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Entry version 106 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

SCO-spondin

Gene

Sspo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SCO-spondin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SspoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1549716, Sspo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024504418 – 5141SCO-spondinAdd BLAST5124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi822N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi895N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi949N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi991N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1357N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1381 ↔ 1394PROSITE-ProRule annotation
Disulfide bondi1388 ↔ 1407PROSITE-ProRule annotation
Disulfide bondi1401 ↔ 1416PROSITE-ProRule annotation
Disulfide bondi1421 ↔ 1433PROSITE-ProRule annotation
Disulfide bondi1428 ↔ 1446PROSITE-ProRule annotation
Disulfide bondi1440 ↔ 1455PROSITE-ProRule annotation
Disulfide bondi1457 ↔ 1469PROSITE-ProRule annotation
Disulfide bondi1464 ↔ 1482PROSITE-ProRule annotation
Disulfide bondi1476 ↔ 1491PROSITE-ProRule annotation
Disulfide bondi1497 ↔ 1509PROSITE-ProRule annotation
Disulfide bondi1504 ↔ 1522PROSITE-ProRule annotation
Disulfide bondi1516 ↔ 1533PROSITE-ProRule annotation
Disulfide bondi1570 ↔ 1582PROSITE-ProRule annotation
Disulfide bondi1577 ↔ 1595PROSITE-ProRule annotation
Disulfide bondi1589 ↔ 1604PROSITE-ProRule annotation
Disulfide bondi1608 ↔ 1621PROSITE-ProRule annotation
Disulfide bondi1615 ↔ 1634PROSITE-ProRule annotation
Disulfide bondi1628 ↔ 1645PROSITE-ProRule annotation
Glycosylationi1655N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1661 ↔ 1671PROSITE-ProRule annotation
Disulfide bondi1666 ↔ 1684PROSITE-ProRule annotation
Glycosylationi1668N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1678 ↔ 1699PROSITE-ProRule annotation
Disulfide bondi1711 ↔ 1747PROSITE-ProRule annotation
Disulfide bondi1715 ↔ 1752PROSITE-ProRule annotation
Glycosylationi1725N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1726 ↔ 1737PROSITE-ProRule annotation
Disulfide bondi1767 ↔ 1964PROSITE-ProRule annotation
Disulfide bondi1771 ↔ 1969PROSITE-ProRule annotation
Disulfide bondi1781 ↔ 1791PROSITE-ProRule annotation
Glycosylationi1814N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2035N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2070 ↔ 2226PROSITE-ProRule annotation
Glycosylationi2130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2236 ↔ 2248PROSITE-ProRule annotation
Disulfide bondi2243 ↔ 2261PROSITE-ProRule annotation
Disulfide bondi2255 ↔ 2270PROSITE-ProRule annotation
Disulfide bondi2392 ↔ 2404PROSITE-ProRule annotation
Disulfide bondi2399 ↔ 2417PROSITE-ProRule annotation
Disulfide bondi2411 ↔ 2426PROSITE-ProRule annotation
Disulfide bondi2449 ↔ 2461PROSITE-ProRule annotation
Disulfide bondi2456 ↔ 2474PROSITE-ProRule annotation
Disulfide bondi2468 ↔ 2483PROSITE-ProRule annotation
Disulfide bondi2486 ↔ 2522PROSITE-ProRule annotation
Disulfide bondi2497 ↔ 2501PROSITE-ProRule annotation
Disulfide bondi2532 ↔ 2537PROSITE-ProRule annotation
Disulfide bondi2552 ↔ 2589PROSITE-ProRule annotation
Disulfide bondi2556 ↔ 2594PROSITE-ProRule annotation
Disulfide bondi2567 ↔ 2579PROSITE-ProRule annotation
Glycosylationi2630N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2679N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2701 ↔ 2739PROSITE-ProRule annotation
Disulfide bondi2712 ↔ 2716PROSITE-ProRule annotation
Disulfide bondi2749 ↔ 2753PROSITE-ProRule annotation
Disulfide bondi2769 ↔ 2807PROSITE-ProRule annotation
Disulfide bondi2773 ↔ 2812PROSITE-ProRule annotation
Disulfide bondi2789 ↔ 2797PROSITE-ProRule annotation
