UniProtKB - Q6ZXV5 (TMTC3_HUMAN)

BLAST

>sp|Q6ZXV5|TMTC3_HUMAN Transmembrane and TPR repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=TMTC3 PE=1 SV=2
MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP
MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS
VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL
VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI
VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL
CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI
PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK
TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI
GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA
NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW
YNLAIVHIELKEPNEALKKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLS
YINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKEL
KALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV
VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGK
KIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVA
ALKRLEEIERILNGE

Align

Format
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History
Entry version 125 (12 Sep 2018)
Sequence version 2 (20 Mar 2007)
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Protein

Transmembrane and TPR repeat-containing protein 3

Gene

TMTC3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.1 Publication

GO - Biological processⁱ

positive regulation of proteasomal protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21603654
response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21603654

View the complete GO annotation on QuickGO ...

Protein family/group databases

TCDBⁱ	8.A.95.1.1 the transmembrane and tpr repeat-containing protein 3 (tmtc3) family

TCDBⁱ

8.A.95.1.1 the transmembrane and tpr repeat-containing protein 3 (tmtc3) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane and TPR repeat-containing protein 3 Alternative name(s): Protein SMILE
Gene namesⁱ	Name:TMTC3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139324.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26899 TMTC3
MIMⁱ	617218 gene
neXtProtⁱ	NX_Q6ZXV5

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	9 – 29	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	94 – 114	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	136 – 158	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	167 – 187	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	194 – 214	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	232 – 252	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	318 – 338	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	354 – 374	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	377 – 397	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Lissencephaly 8 (LIS8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS8 patients manifest delayed psychomotor development, intellectual disability with poor or absent speech, early-onset refractory seizures, hypotonia, cortical gyral abnormalities, and hypoplasia of the corpus callosum, brainstem and cerebellum. LIS8 inheritance is autosomal recessive.

Keywords - Diseaseⁱ

Disease mutation, Lissencephaly

Organism-specific databases

DisGeNET More...DisGeNETⁱ	160418
MalaCards human disease database More...MalaCardsⁱ	TMTC3
MIMⁱ	617255 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000139324
PharmGKBⁱ	PA142670720

Polymorphism and mutation databases

BioMutaⁱ	TMTC3
DMDMⁱ	134035047

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280293	1 – 915	Transmembrane and TPR repeat-containing protein 3Add BLAST		915

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	494	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	503	PhosphotyrosineCombined sources	1
Glycosylationⁱ	541	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q6ZXV5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6ZXV5
PaxDbⁱ	Q6ZXV5
PeptideAtlas More...PeptideAtlasⁱ	Q6ZXV5
PRIDEⁱ	Q6ZXV5
ProteomicsDBⁱ	68498 68499 [Q6ZXV5-2]

PTM databases

iPTMnetⁱ	Q6ZXV5
PhosphoSitePlusⁱ	Q6ZXV5
SwissPalmⁱ	Q6ZXV5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139324 Expressed in 202 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_TMTC3
ExpressionAtlasⁱ	Q6ZXV5 baseline and differential
Genevisibleⁱ	Q6ZXV5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038550

HPAⁱ

HPA038550

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DAB1	O75553	3	EBI-10188441,EBI-7875264

With

Entry

#Exp.

IntAct

Notes

DAB1

O75553

EBI-10188441,EBI-7875264

Protein-protein interaction databases

BioGridⁱ	127757, 27 interactors
IntActⁱ	Q6ZXV5, 5 interactors
STRINGⁱ	9606.ENSP00000266712

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6ZXV5
SMRⁱ	Q6ZXV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	412 – 445	TPR 1Add BLAST	34
Repeatⁱ	446 – 479	TPR 2Add BLAST	34
Repeatⁱ	481 – 513	TPR 3Add BLAST	33
Repeatⁱ	528 – 562	TPR 4Add BLAST	35
Repeatⁱ	563 – 596	TPR 5Add BLAST	34
Repeatⁱ	597 – 631	TPR 6Add BLAST	35
Repeatⁱ	669 – 702	TPR 7Add BLAST	34
Repeatⁱ	704 – 736	TPR 8Add BLAST	33
Repeatⁱ	737 – 771	TPR 9Add BLAST	35
Repeatⁱ	773 – 805	TPR 10Add BLAST	33

Sequence similaritiesⁱ

Belongs to the TMTC family.Curated

Keywords - Domainⁱ

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1124 Eukaryota COG0457 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074327
HOVERGENⁱ	HBG094080
InParanoidⁱ	Q6ZXV5
OMAⁱ	SDYVQAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FWN
PhylomeDBⁱ	Q6ZXV5
TreeFamⁱ	TF328339

