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Protein

Transmembrane protease serine 11F

Gene

TMPRSS11F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei248Charge relay systemBy similarity1
Active sitei293Charge relay systemBy similarity1
Active sitei389Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.321

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11F (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 4
Gene namesi
Name:TMPRSS11F
Synonyms:HATL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000198092.5
HGNCiHGNC:29994 TMPRSS11F
neXtProtiNX_Q6ZWK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini54 – 438ExtracellularSequence analysisAdd BLAST385

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198092
PharmGKBiPA142670730

Polymorphism and mutation databases

BioMutaiTMPRSS11F
DMDMi206729902

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993221 – 438Transmembrane protease serine 11FAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi233 ↔ 249PROSITE-ProRule annotation
Disulfide bondi358 ↔ 374PROSITE-ProRule annotation
Disulfide bondi385 ↔ 413PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6ZWK6
PeptideAtlasiQ6ZWK6
PRIDEiQ6ZWK6
ProteomicsDBi68492

PTM databases

iPTMnetiQ6ZWK6
PhosphoSitePlusiQ6ZWK6

Expressioni

Gene expression databases

BgeeiENSG00000198092 Expressed in 19 organ(s), highest expression level in ectocervix
CleanExiHS_TMPRSS11F

Organism-specific databases

HPAiHPA026911

Structurei

3D structure databases

ProteinModelPortaliQ6ZWK6
SMRiQ6ZWK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 175SEAPROSITE-ProRule annotationAdd BLAST119
Domaini206 – 437Peptidase S1PROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00930000150822
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiQ6ZWK6
KOiK09752
OMAiCNRKDVY
OrthoDBiEOG091G0DF7
PhylomeDBiQ6ZWK6
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZWK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH
60 70 80 90 100
FVVEDDKSFY YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR
110 120 130 140 150
HSSVGGRFIK SHVIKLSPDE QGVDILIVLI FRYPSTDSAE QIKKKIEKAL
160 170 180 190 200
YQSLKTKQLS LTINKPSFRL TPIDSKKMRN LLNSRCGIRM TSSNMPLPAS
210 220 230 240 250
SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN TWLLTAAHCF
260 270 280 290 300
WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
310 320 330 340 350
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV
360 370 380 390 400
ETISTDVCNR KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI
410 420 430
WYIVGIVSWG QSCALPKKPG VYTRVTKYRD WIASKTGM
Length:438
Mass (Da):49,410
Last modified:September 23, 2008 - v2
Checksum:iF36C3D3EFB4D1E9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163I → L in BAC85495 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0348004A → T. Corresponds to variant dbSNP:rs10030708Ensembl.1
Natural variantiVAR_046636124D → N. Corresponds to variant dbSNP:rs1438391Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122625 mRNA Translation: BAC85495.1
AC096727 Genomic DNA No translation available.
AC107054 Genomic DNA No translation available.
CCDSiCCDS3520.1
RefSeqiNP_997290.2, NM_207407.2
UniGeneiHs.677557

Genome annotation databases

EnsembliENST00000356291; ENSP00000348639; ENSG00000198092
GeneIDi389208
KEGGihsa:389208
UCSCiuc003hdt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122625 mRNA Translation: BAC85495.1
AC096727 Genomic DNA No translation available.
AC107054 Genomic DNA No translation available.
CCDSiCCDS3520.1
RefSeqiNP_997290.2, NM_207407.2
UniGeneiHs.677557

3D structure databases

ProteinModelPortaliQ6ZWK6
SMRiQ6ZWK6
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.321

PTM databases

iPTMnetiQ6ZWK6
PhosphoSitePlusiQ6ZWK6

Polymorphism and mutation databases

BioMutaiTMPRSS11F
DMDMi206729902

Proteomic databases

PaxDbiQ6ZWK6
PeptideAtlasiQ6ZWK6
PRIDEiQ6ZWK6
ProteomicsDBi68492

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356291; ENSP00000348639; ENSG00000198092
GeneIDi389208
KEGGihsa:389208
UCSCiuc003hdt.2 human

Organism-specific databases

CTDi389208
EuPathDBiHostDB:ENSG00000198092.5
GeneCardsiTMPRSS11F
HGNCiHGNC:29994 TMPRSS11F
HPAiHPA026911
neXtProtiNX_Q6ZWK6
OpenTargetsiENSG00000198092
PharmGKBiPA142670730
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00930000150822
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiQ6ZWK6
KOiK09752
OMAiCNRKDVY
OrthoDBiEOG091G0DF7
PhylomeDBiQ6ZWK6
TreeFamiTF351684

Miscellaneous databases

ChiTaRSiTMPRSS11F human
GenomeRNAii389208
PROiPR:Q6ZWK6

Gene expression databases

BgeeiENSG00000198092 Expressed in 19 organ(s), highest expression level in ectocervix
CleanExiHS_TMPRSS11F

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM11F_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWK6
Secondary accession number(s): A8MXX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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