Disulfide bondi2827 ↔ 2862PROSITE-ProRule annotation
Disulfide bondi2831 ↔ 2867PROSITE-ProRule annotation
Disulfide bondi2842 ↔ 2852PROSITE-ProRule annotation
Glycosylationi2921N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2951N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2970 ↔ 3008PROSITE-ProRule annotation
Disulfide bondi2981 ↔ 2985PROSITE-ProRule annotation
Disulfide bondi3018 ↔ 3023PROSITE-ProRule annotation
Glycosylationi3046N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3180 ↔ 3229PROSITE-ProRule annotation
Disulfide bondi3184 ↔ 3234PROSITE-ProRule annotation
Disulfide bondi3195 ↔ 3219PROSITE-ProRule annotation
Disulfide bondi3249 ↔ 3286PROSITE-ProRule annotation
Disulfide bondi3253 ↔ 3291PROSITE-ProRule annotation
Disulfide bondi3264 ↔ 3276PROSITE-ProRule annotation
Glycosylationi3295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3384N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3405 ↔ 3448PROSITE-ProRule annotation
Disulfide bondi3409 ↔ 3454PROSITE-ProRule annotation
Disulfide bondi3420 ↔ 3432PROSITE-ProRule annotation
Disulfide bondi3469 ↔ 3504PROSITE-ProRule annotation
Disulfide bondi3472 ↔ 3511PROSITE-ProRule annotation
Disulfide bondi3482 ↔ 3494PROSITE-ProRule annotation
Glycosylationi3506N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3611N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3642 ↔ 3672PROSITE-ProRule annotation
Disulfide bondi3646 ↔ 3677PROSITE-ProRule annotation
Disulfide bondi3657 ↔ 3662PROSITE-ProRule annotation
Glycosylationi3787N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3818 ↔ 3856PROSITE-ProRule annotation
Disulfide bondi3822 ↔ 3861PROSITE-ProRule annotation
Disulfide bondi3834 ↔ 3846PROSITE-ProRule annotation
Glycosylationi3910N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3943 ↔ 3979PROSITE-ProRule annotation
Disulfide bondi3954 ↔ 3958PROSITE-ProRule annotation
Disulfide bondi3992 ↔ 3997PROSITE-ProRule annotation
Disulfide bondi4012 ↔ 4049PROSITE-ProRule annotation
Disulfide bondi4016 ↔ 4054PROSITE-ProRule annotation
Disulfide bondi4027 ↔ 4039PROSITE-ProRule annotation
Glycosylationi4135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4156 ↔ 4192PROSITE-ProRule annotation
Disulfide bondi4167 ↔ 4171PROSITE-ProRule annotation
Disulfide bondi4202 ↔ 4207PROSITE-ProRule annotation
Disulfide bondi4261 ↔ 4298PROSITE-ProRule annotation
Disulfide bondi4265 ↔ 4303PROSITE-ProRule annotation
Disulfide bondi4276 ↔ 4288PROSITE-ProRule annotation
Glycosylationi4345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4365 ↔ 4402PROSITE-ProRule annotation
Disulfide bondi4376 ↔ 4378PROSITE-ProRule annotation
Disulfide bondi4412 ↔ 4417PROSITE-ProRule annotation
Glycosylationi4416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4557N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4609 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4620 ↔ 4624PROSITE-ProRule annotation
Disulfide bondi4653 ↔ 4658PROSITE-ProRule annotation
Glycosylationi4727N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4744N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4749N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4771 ↔ 4806PROSITE-ProRule annotation
Disulfide bondi4775 ↔ 4811PROSITE-ProRule annotation
Disulfide bondi4786 ↔ 4795PROSITE-ProRule annotation
Glycosylationi4899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4942N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4949N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5047 ↔ 5095PROSITE-ProRule annotation
Glycosylationi5055N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5061 ↔ 5112PROSITE-ProRule annotation
Disulfide bondi5071 ↔ 5128PROSITE-ProRule annotation
Disulfide bondi5075 ↔ 5130PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q700K0

