We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q704D1 (KDGA_THETE)
Protein
2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase
Gene
kdgA
Organism
Thermoproteus tenax
Status
Functioni
Involved in the degradation of glucose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is not able to use 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal) as substrate.
3 PublicationsCatalytic activityi
: 2-dehydro-3-deoxy-D-gluconate degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate. This subpathway is part of the pathway 2-dehydro-3-deoxy-D-gluconate degradation, which is itself part of Carbohydrate acid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate, the pathway 2-dehydro-3-deoxy-D-gluconate degradation and in Carbohydrate acid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 148 | Proton shuttle | 1 | |
Active sitei | 173 | Schiff-base intermediate with substrate1 Publication | 1 |
GO - Molecular functioni
- 2-dehydro-3-deoxy-D-gluconate aldolase activity Source: UniProtKB-EC
- 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase |
Biological process | Carbohydrate metabolism |
Ligand | Schiff base |
Enzyme and pathway databases
BRENDAi | 4.1.2.14, 6329 |
UniPathwayi | UPA00856;UER00829 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:kdgA |
Organismi | Thermoproteus tenax |
Taxonomic identifieri | 2271 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422660 | 1 – 306 | 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolaseAdd BLAST | 306 |
Interactioni
Subunit structurei
Homotetramer; dimer of dimers.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q704D1 |
SMRi | Q704D1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q704D1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 61 – 62 | Substrate binding | 2 | |
Regioni | 148 – 150 | Substrate bindingCurated | 3 | |
Regioni | 173 – 175 | Substrate binding | 3 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR002220, DapA-like |
PANTHERi | PTHR12128, PTHR12128, 1 hit |
Pfami | View protein in Pfam PF00701, DHDPS, 1 hit |
PIRSFi | PIRSF001365, DHDPS, 1 hit |
PRINTSi | PR00146, DHPICSNTHASE |
SMARTi | View protein in SMART SM01130, DHDPS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q704D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHPLIPFRA NFLRAPRVLS MEIVAPVITT FRGGRLDPEL FANHVKNITS
60 70 80 90 100
KGVDVVFVAG TTGLGPALSL QEKMELTDAA TSAARRVIVQ VASLNADEAI
110 120 130 140 150
ALAKYAESRG AEAVASLPPY YFPRLSERQI AKYFRDLCSA VSIPVFLYNY
160 170 180 190 200
PAAVGRDVDA RAAKELGCIR GVKDTNESLA HTLAYKRYLP QARVYNGSDS
210 220 230 240 250
LVFASFAVRL DGVVASSANY LPELLAGIRD AVAAGDIERA RSLQFLLDEI
260 270 280 290 300
VESARHIGYA AAVYELVEIF QGYEAGEPRG PVYPLDPEEK AWLRAAVAKA
KSQLRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ621282 Genomic DNA Translation: CAF18463.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ621282 Genomic DNA Translation: CAF18463.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2R91 | X-ray | 2.00 | A/B/C/D | 21-306 | [»] | |
2R94 | X-ray | 2.20 | A/B/C/D | 21-306 | [»] | |
AlphaFoldDBi | Q704D1 | |||||
SMRi | Q704D1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00856;UER00829 |
BRENDAi | 4.1.2.14, 6329 |
Miscellaneous databases
EvolutionaryTracei | Q704D1 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR002220, DapA-like |
PANTHERi | PTHR12128, PTHR12128, 1 hit |
Pfami | View protein in Pfam PF00701, DHDPS, 1 hit |
PIRSFi | PIRSF001365, DHDPS, 1 hit |
PRINTSi | PR00146, DHPICSNTHASE |
SMARTi | View protein in SMART SM01130, DHDPS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KDGA_THETE | |
Accessioni | Q704D1Primary (citable) accession number: Q704D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2013 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families