UniProtKB - Q6ZW49 (PAXI1_HUMAN)
PAX-interacting protein 1
PAXIP1
Functioni
Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity).
Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity).
By similarity7 PublicationsCaution
GO - Biological processi
- adipose tissue development Source: Ensembl
- chorion development Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- endothelial cell migration Source: Ensembl
- histone H3-K4 methylation Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of histone acetylation Source: UniProtKB
- positive regulation of histone H3-K36 methylation Source: UniProtKB
- positive regulation of histone H3-K4 methylation Source: UniProtKB
- positive regulation of isotype switching Source: UniProtKB
- positive regulation of isotype switching to IgG isotypes Source: Ensembl
- positive regulation of protein ubiquitination Source: UniProtKB
- positive regulation of response to DNA damage stimulus Source: Ensembl
- positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
- regulation of cell cycle G2/M phase transition Source: Ensembl
- response to ionizing radiation Source: UniProtKB
- vasculogenesis Source: Ensembl
Keywordsi
Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6ZW49 |
Reactomei | R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5693571, Nonhomologous End-Joining (NHEJ) |
SignaLinki | Q6ZW49 |
SIGNORi | Q6ZW49 |
Names & Taxonomyi
Protein namesi | Recommended name: PAX-interacting protein 1Alternative name(s): PAX transactivation activation domain-interacting protein |
Gene namesi | Name:PAXIP1 Synonyms:PAXIP1L, PTIP ORF Names:CAGF28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8624, PAXIP1 |
MIMi | 608254, gene |
neXtProti | NX_Q6ZW49 |
VEuPathDBi | HostDB:ENSG00000157212 |
Subcellular locationi
Nucleus
- Nucleus matrix By similarity
Other locations
- Chromosome 2 Publications
Note: Localizes to DNA damage foci upon ionizing radiation.2 Publications
Nucleus
- histone methyltransferase complex Source: UniProtKB
- MLL3/4 complex Source: UniProtKB
- nuclear matrix Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 676 | W → A: Abolishes interaction with TP53BP1; prevents recruitment to DNA damage foci. 1 Publication | 1 | |
Mutagenesisi | 910 | R → Q: Abolishes interaction with TP53BP1; impairs intact cellular response to DNA damage. 1 Publication | 1 | |
Mutagenesisi | 929 | W → A: Abolishes interaction with TP53BP1; prevents recruitment to DNA damage foci. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 22976 |
OpenTargetsi | ENSG00000157212 |
PharmGKBi | PA32964 |
Miscellaneous databases
Pharosi | Q6ZW49, Tbio |
Genetic variation databases
BioMutai | PAXIP1 |
DMDMi | 317373316 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296262 | 1 – 1069 | PAX-interacting protein 1Add BLAST | 1069 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 227 | PhosphoserineBy similarity | 1 | |
Modified residuei | 235 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZW49 |
jPOSTi | Q6ZW49 |
MassIVEi | Q6ZW49 |
MaxQBi | Q6ZW49 |
PaxDbi | Q6ZW49 |
PeptideAtlasi | Q6ZW49 |
PRIDEi | Q6ZW49 |
ProteomicsDBi | 68459 [Q6ZW49-6] 68460 [Q6ZW49-1] 68461 [Q6ZW49-2] |
PTM databases
iPTMneti | Q6ZW49 |
PhosphoSitePlusi | Q6ZW49 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157212, Expressed in secondary oocyte and 221 other tissues |
ExpressionAtlasi | Q6ZW49, baseline and differential |
Genevisiblei | Q6ZW49, HS |
Organism-specific databases
HPAi | ENSG00000157212, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with the C-terminal transactivation domain of PAX2 (By similarity).
Forms a constitutive complex with PAGR1 independently of the MLL2/MLL3 complex (By similarity).
Interacts with TP53BP1 (when phosphorylated at the N-terminus by ATM) (PubMed:15456759, PubMed:17690115, PubMed:23727112).
Interacts with HLTF (PubMed:19723507).
Component of the KMT2 family MLL2/MLL3 complex (also named ASCOM complex), at least composed of the HMTs KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; required for the association of PAGR1 with the MLL2/MLL3 complex (PubMed:17178841, PubMed:17500065, PubMed:17761849, PubMed:17925232).
Interacts with NUPR1; this interaction prevents PAXIP1 inhibition of PAX2 transcription factor activity (PubMed:11940591).
