Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (02 Jun 2021)
Sequence version 2 (23 Mar 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Nesprin-2

Gene

Syne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.

By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nesprin-2
Alternative name(s):
KASH domain-containing protein 2
Short name:
KASH2
Nuclear envelope spectrin repeat protein 2
Nucleus and actin connecting element protein
Short name:
Protein NUANCE
Synaptic nuclear envelope protein 2
Short name:
Syne-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syne2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2449316, Syne2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6823CytoplasmicPROSITE-ProRule annotationAdd BLAST6823
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6824 – 6844Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd BLAST21
Topological domaini6845 – 6874Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi128I → A: Impairs interaction with F-actin; when assocoated with A-131. 1 Publication1
Mutagenesisi131I → A: Impairs interaction with F-actin; when assocoated with A-128. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003922101 – 6874Nesprin-2Add BLAST6874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4096PhosphoserineCombined sources1
Modified residuei5772PhosphoserineBy similarity1
Modified residuei6348PhosphoserineBy similarity1
Modified residuei6371PhosphoserineCombined sources1
Modified residuei6400PhosphoserineCombined sources1
Modified residuei6417PhosphoserineCombined sources1
Modified residuei6418PhosphoserineCombined sources1
Modified residuei6419PhosphoserineCombined sources1
Modified residuei6448PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi6851Interchain (with C-577 in SUN2); alternateBy similarity
Disulfide bondi6851Interchain (with C-759 in SUN1); alternateBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The disulfid bond with SUN2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZWQ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZWQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZWQ0

PeptideAtlas

More...
PeptideAtlasi
Q6ZWQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZWQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254736 [Q6ZWQ0-1]
254737 [Q6ZWQ0-2]
254738 [Q6ZWQ0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZWQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZWQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

C-terminal isoforms are highly expressed in the brain, hert and skeletal muscle. Isoform 1 (Nesprin-2 Giant) is most prevalent in the brain, skin, kidney and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063450, Expressed in female gonad and 304 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZWQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZWQ0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, some LINC complex constituents are tissue- or cell type-specific. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. The SUN2:SYNE2/KASH2 complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE2/KASH2 peptides bind at the interface of adjacent SUN domains.

Interacts with EMD, LMNA, MKS3 and F-actin via its N-terminal domain.

Interacts with DCTN1 and DYNC1I1/2; suggesting the association with the dynein-dynactin motor complex. Associates with kinesin motor complexes.

Interacts with TMEM67.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
235364, 56 interactors

Database of interacting proteins

More...
DIPi
DIP-61049N

Protein interaction database and analysis system

More...
IntActi
Q6ZWQ0, 9 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047697

