UniProtKB - Q6ZWV3 (RL10_MOUSE)
Protein
60S ribosomal protein L10
Gene
Rpl10
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.By similarity
GO - Molecular functioni
- structural constituent of ribosome Source: UniProtKB
- translation regulator activity Source: UniProtKB
GO - Biological processi
- embryonic brain development Source: UniProtKB
- liver regeneration Source: Ensembl
- negative regulation of apoptotic process Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of translation Source: UniProtKB
- ribosomal large subunit assembly Source: GO_Central
- translation Source: MGI
Keywordsi
Molecular function | Developmental protein, Ribonucleoprotein, Ribosomal protein |
Biological process | Translation regulation |
Enzyme and pathway databases
Reactomei | R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689 Formation of a pool of free 40S subunits R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L10CuratedAlternative name(s): Protein QM homolog Ribosomal protein L10Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105943 Rpl10 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
- cytosolic large ribosomal subunit Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- protein-containing complex Source: MGI
- synapse Source: SynGO
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000147107 | 1 – 214 | 60S ribosomal protein L10Add BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 32 | Citrulline1 Publication | 1 | |
Cross-linki | 175 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 188 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Citrullinated by PADI4.1 Publication
Keywords - PTMi
Citrullination, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q6ZWV3 |
jPOSTi | Q6ZWV3 |
MaxQBi | Q6ZWV3 |
PaxDbi | Q6ZWV3 |
PeptideAtlasi | Q6ZWV3 |
PRIDEi | Q6ZWV3 |
TopDownProteomicsi | Q6ZWV3 |
PTM databases
iPTMneti | Q6ZWV3 |
PhosphoSitePlusi | Q6ZWV3 |
SwissPalmi | Q6ZWV3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000008682 Expressed in 21 organ(s), highest expression level in zone of skin |
ExpressionAtlasi | Q6ZWV3 baseline and differential |
Genevisiblei | Q6ZWV3 MM |
Interactioni
Subunit structurei
Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
By similarityProtein-protein interaction databases
BioGridi | 226050, 4 interactors |
IntActi | Q6ZWV3, 5 interactors |
MINTi | Q6ZWV3 |
STRINGi | 10090.ENSMUSP00000125806 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL16 family.Curated
Phylogenomic databases
eggNOGi | KOG0857 Eukaryota COG0197 LUCA |
GeneTreei | ENSGT00390000003897 |
InParanoidi | Q6ZWV3 |
KOi | K02866 |
OMAi | HHVIREN |
OrthoDBi | 1215841at2759 |
PhylomeDBi | Q6ZWV3 |
TreeFami | TF300082 |
Family and domain databases
CDDi | cd01433 Ribosomal_L16_L10e, 1 hit |
Gene3Di | 3.90.1170.10, 1 hit |
InterProi | View protein in InterPro IPR001197 Ribosomal_L10e IPR016180 Ribosomal_L10e/L16 IPR036920 Ribosomal_L10e/L16_sf IPR018255 Ribosomal_L10e_CS |
PANTHERi | PTHR11726 PTHR11726, 1 hit |
Pfami | View protein in Pfam PF00252 Ribosomal_L16, 1 hit |
PIRSFi | PIRSF005590 Ribosomal_L10, 1 hit |
SUPFAMi | SSF54686 SSF54686, 1 hit |
TIGRFAMsi | TIGR00279 uL16_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS01257 RIBOSOMAL_L10E, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q6ZWV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG
60 70 80 90 100
HMVSDEYEQL SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN
110 120 130 140 150
KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNKEHVIE
160 170 180 190 200
ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAEKRL IPDGCGVKYI
210
PNRGPLDKWR ALHS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GXC3 | A0A1B0GXC3_MOUSE | 60S ribosomal protein L10 | Rpl10 | 166 | Annotation score: | ||
I7HLV2 | I7HLV2_MOUSE | 60S ribosomal protein L10 | Rpl10 RP23-436K3.4-003 | 201 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | E → G in AAH86917 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93980 mRNA Translation: AAA16894.1 X75312 mRNA Translation: CAA53061.1 AK011022 mRNA Translation: BAB27339.1 AK012561 mRNA Translation: BAB28316.1 AK014054 mRNA Translation: BAB29134.1 AK088777 mRNA Translation: BAC40566.1 AK144831 mRNA Translation: BAE26087.1 AK146217 mRNA Translation: BAE26985.1 AK151416 mRNA Translation: BAE30381.1 AK151655 mRNA Translation: BAE30584.1 AK151736 mRNA Translation: BAE30650.1 AK152123 mRNA Translation: BAE30965.1 AK152854 mRNA Translation: BAE31547.1 AK153345 mRNA Translation: BAE31921.1 AK160618 mRNA Translation: BAE35918.1 AK166610 mRNA Translation: BAE38892.1 AK167239 mRNA Translation: BAE39361.1 AK167966 mRNA Translation: BAE39963.1 AK168854 mRNA Translation: BAE40675.1 CH466519 Genomic DNA Translation: EDL27744.1 CH466650 Genomic DNA Translation: EDL29836.1 BC024901 mRNA Translation: AAH24901.1 BC048872 mRNA Translation: AAH48872.1 BC082293 mRNA Translation: AAH82293.1 BC083327 mRNA Translation: AAH83327.1 BC086917 mRNA Translation: AAH86917.1 BC092383 mRNA Translation: AAH92383.1 BC098204 mRNA Translation: AAH98204.1 BC099437 mRNA Translation: AAH99437.1 |
