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Protein

Regulator of hemoglobinization and erythroid cell expansion protein

Gene

RHEX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874).1 Publication

GO - Molecular functioni

  • erythropoietin receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processDifferentiation, Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of hemoglobinization and erythroid cell expansion proteinImported
Alternative name(s):
Regulator of human erythroid cell expansion protein1 Publication
Gene namesi
Name:RHEXImported
Synonyms:C1orf186Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000263961.6
HGNCiHGNC:25341 RHEX
neXtProtiNX_Q6ZWK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000263961
PharmGKBiPA142672434

Polymorphism and mutation databases

DMDMi74749716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002711031 – 172Regulator of hemoglobinization and erythroid cell expansion proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132Phosphotyrosine1 Publication1
Modified residuei141Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated. Phosphorylation on Tyr-132 and Tyr-141 occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZWK4
PaxDbiQ6ZWK4
PeptideAtlasiQ6ZWK4
PRIDEiQ6ZWK4
ProteomicsDBi68491

PTM databases

iPTMnetiQ6ZWK4
PhosphoSitePlusiQ6ZWK4

Expressioni

Tissue specificityi

Expressed in the proerythroblasts (at protein level) (PubMed:25092874). Expressed strongly in the kidney (PubMed:25092874). Expressed weakly in the pancreas, liver and lung (PubMed:25092874). Expressed strongly in erythroid progenitor cells (EPCs) (PubMed:25092874). Expressed weakly in T-cells and neutrophils (PubMed:25092874).1 Publication

Inductioni

Up-regulated during erythroid differentiation (PubMed:25092874).1 Publication

Gene expression databases

BgeeiENSG00000263961 Expressed in 151 organ(s), highest expression level in endometrium
CleanExiHS_C1orf186
ExpressionAtlasiQ6ZWK4 baseline and differential
GenevisibleiQ6ZWK4 HS

Interactioni

Subunit structurei

Interacts with EPOR; this interaction occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874). Interacts with JAK2; this interaction occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874). Interacts (via tyrosine-phosphorylated form) with GRB2 (PubMed:25092874).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi136831, 14 interactors
IntActiQ6ZWK4, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZWK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXTU Eukaryota
ENOG4111EFH LUCA
GeneTreeiENSGT00390000004770
HOGENOMiHOG000111267
InParanoidiQ6ZWK4
OMAiHPPAAKE
OrthoDBiEOG091G11LC
PhylomeDBiQ6ZWK4
TreeFamiTF353616

Family and domain databases

InterProiView protein in InterPro
IPR031517 RHEX-like
PANTHERiPTHR38491 PTHR38491, 1 hit
PfamiView protein in Pfam
PF15763 DUF4692, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ZWK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTEVMEVWH GLVIAVVSLF LQACFLTAIN YLLSRHMAHK SEQILKAASL
60 70 80 90 100
QVPRPSPGHH HPPAVKEMKE TQTERDIPMS DSLYRHDSDT PSDSLDSSCS
110 120 130 140 150
SPPACQATED VDYTQVVFSD PGELKNDSPL DYENIKEITD YVNVNPERHK
160 170
PSFWYFVNPA LSEPAEYDQV AM
Length:172
Mass (Da):19,405
Last modified:July 5, 2004 - v1
Checksum:i2AE0407D9F05457B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B7E7A0A075B7E7_HUMAN
Regulator of hemoglobinization and ...
RHEX
124Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122631 mRNA Translation: BAC85497.1
BX571818 Genomic DNA No translation available.
BC071785 mRNA Translation: AAH71785.1
CCDSiCCDS73014.1
RefSeqiNP_001007545.1, NM_001007544.3
XP_005272795.1, XM_005272738.3
UniGeneiHs.662248

Genome annotation databases

EnsembliENST00000331555; ENSP00000356093; ENSG00000263961
ENST00000582070; ENSP00000463990; ENSG00000263961
ENST00000603488; ENSP00000474994; ENSG00000263961
GeneIDi440712
KEGGihsa:440712
UCSCiuc001hdt.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122631 mRNA Translation: BAC85497.1
BX571818 Genomic DNA No translation available.
BC071785 mRNA Translation: AAH71785.1
CCDSiCCDS73014.1
RefSeqiNP_001007545.1, NM_001007544.3
XP_005272795.1, XM_005272738.3
UniGeneiHs.662248

3D structure databases

ProteinModelPortaliQ6ZWK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136831, 14 interactors
IntActiQ6ZWK4, 7 interactors

PTM databases

iPTMnetiQ6ZWK4
PhosphoSitePlusiQ6ZWK4

Polymorphism and mutation databases

DMDMi74749716

Proteomic databases

EPDiQ6ZWK4
PaxDbiQ6ZWK4
PeptideAtlasiQ6ZWK4
PRIDEiQ6ZWK4
ProteomicsDBi68491

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331555; ENSP00000356093; ENSG00000263961
ENST00000582070; ENSP00000463990; ENSG00000263961
ENST00000603488; ENSP00000474994; ENSG00000263961
GeneIDi440712
KEGGihsa:440712
UCSCiuc001hdt.3 human

Organism-specific databases

CTDi440712
EuPathDBiHostDB:ENSG00000263961.6
GeneCardsiRHEX
HGNCiHGNC:25341 RHEX
neXtProtiNX_Q6ZWK4
OpenTargetsiENSG00000263961
PharmGKBiPA142672434
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXTU Eukaryota
ENOG4111EFH LUCA
GeneTreeiENSGT00390000004770
HOGENOMiHOG000111267
InParanoidiQ6ZWK4
OMAiHPPAAKE
OrthoDBiEOG091G11LC
PhylomeDBiQ6ZWK4
TreeFamiTF353616

Miscellaneous databases

ChiTaRSiC1orf186 human
GenomeRNAii440712
PROiPR:Q6ZWK4

Gene expression databases

BgeeiENSG00000263961 Expressed in 151 organ(s), highest expression level in endometrium
CleanExiHS_C1orf186
ExpressionAtlasiQ6ZWK4 baseline and differential
GenevisibleiQ6ZWK4 HS

Family and domain databases

InterProiView protein in InterPro
IPR031517 RHEX-like
PANTHERiPTHR38491 PTHR38491, 1 hit
PfamiView protein in Pfam
PF15763 DUF4692, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHEX_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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