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZWQ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZWQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 136Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST106
Domaini183 – 288Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati299 – 380Spectrin 1Add BLAST82
Repeati381 – 474Spectrin 2Add BLAST94
Repeati475 – 577Spectrin 3Add BLAST103
Repeati578 – 680Spectrin 4Add BLAST103
Repeati727 – 834Spectrin 5Add BLAST108
Repeati835 – 928Spectrin 6Add BLAST94
Repeati929 – 1030Spectrin 7Add BLAST102
Repeati1120 – 1211Spectrin 8Add BLAST92
Repeati1262 – 1322Spectrin 9Add BLAST61
Repeati1323 – 1409Spectrin 10Add BLAST87
Repeati1410 – 1514Spectrin 11Add BLAST105
Repeati1515 – 1626Spectrin 12Add BLAST112
Repeati1627 – 1728Spectrin 13Add BLAST102
Repeati1729 – 1820Spectrin 14Add BLAST92
Repeati1821 – 1928Spectrin 15Add BLAST108
Repeati1929 – 2026Spectrin 16Add BLAST98
Repeati2027 – 2122Spectrin 17Add BLAST96
Repeati2123 – 2233Spectrin 18Add BLAST111
Repeati2234 – 2350Spectrin 19Add BLAST117
Repeati2422 – 2503Spectrin 20Add BLAST82
Repeati2504 – 2610Spectrin 21Add BLAST107
Repeati2611 – 2707Spectrin 22Add BLAST97
Repeati2708 – 2821Spectrin 23Add BLAST114
Repeati2822 – 2923Spectrin 24Add BLAST102
Repeati2924 – 3027Spectrin 25Add BLAST104
Repeati3028 – 3133Spectrin 26Add BLAST106
Repeati3134 – 3239Spectrin 27Add BLAST106
Repeati3240 – 3343Spectrin 28Add BLAST104
Repeati3344 – 3456Spectrin 29Add BLAST113
Repeati3457 – 3563Spectrin 30Add BLAST107
Repeati3564 – 3669Spectrin 31Add BLAST106
Repeati3670 – 3767Spectrin 32Add BLAST98
Repeati3768 – 3870Spectrin 33Add BLAST103
Repeati3871 – 3976Spectrin 34Add BLAST106
Repeati3977 – 4074Spectrin 35Add BLAST98
Repeati4218 – 4337Spectrin 36Add BLAST120
Repeati4507 – 4626Spectrin 37Add BLAST120
Repeati4627 – 4714Spectrin 38Add BLAST88
Repeati4715 – 4823Spectrin 39Add BLAST109
Repeati4824 – 4929Spectrin 40Add BLAST106
Repeati4930 – 5037Spectrin 41Add BLAST108
Repeati5038 – 5150Spectrin 42Add BLAST113
Repeati5151 – 5252Spectrin 43Add BLAST102
Repeati5253 – 5377Spectrin 44Add BLAST125
Repeati5378 – 5473Spectrin 45Add BLAST96
Repeati5474 – 5576Spectrin 46Add BLAST103
Repeati5577 – 5691Spectrin 47Add BLAST115
Repeati5692 – 5786Spectrin 48Add BLAST95
Repeati5787 – 5894Spectrin 49Add BLAST108
Repeati5895 – 6004Spectrin 50Add BLAST110
Repeati6005 – 6122Spectrin 51Add BLAST118
Repeati6123 – 6230Spectrin 52Add BLAST108
Repeati6231 – 6342Spectrin 53Add BLAST112
Repeati6450 – 6534Spectrin 54Add BLAST85
Repeati6535 – 6650Spectrin 55Add BLAST116
Repeati6651 – 6767Spectrin 56Add BLAST117
Domaini6815 – 6874KASHPROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 286Actin-bindingAdd BLAST286
Regioni675 – 723DisorderedSequence analysisAdd BLAST49
Regioni2338 – 2397DisorderedSequence analysisAdd BLAST60
Regioni4062 – 4152DisorderedSequence analysisAdd BLAST91
Regioni4171 – 4193DisorderedSequence analysisAdd BLAST23
Regioni4326 – 4348DisorderedSequence analysisAdd BLAST23
Regioni4401 – 4429DisorderedSequence analysisAdd BLAST29
Regioni5435 – 5459DisorderedSequence analysisAdd BLAST25
Regioni6336 – 6473DisorderedSequence analysisAdd BLAST138
Regioni6790 – 6812DisorderedSequence analysisAdd BLAST23
Regioni6861 – 6874Sufficient for interaction with SUN2By similarityAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili299 – 6767Sequence analysisAdd BLAST6469

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi679 – 693Polar residuesSequence analysisAdd BLAST15
Compositional biasi705 – 723Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi4106 – 4122Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi4329 – 4343Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi6336 – 6375Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi6414 – 6428Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi6446 – 6465Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154656

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZWQ0

Database of Orthologous Groups

More...
OrthoDBi
47at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZWQ0

TreeFam database of animal gene trees

More...
TreeFami
TF329280

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR030266, SYNE2

The PANTHER Classification System

More...
PANTHERi
PTHR47535:SF6, PTHR47535:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZWQ0-1) [UniParc]FASTAAdd to basket
Also known as: Nesprin-2 Giant, Nesp2G, NUANCE