By similarity9 PublicationsBinary interactionsi
Q6ZW49
Isoform 2 [Q6ZW49-1]
With | #Exp. | IntAct |
---|---|---|
H2AX [P16104] | 7 | EBI-7521368,EBI-494830 |
Isoform 3 [Q6ZW49-2]
With | #Exp. | IntAct |
---|---|---|
MAPRE2 [Q15555] | 3 | EBI-10236271,EBI-739717 |
NXT1 [Q9UKK6] | 3 | EBI-10236271,EBI-301889 |
POM121 [Q96HA1] | 3 | EBI-10236271,EBI-739990 |
Protein-protein interaction databases
BioGRIDi | 116625, 294 interactors |
ComplexPortali | CPX-7091, Histone-lysine N-methyltransferase complex, KMT2C variant CPX-7104, Histone-lysine N-methyltransferase complex, KMT2D variant |
CORUMi | Q6ZW49 |
DIPi | DIP-41786N |
IntActi | Q6ZW49, 86 interactors |
MINTi | Q6ZW49 |
STRINGi | 9606.ENSP00000384048 |
Miscellaneous databases
RNActi | Q6ZW49, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q6ZW49 |
SMRi | Q6ZW49 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 93 | BRCT 1PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 94 – 183 | BRCT 2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 601 – 694 | BRCT 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 703 – 779 | BRCT 4PROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 866 – 947 | BRCT 5PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 970 – 1059 | BRCT 6PROSITE-ProRule annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 183 | Interaction with PAGR1By similarityAdd BLAST | 90 | |
Regioni | 188 – 271 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 428 – 494 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 543 – 592 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 590 – 1069 | Interaction with TP53BP1Add BLAST | 480 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 702 – 719 | Nuclear localization signalSequence analysisAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 189 – 209 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 213 – 242 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 243 – 258 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 447 – 494 | Polar residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 543 – 574 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2043, Eukaryota |
GeneTreei | ENSGT00940000155757 |
HOGENOMi | CLU_009382_0_0_1 |
InParanoidi | Q6ZW49 |
OMAi | QGPNSIR |
OrthoDBi | 840249at2759 |
PhylomeDBi | Q6ZW49 |
TreeFami | TF329580 |
Family and domain databases
Gene3Di | 3.40.50.10190, 5 hits |
IDEALi | IID00483 |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR037886, Paxip1 |
PANTHERi | PTHR23196:SF31, PTHR23196:SF31, 1 hit |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF12738, PTCB-BRCT, 2 hits PF16770, RTT107_BRCT_5, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 5 hits |
SUPFAMi | SSF52113, SSF52113, 5 hits |
PROSITEi | View protein in PROSITE PS50172, BRCT, 5 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDQAPKVPE EMFREVKYYA VGDIDPQVIQ LLKAGKAKEV SYNALASHII
60 70 80 90 100
SEDGDNPEVG EAREVFDLPV VKPSWVILSV QCGTLLPVNG FSPESCQIFF
110 120 130 140 150
GITACLSQVS SEDRSALWAL VTFYGGDCQL TLNKKCTHLI VPEPKGEKYE
160 170 180 190 200
CALKRASIKI VTPDWVLDCV SEKTKKDEAF YHPRLIIYEE EEEEEEEEEE
210 220 230 240 250
VENEEQDSQN EGSTDEKSSP ASSQEGSPSG DQQFSPKSNT EKSKGELMFD
260 270 280 290 300
DSSDSSPEKQ ERNLNWTPAE VPQLAAAKRR LPQGKEPGLI NLCANVPPVP
310 320 330 340 350
GNILPPEVRG NLMAAGQNLQ SSERSEMIAT WSPAVRTLRN ITNNADIQQM
360 370 380 390 400
NRPSNVAHIL QTLSAPTKNL EQQVNHSQQG HTNANAVLFS QVKVTPETHM
410 420 430 440 450
LQQQQQAQQQ QQQHPVLHLQ PQQIMQLQQQ QQQQISQQPY PQQPPHPFSQ
460 470 480 490 500
QQQQQQQAHP HQFSQQQLQF PQQQLHPPQQ LHRPQQQLQP FQQQHALQQQ
510 520 530 540 550
FHQLQQHQLQ QQQLAQLQQQ HSLLQQQQQQ QIQQQQLQRM HQQQQQQQMQ
560 570 580 590 600
SQTAPHLSQT SQALQHQVPP QQPPQQQQQQ QPPPSPQQHQ LFGHDPAVEI
610 620 630 640 650
PEEGFLLGCV FAIADYPEQM SDKQLLATWK RIIQAHGGTV DPTFTSRCTH
660 670 680 690 700
LLCESQVSSA YAQAIRERKR CVTAHWLNTV LKKKKMVPPH RALHFPVAFP
710 720 730 740 750
PGGKPCSQHI ISVTGFVDSD RDDLKLMAYL AGAKYTGYLC RSNTVLICKE
760 770 780 790 800
PTGLKYEKAK EWRIPCVNAQ WLGDILLGNF EALRQIQYSR YTAFSLQDPF
810 820 830 840 850
APTQHLVLNL LDAWRVPLKV SAELLMSIRL PPKLKQNEVA NVQPSSKRAR
860 870 880 890 900
IEDVPPPTKK LTPELTPFVL FTGFEPVQVQ QYIKKLYILG GEVAESAQKC
910 920 930 940 950
THLIASKVTR TVKFLTAISV VKHIVTPEWL EECFRCQKFI DEQNYILRDA
960 970 980 990 1000
EAEVLFSFSL EESLKRAHVS PLFKAKYFYI TPGICPSLST MKAIVECAGG
1010 1020 1030 1040 1050
KVLSKQPSFR KLMEHKQNSS LSEIILISCE NDLHLCREYF ARGIDVHNAE
1060
FVLTGVLTQT LDYESYKFN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZI8 | H7BZI8_HUMAN | PAX-interacting protein 1 | PAXIP1 | 173 | Annotation score: | ||
F8WC23 | F8WC23_HUMAN | PAX-interacting protein 1 | PAXIP1 | 147 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 121 | V → D in AK307417 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 154 | K → R in CAE45762 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 260 | Q → H in CAE45762 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 406 | Missing in AK307417 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 458 – 581 | Missing in AAB91434 (PubMed:9225980).CuratedAdd BLAST | 124 | |
Sequence conflicti | 847 | K → Q in AAB91434 (PubMed:9225980).Curated | 1 | |
Sequence conflicti | 912 | V → L in AAB91434 (PubMed:9225980).Curated | 1 | |
Sequence conflicti | 916 | T → A in AAB91434 (PubMed:9225980).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034627 | 1013 | M → V1 PublicationCorresponds to variant dbSNP:rs3501Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040303 | 1 – 247 | Missing in isoform 3. 1 PublicationAdd BLAST | 247 | |
Alternative sequenceiVSP_040300 | 1 – 108 | MSDQA…ACLSQ → MVFLQNHVRFFLESLPAFLR VLIQAGALCWSLPELSQGEV GKGACPAEVGKHRDHLPSSD PVLMQAEASVVMCW in isoform 2. 1 PublicationAdd BLAST | 108 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK123044 mRNA Translation: BAC85523.1 Sequence problems. AK123600 mRNA Translation: BAC85657.1 AK307417 mRNA No translation available. BX538201 mRNA Translation: CAD98066.1 BX640616 mRNA Translation: CAE45762.1 AC093726 Genomic DNA Translation: AAP21865.1 Sequence problems. U80735 mRNA Translation: AAB91434.1 Frameshift. BC008328 mRNA Translation: AAH08328.1 BC033781 mRNA Translation: AAH33781.1 Sequence problems. |
CCDSi | CCDS47753.1 [Q6ZW49-6] |
RefSeqi | NP_031375.3, NM_007349.3 [Q6ZW49-6] XP_005249596.1, XM_005249539.1 [Q6ZW49-1] XP_016867370.1, XM_017011881.1 [Q6ZW49-1] |
Genome annotation databases
Ensembli | ENST00000397192.5; ENSP00000380376.1; ENSG00000157212.19 ENST00000404141.6; ENSP00000384048.1; ENSG00000157212.19 |
GeneIDi | 22976 |
KEGGi | hsa:22976 |
MANE-Selecti | ENST00000404141.6; ENSP00000384048.1; NM_007349.4; NP_031375.3 |
UCSCi | uc033aqm.2, human [Q6ZW49-6] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK123044 mRNA Translation: BAC85523.1 Sequence problems. AK123600 mRNA Translation: BAC85657.1 AK307417 mRNA No translation available. BX538201 mRNA Translation: CAD98066.1 BX640616 mRNA Translation: CAE45762.1 AC093726 Genomic DNA Translation: AAP21865.1 Sequence problems. U80735 mRNA Translation: AAB91434.1 Frameshift. BC008328 mRNA Translation: AAH08328.1 BC033781 mRNA Translation: AAH33781.1 Sequence problems. |
