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UniProtKB - Q703G9 (POLS_IPNVS)

Entry version 76 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Structural polyprotein

Gene
N/A
Organism
Infectious pancreatic necrosis virus (strain Sp) (IPNV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capsid protein VP2 self assembles to form an icosahedral capsid with a T=13 symmetry, about 70 nm in diameter, and consisting of 260 VP2 trimers. The capsid encapsulates the genomic dsRNA. VP2 is also involved in attachment and entry into the host cell (By similarity).

By similarity

The precursor of VP2 plays an important role in capsid assembly. First, pre-VP2 and VP2 oligomers assemble to form a procapsid. Then, the pre-VP2 intermediates may be processed into VP2 proteins by proteolytic cleavage mediated by VP4 to obtain the mature virion. The final capsid is composed of pentamers and hexamers but VP2 has a natural tendency to assemble into all-pentameric structures. Therefore pre-VP2 may be required to allow formation of the hexameric structures (By similarity).

By similarity

Protease VP4 is a serine protease that cleaves the polyprotein into its final products. Pre-VP2 is first partially cleaved, and may be completely processed by VP4 upon capsid maturation.

PROSITE-ProRule annotation

Capsid protein VP3 plays a key role in virion assembly by providing a scaffold for the capsid made of VP2. May self-assemble to form a T=4-like icosahedral inner-capsid composed of at least 180 trimers. Plays a role in genomic RNA packaging by recruiting VP1 into the capsid and interacting with the dsRNA genome segments to form a ribonucleoprotein complex. Additionally, the interaction of the VP3 C-terminal tail with VP1 removes the inherent structural blockade of the polymerase active site. Thus, VP3 can also function as a transcriptional activator (By similarity).

By similarity

Structural peptide 1 is a small peptide derived from pre-VP2 C-terminus. It destabilizes and perforates cell membranes, suggesting a role during entry (By similarity).

By similarity

Structural peptide 2 is a small peptide derived from pVP2 C-terminus. It is not essential for the virus viability, but viral growth is affected when missing (By similarity).

By similarity

Structural peptide 3 is a small peptide derived from pVP2 C-terminus. It is not essential for the virus viability, but viral growth is affected when missing (By similarity).

By similarity

Miscellaneous

The sequence shown is that of strain 31-75. Isolate Sp103 is VP5-deficient.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi26Divalent metal cation; shared with trimeric partnersBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei633NucleophilePROSITE-ProRule annotation1 Publication1
Active sitei674PROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandMetal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.115, 6986

Protein family/group databases

MEROPS protease database

More...MEROPSi		S50.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural polyprotein
Short name:
PP
Cleaved into the following 7 chains:
Precursor of VP2
Short name:
Pre-VP2
Capsid protein VP2
Structural peptide 1
Short name:
p1
Structural peptide 2
Short name:
p2
Structural peptide 3
Short name:
p3
Protease VP4 (EC:3.4.21.-)
Alternative name(s):
Non-structural protein VP4
Short name:
NS
Capsid protein VP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiInfectious pancreatic necrosis virus (strain Sp) (IPNV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11005 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Birnaviridae › Aquabirnavirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022]
Salmo [TaxID: 8028]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007213 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi508 – 509AS → QL: Complete loss of pVP2-VP4 cleavage. 1 Publication2
Mutagenesisi547H → S: Strongly reduced VP4-VP3 cleavage. No effect on pVP2-VP4 cleavage. 1 Publication1
Mutagenesisi573D → Q: No effect on polyprotein processing. 1 Publication1
Mutagenesisi585D → I: No effect on polyprotein processing. 1 Publication1
Mutagenesisi595D → L: No effect on polyprotein processing. 1 Publication1
Mutagenesisi601D → S: No effect on polyprotein processing. 1 Publication1
Mutagenesisi633S → A, Q or T: Complete loss of protease activity. 1 Publication1
Mutagenesisi633S → C: Partial loss of protease activity. 1 Publication1
Mutagenesisi644D → I: No effect on polyprotein processing. 1 Publication1
Mutagenesisi660 – 661DD → GS: No effect on polyprotein processing. 1 Publication2
Mutagenesisi672D → N: No effect on polyprotein processing. 1 Publication1
Mutagenesisi674K → A, D, H, Q or R: Complete loss of protease activity. 1 Publication1
Mutagenesisi675A → D: 60% loss of pVP2-VP4 and VP4-VP3 cleavages. 1 Publication1
Mutagenesisi676I → A: No effect on polyprotein processing. 1 Publication1
Mutagenesisi677A → D: 60% loss of pVP2-VP4. Complete loss of VP4-VP3 cleavage. 1 Publication1
Mutagenesisi678A → S: No effect on polyprotein processing. 1 Publication1
Mutagenesisi679H → L: Strongly reduced VP4-VP3 cleavage. No effect on pVP2-VP4 cleavage. 1 Publication1
Mutagenesisi680E → M: No effect on polyprotein processing. 1 Publication1
Mutagenesisi682G → L: No effect on polyprotein processing. 1 Publication1
Mutagenesisi683L → A: 60% loss of pVP2-VP4 and VP4-VP3 cleavages. 1 Publication1
Mutagenesisi684P → Q: No effect on polyprotein processing. 1 Publication1
Mutagenesisi685L → A: 60% loss of pVP2-VP4 and VP4-VP3 cleavages. 1 Publication1
Mutagenesisi686I → A: 20% loss of pVP2-VP4 and VP4-VP3 cleavages. 1 Publication1
Mutagenesisi687G → A: 20% loss of pVP2-VP4 and VP4-VP3 cleavages. 1 Publication1
Mutagenesisi689Q → I: No effect on polyprotein processing. 1 Publication1
Mutagenesisi693D → L: Strongly reduced VP4-VP3 cleavage. No effect on pVP2-VP4 cleavage. 1 Publication1
Mutagenesisi704H → S: No effect on polyprotein processing. 1 Publication1
Mutagenesisi734 – 735AS → LE: Complete loss of VP4-VP3 cleavage. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003925991 – 508Precursor of VP2Add BLAST508
ChainiPRO_00002278731 – 442Capsid protein VP2Add BLAST442
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000227874443 – 486Structural peptide 11 PublicationAdd BLAST44
PeptideiPRO_0000227875487 – 495Structural peptide 21 Publication9
PeptideiPRO_0000227876496 – 508Structural peptide 31 PublicationAdd BLAST13
ChainiPRO_0000227877509 – 734Protease VP4Add BLAST226
ChainiPRO_0000227878735 – 972Capsid protein VP3Add BLAST238