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASPVLPTE DGEGFLGIDD LHFSLQAEQE DTQKKTFTCW INSQLAKHTP
60 70 80 90 100
PSVVSDLFAD IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIEHALTF
110 120 130 140 150
LKNRSIKLIN IHVADIVEGN PSIILGLIWT IILHFHIEKL AQTLSCDYNQ
160 170 180 190 200
PSPEVVSVAA SSPTSSPPTK KCSKAQAQAR WQWSAKKALL QWAQEQCARS
210 220 230 240 250
ESVNVTDFKS SWRNGMAFLA VIHALRPDLI DMDSMRHRSN KDNLKEAFRI
260 270 280 290 300
AEHELKIPKL LEPEDVDVVN PDEKSIMTYV AQFLKYSKDA PGPGDSTQAK
310 320 330 340 350
VRDALVWLTL QEKRFQKMLK DSASETYCNK YHSLLSFMES LNEEKESFID
360 370 380 390 400
VLSLKGRMGE LNEDESRLRQ GWTSLMHQVA AWRAQLDDAL PSPLKETEAW
410 420 430 440 450
LKDIEGVVQE GVPTSQSYSE ARTLIQGKLS SFKSLMGSFD YHSDVLMAFQ
460 470 480 490 500
SNAEKSLPAV PPVKLEEMTR RINNVLGKNF IPLLEFHDSK CSVLALLDEA
510 520 530 540 550
KAKLDVWNGT YESKESVEVL LEDWHKFTGE KKFLIQLDAS FQKCEEMYKN
560 570 580 590 600
SARECESIRE EYMMLEKNVH SCRQYIHNTK ATLQRALMSW ATFEEDLALL
610 620 630 640 650
KASFDLTKKE QIKEVPVETL LQWNTKHTSL NEVGSFLIGV SSREVAASIS
660 670 680 690 700
KELRRLNKRW RKFITKTPLL KLPLVKIQDQ PPGNSSGTSL SKESAMAAEP
710 720 730 740 750
GGSRGEDVKA AEKQEVEDEE SAGQLKVNEE VEGLIKQVTI WESQTKSILD
760 770 780 790 800
LLQHGDHADG SSADTLQHLI AKGSVYEELL ARTEDTLQMD VQSPSNLEPF
810 820 830 840 850
QNVLRAGLQA KIQEAKQGVQ ITMVELSAVL KNLSDEPLEL DLGLKVEEAQ
860 870 880 890 900
KELEVSILRA EQLLGQRERP GGFLLKYKEA LEILNTNSLA KYLRAVEELK
910 920 930 940 950
RTVPGGAKLQ LEEQSRVASA KWEPLRHEIS LYLQQLKIAI EEEKLRDNIA
960 970 980 990 1000
RLEKQINKEK KLIRRGRTRG LRKEHEACLS PESIKCQLEH HVGVLRVLCE
1010 1020 1030 1040 1050
ELTSPEDQQE LKRALRDYEQ KIARLLKCAS EIHTTLQSSQ GGALEERSAL
1060 1070 1080 1090 1100
ITTENGRRDA DGEVPLEIPD NQLSTEKAME PIKNFSQTSE LKPQQEESIM
1110 1120 1130 1140 1150
EKEGKDCSAS LSDLQERYDT QRGLLEQHLQ DSKSRVTSDF ASEQERSSAC
1160 1170 1180 1190 1200
LQSKLAELQV LLADTDAHWE KFEITSLNLR RLMSDAEKPV LNQERDLLKG
1210 1220 1230 1240 1250
NEQVLHGLLN TRMESLEMAL QIVLPLEKEC SLLCASDLPL CTVAVQDLHP
1260 1270 1280 1290 1300
VEIDGVYQNL RDIRDSIAKQ IRVCTSLEEP SNSVPRELHT LDQCAIQDIV
1310 1320 1330 1340 1350
LKCRLQLETM NQKVEMREDA LDALEGFLAS LRAAKLSAEL PADRPAPKAP
1360 1370 1380 1390 1400
EVLSEDILLM KEKAGPLDER LRTLGINIKD AEGGENTTCE RLVGALSVNL
1410 1420 1430 1440 1450
VAMDGQSKEE GPPEDKKLLE ACSSKNLELF KNIQDLQNQI SKIGLKDPTA
1460 1470 1480 1490 1500
PAVKHRKKSL LRLDKDLDGL EEEKVRIQKI AGSLPRFKDG SEKNVIQQCE
1510 1520 1530 1540 1550
DTAALWESTK ASVTESLEQC GSALELLRQY QNIKNNLTAL IQKEEGIISQ
1560 1570 1580 1590 1600
QASYMGKDNL KKKIAEIETV KEEFSDHLEV VDKINQICKN LQYHLNKMKT
1610 1620 1630 1640 1650
FEDPPFEKEA NAIVDRWLDI NEKTEEYGEN LGRALALWDK LFIIKNNIDE
1660 1670 1680 1690 1700
WTEQILGKAE SHELTEEDRG RLKEELKVLE EQSAEFSRRV ADIQSLLQSN
1710 1720 1730 1740 1750
EKPLELQVME SSVLSKMKDV KTHVAGGSNS YAPSGSTAEL REDLDQAKTQ
1760 1770 1780 1790 1800
MGMTESLLNA LSPSDSLEIF TKLEEIQQQI FQQKHSMTVL ENQIGCLTPE
1810 1820 1830 1840 1850
LSELKRQYAS VSNLFNTKKN ALQDHFATFL NEQCKNFNDW FSNVKTNLQE
1860 1870 1880 1890 1900
CFEPPETKLS LEQRLQKLSD FLTLGGGNSK IQQVETVLQH VKMLLPKAHV
1910 1920 1930 1940 1950
KELDSWLRSQ ELELENMESI CQARAGELNN SFQQLLRLED DCRSLSKWLT
1960 1970 1980 1990 2000
NQEENWGKME VSGERMDLFS QALTRKREQF ETVAQLSDSL KEHGLTEGEE
2010 2020 2030 2040 2050
TIKESTHLID RYQALWRQLH EIEEEDKLPA AEDQSFNDLA DDVIHWIKEI
2060 2070 2080 2090 2100
KESLMALNSS EGKMPLEERI QKIKEIIALK PEGDAKIQMV MRQAEHCEAP
2110 2120 2130 2140 2150
LAQETFTDLS NQWDSTLHLA NTYLSHQEKL VLEGEKYLQS KEDLRLMLTE
2160 2170 2180 2190 2200
LKKQQEAGFA LQPGLPEKQA QLKIYKKFLQ KAQDLTSLLE ELKSQGNYLL
2210 2220 2230 2240 2250
ECTKNPSFSE EPWLEVKHLH ESLLQQLQDS VQKLEGHVQE HSSYQVCLTD
2260 2270 2280 2290 2300
LSSTLDDISK EYFSLCDGSK DQIMAKERMQ KLQELESRLR FQGGALKKAS
2310 2320 2330 2340 2350
ALAKSIKQNT SSVGQKIIKD DIRSLKYKQK DLENRIESAK QETENGLNSI
2360 2370 2380 2390 2400
LKSKSSTEKH VKFSLPVEEM PATSEVPKPT RESAAVGESG GARETNTNSA
2410 2420 2430 2440 2450
VEMILSKQLS LNVQESMQNA QDEREVNELQ NQPLELDIML RNEQLKGMEE
2460 2470 2480 2490 2500
LSTHLEARRA AIELLEQSQH LNQTEEQALV LPAARPSVCH LGSLQQELHT
2510 2520 2530 2540 2550
LKKTKERQYG LLSGFQDQLV MAEASLNTSL AEVESLKIGS LDSATYLGKI
2560 2570 2580 2590 2600
KKFLGSVENQ QGSLSKLRTE WAHLSSLLAA ADQKLVESQM KHLEHGWELV
2610 2620 2630 2640 2650
EQLAHRKCFQ QATEHSELTC LLEKLQDLKV SLHQQQQRLT LSLNSPGQQA
2660 2670 2680 2690 2700
AIVDMVTPAA ELQAIKCEFS GLKWQAELHM KRLWGEKDKK TLEDAINNLN
2710 2720 2730 2740 2750
KQMEALEPLN REVENRIKKC ELQNRIKETL SWVKNTMAEL VVPIALLPDN
2760 2770 2780 2790 2800
ILSQIRKCKL IHDGILGNQQ AVELLVEEVR GITPSLAPCE GDGLNALLED
2810 2820 2830 2840 2850
LQSQHQALLL KSTERSQQLE LKLEEKSKLF AIIGKVQLTL EESETLMSPT
2860 2870 2880 2890 2900
GDRASTEAEL ERRLAILKAS QQQLQDTESA LSAHLQELTN AYKDANVFER
2910 2920 2930 2940 2950
LFLDDQLKNL KARTNRTQRF LQNNGSELKQ KMESYREFHD KAAVLQKEAE
2960 2970 2980 2990 3000
CILHGGLLPL RQELEQDAKE QLGNLRDKLA AIRGSLSQVL TSEEVFDTIG
3010 3020 3030 3040 3050
LSWDGSLLAR LQTQVLERER EVEGKIKQLD TFLIARDRHQ ASISKIRAVD
3060 3070 3080 3090 3100
LQIKKGAESL LKVPSMSPES TLLNAQTLIQ KIEKSKRLRD EIIRKLSKNE
3110 3120 3130 3140 3150
AFDDSFKESE MQRLKLCAEE NSRLQEALQN MLLELQPREM GEKEFREKLE
3160 3170 3180 3190 3200
NALHVLKQIQ SRLQQPLCVN LGVQHIQHEK ETWEAFGEQV EAEMCGLRAV
3210 3220 3230 3240 3250
RITEEQREEN DSGTGGMEAK LRDIEGLHME LSKSISLRAD VLNDAYDSAN
3260 3270 3280 3290 3300
RYDELVAGAL RIITSLEATL LSYRVDLHNP QKTLELAHLK QEELQSSVAD
3310 3320 3330 3340 3350
LRSLTETLGA ISSPEAKEQL RCTLEVLAAK NSALKAGLEA QEAEEERCLE
3360 3370 3380 3390 3400
NYKCFRKMKE EICSRLRKME MDLGQSIFPL PRSYKEALAR LEQSKALTSN
3410 3420 3430 3440 3450
LLSTKEDLVK LRQLLRHLRC RSTENDATCA LGVASALWEK WLSLLEAARE
3460 3470 3480 3490 3500
WQQWGGELKR EWKFISEEIE REAIILETLQ EDLPEISKTN AAPTEELWQL
3510 3520 3530 3540 3550
LDSLCQHQES VEKQQLLLAL LLQRVRSIQN IPEGTETGET IPALQEIGSM
3560 3570 3580 3590 3600
QERCDRLLHT TRKNKDLVQA EIQAQQSFLK EIKDVKRVFE QISTSFPNLA
3610 3620 3630 3640 3650
PEGHPERAEQ FEELRSILQK GKLSFENIME KLRIKYSEMY SIVPAEIGSQ
3660 3670 3680 3690 3700
VEECRSALED AEEKMSSEVS KSSPSSIMRR KIERINNGLH CVEKMLQQKS
3710 3720 3730 3740 3750
RNIEEAHEIQ KKIWDELDLW HSKLNELDSE VQDFVEQDPG QAQEWMDNLM
3760 3770 3780 3790 3800
APFQQHQQVS QRAESRTSQL NKATIKMEEY NDLLKSTEVW IEKTSCLLAN
3810 3820 3830 3840 3850
PACYDSSRTL SHRASTLQMA LEDSEQKHSL LHSIFTDLED LSIIFETDDL
3860 3870 3880 3890 3900
IQTIHELSDQ VAALQQQIME ALPHVQQVAD DVVAIESEVK AMEKKVAKIK
3910 3920 3930 3940 3950
AILLSKEIFD FPPEEHLKHG EVILENIHPM KKTIAEIMTY QVELRLPQTG
3960 3970 3980 3990 4000
TKPLPVFQRT SQLLQDVKLL ENVTQEQNEL LKVVIKQTAE CDEEIDSLKQ
4010 4020 4030 4040 4050
MLTNYSAEIS PEHVSQNQVA DLPSLQGEME RLEKQILNLN QKKEDLLVDL
4060 4070 4080 4090 4100
KTAVLNLHEH LKQEQQEVGD KPSAGASECT VAERDASERK LSRTNSMSFL
4110 4120 4130 4140 4150
PVVKEEAEES SVKSEDGRRR TEPPSASWSF LGKHSKDLEG DGASSSSSAT
4160 4170 4180 4190 4200
IVQDADGRIS TCDSSMVHII APDSGSTEEG PAPSPRLSQT DEGATPPIEA
4210 4220 4230 4240 4250
ALLDFPREQG AFESTVERSR PRPADILRVC KTQVAKLELW LQQANVAFEP
4260 4270 4280 4290 4300
ETVDADMQQV VEEELAGCQA MLTEIEYKVA SLLETCKDQG LGDCGTTQQE
4310 4320 4330 4340 4350
AEALSWKLKT VKCNLEKVQM VLQEKFSEDQ HPSTLKKPSE PHDVDQPAGL
4360 4370 4380 4390 4400
SELDSVLTER PQFSRQKDAP QPQILELKPS EQKDLIKFTE LNAKKTWLQG
4410 4420 4430 4440 4450
HQENEDANRQ SASSSKVPSP GNAASDSTLP LQAQSGDKWQ YLHHELTSRP
4460 4470 4480 4490 4500
NPSVPQLVEP QVALTTSTLP SVSVYNFRCP TADELQAYTT QLEELRQEAN
4510 4520 4530 4540 4550
TIQTQGSMTE ETYISLDKRL FELFLSLSRC LGSVEGLLQR PGLLREDACA
4560 4570 4580 4590 4600
QQVFFQKLAL ELKKLYLALG DKKDDFLKAV TWPGKEATLL PECIDALTVS
4610 4620 4630 4640 4650
LESVQSRAAW RDASLKAGLE HSRSYQNEVK RLYSQLIKKK TALQQSLNEI
4660 4670 4680 4690 4700
SGQSISKQLQ KADVHTAELQ NSEKQVAKLR DEGERLRFPH GLLQDVYKLE
4710 4720 4730 4740 4750
DVLDSMWGIL RARYLELSSP FLSKSLQTLL QGMAELVSIG KGKLAADPLQ
4760 4770 4780 4790 4800
HAKSKAALQA QLQDHKAFFQ KLVADMLLIQ TYSATMFPPS LQKGEGFGAE
4810 4820 4830 4840 4850
QVAEVRALEE EACLRGAQLQ SMLQKWEEFD DNYASLEKDL EALISSLPSV
4860 4870 4880 4890 4900
SLVEETEERL LERISFYQQI KRNIDGKHAR LCQTLNEGRQ LAASVSCPEP
4910 4920 4930 4940 4950
EGQIARLEEQ WLSLNKRIDQ ELHRLQTLLK HLLSYSRDSD ELTRWLETSQ
4960 4970 4980 4990 5000
QTLNYWKEQS LNVSQDLNTI RSNIDRFFKF SKEVDERSSL KSAVMSTGNQ
5010 5020 5030 5040 5050
LLHLKEADTA TLRASLAQFE QKWTVLITQL PDIQEKLHQL QMEKLPSREA
5060 5070 5080 5090 5100
ISEMISWMNA VEPQAAGKDT ELSKSSASQV KHLLQKLKEF RMEMDYKQWV
5110 5120 5130 5140 5150
VDFVNQSLLQ LSTCDVESKR YERTEFAEHL GEMNRQWQRV HGTLNRKIQH
5160 5170 5180 5190 5200
LEQLLESITE NENKVQNLNS WLEAQEERLK MLQKPESAVS MEKLLLDCQD
5210 5220 5230 5240 5250
IENQLALKSK ALDELRQSSL TMDGGDVPLL EDMASGIVEL FQKKNNVTSQ
5260 5270 5280 5290 5300
VHQLRASVQS VLQEWKACDK LYDEATMRTT QLTYSMEHSK PAVLSLQALA
