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Entry version 136 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Rho GTPase-activating protein SYDE1

Gene

SYDE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE1
Alternative name(s):
Synapse defective protein 1 homolog 1
Short name:
Protein syd-1 homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYDE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25824 SYDE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617377 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZW31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85360

Open Targets

More...
OpenTargetsi
ENSG00000105137

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670851

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYDE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723056

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003121581 – 735Rho GTPase-activating protein SYDE1Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei224PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei681PhosphoserineBy similarity1
Modified residuei683PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZW31

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZW31

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZW31

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZW31

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZW31

PeptideAtlas

More...
PeptideAtlasi
Q6ZW31

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZW31

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68453 [Q6ZW31-1]
68454 [Q6ZW31-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZW31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZW31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in trophoblast cells of placental villi.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105137 Expressed in 217 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZW31 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZW31 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013328

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124489, 64 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZW31, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341489

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini398 – 604Rho-GAPPROSITE-ProRule annotationAdd BLAST207

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 162Pro-richAdd BLAST131

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1452 Eukaryota
ENOG410XYAD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154469

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZW31

KEGG Orthology (KO)

More...
KOi
K20655

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYEVGPT

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZW31

TreeFam database of animal gene trees

More...
TreeFami
TF323458

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZW31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG
60 70 80 90 100
SQAGAEGPSS PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV
110 120 130 140 150
PGTGEPAGEI WYNPIPEEDP RPPAPEPPGP QPGSAESEGL APQGAAPASP
160 170 180 190 200
PTKASRTKSP GPARRLSIKM KKLPELRRRL SLRGPRAGRE RERAAPAGSV
210 220 230 240 250
ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA GPPSPTSFRP
260 270 280 290 300
YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR
310 320 330 340 350
ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT
360 370 380 390 400
VLLPTVFRGC QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL
410 420 430 440 450
PLLVERERPP GQVPLIIQKC VGQIERRGLR VVGLYRLCGS AAVKKELRDA
460 470 480 490 500
FERDSAAVCL SEDLYPDINV ITGILKDYLR ELPTPLITQP LYKVVLEAMA
510 520 530 540 550
RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS SFHAYNRMTP
560 570 580 590 600
QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW
610 620 630 640 650
PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR
660 670 680 690 700
YAGDWSVCGR DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE
710 720 730
DDFDAPFNPH LNLKDFDALI LDLERELSKQ INVCL
Length:735
Mass (Da):79,793
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87310623E756EB31
GO
Isoform 2 (identifier: Q6ZW31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-96: Missing.

Show »
Length:668
Mass (Da):72,911
Checksum:iABAFE07FDAF5CDCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXZ8M0QXZ8_HUMAN
Rho GTPase-activating protein SYDE1
SYDE1 hCG_38601
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3D3M0R3D3_HUMAN
Rho GTPase-activating protein SYDE1
SYDE1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R101M0R101_HUMAN
Rho GTPase-activating protein SYDE1
SYDE1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062661408R → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772906202Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02971730 – 96Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023573 mRNA Translation: BAB14612.1
AK123686 mRNA Translation: BAC85676.1
CH471106 Genomic DNA Translation: EAW84462.1
CH471106 Genomic DNA Translation: EAW84463.1
BC018942 mRNA Translation: AAH18942.2
BC029926 mRNA Translation: AAH29926.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12324.1 [Q6ZW31-1]
CCDS74299.1 [Q6ZW31-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001287839.1, NM_001300910.1 [Q6ZW31-2]
NP_149014.3, NM_033025.5 [Q6ZW31-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342784; ENSP00000341489; ENSG00000105137 [Q6ZW31-1]
ENST00000600440; ENSP00000470733; ENSG00000105137 [Q6ZW31-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85360

UCSC genome browser

More...
UCSCi
uc002nah.2 human [Q6ZW31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023573 mRNA Translation: BAB14612.1
AK123686 mRNA Translation: BAC85676.1
CH471106 Genomic DNA Translation: EAW84462.1
CH471106 Genomic DNA Translation: EAW84463.1
BC018942 mRNA Translation: AAH18942.2
BC029926 mRNA Translation: AAH29926.1
CCDSiCCDS12324.1 [Q6ZW31-1]
CCDS74299.1 [Q6ZW31-2]
RefSeqiNP_001287839.1, NM_001300910.1 [Q6ZW31-2]
NP_149014.3, NM_033025.5 [Q6ZW31-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124489, 64 interactors
IntActiQ6ZW31, 9 interactors
STRINGi9606.ENSP00000341489

PTM databases

iPTMnetiQ6ZW31
PhosphoSitePlusiQ6ZW31

Polymorphism and mutation databases

BioMutaiSYDE1
DMDMi74723056

Proteomic databases

EPDiQ6ZW31
jPOSTiQ6ZW31
MassIVEiQ6ZW31
MaxQBiQ6ZW31
PaxDbiQ6ZW31
PeptideAtlasiQ6ZW31
PRIDEiQ6ZW31
ProteomicsDBi68453 [Q6ZW31-1]
68454 [Q6ZW31-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85360
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342784; ENSP00000341489; ENSG00000105137 [Q6ZW31-1]
ENST00000600440; ENSP00000470733; ENSG00000105137 [Q6ZW31-2]
GeneIDi85360
KEGGihsa:85360
UCSCiuc002nah.2 human [Q6ZW31-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85360
DisGeNETi85360

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SYDE1
HGNCiHGNC:25824 SYDE1
HPAiHPA013328
MIMi617377 gene
neXtProtiNX_Q6ZW31
OpenTargetsiENSG00000105137
PharmGKBiPA142670851

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1452 Eukaryota
ENOG410XYAD LUCA
GeneTreeiENSGT00950000182819
HOGENOMiHOG000154469
InParanoidiQ6ZW31
KOiK20655
OMAiPYEVGPT
OrthoDBi1300981at2759
PhylomeDBiQ6ZW31
TreeFamiTF323458

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85360

Pharos

More...
Pharosi
Q6ZW31

Protein Ontology

More...
PROi
PR:Q6ZW31

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105137 Expressed in 217 organ(s), highest expression level in placenta
ExpressionAtlasiQ6ZW31 baseline and differential
GenevisibleiQ6ZW31 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYDE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZW31
Secondary accession number(s): Q7L2I8, Q8N6J2, Q9H8K4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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