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages yield mature proteins. The capsid assembly seems to be regulated by polyprotein processing. The protease VP4 cleaves itself off the polyprotein, thus releasing pre-VP2 and VP3 within the infected cell. During capsid assembly, the C-terminus of pre-VP2 is further processed by VP4, giving rise to VP2, the external capsid protein and three small peptides that all stay closely associated with the capsid (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei442 – 443Cleavage; by protease VP42
Sitei486 – 487Cleavage; by protease VP42
Sitei495 – 496Cleavage; by protease VP42
Sitei508 – 509Cleavage; by protease VP42
Sitei715 – 716Cleavage; by protease VP4; subsidiary2
Sitei734 – 735Cleavage; by protease VP42

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q703G9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Capsid protein VP2 is a homotrimer. A central divalent metal stabilizes the VP2 trimer, possibly cobalt (By similarity). Capsid protein VP3 is a homodimer. Capsid protein VP3 interacts (via C-terminus) with VP1 in the cytoplasm Capsid VP3 interacts with VP2 (By similarity).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1972
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q703G9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q703G9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini509 – 734Peptidase S50PROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni794 – 817DisorderedSequence analysisAdd BLAST24
Regioni916 – 972DisorderedSequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi798 – 817Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi924 – 948Basic and acidic residuesSequence analysisAdd BLAST25