5310 5320 5330 5340 5350
CQVQNLEALQ DEAENGERSW EKLQEVIGRL KASCPSMAGI IEEKCQDAHS
5360 5370 5380 5390 5400
RWTQVNQDLA DQLQEARGQL QLWKAPHNAH AEAAAWLQQQ EAKFQQLANT
5410 5420 5430 5440 5450
NLSGDNLADI LPRALKDIKG LQSDLQKTKE AFLENSTLSD QLPQPEERST
5460 5470 5480 5490 5500
PGLHSGQRHS LQTAAYLEKM LLAKSNEFEI VLAQFKDFTD RLAYSKDLIV
5510 5520 5530 5540 5550
HKEENLNKLY HEEKEEVPDL FLNHVLALTA QSPDIERLNE ESLRLPLSDV
5560 5570 5580 5590 5600
TIKTLQSLNR QWIRATATAL DHYSELQGNG LNEKFLHYCE RWIQVLEKIQ
5610 5620 5630 5640 5650
ESLSVEVAHS LPALLEQQKT YEILEAEVST NQAVADAYVT QSLQLLDTAE
5660 5670 5680 5690 5700
IEKRPEFVSE FSKLSDQWQR AARGVRQRKC DISRLVTQWR FFTTSVEDLL
5710 5720 5730 5740 5750
RFLADTSQLL SAVKEQDCYS LCQTRRLVHE LKSKEIHLQR WRTTYALALE
5760 5770 5780 5790 5800
AGEKLRNTPS PETREFVDGQ ISRLQESWKD TELSLGEVIS RLQSTAETWD
5810 5820 5830 5840 5850
QCKKKIKKLK KRLQALKAQS EDPLPELHEA LHEEKELIKE VEKSLANWTH
5860 5870 5880 5890 5900
SLKELQTMKA DLSQHILAED VTVLKEQIQL LHRQWEDLCL RVAIRKQEIE
5910 5920 5930 5940 5950
DRLNSWIVFN EKNKELCAWL VQMENKVLQT ADVSIEEMIE KLQKDCMEEI
5960 5970 5980 5990 6000
SLFTENKLQL KQMGDQLIKA SSKAKAAELE EKLSKINDRW QHLFDVIGSR
6010 6020 6030 6040 6050
VKKLKETFAF IQQLDKNMSN LRTWLARIES ELSKPVVYDV CDNQEIQKRL
6060 6070 6080 6090 6100
AEQQDLQRDI EQHSAGVESV FNICDVLLHD SDACANETEC DSIQQTTRSL
6110 6120 6130 6140 6150
DRRWRNICAM SMERRMKIEE TWRLWQKFLD DYSRFEDWLK SAERTAACPN
6160 6170 6180 6190 6200
SSEVLYTNAK EELKRFEAFQ RQIHERLTQL ELINKQYRRL ARENRTDTAS
6210 6220 6230 6240 6250
KLKQMVHEGN QRWDNLQKRV TAILRRLRYF TNQREEFEGT RESILVWLTE
6260 6270 6280 6290 6300
MDLQLTNVEH FSESDAEDKM RQLNGFQQEI TLNTNKIDQL IVFGEQLIQK
6310 6320 6330 6340 6350
SEPLDAVLIE DELEELHRYC QEVFGRVSRF HRRLTSHTPG LDDEKEASEN
6360 6370 6380 6390 6400
ETDIEDPREI QADSWRKRRE SEEPTSPQSL CHLVPPALGH ERSGCETPVS
6410 6420 6430 6440 6450
VDSIPLEWDH TGDVGGSSSH EDDEEGPFYS ALSGKSISEG HPWHVPDSPS
6460 6470 6480 6490 6500
HSKHHYKHME GDRTEAPVPT DASTPFKSDY VKLLLRQGTD DSKEGLKEAQ
6510 6520 6530 6540 6550
QEDEQLATLT GQQPGAFDRW ELIQAQELHS KLRLKQTVQQ LKSDIGSIAA
6560 6570 6580 6590 6600
WLGKTEAELE ALKLAEPPSD IQEIALRVKR LQEILKAFDT YKALMVSVNV
6610 6620 6630 6640 6650
SHKEYLPSQS PEATELQNRL HQLSLSWDSV QGVLDSWRGD LRQSLMQCQD
6660 6670 6680 6690 6700
FHQLSQDLLL WLATAESRRQ KAHVTSPEAD RQVLLECQKD LMRLEKELVA
6710 6720 6730 6740 6750
RQPQVSSLRE ISSSLLVKGQ GEDYIEAEEK VHVIEKKLKQ LQEQVAQDLM
6760 6770 6780 6790 6800
SLQRSLDPDA SLTSFDEVDS GEQLPAAFAK SPRPRWTFLE EEEEEEETDS
6810 6820 6830 6840 6850
RMPHLDSPGS SQPRRSFLSR VIRAALPLQL LLLLLLLLAC LLPASEDDYS
6860 6870
CTQANNFARS FYPMLRYTNG PPPT
Length:6,874
Mass (Da):782,725
Last modified:March 23, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i379792E42B95B7DB
GO
Isoform 2 (identifier: Q6ZWQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-482: INNVLGKNFIP → FVIVPVHKLCE
     483-6874: Missing.

