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Protein

Ankyrin repeat and SOCS box protein 18

Gene

ASB18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 18
Short name:
ASB-18
Gene namesi
Name:ASB18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000182177.13
HGNCiHGNC:19770 ASB18
neXtProtiNX_Q6ZVZ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182177
PharmGKBiPA134950797

Polymorphism and mutation databases

BioMutaiASB18
DMDMi162416260

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118751 – 466Ankyrin repeat and SOCS box protein 18Add BLAST466

Proteomic databases

PaxDbiQ6ZVZ8
PeptideAtlasiQ6ZVZ8
PRIDEiQ6ZVZ8
ProteomicsDBi68449
68450 [Q6ZVZ8-2]

PTM databases

iPTMnetiQ6ZVZ8
PhosphoSitePlusiQ6ZVZ8

Expressioni

Gene expression databases

BgeeiENSG00000182177 Expressed in 25 organ(s), highest expression level in apex of heart
CleanExiHS_ASB18
ExpressionAtlasiQ6ZVZ8 baseline and differential

Organism-specific databases

HPAiHPA068447

Interactioni

Protein-protein interaction databases

BioGridi134882, 23 interactors
STRINGi9606.ENSP00000386532

Structurei

3D structure databases

ProteinModelPortaliQ6ZVZ8
SMRiQ6ZVZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati119 – 148ANK 1Add BLAST30
Repeati151 – 180ANK 2Add BLAST30
Repeati184 – 213ANK 3Add BLAST30
Repeati218 – 247ANK 4Add BLAST30
Repeati251 – 288ANK 5Add BLAST38
Repeati292 – 321ANK 6Add BLAST30
Domaini405 – 463SOCS boxPROSITE-ProRule annotationAdd BLAST59

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000011960
HOGENOMiHOG000232066
HOVERGENiHBG073573
InParanoidiQ6ZVZ8
KOiK10340
OMAiLFGKRCF
OrthoDBiEOG091G0543
PhylomeDBiQ6ZVZ8
TreeFamiTF323921

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037341 ASB18
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44561 PTHR44561, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13606 Ank_3, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50225 SOCS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZVZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNSDYLPDY PLNSDLVKRL KSALDAKDEE RVRDLICTEI TPVDAVIELA
60 70 80 90 100
NDDWMKDPSA QLPTGMLLGD LDHLKPLMDQ FFQDANVVFE INKDEMEWQV
110 120 130 140 150
KSPATFGLSG LWTLEYKREL TTPLCIAAAH GHTACVRHLL GRGADPDASP
160 170 180 190 200
GGRGALHEAC LGGHTACVRL LLQHRADPDL LSAEGLAPLH LCRTAASLGC
210 220 230 240 250
AQALLEHGAS VQRVGGTGRD TPLHVAAQRG LDEHARLYLG RGAHVDARNG
260 270 280 290 300
RGETALSAAC GAARRPDEHG RCLRLCALLL RRGAEADARD EDERSPLHKA
310 320 330 340 350
CGHASHSLAR LLLRHGADAG ALDYGGASPL GRVLQTASCA LQASPQRTVQ
360 370 380 390 400
ALLNHGSPTV WPDAFPKVLK TCASVPAVIE VLFNSYPQLC LSESWKEVIP
410 420 430 440 450
EEVFQMHKPF YQSLFALALT PRCLQHLCRC ALRRLFGKRC FDLIPLLPLP
460
KPLQNYLLLE PQGVLH
Length:466
Mass (Da):50,803
Last modified:December 4, 2007 - v2
Checksum:i80AA94D1846D4D85
GO
Isoform 2 (identifier: Q6ZVZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MSNSDYLPDY...SAQLPTGMLL → MERQPGPVRG...VQEYHTALVA

Note: No experimental confirmation available.
Show »
Length:437
Mass (Da):47,516
Checksum:i6DDE5787E9745D35
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3E8H7C3E8_HUMAN
Ankyrin repeat and SOCS box protein...
ASB18
148Annotation score:
C9JFL4C9JFL4_HUMAN
Ankyrin repeat and SOCS box protein...
ASB18
195Annotation score:

Sequence cautioni

The sequence BAC85710 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048289104A → T. Corresponds to variant dbSNP:rs6756597Ensembl.1
Natural variantiVAR_037331127A → P. Corresponds to variant dbSNP:rs7588748Ensembl.1
Natural variantiVAR_059128261G → S. Corresponds to variant dbSNP:rs6431437Ensembl.1
Natural variantiVAR_048290407H → N. Corresponds to variant dbSNP:rs10177957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296211 – 68MSNSD…TGMLL → MERQPGPVRGKLQIFQKTEK DPQARAGSPVQEYHTALVA in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123854 mRNA Translation: BAC85710.1 Sequence problems.
AC019068 Genomic DNA No translation available.
AC079135 Genomic DNA No translation available.
CCDSiCCDS46548.1 [Q6ZVZ8-1]
RefSeqiNP_997721.2, NM_212556.3 [Q6ZVZ8-1]
UniGeneiHs.639909

Genome annotation databases

EnsembliENST00000409749; ENSP00000386532; ENSG00000182177 [Q6ZVZ8-1]
ENST00000645891; ENSP00000496134; ENSG00000182177 [Q6ZVZ8-2]
GeneIDi401036
KEGGihsa:401036
UCSCiuc010znh.2 human [Q6ZVZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123854 mRNA Translation: BAC85710.1 Sequence problems.
AC019068 Genomic DNA No translation available.
AC079135 Genomic DNA No translation available.
CCDSiCCDS46548.1 [Q6ZVZ8-1]
RefSeqiNP_997721.2, NM_212556.3 [Q6ZVZ8-1]
UniGeneiHs.639909

3D structure databases

ProteinModelPortaliQ6ZVZ8
SMRiQ6ZVZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134882, 23 interactors
STRINGi9606.ENSP00000386532

PTM databases

iPTMnetiQ6ZVZ8
PhosphoSitePlusiQ6ZVZ8

Polymorphism and mutation databases

BioMutaiASB18
DMDMi162416260

Proteomic databases

PaxDbiQ6ZVZ8
PeptideAtlasiQ6ZVZ8
PRIDEiQ6ZVZ8
ProteomicsDBi68449
68450 [Q6ZVZ8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409749; ENSP00000386532; ENSG00000182177 [Q6ZVZ8-1]
ENST00000645891; ENSP00000496134; ENSG00000182177 [Q6ZVZ8-2]
GeneIDi401036
KEGGihsa:401036
UCSCiuc010znh.2 human [Q6ZVZ8-1]

Organism-specific databases

CTDi401036
EuPathDBiHostDB:ENSG00000182177.13
GeneCardsiASB18
HGNCiHGNC:19770 ASB18
HPAiHPA068447
neXtProtiNX_Q6ZVZ8
OpenTargetsiENSG00000182177
PharmGKBiPA134950797
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000011960
HOGENOMiHOG000232066
HOVERGENiHBG073573
InParanoidiQ6ZVZ8
KOiK10340
OMAiLFGKRCF
OrthoDBiEOG091G0543
PhylomeDBiQ6ZVZ8
TreeFamiTF323921

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiASB18 human
GenomeRNAii401036
PROiPR:Q6ZVZ8

Gene expression databases

BgeeiENSG00000182177 Expressed in 25 organ(s), highest expression level in apex of heart
CleanExiHS_ASB18
ExpressionAtlasiQ6ZVZ8 baseline and differential

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037341 ASB18
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44561 PTHR44561, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13606 Ank_3, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB18_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVZ8
Secondary accession number(s): B6ZDL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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