PRoteomics IDEntifications database

More...
PRIDEi
Q700K0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q700K0, 43 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000025848, Expressed in adult mammalian kidney and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q700K0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000037189

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q700K0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 102EMIAdd BLAST85
Domaini194 – 400VWFD 1PROSITE-ProRule annotationAdd BLAST207
Domaini472 – 527TIL 1Sequence analysisAdd BLAST56
Domaini566 – 776VWFD 2PROSITE-ProRule annotationAdd BLAST211
Domaini830 – 883TIL 2Sequence analysisAdd BLAST54
Domaini1018 – 1224VWFD 3PROSITE-ProRule annotationAdd BLAST207
Domaini1280 – 1336TIL 3Sequence analysisAdd BLAST57
Domaini1380 – 1417LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini1420 – 1456LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini1456 – 1492LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini1496 – 1534LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1569 – 1605LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37
Domaini1607 – 1646LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini1660 – 1700LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST41
Domaini1699 – 1753TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini1755 – 1970TSP type-1 2PROSITE-ProRule annotationAdd BLAST216
Domaini1829 – 1868EGF-like 1Add BLAST40
Domaini1869 – 1895EGF-like 2Add BLAST27
Domaini1970 – 2030VWFC 1PROSITE-ProRule annotationAdd BLAST61
Domaini2070 – 2226F5/8 type CPROSITE-ProRule annotationAdd BLAST157
Domaini2235 – 2271LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST37
Domaini2391 – 2427LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST37
Domaini2448 – 2484LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST37
Domaini2485 – 2538TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini2540 – 2595TSP type-1 4PROSITE-ProRule annotationAdd BLAST56
Domaini2618 – 2660TIL 4Sequence analysisAdd BLAST43
Domaini2700 – 2754TSP type-1 5PROSITE-ProRule annotationAdd BLAST55
Domaini2758 – 2813TSP type-1 6PROSITE-ProRule annotationAdd BLAST56
Domaini2815 – 2868TSP type-1 7PROSITE-ProRule annotationAdd BLAST54
Domaini2969 – 3024TSP type-1 8PROSITE-ProRule annotationAdd BLAST56
Domaini3025 – 3068TSP type-1 9PROSITE-ProRule annotationAdd BLAST44
Domaini3075 – 3127TIL 5Sequence analysisAdd BLAST53
Domaini3168 – 3235TSP type-1 10PROSITE-ProRule annotationAdd BLAST68
Domaini3237 – 3292TSP type-1 11PROSITE-ProRule annotationAdd BLAST56
Domaini3300 – 3350TIL 6Sequence analysisAdd BLAST51
Domaini3393 – 3455TSP type-1 12PROSITE-ProRule annotationAdd BLAST63
Domaini3457 – 3512TSP type-1 13PROSITE-ProRule annotationAdd BLAST56
Domaini3514 – 3570TIL 7Sequence analysisAdd BLAST57
Domaini3630 – 3678TSP type-1 14PROSITE-ProRule annotationAdd BLAST49
Domaini3806 – 3862TSP type-1 15PROSITE-ProRule annotationAdd BLAST57
Domaini3876 – 3928TSP type-1 16PROSITE-ProRule annotationAdd BLAST53
Domaini3942 – 3998TSP type-1 17PROSITE-ProRule annotationAdd BLAST57
Domaini4000 – 4055TSP type-1 18PROSITE-ProRule annotationAdd BLAST56
Domaini4058 – 4113TIL 8Sequence analysisAdd BLAST56
Domaini4155 – 4208TSP type-1 19PROSITE-ProRule annotationAdd BLAST54
Domaini4249 – 4304TSP type-1 20PROSITE-ProRule annotationAdd BLAST56
Domaini4306 – 4362TSP type-1 21PROSITE-ProRule annotationAdd BLAST57
Domaini4364 – 4418TSP type-1 22PROSITE-ProRule annotationAdd BLAST55
Domaini4422 – 4477TIL 9Sequence analysisAdd BLAST56
Domaini4608 – 4659TSP type-1 23PROSITE-ProRule annotationAdd BLAST52
Domaini4673 – 4719TIL 10Sequence analysisAdd BLAST47
Domaini4759 – 4812TSP type-1 24PROSITE-ProRule annotationAdd BLAST54
Domaini4814 – 4868TIL 11Sequence analysisAdd BLAST55
Domaini4920 – 4978TIL 12Sequence analysisAdd BLAST59
Domaini4978 – 5036VWFC 2PROSITE-ProRule annotationAdd BLAST59
Domaini5047 – 5134CTCKPROSITE-ProRule annotationAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi896 – 899Poly-Thr4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215, Eukaryota
KOG1216, Eukaryota
KOG3509, Eukaryota
KOG3538, Eukaryota
KOG4475, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155829

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_223278_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q700K0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MQTKNEL

