Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 113 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Xin actin-binding repeat-containing protein 1

Gene

XIRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protects actin filaments from depolymerization.1 Publication

Miscellaneous

'Xin' means 'heart' in Chinese.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Xin actin-binding repeat-containing protein 1
Alternative name(s):
Cardiomyopathy-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XIRP1
Synonyms:CMYA1, XIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14301 XIRP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609777 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q702N8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
165904

Open Targets

More...
OpenTargetsi
ENSG00000168334

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409336

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XIRP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74712579

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169831 – 1843Xin actin-binding repeat-containing protein 1Add BLAST1843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q702N8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q702N8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q702N8

PeptideAtlas

More...
PeptideAtlasi
Q702N8

PRoteomics IDEntifications database

More...
PRIDEi
Q702N8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68504 [Q702N8-1]
68505 [Q702N8-2]
68506 [Q702N8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q702N8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q702N8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A, isoform B and isoform C are expressed in heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168334 Expressed in 106 organ(s), highest expression level in heart left ventricle

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q702N8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026391
HPA016750
HPA018458

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1 (By similarity).

Interacts with F-actin, FLNC and VASP.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127921, 7 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q702N8

Protein interaction database and analysis system

More...
IntActi
Q702N8, 5 interactors

Molecular INTeraction database

More...
MINTi
Q702N8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343140

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q702N8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati89 – 104Xin 1Add BLAST16
Repeati121 – 136Xin 2Add BLAST16
Repeati151 – 166Xin 3Add BLAST16
Repeati186 – 201Xin 4Add BLAST16
Repeati226 – 241Xin 5Add BLAST16
Repeati264 – 279Xin 6Add BLAST16
Repeati302 – 317Xin 7Add BLAST16
Repeati340 – 355Xin 8Add BLAST16
Repeati376 – 391Xin 9Add BLAST16
Repeati436 – 451Xin 10Add BLAST16
Repeati507 – 522Xin 11Add BLAST16
Repeati545 – 560Xin 12Add BLAST16
Repeati589 – 604Xin 13Add BLAST16
Repeati621 – 636Xin 14Add BLAST16
Repeati654 – 669Xin 15Add BLAST16
Repeati691 – 706Xin 16Add BLAST16
Repeati723 – 738Xin 17Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54Interaction with VASP1 PublicationAdd BLAST54
Regioni531 – 632Interaction with CTNNB1By similarityAdd BLAST102
Regioni1685 – 1843Interaction with FLNC1 PublicationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1462 – 1490Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 28Poly-Pro6
Compositional biasi343 – 346Poly-Gln4
Compositional biasi1247 – 1350Pro-richAdd BLAST104

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Xin repeats bind F-actin.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Xin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF8Z Eukaryota
ENOG410ZM11 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063779

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q702N8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGYRWMF

Database of Orthologous Groups

More...
OrthoDBi
34408at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q702N8

TreeFam database of animal gene trees

More...
TreeFami
TF330745

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012510 Actin-binding_Xin_repeat
IPR030072 XIRP1/XIRP2