Show »
Length:482
Mass (Da):54,303
Checksum:i831CAE7F3FAEED80
GO
Isoform 3 (identifier: Q6ZWQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4994: Missing.
     6781-6789: SPRPRWTFL → FGV

Show »
Length:1,874
Mass (Da):216,116
Checksum:iDDB0DAC2C23CC801
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6DFZ2Q6DFZ2_MOUSE
Nesprin-2
Syne2
2,152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QP46E9QP46_MOUSE
Nesprin-2
Syne2
6,870Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W8R9F6W8R9_MOUSE
Nesprin-2
Syne2
1,644Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BX34F7BX34_MOUSE
Nesprin-2
Syne2
733Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VTU3F6VTU3_MOUSE
Nesprin-2
Syne2
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVK9D3YVK9_MOUSE
Nesprin-2
Syne2
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2J8D3Z2J8_MOUSE
Nesprin-2
Syne2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2P5D3Z2P5_MOUSE
Nesprin-2
Syne2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6ZWN0Q6ZWN0_MOUSE
Nesprin-2
Syne2
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z412D3Z412_MOUSE
Nesprin-2
Syne2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0387991 – 4994Missing in isoform 3. 1 PublicationAdd BLAST4994
Alternative sequenceiVSP_038800472 – 482INNVLGKNFIP → FVIVPVHKLCE in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_038801483 – 6874Missing in isoform 2. 1 PublicationAdd BLAST6392
Alternative sequenceiVSP_0388026781 – 6789SPRPRWTFL → FGV in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK052521 mRNA Translation: BAC35023.1
AC115714 Genomic DNA No translation available.
AC159897 Genomic DNA No translation available.
AC164121 Genomic DNA No translation available.
AC166991 Genomic DNA No translation available.
BC082586 mRNA Translation: AAH82586.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49091.1 [Q6ZWQ0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001005510.2, NM_001005510.2 [Q6ZWQ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044217; ENSMUSP00000047697; ENSMUSG00000063450 [Q6ZWQ0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
319565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:319565

