UniProtKB - Q6ZWT7 (MBOA2_HUMAN)
Protein
Lysophospholipid acyltransferase 2
Gene
MBOAT2
Organism
Homo sapiens (Human)
Status
Functioni
Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity).By similarity1 Publication
Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA1 PublicationEC:2.3.1.231 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA1 PublicationEC:2.3.1.n71 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA1 PublicationEC:2.3.1.511 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Partially inhibited by thimerosal.1 Publication
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 342 | By similarity | 1 | |
Active sitei | 373 | By similarity | 1 |
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB-EC
- 1-acylglycerophosphocholine O-acyltransferase activity Source: UniProtKB
- 1-acylglycerophosphoethanolamine O-acyltransferase activity Source: UniProtKB
- 1-acylglycerophosphoserine O-acyltransferase activity Source: UniProtKB
- transferase activity, transferring acyl groups Source: GO_Central
GO - Biological processi
- lipid modification Source: GO_Central
- phosphatidylcholine acyl-chain remodeling Source: UniProtKB
- phosphatidylethanolamine acyl-chain remodeling Source: UniProtKB
- phosphatidylserine acyl-chain remodeling Source: UniProtKB
- phospholipid biosynthetic process Source: UniProtKB-KW
- regulation of chondrocyte differentiation Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.23, 2681 |
PathwayCommonsi | Q6ZWT7 |
Reactomei | R-HSA-1482788, Acyl chain remodelling of PC R-HSA-1482839, Acyl chain remodelling of PE |
UniPathwayi | UPA00085 |
Chemistry databases
SwissLipidsi | SLP:000000134 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipid acyltransferase 2Curated (EC:2.3.1.-1 Publication)Short name: LPLAT 2 Alternative name(s): 1-acylglycerophosphate O-acyltransferase MBOAT2Curated (EC:2.3.1.511 Publication) 1-acylglycerophosphocholine O-acyltransferase MBOAT2Curated (EC:2.3.1.231 Publication) 1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferaseCurated (EC:2.3.1.n71 Publication) Lysophosphatidic acid acyltransferase Short name: LPAAT Short name: Lyso-PA acyltransferase Lysophosphatidylcholine acyltransferase Short name: LPCAT Short name: Lyso-PC acyltransferase Lysophosphatidylcholine acyltransferase 4 Short name: Lyso-PC acyltransferase 4 Lysophosphatidylethanolamine acyltransferase Short name: LPEAT Short name: Lyso-PE acyltransferase Membrane-bound O-acyltransferase domain-containing protein 2 Short name: O-acyltransferase domain-containing protein 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000143797.11 |
HGNCi | HGNC:25193, MBOAT2 |
MIMi | 611949, gene |
neXtProti | NX_Q6ZWT7 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 61 – 81 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 184 – 204 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 416 – 436 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 444 – 464 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 129642 |
OpenTargetsi | ENSG00000143797 |
PharmGKBi | PA134987740 |
Miscellaneous databases
Pharosi | Q6ZWT7, Tbio |
Polymorphism and mutation databases
BioMutai | MBOAT2 |
