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Protein

Ubiquitin-conjugating enzyme E2 R2

Gene

Ube2r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 R2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme R2
Ubiquitin carrier protein R2
Ubiquitin-conjugating enzyme E2-CDC34B
Ubiquitin-protein ligase R2
Gene namesi
Name:Ube2r2
Synonyms:Cdc34b, Ubc3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914865 Ube2r2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805141 – 238Ubiquitin-conjugating enzyme E2 R2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZWZ2
MaxQBiQ6ZWZ2
PaxDbiQ6ZWZ2
PeptideAtlasiQ6ZWZ2
PRIDEiQ6ZWZ2

PTM databases

iPTMnetiQ6ZWZ2
PhosphoSitePlusiQ6ZWZ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000036241 Expressed in 297 organ(s), highest expression level in blood
CleanExiMM_UBE2R2
GenevisibleiQ6ZWZ2 MM

Interactioni

Subunit structurei

When phosphorylated, interacts with beta-TrCP (BTRC).By similarity

Protein-protein interaction databases

BioGridi212312, 3 interactors
IntActiQ6ZWZ2, 4 interactors
MINTiQ6ZWZ2
STRINGi10090.ENSMUSP00000038813

Structurei

3D structure databases

ProteinModelPortaliQ6ZWZ2
SMRiQ6ZWZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 238Asp/Glu-rich (acidic)Add BLAST39

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiQ6ZWZ2
KOiK02207
OMAiNKRAEFD
OrthoDBiEOG091G0O9F
PhylomeDBiQ6ZWZ2
TreeFamiTF101107

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZWZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN
60 70 80 90 100
TLYEGGYFKA HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP
110 120 130 140 150
VDDPQSGELP SERWNPTQNV RTILLSVISL LNEPNTFSPA NVDASVMFRK
160 170 180 190 200
WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG VKVPTTLAEY CIKTKVPSND
210 220 230
NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES
Length:238
Mass (Da):27,166
Last modified:July 5, 2004 - v1
Checksum:iE896CF0116A56308
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16E → D in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti29R → L in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti33V → L in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti35E → Y in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti37D → Y in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti149R → T in CAC80335 (PubMed:12037680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ240086 mRNA Translation: CAC80335.1
AK003550 mRNA Translation: BAB22850.1
AK007517 mRNA Translation: BAB25085.1
AK075703 mRNA Translation: BAC35899.1
AK075714 mRNA Translation: BAC35904.1
AL807823, AL954379 Genomic DNA Translation: CAM20979.1
AL807823, AL954379 Genomic DNA Translation: CAM27658.1
BC011112 mRNA Translation: AAH11112.1
CCDSiCCDS18057.1
RefSeqiNP_080551.1, NM_026275.4
UniGeneiMm.389540

Genome annotation databases

EnsembliENSMUST00000040008; ENSMUSP00000038813; ENSMUSG00000036241
GeneIDi67615
KEGGimmu:67615
UCSCiuc008sij.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ240086 mRNA Translation: CAC80335.1
AK003550 mRNA Translation: BAB22850.1
AK007517 mRNA Translation: BAB25085.1
AK075703 mRNA Translation: BAC35899.1
AK075714 mRNA Translation: BAC35904.1
AL807823, AL954379 Genomic DNA Translation: CAM20979.1
AL807823, AL954379 Genomic DNA Translation: CAM27658.1
BC011112 mRNA Translation: AAH11112.1
CCDSiCCDS18057.1
RefSeqiNP_080551.1, NM_026275.4
UniGeneiMm.389540

3D structure databases

ProteinModelPortaliQ6ZWZ2
SMRiQ6ZWZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212312, 3 interactors
IntActiQ6ZWZ2, 4 interactors
MINTiQ6ZWZ2
STRINGi10090.ENSMUSP00000038813

PTM databases

iPTMnetiQ6ZWZ2
PhosphoSitePlusiQ6ZWZ2

Proteomic databases

EPDiQ6ZWZ2
MaxQBiQ6ZWZ2
PaxDbiQ6ZWZ2
PeptideAtlasiQ6ZWZ2
PRIDEiQ6ZWZ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040008; ENSMUSP00000038813; ENSMUSG00000036241
GeneIDi67615
KEGGimmu:67615
UCSCiuc008sij.1 mouse

Organism-specific databases

CTDi54926
MGIiMGI:1914865 Ube2r2

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiQ6ZWZ2
KOiK02207
OMAiNKRAEFD
OrthoDBiEOG091G0O9F
PhylomeDBiQ6ZWZ2
TreeFamiTF101107

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiUbe2r2 mouse
PROiPR:Q6ZWZ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036241 Expressed in 297 organ(s), highest expression level in blood
CleanExiMM_UBE2R2
GenevisibleiQ6ZWZ2 MM

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2R2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWZ2
Secondary accession number(s): Q8BW18, Q8VDE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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