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Entry version 128 (12 Aug 2020)
Sequence version 2 (18 Mar 2008)
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Protein

Pleckstrin homology domain-containing family M member 3

Gene

PLEKHM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri669 – 722Phorbol-ester/DAG-typeAdd BLAST54

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZWE6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family M member 3
Short name:
PH domain-containing family M member 3
Alternative name(s):
Differentiation associated proteinBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHM3Imported
Synonyms:DAPRBy similarity, PLEKHM1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178385.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34006, PLEKHM3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZWE6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
389072

Open Targets

More...
OpenTargetsi
ENSG00000178385

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399738

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZWE6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260341 – 761Pleckstrin homology domain-containing family M member 3Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZWE6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZWE6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZWE6

PeptideAtlas

More...
PeptideAtlasi
Q6ZWE6

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZWE6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68476 [Q6ZWE6-1]
68477 [Q6ZWE6-2]
68478 [Q6ZWE6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZWE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZWE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178385, Expressed in corpus callosum and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZWE6, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000178385, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AKT1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132958, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZWE6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417003

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZWE6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini211 – 308PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini361 – 456PH 2PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi169 – 175Poly-Gln7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 722Phorbol-ester/DAG-typeAdd BLAST54

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1829, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021585_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZWE6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACNMFEL

Database of Orthologous Groups

More...
OrthoDBi
177737at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZWE6

TreeFam database of animal gene trees

More...
TreeFami
TF317067

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14674, PH_PLEKHM3_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037812, PLEKHM3_PH_1
IPR025258, Zf-RING_9

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF13901, zf-RING_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01175, DUF4206, 1 hit
SM00233, PH, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZWE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALEVDDIS PALEVTEEFF STLDSNLEKA VQQAEVYGIQ EVPELVGHEV
60 70 80 90 100
LSNITDNGAM RNVTSLGKGG MIWDHCKSRL LETKAQNVFP AKEQFMVQRG
110 120 130 140 150
TTPDNLSWME QKEASTFNFF NICQRRRDRP RSVNDLLDET STFKPGHARS
160 170 180 190 200
RSDITQVDWR VVLKTTPLQQ QQQQQPLLQG PHVTRPSFLL PSPNKIEDAQ
210 220 230 240 250
GNTEHKQTFP NILKKGYLEI RKDHDSYWQS CYAELSPYNL YFYSLDSSGN
260 270 280 290 300
QNLYATYQLS HFQSISVLGN LEARMVDTVL YDNTQLQLKA ESPWEALDWG
310 320 330 340 350
QKLWEVVHAA VPGYMGRQNE LTISPGLGHH DDYTQNHSFQ KKTSGLLPPS
360 370 380 390 400
PVLDSSKQYQ NILKSGTLYR LTVQNNWKAF TFVLSRAYLM AFQPGKLDED
410 420 430 440 450
PLLSYNVDVC LAVQMDNLDG CDSCFQVIFP QDVLRLRAET RQRAQEWMEA
460 470 480 490 500
LKIAANVARS SEQNLQVTLR NKPKDQMGGH ELRKNKRQSV TTSFLSILTT
510 520 530 540 550
LSLERGLTAQ SFKCAGCQRS IGLSNGKAKV CNYSGWYYCS SCHVDDSFLI
560 570 580 590 600
PARIVHNWDT SKYKVSKQAK EFLEYVYEEP LIDIQQENAM LYHHAEPLAA
610 620 630 640 650
VLRLRQRLKS LRAYLFSCRA AVAEDLRRRI FPREYLLQQI HLYSLADLQQ
660 670 680 690 700
VIEGKLAPFL GKVIKFATSH VYSCSLCSQK GFICEICNNG EILYPFEDIS
710 720 730 740 750
TSRCESCGAV FHSECKEKSV PCPRCVRREL QKKQKSFWQR LNMDESLEEA
760
CTMFELSYQN T
Length:761
Mass (Da):87,166
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53A2BCF3580CAE14
GO
Isoform 2 (identifier: Q6ZWE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-761: CESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEACTMFELSYQNT → FGDPYADLLQGYVA

Show »
Length:717
Mass (Da):81,845
Checksum:i3DE5F628348736F6
GO
Isoform 3 (identifier: Q6ZWE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-523: CQRSIGL → MKQIFSL
     524-761: Missing.