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q700K0

TreeFam database of animal gene trees

More...
TreeFami
TF344272

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 23 hits
2.60.120.260, 1 hit
4.10.400.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207, Cys_knot_C
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR030119, SCO-spondin
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

The PANTHER Classification System

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PANTHERi
PTHR11339:SF358, PTHR11339:SF358, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF08742, C8, 3 hits
PF00754, F5_F8_type_C, 1 hit
PF00057, Ldl_recept_a, 8 hits
PF01826, TIL, 13 hits
PF00090, TSP_1, 23 hits
PF00094, VWD, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 3 hits
SM00192, LDLa, 10 hits
SM00209, TSP1, 25 hits
SM00214, VWC, 5 hits
SM00215, VWC_out, 9 hits
SM00216, VWD, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49785, SSF49785, 1 hit
SSF57424, SSF57424, 10 hits
SSF57567, SSF57567, 15 hits
SSF82895, SSF82895, 25 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01225, CTCK_2, 1 hit
PS01186, EGF_2, 2 hits
PS50022, FA58C_3, 1 hit
PS01209, LDLRA_1, 8 hits
PS50068, LDLRA_2, 10 hits
PS50092, TSP1, 24 hits
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 2 hits
PS51233, VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q700K0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR
60 70 80 90 100
LGWKLDLSWG GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG
110 120 130 140 150
IHCTEALAEA SPKGHCFVTW HCQPLAGSAN SSAGSLEECC AQPWGHSWWN
160 170 180 190 200
SSSQMCLSCS GQHRPGNASS EGLLQPLAGA VGQLWSQRQR PSATCATWSG
210 220 230 240 250
FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP QPRQCWLVQV
260 270 280 290 300
IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV
310 320 330 340 350
VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF
360 370 380 390 400
GNSWRLPGYE PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL
410 420 430 440 450
LEDPFSQCHG QVPPDEYHET CLFAYCVGAT AGSGPEEQVK AVCATFANYA
460 470 480 490 500
QACARQHIYV HWRKPGFCER LCPGGQLYSD CISSCPPSCS AVAQGEEGSC
510 520 530 540 550
GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD TVKQQCNPCV
560 570 580 590 600
CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV
610 620 630 640 650
KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW
660 670 680 690 700
IGAEGFNVSH ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC
710 720 730 740 750
GTFTWKQQDD FLTPAGDIET SVTAFASKFQ VSGDGRCPLV DNTPLSSCST
760 770 780 790 800
YSQRLAFAEA ACAALHGHAF QECHGLVERE PFRLRCLESM CSCAPGRDCL
810 820 830 840 850
CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA PACGHYCGEP
860 870 880 890 900
EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL
910 920 930 940 950
KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH
960 970 980 990 1000
SCLAGSTDGC VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI
1010 1020 1030 1040 1050
CVCQNQRWHC TGQRCSGWCQ ASGAPHYVTF DGLVFTFPGA CEYLLVREAG
1060 1070 1080 1090 1100
GRFSVSIQNL PCGASGLTCT KALAVRLDST VVHMLRGQAV TVNGVSIKLP
1110 1120 1130 1140 1150
KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS PHFHGRVTGL
1160 1170 1180 1190 1200
CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA
1210 1220 1230 1240 1250
HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL
1260 1270 1280 1290 1300
CSAIATYADE CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH
1310 1320 1330 1340 1350
HPELRWHCQA ITCVEGCFCP EGTLLHGGTC VELTDCPCEW QGSFFPPGAV
1360 1370 1380 1390 1400
LQKDCGNCTC QESQWHCNPS GAPCEEMEPG CAEGEALCRE SGHCVPLEWL
1410 1420 1430 1440 1450
CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC DGQDDCGDGT
1460 1470 1480 1490 1500
DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG
1510 1520 1530 1540 1550
EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS
1560 1570 1580 1590 1600
TSSPDTSPSP VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD
1610 1620 1630 1640 1650
ELDCGGPCKL YQMPCAHGPH CLSPGQLCDG VAQCPDGSDE DPDVCEERSA
1660 1670 1680 1690 1700
SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG SPDCELADET EPSLDEQGCG
1710 1720 1730 1740 1750
TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL QHQSQSCFTE
1760 1770 1780 1790 1800
ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS
1810 1820 1830 1840 1850
THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS
1860 1870 1880 1890 1900
PGCWCPEGKV LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG
1910 1920 1930 1940 1950
QPHRCRPNPE CAVDCGWSSW SPWAECLGPC SSQSLQWSFR SPNNPRLSGH
1960 1970 1980 1990 2000
GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH VGERWRGGPC TVCECLHRSI
2010 2020 2030 2040 2050
TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP VTTPAPVPTP
2060 2070 2080 2090 2100
SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP
2110 2120 2130 2140 2150
TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS
2160 2170 2180 2190 2200
LQFSSDGLQW HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI
2210 2220 2230 2240 2250
RVWPHGSHLR DNNQQDIFLW VELLGCKPVP PLAPLCPGTR HRCANGDCAL
2260 2270 2280 2290 2300