Family and domain databases

Gene3Dⁱ	1.25.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR013618 DUF1736 IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08409 DUF1736, 1 hit PF13174 TPR_6, 1 hit PF13181 TPR_8, 3 hits
SMARTⁱ	View protein in SMART SM00028 TPR, 9 hits
SUPFAMⁱ	SSF48452 SSF48452, 2 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 9 hits PS50293 TPR_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6ZXV5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANINLKEIT LIVGVVTACY WNSLFCGFVF DDVSAILDNK DLHPSTPLKT 
        60         70         80         90        100
LFQNDFWGTP MSEERSHKSY RPLTVLTFRL NYLLSELKPM SYHLLNMIFH 
       110        120        130        140        150
AVVSVIFLKV CKLFLDNKSS VIASLLFAVH PIHTEAVTGV VGRAELLSSI 
       160        170        180        190        200
FFLAAFLSYT RSKGPDNSII WTPIALTVFL VAVATLCKEQ GITVVGICCV 
       210        220        230        240        250
YEVFIAQGYT LPLLCTTAGQ FLRGKGSIPF SMLQTLVKLI VLMFSTLLLV 
       260        270        280        290        300
VIRVQVIQSQ LPVFTRFDNP AAVSPTPTRQ LTFNYLLPVN AWLLLNPSEL 
       310        320        330        340        350
CCDWTMGTIP LIESLLDIRN LATFTFFCFL GMLGVFSIRY SGDSSKTVLM 
       360        370        380        390        400
ALCLMALPFI PASNLFFPVG FVVAERVLYV PSMGFCILVA HGWQKISTKS 
       410        420        430        440        450
VFKKLSWICL SMVILTHSLK TFHRNWDWES EYTLFMSALK VNKNNAKLWN 
       460        470        480        490        500
NVGHALENEK NFERALKYFL QATHVQPDDI GAHMNVGRTY KNLNRTKEAE 
       510        520        530        540        550
ESYMMAKSLM PQIIPGKKYA ARIAPNHLNV YINLANLIRA NESRLEEADQ 
       560        570        580        590        600
LYRQAISMRP DFKQAYISRG ELLLKMNKPL KAKEAYLKAL ELDRNNADLW 
       610        620        630        640        650
YNLAIVHIEL KEPNEALKKN FNRALELNPK HKLALFNSAI VMQESGEVKL 
       660        670        680        690        700
RPEARKRLLS YINEEPLDAN GYFNLGMLAM DDKKDNEAEI WMKKAIKLQA 
       710        720        730        740        750
DFRSALFNLA LLYSQTAKEL KALPILEELL RYYPDHIKGL ILKGDILMNQ 
       760        770        780        790        800
KKDILGAKKC FERILEMDPS NVQGKHNLCV VYFEEKDLLK AERCLLETLA 
       810        820        830        840        850
LAPHEEYIQR HLNIVRDKIS SSSFIEPIFP TSKISSVEGK KIPTESVKEI 
       860        870        880        890        900
RGESRQTQIV KTSDNKSQSK SNKQLGKNGD EETPHKTTKD IKEIEKKRVA 
       910 
ALKRLEEIER ILNGE

Length:915

Mass (Da):104,009

Last modified:March 20, 2007 - v2

Checksum:ⁱ2B6787CE1B7CB83C

Isoform 2 (identifier: Q6ZXV5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
618-618: Missing.