CCDSi | CCDS41019.1 |
PIRi | JC2013 |
RefSeqi | NP_443067.1, NM_052835.3 |
Genome annotation databases
Ensembli | ENSMUST00000008826; ENSMUSP00000008826; ENSMUSG00000008682 ENSMUST00000074085; ENSMUSP00000082055; ENSMUSG00000008682 ENSMUST00000076364; ENSMUSP00000125806; ENSMUSG00000058443 |
GeneIDi | 110954 |
KEGGi | mmu:110954 |
UCSCi | uc009toc.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93980 mRNA Translation: AAA16894.1 X75312 mRNA Translation: CAA53061.1 AK011022 mRNA Translation: BAB27339.1 AK012561 mRNA Translation: BAB28316.1 AK014054 mRNA Translation: BAB29134.1 AK088777 mRNA Translation: BAC40566.1 AK144831 mRNA Translation: BAE26087.1 AK146217 mRNA Translation: BAE26985.1 AK151416 mRNA Translation: BAE30381.1 AK151655 mRNA Translation: BAE30584.1 AK151736 mRNA Translation: BAE30650.1 AK152123 mRNA Translation: BAE30965.1 AK152854 mRNA Translation: BAE31547.1 AK153345 mRNA Translation: BAE31921.1 AK160618 mRNA Translation: BAE35918.1 AK166610 mRNA Translation: BAE38892.1 AK167239 mRNA Translation: BAE39361.1 AK167966 mRNA Translation: BAE39963.1 AK168854 mRNA Translation: BAE40675.1 CH466519 Genomic DNA Translation: EDL27744.1 CH466650 Genomic DNA Translation: EDL29836.1 BC024901 mRNA Translation: AAH24901.1 BC048872 mRNA Translation: AAH48872.1 BC082293 mRNA Translation: AAH82293.1 BC083327 mRNA Translation: AAH83327.1 BC086917 mRNA Translation: AAH86917.1 BC092383 mRNA Translation: AAH92383.1 BC098204 mRNA Translation: AAH98204.1 BC099437 mRNA Translation: AAH99437.1 |
CCDSi | CCDS41019.1 |
PIRi | JC2013 |
RefSeqi | NP_443067.1, NM_052835.3 |
3D structure databases
SMRi | Q6ZWV3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 226050, 4 interactors |
IntActi | Q6ZWV3, 5 interactors |
MINTi | Q6ZWV3 |
STRINGi | 10090.ENSMUSP00000125806 |
PTM databases
iPTMneti | Q6ZWV3 |
PhosphoSitePlusi | Q6ZWV3 |
SwissPalmi | Q6ZWV3 |
Proteomic databases
EPDi | Q6ZWV3 |
jPOSTi | Q6ZWV3 |
MaxQBi | Q6ZWV3 |
PaxDbi | Q6ZWV3 |
PeptideAtlasi | Q6ZWV3 |
PRIDEi | Q6ZWV3 |
TopDownProteomicsi | Q6ZWV3 |
Genome annotation databases
Ensembli | ENSMUST00000008826; ENSMUSP00000008826; ENSMUSG00000008682 ENSMUST00000074085; ENSMUSP00000082055; ENSMUSG00000008682 ENSMUST00000076364; ENSMUSP00000125806; ENSMUSG00000058443 |
GeneIDi | 110954 |
KEGGi | mmu:110954 |
UCSCi | uc009toc.2 mouse |
Organism-specific databases
CTDi | 6134 |
MGIi | MGI:105943 Rpl10 |
Phylogenomic databases
eggNOGi | KOG0857 Eukaryota COG0197 LUCA |
GeneTreei | ENSGT00390000003897 |
InParanoidi | Q6ZWV3 |
KOi | K02866 |
OMAi | HHVIREN |
OrthoDBi | 1215841at2759 |
PhylomeDBi | Q6ZWV3 |
TreeFami | TF300082 |
Enzyme and pathway databases
Reactomei | R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689 Formation of a pool of free 40S subunits R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
ChiTaRSi | Rpl10 mouse |
PROi | PR:Q6ZWV3 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000008682 Expressed in 21 organ(s), highest expression level in zone of skin |
ExpressionAtlasi | Q6ZWV3 baseline and differential |
Genevisiblei | Q6ZWV3 MM |
Family and domain databases
CDDi | cd01433 Ribosomal_L16_L10e, 1 hit |
Gene3Di | 3.90.1170.10, 1 hit |
InterProi | View protein in InterPro IPR001197 Ribosomal_L10e IPR016180 Ribosomal_L10e/L16 IPR036920 Ribosomal_L10e/L16_sf IPR018255 Ribosomal_L10e_CS |
PANTHERi | PTHR11726 PTHR11726, 1 hit |
Pfami | View protein in Pfam PF00252 Ribosomal_L16, 1 hit |
PIRSFi | PIRSF005590 Ribosomal_L10, 1 hit |
SUPFAMi | SSF54686 SSF54686, 1 hit |
TIGRFAMsi | TIGR00279 uL16_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS01257 RIBOSOMAL_L10E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL10_MOUSE | |
Accessioni | Q6ZWV3Primary (citable) accession number: Q6ZWV3 Secondary accession number(s): P45634, Q569M8, Q5M9K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | October 16, 2019 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot