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Protein

Serine/threonine-protein kinase Nek10

Gene

NEK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei548ATPPROSITE-ProRule annotation1
Active sitei655Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi525 – 533ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6ZWH5

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek10 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 10
Short name:
NimA-related protein kinase 10
Gene namesi
Name:NEK10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163491.16
HGNCiHGNC:18592 NEK10
neXtProtiNX_Q6ZWH5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi152110
OpenTargetsiENSG00000163491
PharmGKBiPA38594

Chemistry databases

ChEMBLiCHEMBL3108655

Polymorphism and mutation databases

BioMutaiNEK10
DMDMi380865464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002597671 – 1172Serine/threonine-protein kinase Nek10Add BLAST1172

Proteomic databases

EPDiQ6ZWH5
PaxDbiQ6ZWH5
PeptideAtlasiQ6ZWH5
PRIDEiQ6ZWH5
ProteomicsDBi68479
68480 [Q6ZWH5-2]
68481 [Q6ZWH5-3]
68482 [Q6ZWH5-4]
68483 [Q6ZWH5-5]
68484 [Q6ZWH5-6]
68485 [Q6ZWH5-7]

PTM databases

iPTMnetiQ6ZWH5
PhosphoSitePlusiQ6ZWH5

Expressioni

Gene expression databases

BgeeiENSG00000163491 Expressed in 117 organ(s), highest expression level in testis
CleanExiHS_NEK10
ExpressionAtlasiQ6ZWH5 baseline and differential
GenevisibleiQ6ZWH5 HS

Organism-specific databases

HPAiHPA038941

Interactioni

Protein-protein interaction databases

BioGridi127428, 4 interactors
IntActiQ6ZWH5, 2 interactors
STRINGi9606.ENSP00000343847

Structurei

3D structure databases

ProteinModelPortaliQ6ZWH5
SMRiQ6ZWH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati209 – 251ARMAdd BLAST43
Domaini519 – 712Protein kinasePROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili481 – 514Sequence analysisAdd BLAST34

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00910000144066
HOVERGENiHBG108180
InParanoidiQ6ZWH5
KOiK20879
OMAiTEHPARS
OrthoDBiEOG091G01FT
TreeFamiTF336430

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZWH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF
60 70 80 90 100
DSAQNSMTKS EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH
110 120 130 140 150
PQRKLFQEIF TALVKNRLIS REWVNRAPSI HFLRVLICLR LLMRDPCYQE
160 170 180 190 200
ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH TVDKLVNMTY IFQKLAAVKD
210 220 230 240 250
QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ ECREKISELN
260 270 280 290 300
IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL
310 320 330 340 350
HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD
360 370 380 390 400
HSSIGSLSSA NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL
410 420 430 440 450
NDTNAHQVVQ ENGVYTIAKL ILPNKQKNAA KSNLLQCYAF RALRFLFSME
460 470 480 490 500
RNRPLFKRLF PTDLFEIFID IGHYVRDISA YEELVSKLNL LVEDELKQIA
510 520 530 540 550
ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS GQNLLAMKEV
560 570 580 590 600
NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL
610 620 630 640 650
YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR
660 670 680 690 700
IVHRDLTPNN IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV
710 720 730 740 750
LKSEPYGEKA DVWAVGCILY QMATLSPPFY STNMLSLATK IVEAVYEPVP
760 770 780 790 800
EGIYSEKVTD TISRCLTPDA EARPDIVEVS SMISDVMMKY LDNLSTSQLS
810 820 830 840 850
LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK ASLSSSSSGA
860 870 880 890 900
ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS
910 920 930 940 950
EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT
960 970 980 990 1000
GSRPRPALLP LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL
1010 1020 1030 1040 1050
KDHGPQMGTF LWQASAGIAV SQRKVRQISD PIQQILIQLH KIIYITQLPP
1060 1070 1080 1090 1100
ALHHNLKRRV IERFKKSLFS QQSNPCNLKS EIKKLSQGSP EPIEPNFFTA
1110 1120 1130 1140 1150
DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV IEEVLEESGY
1160 1170
YNFTSNRYHS YPWGTKNHPT KR
Length:1,172
Mass (Da):133,259
Last modified:March 21, 2012 - v3
Checksum:i28D76407922020C8
GO
Isoform 2 (identifier: Q6ZWH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
     726-1172: Missing.

Note: No experimental confirmation available.
Show »
Length:725
Mass (Da):82,881
Checksum:iBBFE5EC46CAAB90B
GO
Isoform 3 (identifier: Q6ZWH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
     219-1172: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):25,494
Checksum:i860A31E47BF3805E
GO
Isoform 4 (identifier: Q6ZWH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
     713-1172: Missing.

Show »
Length:712
Mass (Da):81,624
Checksum:i58ECB713BC90B8A2
GO
Isoform 5 (identifier: Q6ZWH5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP

Show »
Length:484
Mass (Da):54,221
Checksum:i8FDE78BFA255BEB3
GO
Isoform 6 (identifier: Q6ZWH5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     1004-1013: Missing.

Show »
Length:474
Mass (Da):53,075
Checksum:iD698CFEC2B43130F
GO
Isoform 7 (identifier: Q6ZWH5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     957-1013: Missing.

Show »
Length:427
Mass (Da):47,765
Checksum:i4F318F1B2DED28C9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C000H7C000_HUMAN
Serine/threonine-protein kinase Nek...
NEK10
196Annotation score:
A0A0A0MRY8A0A0A0MRY8_HUMAN
Serine/threonine-protein kinase Nek...
NEK10
418Annotation score:
H7C3L8H7C3L8_HUMAN
Serine/threonine-protein kinase Nek...
NEK10
166Annotation score:
C9JJN0C9JJN0_HUMAN
Serine/threonine-protein kinase Nek...
NEK10
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239S → G in CAD97860 (PubMed:17974005).Curated1
Sequence conflicti762I → F in AAZ20184 (Ref. 2) Curated1
Sequence conflicti898T → A in AAZ20184 (Ref. 2) Curated1
Sequence conflicti1155S → P in AAZ20184 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04092850F → L1 PublicationCorresponds to variant dbSNP:rs56125830Ensembl.1
Natural variantiVAR_04092966A → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs201821707Ensembl.1
Natural variantiVAR_04093067G → S1 PublicationCorresponds to variant dbSNP:rs55958314Ensembl.1
Natural variantiVAR_040931379E → K in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040932513L → S2 PublicationsCorresponds to variant dbSNP:rs10510592Ensembl.1
Natural variantiVAR_040933659N → S1 PublicationCorresponds to variant dbSNP:rs55833401Ensembl.1
Natural variantiVAR_040934701L → V1 PublicationCorresponds to variant dbSNP:rs34313679Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356881 – 688Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST688
Alternative sequenceiVSP_021534190 – 218YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_021535219 – 1172Missing in isoform 3. 1 PublicationAdd BLAST954
Alternative sequenceiVSP_021536672 – 725TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_035689689 – 697VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7. 3 Publications9
Alternative sequenceiVSP_035690698 – 712PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_035691713 – 1172Missing in isoform 4. 1 PublicationAdd BLAST460
Alternative sequenceiVSP_035692726 – 1172Missing in isoform 2. 1 PublicationAdd BLAST447
Alternative sequenceiVSP_035693957 – 1013Missing in isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0356941004 – 1013Missing in isoform 6. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057247 mRNA Translation: BAB71395.1
AK123061 mRNA Translation: BAC85527.1
AK128585 mRNA Translation: BAC87513.1
DQ104438 mRNA Translation: AAZ20184.1
AC133142 Genomic DNA No translation available.
AC093555 Genomic DNA No translation available.
AC098931 Genomic DNA No translation available.
AC099535 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64376.1
BC045758 mRNA Translation: AAH45758.1
BX537852 mRNA Translation: CAD97860.1
CCDSiCCDS46781.1 [Q6ZWH5-4]
CCDS77713.1 [Q6ZWH5-5]
RefSeqiNP_001026911.1, NM_001031741.3 [Q6ZWH5-6]
NP_001291313.1, NM_001304384.1 [Q6ZWH5-5]
NP_689747.3, NM_152534.4 [Q6ZWH5-1]
NP_955379.2, NM_199347.3 [Q6ZWH5-4]
XP_016861250.1, XM_017005761.1 [Q6ZWH5-1]
XP_016861251.1, XM_017005762.1 [Q6ZWH5-1]
XP_016861252.1, XM_017005763.1 [Q6ZWH5-1]
XP_016861253.1, XM_017005764.1 [Q6ZWH5-1]
XP_016861254.1, XM_017005765.1 [Q6ZWH5-1]
UniGeneiHs.506115
Hs.743887

Genome annotation databases

EnsembliENST00000295720; ENSP00000295720; ENSG00000163491 [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491 [Q6ZWH5-4]
ENST00000383771; ENSP00000373281; ENSG00000163491 [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491 [Q6ZWH5-1]
GeneIDi152110
KEGGihsa:152110
UCSCiuc003cdt.3 human [Q6ZWH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057247 mRNA Translation: BAB71395.1
AK123061 mRNA Translation: BAC85527.1
AK128585 mRNA Translation: BAC87513.1
DQ104438 mRNA Translation: AAZ20184.1
AC133142 Genomic DNA No translation available.
AC093555 Genomic DNA No translation available.
AC098931 Genomic DNA No translation available.
AC099535 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64376.1
BC045758 mRNA Translation: AAH45758.1
BX537852 mRNA Translation: CAD97860.1
CCDSiCCDS46781.1 [Q6ZWH5-4]
CCDS77713.1 [Q6ZWH5-5]
RefSeqiNP_001026911.1, NM_001031741.3 [Q6ZWH5-6]
NP_001291313.1, NM_001304384.1 [Q6ZWH5-5]
NP_689747.3, NM_152534.4 [Q6ZWH5-1]
NP_955379.2, NM_199347.3 [Q6ZWH5-4]
XP_016861250.1, XM_017005761.1 [Q6ZWH5-1]
XP_016861251.1, XM_017005762.1 [Q6ZWH5-1]
XP_016861252.1, XM_017005763.1 [Q6ZWH5-1]
XP_016861253.1, XM_017005764.1 [Q6ZWH5-1]
XP_016861254.1, XM_017005765.1 [Q6ZWH5-1]
UniGeneiHs.506115
Hs.743887

3D structure databases

ProteinModelPortaliQ6ZWH5
SMRiQ6ZWH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127428, 4 interactors
IntActiQ6ZWH5, 2 interactors
STRINGi9606.ENSP00000343847

Chemistry databases

ChEMBLiCHEMBL3108655

PTM databases

iPTMnetiQ6ZWH5
PhosphoSitePlusiQ6ZWH5

Polymorphism and mutation databases

BioMutaiNEK10
DMDMi380865464

Proteomic databases

EPDiQ6ZWH5
PaxDbiQ6ZWH5
PeptideAtlasiQ6ZWH5
PRIDEiQ6ZWH5
ProteomicsDBi68479
68480 [Q6ZWH5-2]
68481 [Q6ZWH5-3]
68482 [Q6ZWH5-4]
68483 [Q6ZWH5-5]
68484 [Q6ZWH5-6]
68485 [Q6ZWH5-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295720; ENSP00000295720; ENSG00000163491 [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491 [Q6ZWH5-4]
ENST00000383771; ENSP00000373281; ENSG00000163491 [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491 [Q6ZWH5-1]
GeneIDi152110
KEGGihsa:152110
UCSCiuc003cdt.3 human [Q6ZWH5-1]

Organism-specific databases

CTDi152110
DisGeNETi152110
EuPathDBiHostDB:ENSG00000163491.16
GeneCardsiNEK10
HGNCiHGNC:18592 NEK10
HPAiHPA038941
neXtProtiNX_Q6ZWH5
OpenTargetsiENSG00000163491
PharmGKBiPA38594
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00910000144066
HOVERGENiHBG108180
InParanoidiQ6ZWH5
KOiK20879
OMAiTEHPARS
OrthoDBiEOG091G01FT
TreeFamiTF336430

Enzyme and pathway databases

SignaLinkiQ6ZWH5

Miscellaneous databases

ChiTaRSiNEK10 human
GenomeRNAii152110
PROiPR:Q6ZWH5

Gene expression databases

BgeeiENSG00000163491 Expressed in 117 organ(s), highest expression level in testis
CleanExiHS_NEK10
ExpressionAtlasiQ6ZWH5 baseline and differential
GenevisibleiQ6ZWH5 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEK10_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWH5
Secondary accession number(s): A8MWG1
, B9ZVR0, Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 21, 2012
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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