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.620, 1 hit
1.10.8.880, 1 hit
2.60.120.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002662, Birna_VP2
IPR002663, Birna_VP3
IPR043048, Birna_VP3_dom1
IPR043049, Birna_VP3_dom2
IPR025775, Birna_VP4_Prtase_dom
IPR029053, Viral_coat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01766, Birna_VP2, 1 hit
PF01767, Birna_VP3, 1 hit
PF01768, Birna_VP4, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51548, BIRNAVIRUS_VP4_PRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q703G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTNKATATY LKSIMLPETG PASIPDDITE RHILKQETSS YNLEVSESGS 
        60         70         80         90        100
GVLVCFPGAP GSRIGAHYRW NANQTGLEFD QWLETSQDLK KAFNYGRLIS 
       110        120        130        140        150
RKYDIQSSTL PAGLYALNGT LNAATFEGSL SEVESLTYNS LMSLTTNPQD 
       160        170        180        190        200
KVNNQLVTKG VTVLNLPTGF DKPYVRLEDE TPQGLQSMNG AKMRCTAAIA 
       210        220        230        240        250
PRRYEIDLPS QRLPPVPATG TLTTLYEGNA DIVNSTTVTG DINFSLAEQP 
       260        270        280        290        300
ADETKFDFQL DFMGLDNDVP VVTVVSSVLA TNDNYRGVSA KMTQSIPTEN 
       310        320        330        340        350
ITKPITRVKL SYKINQQTAI GNVATLGTMG PASVSFSSGN GNVPGVLRPI 
       360        370        380        390        400
TLVAYEKMTP LSILTVAGVS NYELIPNPEL LKNMVTRYGK YDPEGLNYAK 
       410        420        430        440        450
MILSHREELD IRTVWRTEEY KERTRVFNEI TDFSSDLPTS KAWGWRDIVR 
       460        470        480        490        500
GIRKVAAPVL STLFPMAAPL IGMADQFIGD LTKTNAAGGR YHSMAAGGRY 
       510        520        530        540        550
KDVLESWASG GPDGKFSRAL KNRLESANYE EVELPPPSKG VIVPVVHTVK 
       560        570        580        590        600
SAPGEAFGSL AIIIPGEYPE LLDANQQVLS HFANDTGSVW GIGEDIPFEG 
       610        620        630        640        650
DNMCYTALPL KEIKRNGNIV VEKIFAGPIM GPSAQLGLSL LVNDIEDGVP 
       660        670        680        690        700
RMVFTGEIAD DEETIIPICG VDIKAIAAHE QGLPLIGNQP GVDEEVRNTS 
       710        720        730        740        750
LAAHLIQTGT LPVQRAKGSN KRIKYLGELM ASNASGMDEE LQRLLNATMA 
       760        770        780        790        800
RAKEVQDAEI YKLLKLMAWT RKNDLTDHMY EWSKEDPDAL KFGKLISTPP 
       810        820        830        840        850
KHPEKPKGPD QHHAQEARAT RISLDAVRAG ADFATPEWVA LNNYRGPSPG 
       860        870        880        890        900
QFKYYLITGR EPEPGDEYED YIKQPIVKPT DMNKIRRLAN SVYGLPHQEP 
       910        920        930        940        950
APEEFYDAVA AVFAQNGGRG PDQDQMQDLR ELARQMKRRP RNADAPRRTR 
       960        970 
APAEPAPPGR SRFTPSGDNA EV
Length:972
Mass (Da):106,646
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1448E99800E3C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti883N → Y in AAR10446 (PubMed:15584407).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti36Q → P in strain: Isolate Mason. 1
Natural varianti46S → P in strain: Isolate Mason. 1
Natural varianti52V → I in strain: Isolate Mason, Isolate Tseng, Isolate Blake, Isolate Sp103, Isolate Sp116, Isolate Sp122, Isolate NVI-001, Isolate NVI-011, Isolate NVI-013, Isolate NVI-015, Isolate NVI-016, Isolate NVI-020 and NVI-023. 1
Natural varianti54V → I in strain: Isolate NVI-010. 1
Natural varianti82 – 85WLET → CWRA in strain: Isolate Mason. 4
Natural varianti152V → A in strain: Isolate Mason, Isolate Blake and Isolate Tseng. 1
Natural varianti192K → R in strain: Isolate Mason, Isolate Blake and Isolate Tseng. 1
Natural varianti199I → T in strain: Isolate Sp103 and Isolate Sp122. 1
Natural varianti212R → S in strain: Isolate Mason, Isolate Blake and Isolate Tseng. 1
Natural varianti217P → T in strain: Isolate Sp122, Isolate NVI-001, Isolate NVI-011, Isolate NVI-013, Isolate NVI-015, Isolate NVI-020 and Isolate NVI-023. 1
Natural varianti219T → I in strain: Isolate NVI-010. 1
Natural varianti221T → A in strain: Isolate NVI-001, Isolate NVI-013, Isolate NVI-015, Isolate Sp116 and Isolate NVI-023. 1
Natural varianti222L → P in strain: Isolate NVI-011. 1
Natural varianti234N → S in strain: Isolate Tseng. 1
Natural varianti247A → T in strain: Isolate Sp122, Isolate NVI-001, Isolate NVI-013, Isolate NVI-015 and Isolate NVI-023. 1
Natural varianti249Q → R in strain: Isolate Tseng. 1
Natural varianti252D → N in strain: Isolate Mason, Isolate Tseng, Isolate Blake, Isolate Sp103, Isolate NVI-010 and Isolate NVI-016. 1