The PANTHER Classification System

More...
PANTHERi
PTHR22591 PTHR22591, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08043 Xin, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51389 XIN, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q702N8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTQTQVAP TPTMRMATAE DLPLPPPPAL EDLPLPPPKE SFSKFHQQRQ
60 70 80 90 100
ASELRRLYRH IHPELRKNLA EAVAEDLAEV LGSEEPTEGD VQCMRWIFEN
110 120 130 140 150
WRLDAIGEHE RPAAKEPVLC GDVQATSRKF EEGSFANSTD QEPTRPQPGG
160 170 180 190 200
GDVRAARWLF ETKPLDELTG QAKELEATVR EPAASGDVQG TRMLFETRPL
210 220 230 240 250
DRLGSRPSLQ EQSPLELRSE IQELKGDVKK TVKLFQTEPL CAIQDAEGAI
260 270 280 290 300
HEVKAACREE IQSNAVRSAR WLFETRPLDA INQDPSQVRV IRGISLEEGA
310 320 330 340 350
RPDVSATRWI FETQPLDAIR EILVDEKDFQ PSPDLIPPGP DVQQQQHLFE
360 370 380 390 400
TRALDTLKGD EEAGAEAPPK EEVVPGDVRS TLWLFETKPL DAFRDKVQVG
410 420 430 440 450
HLQRVDPQDG EGHLSSDSSS ALPFSQSAPQ RDELKGDVKT FKNLFETLPL
460 470 480 490 500
DSIGQGEVLA HGSPSREEGT DSAGQAQGIG SPVYAMQDSK GRLHALTSVS
510 520 530 540 550
REQIVGGDVQ GYRWMFETQP LDQLGRSPST IDVVRGITRQ EVVAGDVGTA
560 570 580 590 600
RWLFETQPLE MIHQREQQER QKEEGKSQGD PQPEAPPKGD VQTIRWLFET
610 620 630 640 650
CPMSELAEKQ GSEVTDPTAK AEAQSCTWMF KPQPVDRPVG SREQHLQVSQ
660 670 680 690 700
VPAGERQTDR HVFETEPLQA SGRPCGRRPV RYCSRVEIPS GQVSRQKEVF
710 720 730 740 750
QALEAGKKEE QEPRVIAGSI PAGSVHKFTW LFENCPMGSL AAESIQGGNL
760 770 780 790 800
LEEQPMSPSG NRMQESQETA AEGTLRTLHA TPGILHHGGI LMEARGPGEL
810 820 830 840 850
CLAKYVLSGT GQGHPYIRKE ELVSGELPRI ICQVLRRPDV DQQGLLVQED
860 870 880 890 900
PTGQLQLKPL RLPTPGSSGN IEDMDPELQQ LLACGLGTSV ARTGLVMQET
910 920 930 940 950
EQGLVALTAY SLQPRLTSKA SERSSVQLLA SCIDKGDLSG LHSLRWEPPA
960 970 980 990 1000
DPSPVPASEG AQSLHPTESI IHVPPLDPSM GMGHLRASGA TPCPPQAIGK
1010 1020 1030 1040 1050
AVPLAGEAAA PAQLQNTEKQ EDSHSGQKGM AVLGKSEGAT TTPPGPGAPD
1060 1070 1080 1090 1100
LLAAMQSLRM ATAEAQSLHQ QVLNKHKQGP TPTATSNPIQ DGLRKAGATQ
1110 1120 1130 1140 1150
SNIRPGGGSD PRIPAAPRKV SREEQALPRG LPGGWVTIQD GIYTAHPVRT
1160 1170 1180 1190 1200
FDPPGGVQLS QREPQSRHRE TALSVQAPRP LQGGPGQSTG PGREEPGGCT
1210 1220 1230 1240 1250
QMAWGPPGKA MAEVCPGGLQ AAETTLKTAP LGRHILASGP QAAGASPHPH
1260 1270 1280 1290 1300
NAFVPPPPTL PAAVTGPDFP AGAHRAEDSI QQASEPLKDP LLHSHSSPAG
1310 1320 1330 1340 1350
QRTPGGSQTK TPKLDPTMPP KKKPQLPPKP AHLTQSHPPQ RLPKPLPLSP
1360 1370 1380 1390 1400
SFSSEVGQRE HQRGERDTAI PQPAKVPTTV DQGHIPLARC PSGHSQPSLQ
1410 1420 1430 1440 1450
HGLSTTAPRP TKNQATGSNA QSSEPPKLNA LNHDPTSPQW GPGPSGEQPM
1460 1470 1480 1490 1500
EGSHQGAPES PDSLQRNQKE LQGLLNQVQA LEKEAASSVD VQALRRLFEA
1510 1520 1530 1540 1550
VPQLGGAAPQ APAAHQKPEA SVEQAFGELT RVSTEVAQLK EQTLARLLDI
1560 1570 1580 1590 1600
EEAVHKALSS MSSLQPEASA RGHFQGPPKD HSAHKISVTV SSSARPSGSG
1610 1620 1630 1640 1650
QEVGGQTAVK NQAKVECHTE AQSQVKIRNH TEARGHTAST APSTRRQETS
1660 1670 1680 1690 1700
REYLCPPRVL PSSRDSPSSP TFISIQSATR KPLETPSFKG NPDVSVKSTQ
1710 1720 1730 1740 1750
LAQDIGQALL HQKGVQDKTG KKDITQCSVQ PEPAPPSASP LPRGWQKSVL
1760 1770 1780 1790 1800
ELQTGPGSSQ HYGAMRTVTE QYEEVDQFGN TVLMSSTTVT EQAEPPRNPG
1810 1820 1830 1840
SHLGLHASPL LRQFLHSPAG FSSDLTEAET VQVSCSYSQP AAQ
Length:1,843
Mass (Da):198,561
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41A5CC13FE1955CB
GO
Isoform B (identifier: Q702N8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1121: VS → LL
     1122-1843: Missing.