KGGPCDGAVD CEDGSDEEGC GPLRASTASR VHSTARTPAL SPTQPGKFPF
2310 2320 2330 2340 2350
HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS MQTLTTTSTF
2360 2370 2380 2390 2400
PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD
2410 2420 2430 2440 2450
VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS
2460 2470 2480 2490 2500
PSQLSCGSGE CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS
2510 2520 2530 2540 2550
CGLGLIFQHR ELLRPPLPGG SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE
2560 2570 2580 2590 2600
PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP GPSHEKVLCN LQLCPGDTDC
2610 2620 2630 2640 2650
EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG CRCPPGLFLQ
2660 2670 2680 2690 2700
DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS
2710 2720 2730 2740 2750
CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY
2760 2770 2780 2790 2800
TDCGTDIPGW TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE
2810 2820 2830 2840 2850
ATQEEPCSPS LCPVPSAWGL WASWSACSAS CNGGIQTRGR SCSGSAPGNP
2860 2870 2880 2890 2900
VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA EKCLEEGGPC PQLCLAQDPG
2910 2920 2930 2940 2950
VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA PGAVARLDCN
2960 2970 2980 2990 3000
NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP
3010 3020 3030 3040 3050
AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG
3060 3070 3080 3090 3100
SGRHSPVEFS TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA
3110 3120 3130 3140 3150
NQTCHPGCYC LSGMLLLNNV CVPAQDCPCA HRGRLHSPGS AVILPCENCS
3160 3170 3180 3190 3200
CVSGLITNCS SWPCEEGQPA WSSWTPWSVC SASCSPARRH RRRFCVRPST
3210 3220 3230 3240 3250
TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW GPWSPWSGCS
3260 3270 3280 3290 3300
RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE
3310 3320 3330 3340 3350
GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC
3360 3370 3380 3390 3400
SCLDLLTGKR HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS
3410 3420 3430 3440 3450
EWTACSQPCR GQTRTRSRAC VCPAPQHGGA PCPEEAGETG VQHQMEACPN
3460 3470 3480 3490 3500
PTACPVDGAW SPWGSWSPCD ACLGQSYRSR MCSHPPPSDG GTPCLGGHQQ
3510 3520 3530 3540 3550
SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC QPGSSGCQSG
3560 3570 3580 3590 3600
CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE
3610 3620 3630 3640 3650
PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE
3660 3670 3680 3690 3700
QLRSRQCARP PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS
3710 3720 3730 3740 3750
CAHVTGQVAC FSESCEEGCH CPEGTFQHHS ACVQECPCVL TVSLLQELGV
3760 3770 3780 3790 3800
ASTALRSYPV LLGDEGQPLG PGDELDPGQM LQTVCGNCSC VHGKLSCSME
3810 3820 3830 3840 3850
ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA PAGLSCRGPL
3860 3870 3880 3890 3900
QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW
3910 3920 3930 3940 3950
RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP
3960 3970 3980 3990 4000
WEPCSRSCGV GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP
4010 4020 4030 4040 4050
GGWSHWSPWS WCDRSCGGGR SLRSRSCSSP PPKNGGASCV GERHHVRSCN
4060 4070 4080 4090 4100
PMPCEKDCPA GMEMVSCANR CPYSCSDLQE AVMCQEDQAC QLGCRCSEGF
4110 4120 4130 4140 4150
LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA GQLSCTAQPC
4160 4170 4180 4190 4200
PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ
4210 4220 4230 4240 4250
PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG
4260 4270 4280 4290 4300
GWTLWSSWSY CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ
4310 4320 4330 4340 4350
QLCLQLLEIC SWGPWGPCSR SCGTGLASRS GSCPCLLTKE DSECNDTFSG
4360 4370 4380 4390 4400
LDTQACYPGP CQEDCMWSDW SSWTRCSCKI LVQQRYRHQV PAPGQAGEGT
4410 4420 4430 4440 4450
LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA THLSHQLCQD
4460 4470 4480 4490 4500
LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG
4510 4520 4530 4540 4550
CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL
4560 4570 4580 4590 4600
EVHWPLNTSV TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS
4610 4620 4630 4640 4650
DPGACHDTCQ WGPWGPWSPC QVPCSGGFKL RWREASDNSV GECRGPWAQT
4660 4670 4680 4690 4700
ESCNMGSCPG ESCETRDTVF TLDCANQCPR SCADLWEGVQ CLQGPCSPGC
4710 4720 4730 4740 4750
RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL DCHNCTCING
4760 4770 4780 4790 4800
TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM
4810 4820 4830 4840 4850
EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG
4860 4870 4880 4890 4900
CPGGQLLHSG TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC
4910 4920 4930 4940 4950
THCTCQGGVF TCSHTDCQEC PPGEILQLGE LRPCEKTCLE MNKTQAWSNC
4960 4970 4980 4990 5000
TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC WHHGSPHLPG SEWQEACESC
5010 5020 5030 5040 5050
RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL EEEPVSCRHL
5060 5070 5080 5090 5100
TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD
5110 5120 5130 5140
PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H
Length:5,141
Mass (Da):550,649
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1772AE67F02CA5E3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ629845 mRNA Translation: CAF33425.1

