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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

Lsm8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:Lsm8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923772 Lsm8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001255832 – 96U6 snRNA-associated Sm-like protein LSm8Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZWM4
MaxQBiQ6ZWM4
PaxDbiQ6ZWM4
PeptideAtlasiQ6ZWM4
PRIDEiQ6ZWM4
TopDownProteomicsiQ6ZWM4

PTM databases

PhosphoSitePlusiQ6ZWM4

Expressioni

Gene expression databases

BgeeiENSMUSG00000044155 Expressed in 285 organ(s), highest expression level in forelimb bud
ExpressionAtlasiQ6ZWM4 baseline and differential
GenevisibleiQ6ZWM4 MM

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.By similarity

Protein-protein interaction databases

IntActiQ6ZWM4, 1 interactor
MINTiQ6ZWM4
STRINGi10090.ENSMUSP00000057238

Structurei

3D structure databases

ProteinModelPortaliQ6ZWM4
SMRiQ6ZWM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1784 Eukaryota
ENOG41124H7 LUCA
GeneTreeiENSGT00730000111212
HOVERGENiHBG105578
InParanoidiQ6ZWM4
KOiK12627
OMAiRGDNVCS
OrthoDBiEOG091G126L
PhylomeDBiQ6ZWM4
TreeFamiTF314555

Family and domain databases

CDDicd01727 LSm8, 1 hit
InterProiView protein in InterPro
IPR034103 Lsm8
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ZWM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUZ3A0A0N4SUZ3_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm8 LSM8
100Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088664 mRNA Translation: BAC40488.1
AK167674 mRNA Translation: BAE39723.1
BC019458 mRNA Translation: AAH19458.1
CCDSiCCDS39433.1
RefSeqiNP_598700.1, NM_133939.1
UniGeneiMm.275158

Genome annotation databases

EnsembliENSMUST00000056398; ENSMUSP00000057238; ENSMUSG00000044155
GeneIDi76522
KEGGimmu:76522
UCSCiuc009bao.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088664 mRNA Translation: BAC40488.1
AK167674 mRNA Translation: BAE39723.1
BC019458 mRNA Translation: AAH19458.1
CCDSiCCDS39433.1
RefSeqiNP_598700.1, NM_133939.1
UniGeneiMm.275158

3D structure databases

ProteinModelPortaliQ6ZWM4
SMRiQ6ZWM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZWM4, 1 interactor
MINTiQ6ZWM4
STRINGi10090.ENSMUSP00000057238

PTM databases

PhosphoSitePlusiQ6ZWM4

Proteomic databases

EPDiQ6ZWM4
MaxQBiQ6ZWM4
PaxDbiQ6ZWM4
PeptideAtlasiQ6ZWM4
PRIDEiQ6ZWM4
TopDownProteomicsiQ6ZWM4

Protocols and materials databases

DNASUi76522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056398; ENSMUSP00000057238; ENSMUSG00000044155
GeneIDi76522
KEGGimmu:76522
UCSCiuc009bao.1 mouse

Organism-specific databases

CTDi51691
MGIiMGI:1923772 Lsm8

Phylogenomic databases

eggNOGiKOG1784 Eukaryota
ENOG41124H7 LUCA
GeneTreeiENSGT00730000111212
HOVERGENiHBG105578
InParanoidiQ6ZWM4
KOiK12627
OMAiRGDNVCS
OrthoDBiEOG091G126L
PhylomeDBiQ6ZWM4
TreeFamiTF314555

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q6ZWM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044155 Expressed in 285 organ(s), highest expression level in forelimb bud
ExpressionAtlasiQ6ZWM4 baseline and differential
GenevisibleiQ6ZWM4 MM

Family and domain databases

CDDicd01727 LSm8, 1 hit
InterProiView protein in InterPro
IPR034103 Lsm8
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM8_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWM4
Secondary accession number(s): Q3TIX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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