the amplification of TFEB locus was found only in the aggressive t(6;11) Renal Cell Carcinoma.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

  25. 25
    "Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance."
    Zhitomirsky B., Assaraf Y.G.
    Oncotarget 6:1143-1156(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Data show that drug-induced TFEB-associated lysosomal biogenesis is a determinant of multidrug resistance (MDR) and suggest that circumvention of lysosomal drug sequestration is a strategy to overcome chemoresistance.
    Source: GeneRIF:7942.

    This publication is mapped to 10 other entries.

1 to 25 of 74  Show
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