CCDSi | CCDS47753.1 [Q6ZW49-6] |
RefSeqi | NP_031375.3, NM_007349.3 [Q6ZW49-6] XP_005249596.1, XM_005249539.1 [Q6ZW49-1] XP_016867370.1, XM_017011881.1 [Q6ZW49-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3SQD | X-ray | 2.15 | A/B | 860-1069 | [»] | |
AlphaFoldDBi | Q6ZW49 | |||||
SMRi | Q6ZW49 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116625, 294 interactors |
ComplexPortali | CPX-7091, Histone-lysine N-methyltransferase complex, KMT2C variant CPX-7104, Histone-lysine N-methyltransferase complex, KMT2D variant |
CORUMi | Q6ZW49 |
DIPi | DIP-41786N |
IntActi | Q6ZW49, 86 interactors |
MINTi | Q6ZW49 |
STRINGi | 9606.ENSP00000384048 |
PTM databases
iPTMneti | Q6ZW49 |
PhosphoSitePlusi | Q6ZW49 |
Genetic variation databases
BioMutai | PAXIP1 |
DMDMi | 317373316 |
Proteomic databases
EPDi | Q6ZW49 |
jPOSTi | Q6ZW49 |
MassIVEi | Q6ZW49 |
MaxQBi | Q6ZW49 |
PaxDbi | Q6ZW49 |
PeptideAtlasi | Q6ZW49 |
PRIDEi | Q6ZW49 |
ProteomicsDBi | 68459 [Q6ZW49-6] 68460 [Q6ZW49-1] 68461 [Q6ZW49-2] |
Protocols and materials databases
Antibodypediai | 1874, 125 antibodies from 25 providers |
DNASUi | 22976 |
Genome annotation databases
Ensembli | ENST00000397192.5; ENSP00000380376.1; ENSG00000157212.19 ENST00000404141.6; ENSP00000384048.1; ENSG00000157212.19 |
GeneIDi | 22976 |
KEGGi | hsa:22976 |
MANE-Selecti | ENST00000404141.6; ENSP00000384048.1; NM_007349.4; NP_031375.3 |
UCSCi | uc033aqm.2, human [Q6ZW49-6] |
Organism-specific databases
CTDi | 22976 |
DisGeNETi | 22976 |
GeneCardsi | PAXIP1 |
HGNCi | HGNC:8624, PAXIP1 |
HPAi | ENSG00000157212, Tissue enhanced (lymphoid) |
MIMi | 608254, gene |
neXtProti | NX_Q6ZW49 |
OpenTargetsi | ENSG00000157212 |
PharmGKBi | PA32964 |
VEuPathDBi | HostDB:ENSG00000157212 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2043, Eukaryota |
GeneTreei | ENSGT00940000155757 |
HOGENOMi | CLU_009382_0_0_1 |
InParanoidi | Q6ZW49 |
OMAi | QGPNSIR |
OrthoDBi | 840249at2759 |
PhylomeDBi | Q6ZW49 |
TreeFami | TF329580 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZW49 |
Reactomei | R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5693571, Nonhomologous End-Joining (NHEJ) |
SignaLinki | Q6ZW49 |
SIGNORi | Q6ZW49 |
Miscellaneous databases
BioGRID-ORCSi | 22976, 157 hits in 1087 CRISPR screens |
ChiTaRSi | PAXIP1, human |
GeneWikii | PAXIP1 |
GenomeRNAii | 22976 |
Pharosi | Q6ZW49, Tbio |
PROi | PR:Q6ZW49 |
RNActi | Q6ZW49, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157212, Expressed in secondary oocyte and 221 other tissues |
ExpressionAtlasi | Q6ZW49, baseline and differential |
Genevisiblei | Q6ZW49, HS |
Family and domain databases
Gene3Di | 3.40.50.10190, 5 hits |
IDEALi | IID00483 |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR037886, Paxip1 |
PANTHERi | PTHR23196:SF31, PTHR23196:SF31, 1 hit |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF12738, PTCB-BRCT, 2 hits PF16770, RTT107_BRCT_5, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 5 hits |
SUPFAMi | SSF52113, SSF52113, 5 hits |
PROSITEi | View protein in PROSITE PS50172, BRCT, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PAXI1_HUMAN | |
Accessioni | Q6ZW49Primary (citable) accession number: Q6ZW49 Secondary accession number(s): O15404 Q96HP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | January 11, 2011 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references