Show »
Length:1,121
Mass (Da):122,134
Checksum:i6BC1414DF33DE804
GO
Isoform C (identifier: Q702N8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1317: Missing.

Show »
Length:526
Mass (Da):56,273
Checksum:i79911F6ED688EBE6
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC86519 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC81057 differs from that shown. Reason: Frameshift at position 1594.Curated
The sequence CAD28459 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21D → G in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti106I → T in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti274E → G in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti754Q → P in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti813G → R in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti1556K → R in BAC04783 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0384393D → N. Corresponds to variant dbSNP:rs2271488Ensembl.1
Natural variantiVAR_038440346Q → R1 PublicationCorresponds to variant dbSNP:rs6805248Ensembl.1
Natural variantiVAR_038441551R → Q. Corresponds to variant dbSNP:rs34121641Ensembl.1
Natural variantiVAR_061722695R → C. Corresponds to variant dbSNP:rs60540208Ensembl.1
Natural variantiVAR_061723776R → W. Corresponds to variant dbSNP:rs9823779Ensembl.1
Natural variantiVAR_038442929L → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_038443965H → P. Corresponds to variant dbSNP:rs11711871Ensembl.1
Natural variantiVAR_0384441046P → A. Corresponds to variant dbSNP:rs35649793Ensembl.1
Natural variantiVAR_0617241061A → V. Corresponds to variant dbSNP:rs35795536Ensembl.1
Natural variantiVAR_0384451604G → R1 PublicationCorresponds to variant dbSNP:rs3732383Ensembl.1
Natural variantiVAR_0384461608A → V. Corresponds to variant dbSNP:rs34810344Ensembl.1
Natural variantiVAR_0384471634R → K in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs768911526Ensembl.1
Natural variantiVAR_0617251707Q → H. Corresponds to variant dbSNP:rs34053674Ensembl.1
Natural variantiVAR_0384481724I → V. Corresponds to variant dbSNP:rs9827576Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0308431 – 1317Missing in isoform C. 2 PublicationsAdd BLAST1317
Alternative sequenceiVSP_0308441120 – 1121VS → LL in isoform B. 2 Publications2
Alternative sequenceiVSP_0308451122 – 1843Missing in isoform B. 2 PublicationsAdd BLAST722

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ626899 mRNA Translation: CAF25191.1
AJ626900 mRNA Translation: CAF25192.1
AY375160 mRNA Translation: AAQ64003.1
AK095941 mRNA Translation: BAC04655.1
AK096421 mRNA Translation: BAC04783.1
AK126299 mRNA Translation: BAC86519.1 Different initiation.
AL713648 mRNA Translation: CAD28459.1 Different initiation.
CR749430 mRNA Translation: CAH18268.1
BC127119 mRNA Translation: AAI27120.1
BC139782 mRNA Translation: AAI39783.1
AJ271461 mRNA Translation: CAC81057.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2683.1 [Q702N8-1]
CCDS56245.1 [Q702N8-2]
CCDS87065.1 [Q702N8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001185550.1, NM_001198621.2 [Q702N8-2]
NP_919269.2, NM_194293.2 [Q702N8-1]
XP_005264966.1, XM_005264909.3 [Q702N8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340369; ENSP00000343140; ENSG00000168334 [Q702N8-1]
ENST00000396251; ENSP00000379550; ENSG00000168334 [Q702N8-2]
ENST00000421646; ENSP00000391645; ENSG00000168334 [Q702N8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
165904