UCSC genome browser

More...
UCSCi
uc007nxm.1, mouse [Q6ZWQ0-2]
uc007nxp.1, mouse [Q6ZWQ0-1]
uc007nxs.1, mouse [Q6ZWQ0-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052521 mRNA Translation: BAC35023.1
AC115714 Genomic DNA No translation available.
AC159897 Genomic DNA No translation available.
AC164121 Genomic DNA No translation available.
AC166991 Genomic DNA No translation available.
BC082586 mRNA Translation: AAH82586.1
CCDSiCCDS49091.1 [Q6ZWQ0-1]
RefSeqiNP_001005510.2, NM_001005510.2 [Q6ZWQ0-1]

3D structure databases

SMRiQ6ZWQ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi235364, 56 interactors
DIPiDIP-61049N
IntActiQ6ZWQ0, 9 interactors
STRINGi10090.ENSMUSP00000047697

PTM databases

iPTMnetiQ6ZWQ0
PhosphoSitePlusiQ6ZWQ0

Proteomic databases

EPDiQ6ZWQ0
jPOSTiQ6ZWQ0
PaxDbiQ6ZWQ0
PeptideAtlasiQ6ZWQ0
PRIDEiQ6ZWQ0
ProteomicsDBi254736 [Q6ZWQ0-1]
254737 [Q6ZWQ0-2]
254738 [Q6ZWQ0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
189, 177 antibodies

Genome annotation databases

EnsembliENSMUST00000044217; ENSMUSP00000047697; ENSMUSG00000063450 [Q6ZWQ0-1]
GeneIDi319565
KEGGimmu:319565
UCSCiuc007nxm.1, mouse [Q6ZWQ0-2]
uc007nxp.1, mouse [Q6ZWQ0-1]
uc007nxs.1, mouse [Q6ZWQ0-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23224
MGIiMGI:2449316, Syne2

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000154656
InParanoidiQ6ZWQ0
OrthoDBi47at2759
PhylomeDBiQ6ZWQ0
TreeFamiTF329280

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
319565, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Syne2, mouse

Protein Ontology

More...
PROi
PR:Q6ZWQ0
RNActiQ6ZWQ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063450, Expressed in female gonad and 304 other tissues
ExpressionAtlasiQ6ZWQ0, baseline and differential
GenevisibleiQ6ZWQ0, MM

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR030266, SYNE2
PANTHERiPTHR47535:SF6, PTHR47535:SF6, 1 hit
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 2 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 17 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYNE2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZWQ0
Secondary accession number(s): Q640M5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 2, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again