Show »
Length:523
Mass (Da):59,587
Checksum:i158ED5CF6FB4554B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J119C9J119_HUMAN
Pleckstrin homology domain-containi...
PLEKHM3
672Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0J9H7C0J9_HUMAN
Pleckstrin homology domain-containi...
PLEKHM3
469Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85557 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032511517 – 523CQRSIGL → MKQIFSL in isoform 3. 1 Publication7
Alternative sequenceiVSP_032512524 – 761Missing in isoform 3. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_032513704 – 761CESCG…SYQNT → FGDPYADLLQGYVA in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC083900 Genomic DNA No translation available.
AC096772 Genomic DNA No translation available.
BC020812 mRNA Translation: AAH20812.1
BC151137 mRNA Translation: AAI51138.1
AK123204 mRNA Translation: BAC85557.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42808.1 [Q6ZWE6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001073944.1, NM_001080475.2 [Q6ZWE6-1]
XP_011509462.1, XM_011511160.2 [Q6ZWE6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000427836; ENSP00000417003; ENSG00000178385 [Q6ZWE6-1]
ENST00000642765; ENSP00000496194; ENSG00000285005 [Q6ZWE6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389072

UCSC genome browser

More...
UCSCi
uc002vcl.3, human [Q6ZWE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083900 Genomic DNA No translation available.
AC096772 Genomic DNA No translation available.
BC020812 mRNA Translation: AAH20812.1
BC151137 mRNA Translation: AAI51138.1
AK123204 mRNA Translation: BAC85557.1 Different initiation.
CCDSiCCDS42808.1 [Q6ZWE6-1]
RefSeqiNP_001073944.1, NM_001080475.2 [Q6ZWE6-1]
XP_011509462.1, XM_011511160.2 [Q6ZWE6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132958, 2 interactors
IntActiQ6ZWE6, 5 interactors
STRINGi9606.ENSP00000417003

PTM databases

iPTMnetiQ6ZWE6
PhosphoSitePlusiQ6ZWE6

Polymorphism and mutation databases

BioMutaiPLEKHM3
DMDMi172046173

Proteomic databases

jPOSTiQ6ZWE6
MassIVEiQ6ZWE6
PaxDbiQ6ZWE6
PeptideAtlasiQ6ZWE6
PRIDEiQ6ZWE6
ProteomicsDBi68476 [Q6ZWE6-1]
68477 [Q6ZWE6-2]
68478 [Q6ZWE6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34191, 55 antibodies

The DNASU plasmid repository

More...
DNASUi
389072

Genome annotation databases

EnsembliENST00000427836; ENSP00000417003; ENSG00000178385 [Q6ZWE6-1]
ENST00000642765; ENSP00000496194; ENSG00000285005 [Q6ZWE6-1]
GeneIDi389072
KEGGihsa:389072
UCSCiuc002vcl.3, human [Q6ZWE6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389072
DisGeNETi389072
EuPathDBiHostDB:ENSG00000178385.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLEKHM3
HGNCiHGNC:34006, PLEKHM3
HPAiENSG00000178385, Low tissue specificity
neXtProtiNX_Q6ZWE6
OpenTargetsiENSG00000178385
PharmGKBiPA162399738

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1829, Eukaryota
GeneTreeiENSGT00940000159743
HOGENOMiCLU_021585_0_0_1
InParanoidiQ6ZWE6
OMAiACNMFEL
OrthoDBi177737at2759
PhylomeDBiQ6ZWE6
TreeFamiTF317067

Enzyme and pathway databases

PathwayCommonsiQ6ZWE6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
389072, 2 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLEKHM3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389072
PharosiQ6ZWE6, Tdark

Protein Ontology

More...
PROi
PR:Q6ZWE6
RNActiQ6ZWE6, protein

Gene expression databases

BgeeiENSG00000178385, Expressed in corpus callosum and 121 other tissues
ExpressionAtlasiQ6ZWE6, baseline and differential

Family and domain databases

CDDicd14674, PH_PLEKHM3_1, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037812, PLEKHM3_PH_1
IPR025258, Zf-RING_9
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF13901, zf-RING_9, 1 hit
SMARTiView protein in SMART
SM01175, DUF4206, 1 hit
SM00233, PH, 2 hits
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZWE6
Secondary accession number(s): B9EKV2, Q8WW68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: August 12, 2020
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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