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:165904

UCSC genome browser

More...
UCSCi
uc003cji.4 human [Q702N8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ626899 mRNA Translation: CAF25191.1
AJ626900 mRNA Translation: CAF25192.1
AY375160 mRNA Translation: AAQ64003.1
AK095941 mRNA Translation: BAC04655.1
AK096421 mRNA Translation: BAC04783.1
AK126299 mRNA Translation: BAC86519.1 Different initiation.
AL713648 mRNA Translation: CAD28459.1 Different initiation.
CR749430 mRNA Translation: CAH18268.1
BC127119 mRNA Translation: AAI27120.1
BC139782 mRNA Translation: AAI39783.1
AJ271461 mRNA Translation: CAC81057.1 Frameshift.
CCDSiCCDS2683.1 [Q702N8-1]
CCDS56245.1 [Q702N8-2]
CCDS87065.1 [Q702N8-3]
RefSeqiNP_001185550.1, NM_001198621.2 [Q702N8-2]
NP_919269.2, NM_194293.2 [Q702N8-1]
XP_005264966.1, XM_005264909.3 [Q702N8-1]

3D structure databases

SMRiQ702N8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127921, 7 interactors
ELMiQ702N8
IntActiQ702N8, 5 interactors
MINTiQ702N8
STRINGi9606.ENSP00000343140

PTM databases

iPTMnetiQ702N8
PhosphoSitePlusiQ702N8

Polymorphism and mutation databases

BioMutaiXIRP1
DMDMi74712579

Proteomic databases

EPDiQ702N8
jPOSTiQ702N8
PaxDbiQ702N8
PeptideAtlasiQ702N8
PRIDEiQ702N8
ProteomicsDBi68504 [Q702N8-1]
68505 [Q702N8-2]
68506 [Q702N8-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
165904
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340369; ENSP00000343140; ENSG00000168334 [Q702N8-1]
ENST00000396251; ENSP00000379550; ENSG00000168334 [Q702N8-2]
ENST00000421646; ENSP00000391645; ENSG00000168334 [Q702N8-3]
GeneIDi165904
KEGGihsa:165904
UCSCiuc003cji.4 human [Q702N8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
165904
DisGeNETi165904

GeneCards: human genes, protein and diseases

More...
GeneCardsi
XIRP1
HGNCiHGNC:14301 XIRP1
HPAiCAB026391
HPA016750
HPA018458
MIMi609777 gene
neXtProtiNX_Q702N8
OpenTargetsiENSG00000168334
PharmGKBiPA162409336

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF8Z Eukaryota
ENOG410ZM11 LUCA
GeneTreeiENSGT00530000063779
InParanoidiQ702N8
OMAiQGYRWMF
OrthoDBi34408at2759
PhylomeDBiQ702N8
TreeFamiTF330745

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
XIRP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
165904

Protein Ontology

More...
PROi
PR:Q702N8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168334 Expressed in 106 organ(s), highest expression level in heart left ventricle
GenevisibleiQ702N8 HS

Family and domain databases

InterProiView protein in InterPro
IPR012510 Actin-binding_Xin_repeat
IPR030072 XIRP1/XIRP2
PANTHERiPTHR22591 PTHR22591, 2 hits
PfamiView protein in Pfam
PF08043 Xin, 9 hits
PROSITEiView protein in PROSITE
PS51389 XIN, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXIRP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q702N8
Secondary accession number(s): A0JP25
, A4QPE2, Q68DF2, Q6ZTR3, Q702N9, Q8IVN7, Q8N1N3, Q8N904, Q8TCG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again