DMDMi | 143811417 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273020 | 1 – 520 | Lysophospholipid acyltransferase 2Add BLAST | 520 |
Proteomic databases
EPDi | Q6ZWT7 |
jPOSTi | Q6ZWT7 |
MassIVEi | Q6ZWT7 |
MaxQBi | Q6ZWT7 |
PaxDbi | Q6ZWT7 |
PeptideAtlasi | Q6ZWT7 |
PRIDEi | Q6ZWT7 |
ProteomicsDBi | 68497 |
PTM databases
iPTMneti | Q6ZWT7 |
PhosphoSitePlusi | Q6ZWT7 |
SwissPalmi | Q6ZWT7 |
Expressioni
Tissue specificityi
Expressed in neutrophils.1 Publication
Gene expression databases
Bgeei | ENSG00000143797, Expressed in corpus callosum and 234 other tissues |
ExpressionAtlasi | Q6ZWT7, baseline and differential |
Genevisiblei | Q6ZWT7, HS |
Organism-specific databases
HPAi | ENSG00000143797, Tissue enhanced (parathyroid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126201, 6 interactors |
IntActi | Q6ZWT7, 3 interactors |
MINTi | Q6ZWT7 |
STRINGi | 9606.ENSP00000302177 |
Miscellaneous databases
RNActi | Q6ZWT7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the membrane-bound acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2704, Eukaryota |
GeneTreei | ENSGT01000000214495 |
HOGENOMi | CLU_011340_3_0_1 |
InParanoidi | Q6ZWT7 |
OMAi | WAISIFE |
OrthoDBi | 881262at2759 |
PhylomeDBi | Q6ZWT7 |
TreeFami | TF314906 |
Family and domain databases
InterProi | View protein in InterPro IPR004299, MBOAT_fam |
Pfami | View protein in Pfam PF03062, MBOAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q6ZWT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAI WFRTYLHSSK
60 70 80 90 100
TSSFIRHVVA TLLGLYLALF CFGWYALHFL VQSGISYCIM IIIGVENMHN
110 120 130 140 150
YCFVFALGYL TVCQVTRVYI FDYGQYSADF SGPMMIITQK ITSLACEIHD
160 170 180 190 200
GMFRKDEELT SSQRDLAVRR MPSLLEYLSY NCNFMGILAG PLCSYKDYIT
210 220 230 240 250
FIEGRSYHIT QSGENGKEET QYERTEPSPN TAVVQKLLVC GLSLLFHLTI
260 270 280 290 300
CTTLPVEYNI DEHFQATASW PTKIIYLYIS LLAARPKYYF AWTLADAINN
310 320 330 340 350
AAGFGFRGYD ENGAARWDLI SNLRIQQIEM STSFKMFLDN WNIQTALWLK
360 370 380 390 400
RVCYERTSFS PTIQTFILSA IWHGVYPGYY LTFLTGVLMT LAARAMRNNF
410 420 430 440 450
RHYFIEPSQL KLFYDVITWI VTQVAISYTV VPFVLLSIKP SLTFYSSWYY
460 470 480 490 500
CLHILGILVL LLLPVKKTQR RKNTHENIQL SQSKKFDEGE NSLGQNSFST
510 520
TNNVCNQNQE IASRHSSLKQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J2H7 | C9J2H7_HUMAN | Lysophospholipid acyltransferase 2 | MBOAT2 | 176 | Annotation score: | ||
H7C5D1 | H7C5D1_HUMAN | Lysophospholipid acyltransferase 2 | MBOAT2 | 158 | Annotation score: | ||
F8WDJ6 | F8WDJ6_HUMAN | Lysophospholipid acyltransferase 2 | MBOAT2 | 46 | Annotation score: |
Sequence cautioni
The sequence BAC11204 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 402 | H → R in BAC11204 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 484 | K → R in BAC85105 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030068 | 501 | T → A. Corresponds to variant dbSNP:rs16866827Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB305044 mRNA Translation: BAF93900.1 AK027321 mRNA Translation: BAC85105.1 AC012495 Genomic DNA No translation available. AC112723 Genomic DNA No translation available. BC016005 mRNA Translation: AAH16005.1 BC146871 mRNA Translation: AAI46872.1 BC157827 mRNA Translation: AAI57828.1 AK074779 mRNA Translation: BAC11204.1 Different initiation. |