« Hide

        10         20         30         40         50
MANINLKEIT LIVGVVTACY WNSLFCGFVF DDVSAILDNK DLHPSTPLKT 
        60         70         80         90        100
LFQNDFWGTP MSEERSHKSY RPLTVLTFRL NYLLSELKPM SYHLLNMIFH 
       110        120        130        140        150
AVVSVIFLKV CKLFLDNKSS VIASLLFAVH PIHTEAVTGV VGRAELLSSI 
       160        170        180        190        200
FFLAAFLSYT RSKGPDNSII WTPIALTVFL VAVATLCKEQ GITVVGICCV 
       210        220        230        240        250
YEVFIAQGYT LPLLCTTAGQ FLRGKGSIPF SMLQTLVKLI VLMFSTLLLV 
       260        270        280        290        300
VIRVQVIQSQ LPVFTRFDNP AAVSPTPTRQ LTFNYLLPVN AWLLLNPSEL 
       310        320        330        340        350
CCDWTMGTIP LIESLLDIRN LATFTFFCFL GMLGVFSIRY SGDSSKTVLM 
       360        370        380        390        400
ALCLMALPFI PASNLFFPVG FVVAERVLYV PSMGFCILVA HGWQKISTKS 
       410        420        430        440        450
VFKKLSWICL SMVILTHSLK TFHRNWDWES EYTLFMSALK VNKNNAKLWN 
       460        470        480        490        500
NVGHALENEK NFERALKYFL QATHVQPDDI GAHMNVGRTY KNLNRTKEAE 
       510        520        530        540        550
ESYMMAKSLM PQIIPGKKYA ARIAPNHLNV YINLANLIRA NESRLEEADQ 
       560        570        580        590        600
LYRQAISMRP DFKQAYISRG ELLLKMNKPL KAKEAYLKAL ELDRNNADLW 
       610        620        630        640        650
YNLAIVHIEL KEPNEALKNF NRALELNPKH KLALFNSAIV MQESGEVKLR 
       660        670        680        690        700
PEARKRLLSY INEEPLDANG YFNLGMLAMD DKKDNEAEIW MKKAIKLQAD 
       710        720        730        740        750
FRSALFNLAL LYSQTAKELK ALPILEELLR YYPDHIKGLI LKGDILMNQK 
       760        770        780        790        800
KDILGAKKCF ERILEMDPSN VQGKHNLCVV YFEEKDLLKA ERCLLETLAL 
       810        820        830        840        850
APHEEYIQRH LNIVRDKISS SSFIEPIFPT SKISSVEGKK IPTESVKEIR 
       860        870        880        890        900
GESRQTQIVK TSDNKSQSKS NKQLGKNGDE ETPHKTTKDI KEIEKKRVAA 
       910 
LKRLEEIERI LNGE

Show »

Length:914

Mass (Da):103,881

Checksum:ⁱ45BD2C36C36B9E1D

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VRY4	F8VRY4_HUMAN	Transmembrane and TPR repeat-contai... Transmembrane and TPR repeat-containing protein 3	TMTC3	406	Annotation score:
F8W044	F8W044_HUMAN	Transmembrane and TPR repeat-contai... Transmembrane and TPR repeat-containing protein 3	TMTC3	148	Annotation score:
F8VR71	F8VR71_HUMAN	Transmembrane and TPR repeat-contai... Transmembrane and TPR repeat-containing protein 3	TMTC3	145	Annotation score:

Sequence cautionⁱ

The sequence BAC11325 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	120	S → R in CAH18164 (PubMed:17974005).Curated	1
Sequence conflictⁱ	158	S → P in BAC11325 (PubMed:15489334).Curated	1
Sequence conflictⁱ	201	Y → C in BAC11325 (PubMed:15489334).Curated	1
Sequence conflictⁱ	348	V → G in CAD98046 (PubMed:17974005).Curated	1
Sequence conflictⁱ	489	T → A in CAH18100 (PubMed:17974005).Curated	1
Sequence conflictⁱ	538	I → V in CAI45938 (PubMed:17974005).Curated	1
Sequence conflictⁱ	639	A → V in CAD98046 (PubMed:17974005).Curated	1
Sequence conflictⁱ	864	D → N in CAD98046 (PubMed:17974005).Curated	1
Sequence conflictⁱ	883	T → A in CAD98046 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077900	67	H → D in LIS8. 1 Publication		1
Natural variantⁱVAR_077901	384	G → E in LIS8. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023619	618	Missing in isoform 2. 4 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ697717 mRNA Translation: CAG26973.1 BX538169 mRNA Translation: CAD98046.1 CR749244 mRNA Translation: CAH18100.1 CR749309 mRNA Translation: CAH18164.1 CR933632 mRNA Translation: CAI45938.1 CR936640 mRNA Translation: CAI56780.1 BC117175 mRNA Translation: AAI17176.1 BC117177 mRNA Translation: AAI17178.1 AK074973 mRNA Translation: BAC11325.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9032.1 [Q6ZXV5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_861448.2, NM_181783.3 [Q6ZXV5-2]
UniGeneⁱ	Hs.331268

Genome annotation databases

Ensemblⁱ	ENST00000266712; ENSP00000266712; ENSG00000139324 [Q6ZXV5-2]
GeneIDⁱ	160418
KEGGⁱ	hsa:160418
UCSC genome browser More...UCSCⁱ	uc001tau.3 human [Q6ZXV5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6ZXV5	Transmembrane and TPR repeat-containing protein 3		MOUSE		920	UniRef90_Q6ZXV5
transmembrane and TPR repeat-containing protein 3 isoform X1		TURTR		1011
Transmembrane and tetratricopeptide repeat containing 3		CALJA		958
Uncharacterized protein		PIG		939
transmembrane and TPR repeat-containing protein 3 isoform X1		NEOSC		925
+157

