gE - Envelope glycoprotein E precursor - Human herpesvirus 1 (strain F) (HHV-1)

Functionⁱ

In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.4 Publications

The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses (By similarity).By similarity

GO - Biological processⁱ

evasion or tolerance by virus of host immune response Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Viral immunoevasion

Biological process

Host-virus interaction, Viral immunoevasion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Envelope glycoprotein E Short name: gE Alternative name(s): gE-1
Gene namesⁱ	Name:gE ORF Names:US8
Organismⁱ	Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10304 [NCBI]
Taxonomic lineageⁱ	Viruses › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]

Subcellular locationⁱ

Note:

During virion morphogenesis, this protein probably accumulates in host trans-Golgi where secondary envelopment occurs. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection.1 Publication

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 421	Virion surfaceSequence analysisAdd BLAST	401
Transmembraneⁱ	422 – 442	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	443 – 552	IntravirionSequence analysisAdd BLAST	110

GO - Cellular componentⁱ

host cell Golgi apparatus Source: UniProtKB-SubCell
host cell junction Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW
viral envelope Source: UniProtKB-KW
virion membrane Source: UniProtKB-SubCell

Complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cell junction, Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000038226	21 – 552	Envelope glycoprotein EAdd BLAST		532

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	124	N-linked (GlcNAc...) asparagine; by hostSequence analysis	1
Modified residueⁱ	176	Sulfotyrosine; by hostSequence analysis	1
Glycosylationⁱ	245	N-linked (GlcNAc...) asparagine; by hostSequence analysis	1
Disulfide bondⁱ	273 ↔ 299	By similarity
Disulfide bondⁱ	282 ↔ 291	By similarity
Disulfide bondⁱ	316 ↔ 325	By similarity
Modified residueⁱ	478	Phosphoserine; by host CK2By similarity	1
Modified residueⁱ	479	Phosphoserine; by host CK2By similarity	1
Modified residueⁱ	505	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on serines within the acidic cluster. Phosphorylation determines whether endocytosed viral gE traffics to the trans-Golgi network or recycles to the cell membrane.Curated

N-glycosylated, and sulfated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PRIDEⁱ	Q703F0

PRIDEⁱ

Q703F0

Interactionⁱ

Subunit structureⁱ

Interacts with gI; this interaction enhances the Fc receptor function of gE. The heterodimer gE/gI interacts with the Fc part of host IgG.

Interacts (via C-terminus) with VP22 tegument protein; this interaction is necessary for the recruitment of VP22 to the Golgi and its packaging into virions.

Interacts (via C-terminus) with UL11 tegument protein (By similarity).

By similarity

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	63 – 88	Interaction with gIBy similarityAdd BLAST	26
Regionⁱ	237 – 382	Fc-bindingBy similarityAdd BLAST	146
Regionⁱ	472 – 497	Interaction with VP22 and UL11By similarityAdd BLAST	26
Regionⁱ	478 – 486	AcidicBy similarity	9

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	465 – 468	Internalization motifSequence analysis		4
Motifⁱ	474 – 477	Internalization motifSequence analysis		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	163 – 216	Pro-richAdd BLAST		54

Sequence similaritiesⁱ

Belongs to the alphaherpesvirinae glycoprotein E family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003404 Herpes_glycopE IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02480 Herpes_gE, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q703F0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDRGAVVGFL LGVCVVSCLA GTPKTSWRRV SVGEDVSLLP APGPTGRGPT 
        60         70         80         90        100
QKLLWAVEPL DGCGPLHPSW XSLMPPKQVP ETVVDAACMR APVPLAMAYA 
       110        120        130        140        150
PPAPSATGGL RTDFVWQERA AVVNRSLVIY GVRETDSGLY TLSVGDIKDP 
       160        170        180        190        200
ARQVASVVLV VQPAPVPTPP PTPADYDEDD NDEGEGEDES LAGTPASGTP 
       210        220        230        240        250
RLPPPPAPPR SWPSAPEVSH VRGVTVRMET PEAILFSPGE AFSTNVSIHA 
       260        270        280        290        300
IAHDDQTYTM DVVWLRFDVP TSCAEMRIYE SCLYHPQLPE CLSPADAPCA 
       310        320        330        340        350
ASTWTSRLAV RSYAGCSRTN PPPRCSAEAH MEPVPGLAWQ AASVNLEFRD 
       360        370        380        390        400
ASPQHSGLYL CVVYVNDHIH AWGHITISTA AXYRNAVVEQ PLPQRGADLA 
       410        420        430        440        450
EPTHPHVGAP PHAPPTHGAL RLGAVMGAAL LLSVLGLSVW ACMTCWRRRA 
       460        470        480        490        500
WRAVKSRASG KGPTYIRVAD SELYADWSSD SEGERDQVPW LAPPERPDSP 
       510        520        530        540        550
STNGSGFEIL SPTAPSVYPR SDGHQSRRQL TTFGSGRPDR RYSQASDSSV 

FW

Length:552

Mass (Da):59,313

Last modified:July 5, 2004 - v1

Checksum:ⁱ8F689BF77BE07BB7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ626469 Genomic DNA Translation: CAF24756.1 S62895 Genomic DNA Translation: AAB27080.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AJ626469 Genomic DNA Translation: CAF24756.1
S62895 Genomic DNA Translation: AAB27080.1

Protein	Similar proteins		Species	Score	Length	Source
Q703F0	Glycoprotein E (Fragment)		HHV1		71	UniRef100_Q703F0
Glycoprotein E (Fragment)		HHV1		105
Glycoprotein E (Fragment)		HHV1		105
Glycoprotein E (Fragment)		HHV1		108
Glycoprotein E (Fragment)		HHV1		101
+26

Protein	Similar proteins		Species	Score	Length	Source
Q703F0	Envelope glycoprotein E	)	HHV11		550	UniRef90_P04488
Envelope glycoprotein E		HHV1		550
Uncharacterized protein (Fragment)		Corallococcus sp. AB043A		138
Envelope glycoprotein E		Human alphaherpesvirus 1 strain RH2		550
Glycoprotein E (Fragment)		HHV1		550
+198

Protein	Similar proteins		Species	Score	Length	Source
Q703F0	Envelope glycoprotein E	)	HHV11		550	UniRef50_P04488
Envelope glycoprotein E		HHV2H		545
Envelope glycoprotein E		HHV1		550
Uncharacterized protein (Fragment)		Corallococcus sp. AB043A		138
Envelope glycoprotein E		Human alphaherpesvirus 1 strain RH2		550
+297

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ626469 Genomic DNA Translation: CAF24756.1 S62895 Genomic DNA Translation: AAB27080.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AJ626469 Genomic DNA Translation: CAF24756.1
S62895 Genomic DNA Translation: AAB27080.1

3D structure databases

ModBaseⁱ	Search...

ModBaseⁱ

Search...

Proteomic databases

PRIDEⁱ	Q703F0

PRIDEⁱ

Q703F0

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003404 Herpes_glycopE IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold
Pfamⁱ	View protein in Pfam PF02480 Herpes_gE, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GE_HHV1F
Accessionⁱ	Q703F0Primary (citable) accession number: Q703F0 Secondary accession number(s): Q86624
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
	Last sequence update:	July 5, 2004
	Last modified:	December 11, 2019
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

UniProtKB - Q703F0 (GE_HHV1F)

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Envelope glycoprotein E

gE

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Region

Motif

Compositional bias

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Documents

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q703F0 (GE_HHV1F)

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Envelope glycoprotein E

gE

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