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Protein

BTB/POZ domain-containing protein KCTD8

Gene

KCTD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD8
Gene namesi
Name:KCTD8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000183783.6
HGNCiHGNC:22394 KCTD8
neXtProtiNX_Q6ZWB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183783
PharmGKBiPA134909779

Chemistry databases

GuidetoPHARMACOLOGYi1917

Polymorphism and mutation databases

BioMutaiKCTD8
DMDMi74749707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514811 – 473BTB/POZ domain-containing protein KCTD8Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1
Modified residuei80Omega-N-methylarginineBy similarity1
Modified residuei410PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ6ZWB6
MaxQBiQ6ZWB6
PaxDbiQ6ZWB6
PeptideAtlasiQ6ZWB6
PRIDEiQ6ZWB6
ProteomicsDBi68472

PTM databases

iPTMnetiQ6ZWB6
PhosphoSitePlusiQ6ZWB6

Expressioni

Gene expression databases

BgeeiENSG00000183783 Expressed in 80 organ(s), highest expression level in cerebellar vermis
CleanExiHS_KCTD8
ExpressionAtlasiQ6ZWB6 baseline and differential

Organism-specific databases

HPAiHPA031562

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.By similarity

Protein-protein interaction databases

BioGridi132113, 2 interactors
CORUMiQ6ZWB6
IntActiQ6ZWB6, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZWB6
SMRiQ6ZWB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 122BTBAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 25Poly-Ser5
Compositional biasi194 – 200Poly-Gly7

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000041197
HOVERGENiHBG052218
InParanoidiQ6ZWB6
KOiK21918
OMAiDHEERKH
OrthoDBiEOG091G0P3F
PhylomeDBiQ6ZWB6
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ZWB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV
60 70 80 90 100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID
110 120 130 140 150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEYFQLT DLVKLLSPKV
160 170 180 190 200
TKQNSLNDEG CQSDLEDNVS QGSSDALLLR GAAAAVPSGP GAHGGGGGGG
210 220 230 240 250
AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR IALAKEVFGD
260 270 280 290 300
TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA
310 320 330 340 350
FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT
360 370 380 390 400
SCNELSTSSC DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW
410 420 430 440 450
IPPPDKRRNS ELFQTLISKS RETNLSKKKV CEKLSVEEEM KKCIQDFKKI
460 470
HIPDYFPERK RQWQSELLQK YGL
Length:473
Mass (Da):52,440
Last modified:July 5, 2004 - v1
Checksum:iD5AA3F75716D3715
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9S2H0Y9S2_HUMAN
BTB/POZ domain-containing protein K...
KCTD8
155Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027692329P → L. Corresponds to variant dbSNP:rs13115990Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123347 mRNA Translation: BAC85588.1
BC132743 mRNA Translation: AAI32744.1
BC136793 mRNA Translation: AAI36794.1
CCDSiCCDS3467.1
RefSeqiNP_938167.1, NM_198353.2
UniGeneiHs.479644

Genome annotation databases

EnsembliENST00000360029; ENSP00000353129; ENSG00000183783
GeneIDi386617
KEGGihsa:386617
UCSCiuc003gwu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123347 mRNA Translation: BAC85588.1
BC132743 mRNA Translation: AAI32744.1
BC136793 mRNA Translation: AAI36794.1
CCDSiCCDS3467.1
RefSeqiNP_938167.1, NM_198353.2
UniGeneiHs.479644

3D structure databases

ProteinModelPortaliQ6ZWB6
SMRiQ6ZWB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132113, 2 interactors
CORUMiQ6ZWB6
IntActiQ6ZWB6, 2 interactors

Chemistry databases

GuidetoPHARMACOLOGYi1917

PTM databases

iPTMnetiQ6ZWB6
PhosphoSitePlusiQ6ZWB6

Polymorphism and mutation databases

BioMutaiKCTD8
DMDMi74749707

Proteomic databases

EPDiQ6ZWB6
MaxQBiQ6ZWB6
PaxDbiQ6ZWB6
PeptideAtlasiQ6ZWB6
PRIDEiQ6ZWB6
ProteomicsDBi68472

Protocols and materials databases

DNASUi386617
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360029; ENSP00000353129; ENSG00000183783
GeneIDi386617
KEGGihsa:386617
UCSCiuc003gwu.4 human

Organism-specific databases

CTDi386617
EuPathDBiHostDB:ENSG00000183783.6
GeneCardsiKCTD8
HGNCiHGNC:22394 KCTD8
HPAiHPA031562
neXtProtiNX_Q6ZWB6
OpenTargetsiENSG00000183783
PharmGKBiPA134909779
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000041197
HOVERGENiHBG052218
InParanoidiQ6ZWB6
KOiK21918
OMAiDHEERKH
OrthoDBiEOG091G0P3F
PhylomeDBiQ6ZWB6
TreeFamiTF315332

Miscellaneous databases

ChiTaRSiKCTD8 human
GenomeRNAii386617
PROiPR:Q6ZWB6

Gene expression databases

BgeeiENSG00000183783 Expressed in 80 organ(s), highest expression level in cerebellar vermis
CleanExiHS_KCTD8
ExpressionAtlasiQ6ZWB6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD8_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWB6
Secondary accession number(s): A2RU39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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