Natural varianti252D → V in strain: Isolate NVI-001, Isolate NVI-011, Isolate NVI-013, Isolate NVI-015, Isolate NVI-020, Isolate NVI-023, Isolate Sp116 and Isolate Sp122. 1
Natural varianti255K → R in strain: Isolate Mason, Isolate Blake and Isolate Tseng. 1
Natural varianti262F → L in strain: Isolate Mason. 1
Natural varianti288V → A in strain: Isolate Sp116. 1
Natural varianti319A → E in strain: Isolate NVI-016. 1
Natural varianti323V → A in strain: Isolate NVI-020. 1
Natural varianti323V → F in strain: Isolate NVI-016. 1
Natural varianti432 – 434DFS → EKT in strain: Isolate Mason. 3
Natural varianti455V → I in strain: Isolate Mason. 1
Natural varianti473M → T in strain: Isolate Mason, Isolate Heppel and Isolate Blake. 1
Natural varianti500Y → H in strain: Isolate Heppel, Isolate NVI-010, Isolate NVI-011, Isolate NVI-020, Isolate Sp103 and Isolate Sp116. 1
Natural varianti565P → R in strain: Isolate Mason. 1
Natural varianti570 – 571EL → SF in strain: Isolate Mason. 2
Natural varianti672D → A in strain: Isolate NVI-016. 1
Natural varianti717K → Q in strain: Isolate NVI-016. 1
Natural varianti788D → G in strain: Isolate NVI-011. 1
Natural varianti788D → Y in strain: Isolate NVI-001. 1
Natural varianti802H → R in strain: Isolate NVI-015 and Isolate NVI-016. 1
Natural varianti841L → M in strain: Isolate NVI-016. 1
Natural varianti867E → Q in strain: Isolate Mason and Isolate Blake. 1
Natural varianti875P → S in strain: Isolate NVI-016. 1
Natural varianti882M → T in strain: Isolate Tseng. 1
Natural varianti953 – 954AE → GK in strain: Isolate Mason. 2
Natural varianti959 – 960GR → DV in strain: Isolate Mason. 2
Natural varianti968D → N in strain: Isolate Sp116. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ622822 Genomic RNA Translation: CAF22217.1
U48225 Genomic RNA Translation: AAD11535.1
U56907 Genomic RNA Translation: AAB39512.1
AY374435 Genomic RNA Translation: AAQ75364.1
AY379735 Genomic RNA Translation: AAQ75348.1
AY379736 Genomic RNA Translation: AAQ75350.1
AY379737 Genomic RNA Translation: AAQ75352.1
AY379738 Genomic RNA Translation: AAQ75354.1
AY379740 Genomic RNA Translation: AAQ75357.1
AY379742 Genomic RNA Translation: AAQ75360.1
AY379744 Genomic RNA Translation: AAQ75363.1
AY354519 Genomic RNA Translation: AAR10446.1
AY354520 Genomic RNA Translation: AAR10449.1
AY354521 Genomic RNA Translation: AAR10452.1
AY823632 Genomic RNA Translation: AAX24140.1
AF342728 mRNA Translation: AAK32154.1
L13988 Genomic RNA Translation: AAB00986.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ622822 Genomic RNA Translation: CAF22217.1
U48225 Genomic RNA Translation: AAD11535.1
U56907 Genomic RNA Translation: AAB39512.1
AY374435 Genomic RNA Translation: AAQ75364.1
AY379735 Genomic RNA Translation: AAQ75348.1
AY379736 Genomic RNA Translation: AAQ75350.1
AY379737 Genomic RNA Translation: AAQ75352.1
AY379738 Genomic RNA Translation: AAQ75354.1
AY379740 Genomic RNA Translation: AAQ75357.1
AY379742 Genomic RNA Translation: AAQ75360.1
AY379744 Genomic RNA Translation: AAQ75363.1
AY354519 Genomic RNA Translation: AAR10446.1
AY354520 Genomic RNA Translation: AAR10449.1
AY354521 Genomic RNA Translation: AAR10452.1
AY823632 Genomic RNA Translation: AAX24140.1
AF342728 mRNA Translation: AAK32154.1
L13988 Genomic RNA Translation: AAB00986.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PNLX-ray2.21A/B/C/D/E/F/G/H/I/J514-716[»]
2PNMX-ray2.30A524-716[»]
3IDEX-ray3.35A/B/C/D/E1-442[»]
SMRiQ703G9
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

MEROPSiS50.001

Proteomic databases

PRIDEiQ703G9

Enzyme and pathway databases

BRENDAi3.4.21.115, 6986

Miscellaneous databases

EvolutionaryTraceiQ703G9

Family and domain databases

Gene3Di1.10.150.620, 1 hit
1.10.8.880, 1 hit
2.60.120.20, 1 hit
InterProiView protein in InterPro
IPR002662, Birna_VP2
IPR002663, Birna_VP3
IPR043048, Birna_VP3_dom1
IPR043049, Birna_VP3_dom2
IPR025775, Birna_VP4_Prtase_dom
IPR029053, Viral_coat
PfamiView protein in Pfam
PF01766, Birna_VP2, 1 hit
PF01767, Birna_VP3, 1 hit
PF01768, Birna_VP4, 1 hit
PROSITEiView protein in PROSITE
PS51548, BIRNAVIRUS_VP4_PRO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLS_IPNVS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q703G9
Secondary accession number(s): P90205
, Q4KTX8, Q69CH7, Q69CI0, Q69CI3, Q6U2N3, Q6U2N5, Q6U2N8, Q6U2P1, Q6U2P5, Q6U2P7, Q6UAY7, Q82733, Q990Q0, Q9YJV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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