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Protein

40S ribosomal protein S27

Gene

Rps27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity).By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 60C4-typeSequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S27
Gene namesi
Name:Rps27Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 3, Chromosome 9

Organism-specific databases

MGIiMGI:1888676 Rps27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490521 – 8440S ribosomal protein S27Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZWU9
MaxQBiQ6ZWU9
PaxDbiQ6ZWU9
PeptideAtlasiQ6ZWU9
PRIDEiQ6ZWU9
TopDownProteomicsiQ6ZWU9

PTM databases

iPTMnetiQ6ZWU9
PhosphoSitePlusiQ6ZWU9
SwissPalmiQ6ZWU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000050621 Expressed in 20 organ(s), highest expression level in embryonic stem cell
CleanExiMM_RPS27
ExpressionAtlasiQ6ZWU9 baseline and differential
GenevisibleiQ6ZWU9 MM

Interactioni

Subunit structurei

Component of the small ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi208248, 3 interactors
IntActiQ6ZWU9, 2 interactors
MINTiQ6ZWU9
STRINGi10090.ENSMUSP00000132102

Structurei

3D structure databases

ProteinModelPortaliQ6ZWU9
SMRiQ6ZWU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 60C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1779 Eukaryota
COG2051 LUCA
GeneTreeiENSGT00390000013514
HOVERGENiHBG000252
InParanoidiQ6ZWU9
KOiK02978
OMAiQEGCSFR
OrthoDBiEOG091G157G
PhylomeDBiQ6ZWU9
TreeFamiTF300265

Family and domain databases

HAMAPiMF_00371 Ribosomal_S27e, 1 hit
InterProiView protein in InterPro
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR11594 PTHR11594, 1 hit
PfamiView protein in Pfam
PF01667 Ribosomal_S27e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004466 Ribosomal_S27e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01168 RIBOSOMAL_S27E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q6ZWU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA
60 70 80
QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH
Length:84
Mass (Da):9,461
Last modified:January 23, 2007 - v3
Checksum:i242C4466AC8A8900
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDW7A0A0G2JDW7_MOUSE
40S ribosomal protein S27
Rps27
82Annotation score:
A0A0G2JG29A0A0G2JG29_MOUSE
40S ribosomal protein S27
Rps27
83Annotation score:
A0A0G2JEX7A0A0G2JEX7_MOUSE
40S ribosomal protein S27
Rps27 mCG_22228
52Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014294 mRNA Translation: BAB29250.1
AK088320 mRNA Translation: BAC40279.1
AK166551 mRNA Translation: BAE38849.1
BC048352 mRNA Translation: AAH48352.1
BC055693 mRNA Translation: AAH55693.1
CCDSiCCDS50970.1
RefSeqiNP_001177187.1, NM_001190258.1
NP_081291.1, NM_027015.4
UniGeneiMm.270283
Mm.371611

Genome annotation databases

EnsembliENSMUST00000053150; ENSMUSP00000060523; ENSMUSG00000050621
ENSMUST00000170122; ENSMUSP00000132102; ENSMUSG00000090733
GeneIDi100043813
57294
KEGGimmu:100043813
mmu:57294
UCSCiuc008qbl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRS27_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWU9
Secondary accession number(s): Q3TLE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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