NCBI Reference Sequences

More...
RefSeqi
NP_001007017.1, NM_001007016.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
474348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:474348

UCSC genome browser

More...
UCSCi
RGD:1549716, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ629845 mRNA Translation: CAF33425.1
RefSeqiNP_001007017.1, NM_001007016.1

3D structure databases

SMRiQ700K0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ700K0, 1 interactor
STRINGi10116.ENSRNOP00000037189

PTM databases

GlyGeniQ700K0, 43 sites

Proteomic databases

PaxDbiQ700K0
PRIDEiQ700K0

Genome annotation databases

EnsembliENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848
GeneIDi474348
KEGGirno:474348
UCSCiRGD:1549716, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
243369
RGDi1549716, Sspo

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
KOG1216, Eukaryota
KOG3509, Eukaryota
KOG3538, Eukaryota
KOG4475, Eukaryota
GeneTreeiENSGT00940000155829
HOGENOMiCLU_223278_0_0_1
InParanoidiQ700K0
OMAiMQTKNEL
OrthoDBi12226at2759
PhylomeDBiQ700K0
TreeFamiTF344272

Enzyme and pathway databases

ReactomeiR-RNO-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q700K0

Gene expression databases

BgeeiENSRNOG00000025848, Expressed in adult mammalian kidney and 14 other tissues

Family and domain databases

CDDicd00112, LDLa, 9 hits
Gene3Di2.20.100.10, 23 hits
2.60.120.260, 1 hit
4.10.400.10, 9 hits
InterProiView protein in InterPro
IPR006207, Cys_knot_C
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR030119, SCO-spondin
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PANTHERiPTHR11339:SF358, PTHR11339:SF358, 2 hits
PfamiView protein in Pfam
PF08742, C8, 3 hits
PF00754, F5_F8_type_C, 1 hit
PF00057, Ldl_recept_a, 8 hits
PF01826, TIL, 13 hits
PF00090, TSP_1, 23 hits
PF00094, VWD, 3 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00832, C8, 3 hits
SM00192, LDLa, 10 hits
SM00209, TSP1, 25 hits
SM00214, VWC, 5 hits
SM00215, VWC_out, 9 hits
SM00216, VWD, 3 hits
SUPFAMiSSF49785, SSF49785, 1 hit
SSF57424, SSF57424, 10 hits
SSF57567, SSF57567, 15 hits
SSF82895, SSF82895, 25 hits
PROSITEiView protein in PROSITE
PS01225, CTCK_2, 1 hit
PS01186, EGF_2, 2 hits
PS50022, FA58C_3, 1 hit
PS01209, LDLRA_1, 8 hits
PS50068, LDLRA_2, 10 hits
PS50092, TSP1, 24 hits
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 2 hits
PS51233, VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSPO_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q700K0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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