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Entry version 144 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Ankyrin repeat and SAM domain-containing protein 3

Gene

ANKS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in vasopressin signaling in the kidney.By similarity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZW76

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and SAM domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKS3
Synonyms:KIAA1977
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29422, ANKS3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZW76

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000168096.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi450D → K: Decreased homooligomerization. No effect on interaction with ANKS6. 1 Publication1
Mutagenesisi455I → E: Decreased homooligomerization. No effect on interaction with ANKS6. 1 Publication1
Mutagenesisi466E → K: Decreased homooligomerization. No effect on interaction with ANKS6. 1 Publication1
Mutagenesisi471L → E: Decreased homooligomerization. Decreased interaction with ANKS6. 1 Publication1
Mutagenesisi472F → E: Decreased homooligomerization. Decreased interaction with ANKS6. 1 Publication1
Mutagenesisi477K → E: Decreased homooligomerization. Decreased interaction with ANKS6. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
124401

MalaCards human disease database

More...
MalaCardsi
ANKS3

Open Targets

More...
OpenTargetsi
ENSG00000168096

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
101063, Situs inversus totalis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485303

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZW76, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKS3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749704

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002307771 – 656Ankyrin repeat and SAM domain-containing protein 3Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei963-hydroxyasparagineBy similarity1
Modified residuei201PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei319PhosphothreonineBy similarity1
Modified residuei320PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hydroxylated at Asn-96, most probably by HIF1AN.By similarity
Phosphorylations at Ser-5, Ser-225, Thr-319, Ser-320, Ser-368 and Ser-371 occur in a NEK7-dependent manner.By similarity
Polyubiquitinated.By similarity

Keywords - PTMi

Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZW76

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZW76

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZW76

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZW76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZW76

PeptideAtlas

More...
PeptideAtlasi
Q6ZW76

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZW76

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68467 [Q6ZW76-1]
68468 [Q6ZW76-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZW76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZW76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168096, Expressed in muscle tissue and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZW76, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZW76, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168096, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:24998259).

Interacts (via SAM domain) with ANKS6 (via SAM domain) (PubMed:24998259).

Interacts with BICC1 (By similarity).

Interacts with NPHP1 (By similarity).

Interacts with NEK8 (By similarity).

Interacts with HIF1AN (By similarity).

Interacts with NEK7; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125861, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZW76, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304586

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZW76, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1656
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZW76

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 64ANK 1Add BLAST31
Repeati68 – 97ANK 2Add BLAST30
Repeati101 – 130ANK 3Add BLAST30
Repeati134 – 163ANK 4Add BLAST30
Repeati168 – 197ANK 5Add BLAST30
Repeati201 – 220ANK 6Add BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini425 – 488SAMPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 422Interaction with NEK7By similarityAdd BLAST422

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili501 – 526Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi329 – 382Ser-richAdd BLAST54

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAM domain mediates homooligomerization.1 Publication

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156610

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014543_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZW76

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQGYVTF

Database of Orthologous Groups

More...
OrthoDBi
58543at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZW76

TreeFam database of animal gene trees

More...
TreeFami
TF331487

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF00536, SAM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZW76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSELSDEASE PELLNRSLSM WHGLGTQVSG EELDVPLDLH TAASIGQYEV
60 70 80 90 100
VKECVQRREL DLNKKNGGGW TPLMYASYIG HDTIVHLLLE AGVSVNVPTP
110 120 130 140 150
EGQTPLMLAS SCGNESIAYF LLQQGAELEM KDIQGWTALF HCTSAGHQHM
160 170 180 190 200
VRFLLDSGAN ANVREPICGF TPLMEAAAAG HEIIVQYFLN HGVKVDARDH
210 220 230 240 250
SGATARMLAK QYGHMKIVAL MDTYSPSLPK SLYRSPEKYE DLSSSDESCP
260 270 280 290 300
APQRQRPCRK KGVSIHEGPR ALARITGIGL GGRAPRPRYE QAPPRGYVTF
310 320 330 340 350
NSSGENPLEE EGLCCRDVTS PINERDVESS SSSSSREEHA FCANLGPVQS
360 370 380 390 400
SSSSEGLARA QGLSSEASVE SNEDSDHACK SSARKQAKSY MKTKNPDSQW
410 420 430 440 450
PPRAATDREG FLAESSPQTQ RAPYSGPQDL AALLEQIGCL KYLQVFEEQD
460 470 480 490 500
VDLRIFLTLT ESDLKEIGIT LFGPKRKMTS AIARWHSSAR PPGDALELAY
510 520 530 540 550
ADRLEAEMQE LAIQLHKRCE EVEATRGQVC QEQELRAVVE SCLLEQDRAR
560 570 580 590 600
EDLQARLRET WALARDAALV LDQLRACQAE LSSRVRQDQP PGAATLGLAV
610 620 630 640 650
PPADSKGWQA SLQAMSLPEL SGALEDRVRE MGQALCLVTQ SLEKLQVLNG

KKWRET
Length:656
Mass (Da):72,038
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67BD772ED762A5BA
GO
Isoform 2 (identifier: Q6ZW76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:583
Mass (Da):63,990
Checksum:iDF9E2FBF2C4F959A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WF08F6WF08_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
549Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3DUE4D3DUE4_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3 hCG_15183
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELU8K7ELU8_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERF3K7ERF3_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJS9K7EJS9_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJY2K7EJY2_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKD2K7EKD2_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPL7K7EPL7_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM53K7EM53_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERR7K7ERR7_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS3
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51 – 56VKECVQ → HILRLF in BAB85563 (PubMed:11853319).Curated6
Sequence conflicti472F → S in BAG63156 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048283404A → T1 PublicationCorresponds to variant dbSNP:rs863980Ensembl.1
Natural variantiVAR_048284593A → T. Corresponds to variant dbSNP:rs9936675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0381831 – 73Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK123496 mRNA Translation: BAC85629.1
AK301683 mRNA Translation: BAG63156.1
CH471112 Genomic DNA Translation: EAW85271.1
CH471112 Genomic DNA Translation: EAW85272.1
CH471112 Genomic DNA Translation: EAW85273.1
AB075857 mRNA Translation: BAB85563.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10520.1 [Q6ZW76-1]

NCBI Reference Sequences

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RefSeqi
NP_001229858.1, NM_001242929.1
NP_001295018.1, NM_001308089.1
NP_597707.1, NM_133450.3 [Q6ZW76-1]
XP_005255176.1, XM_005255119.3
XP_011520675.1, XM_011522373.1 [Q6ZW76-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000304283; ENSP00000304586; ENSG00000168096 [Q6ZW76-1]
ENST00000585773; ENSP00000465294; ENSG00000168096 [Q6ZW76-2]
ENST00000614075; ENSP00000480350; ENSG00000168096 [Q6ZW76-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
124401

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:124401

UCSC genome browser

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UCSCi
uc002cxj.3, human [Q6ZW76-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123496 mRNA Translation: BAC85629.1
AK301683 mRNA Translation: BAG63156.1
CH471112 Genomic DNA Translation: EAW85271.1
CH471112 Genomic DNA Translation: EAW85272.1
CH471112 Genomic DNA Translation: EAW85273.1
AB075857 mRNA Translation: BAB85563.1
CCDSiCCDS10520.1 [Q6ZW76-1]
RefSeqiNP_001229858.1, NM_001242929.1
NP_001295018.1, NM_001308089.1
NP_597707.1, NM_133450.3 [Q6ZW76-1]
XP_005255176.1, XM_005255119.3
XP_011520675.1, XM_011522373.1 [Q6ZW76-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NJ8X-ray1.60A/B421-490[»]
4NL9X-ray1.50A/B421-490[»]
SMRiQ6ZW76
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125861, 15 interactors
IntActiQ6ZW76, 10 interactors
STRINGi9606.ENSP00000304586

PTM databases

iPTMnetiQ6ZW76
PhosphoSitePlusiQ6ZW76

Genetic variation databases

BioMutaiANKS3
DMDMi74749704

Proteomic databases

EPDiQ6ZW76
jPOSTiQ6ZW76
MassIVEiQ6ZW76
MaxQBiQ6ZW76
PaxDbiQ6ZW76
PeptideAtlasiQ6ZW76
PRIDEiQ6ZW76
ProteomicsDBi68467 [Q6ZW76-1]
68468 [Q6ZW76-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24396, 85 antibodies

Genome annotation databases

EnsembliENST00000304283; ENSP00000304586; ENSG00000168096 [Q6ZW76-1]
ENST00000585773; ENSP00000465294; ENSG00000168096 [Q6ZW76-2]
ENST00000614075; ENSP00000480350; ENSG00000168096 [Q6ZW76-1]
GeneIDi124401
KEGGihsa:124401
UCSCiuc002cxj.3, human [Q6ZW76-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
124401
DisGeNETi124401

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKS3
HGNCiHGNC:29422, ANKS3
HPAiENSG00000168096, Low tissue specificity
MalaCardsiANKS3
neXtProtiNX_Q6ZW76
OpenTargetsiENSG00000168096
Orphaneti101063, Situs inversus totalis
PharmGKBiPA143485303
VEuPathDBiHostDB:ENSG00000168096.14

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000156610
HOGENOMiCLU_014543_0_0_1
InParanoidiQ6ZW76
OMAiPQGYVTF
OrthoDBi58543at2759
PhylomeDBiQ6ZW76
TreeFamiTF331487

Enzyme and pathway databases

PathwayCommonsiQ6ZW76

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
124401, 5 hits in 996 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
124401
PharosiQ6ZW76, Tdark

Protein Ontology

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PROi
PR:Q6ZW76
RNActiQ6ZW76, protein

Gene expression databases

BgeeiENSG00000168096, Expressed in muscle tissue and 174 other tissues
ExpressionAtlasiQ6ZW76, baseline and differential
GenevisibleiQ6ZW76, HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF00536, SAM_1, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS50105, SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANKS3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZW76
Secondary accession number(s): B4DWU4, D3DUE2, Q8TF25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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