Protein	Similar proteins		Species	Score	Length	Source
Q6ZXV5	Transmembrane and TPR repeat-containing protein 3		MOUSE		920	UniRef50_Q6ZXV5
transmembrane and TPR repeat-containing protein 3 isoform X1		TURTR		1011
Transmembrane and tetratricopeptide repeat containing 3		CALJA		958
Uncharacterized protein		PIG		939
transmembrane and TPR repeat-containing protein 3 isoform X1		NEOSC		925
+429

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ697717 mRNA Translation: CAG26973.1 BX538169 mRNA Translation: CAD98046.1 CR749244 mRNA Translation: CAH18100.1 CR749309 mRNA Translation: CAH18164.1 CR933632 mRNA Translation: CAI45938.1 CR936640 mRNA Translation: CAI56780.1 BC117175 mRNA Translation: AAI17176.1 BC117177 mRNA Translation: AAI17178.1 AK074973 mRNA Translation: BAC11325.1 Different initiation.
CCDSⁱ	CCDS9032.1 [Q6ZXV5-2]
RefSeqⁱ	NP_861448.2, NM_181783.3 [Q6ZXV5-2]
UniGeneⁱ	Hs.331268

3D structure databases

ProteinModelPortalⁱ	Q6ZXV5
SMRⁱ	Q6ZXV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127757, 27 interactors
IntActⁱ	Q6ZXV5, 5 interactors
STRINGⁱ	9606.ENSP00000266712

Protein family/group databases

TCDBⁱ	8.A.95.1.1 the transmembrane and tpr repeat-containing protein 3 (tmtc3) family

TCDBⁱ

8.A.95.1.1 the transmembrane and tpr repeat-containing protein 3 (tmtc3) family

PTM databases

iPTMnetⁱ	Q6ZXV5
PhosphoSitePlusⁱ	Q6ZXV5
SwissPalmⁱ	Q6ZXV5

Polymorphism and mutation databases

BioMutaⁱ	TMTC3
DMDMⁱ	134035047

Proteomic databases

EPDⁱ	Q6ZXV5
MaxQBⁱ	Q6ZXV5
PaxDbⁱ	Q6ZXV5
PeptideAtlasⁱ	Q6ZXV5
PRIDEⁱ	Q6ZXV5
ProteomicsDBⁱ	68498 68499 [Q6ZXV5-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	160418
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000266712; ENSP00000266712; ENSG00000139324 [Q6ZXV5-2]
GeneIDⁱ	160418
KEGGⁱ	hsa:160418
UCSCⁱ	uc001tau.3 human [Q6ZXV5-1]

Organism-specific databases

CTDⁱ	160418
DisGeNETⁱ	160418
EuPathDBⁱ	HostDB:ENSG00000139324.11
GeneCardsⁱ	TMTC3
HGNCⁱ	HGNC:26899 TMTC3
HPAⁱ	HPA038550
MalaCardsⁱ	TMTC3
MIMⁱ	617218 gene 617255 phenotype
neXtProtⁱ	NX_Q6ZXV5
OpenTargetsⁱ	ENSG00000139324
PharmGKBⁱ	PA142670720
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1124 Eukaryota COG0457 LUCA
GeneTreeⁱ	ENSGT00550000074327
HOVERGENⁱ	HBG094080
InParanoidⁱ	Q6ZXV5
OMAⁱ	SDYVQAY
OrthoDBⁱ	EOG091G0FWN
PhylomeDBⁱ	Q6ZXV5
TreeFamⁱ	TF328339

Miscellaneous databases

ChiTaRSⁱ	TMTC3 human
GenomeRNAiⁱ	160418
Protein Ontology More...PROⁱ	PR:Q6ZXV5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139324 Expressed in 202 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_TMTC3
ExpressionAtlasⁱ	Q6ZXV5 baseline and differential
Genevisibleⁱ	Q6ZXV5 HS

Family and domain databases

Gene3Dⁱ	1.25.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR013618 DUF1736 IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat
Pfamⁱ	View protein in Pfam PF08409 DUF1736, 1 hit PF13174 TPR_6, 1 hit PF13181 TPR_8, 3 hits
SMARTⁱ	View protein in SMART SM00028 TPR, 9 hits
SUPFAMⁱ	SSF48452 SSF48452, 2 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 9 hits PS50293 TPR_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMTC3_HUMAN
Accessionⁱ	Q6ZXV5Primary (citable) accession number: Q6ZXV5 Secondary accession number(s): Q5CZ86 , Q5H9T6, Q68DQ6, Q68DX0, Q7Z332, Q8NC50
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	September 12, 2018
	This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Supporting data

UniProtKB - Q6ZXV5 (TMTC3_HUMAN)

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Transmembrane and TPR repeat-containing protein 3

TMTC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