CCDSi | CCDS1660.1 |
RefSeqi | NP_001308194.1, NM_001321265.1 NP_001308195.1, NM_001321266.1 NP_001308196.1, NM_001321267.1 NP_620154.2, NM_138799.3 |
Genome annotation databases
Ensembli | ENST00000305997; ENSP00000302177; ENSG00000143797 |
GeneIDi | 129642 |
KEGGi | hsa:129642 |
UCSCi | uc002qzg.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB305044 mRNA Translation: BAF93900.1 AK027321 mRNA Translation: BAC85105.1 AC012495 Genomic DNA No translation available. AC112723 Genomic DNA No translation available. BC016005 mRNA Translation: AAH16005.1 BC146871 mRNA Translation: AAI46872.1 BC157827 mRNA Translation: AAI57828.1 AK074779 mRNA Translation: BAC11204.1 Different initiation. |
CCDSi | CCDS1660.1 |
RefSeqi | NP_001308194.1, NM_001321265.1 NP_001308195.1, NM_001321266.1 NP_001308196.1, NM_001321267.1 NP_620154.2, NM_138799.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126201, 6 interactors |
IntActi | Q6ZWT7, 3 interactors |
MINTi | Q6ZWT7 |
STRINGi | 9606.ENSP00000302177 |
Chemistry databases
SwissLipidsi | SLP:000000134 |
PTM databases
iPTMneti | Q6ZWT7 |
PhosphoSitePlusi | Q6ZWT7 |
SwissPalmi | Q6ZWT7 |
Polymorphism and mutation databases
BioMutai | MBOAT2 |
DMDMi | 143811417 |
Proteomic databases
EPDi | Q6ZWT7 |
jPOSTi | Q6ZWT7 |
MassIVEi | Q6ZWT7 |
MaxQBi | Q6ZWT7 |
PaxDbi | Q6ZWT7 |
PeptideAtlasi | Q6ZWT7 |
PRIDEi | Q6ZWT7 |
ProteomicsDBi | 68497 |
Protocols and materials databases
Antibodypediai | 12361, 76 antibodies |
Genome annotation databases
Ensembli | ENST00000305997; ENSP00000302177; ENSG00000143797 |
GeneIDi | 129642 |
KEGGi | hsa:129642 |
UCSCi | uc002qzg.2, human |
Organism-specific databases
CTDi | 129642 |
DisGeNETi | 129642 |
EuPathDBi | HostDB:ENSG00000143797.11 |
GeneCardsi | MBOAT2 |
HGNCi | HGNC:25193, MBOAT2 |
HPAi | ENSG00000143797, Tissue enhanced (parathyroid) |
MIMi | 611949, gene |
neXtProti | NX_Q6ZWT7 |
OpenTargetsi | ENSG00000143797 |
PharmGKBi | PA134987740 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2704, Eukaryota |
GeneTreei | ENSGT01000000214495 |
HOGENOMi | CLU_011340_3_0_1 |
InParanoidi | Q6ZWT7 |
OMAi | WAISIFE |
OrthoDBi | 881262at2759 |
PhylomeDBi | Q6ZWT7 |
TreeFami | TF314906 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
BRENDAi | 2.3.1.23, 2681 |
PathwayCommonsi | Q6ZWT7 |
Reactomei | R-HSA-1482788, Acyl chain remodelling of PC R-HSA-1482839, Acyl chain remodelling of PE |
Miscellaneous databases
BioGRID-ORCSi | 129642, 17 hits in 845 CRISPR screens |
ChiTaRSi | MBOAT2, human |
GenomeRNAii | 129642 |
Pharosi | Q6ZWT7, Tbio |
PROi | PR:Q6ZWT7 |
RNActi | Q6ZWT7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143797, Expressed in corpus callosum and 234 other tissues |
ExpressionAtlasi | Q6ZWT7, baseline and differential |
Genevisiblei | Q6ZWT7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004299, MBOAT_fam |
Pfami | View protein in Pfam PF03062, MBOAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBOA2_HUMAN | |
Accessioni | Q6ZWT7Primary (citable) accession number: Q6ZWT7 Secondary accession number(s): A9EDR2, Q8NCE7, Q96KY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations