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Protein

Membrane progestin receptor epsilon

Gene

PAQR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).1 Publication1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor epsilon1 Publication
Short name:
mPR epsilon1 Publication
Alternative name(s):
Membrane progesterone P4 receptor epsilon1 Publication
Membrane progesterone receptor epsilon1 Publication
Progesterone and adipoQ receptor family member 9
Progestin and adipoQ receptor family member 9
Progestin and adipoQ receptor family member IX
Gene namesi
Name:PAQR9Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000188582.8
HGNCiHGNC:30131 PAQR9
MIMi614580 gene
neXtProtiNX_Q6ZVX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 116ExtracellularSequence analysis9
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 162CytoplasmicSequence analysisAdd BLAST25
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 205ExtracellularSequence analysisAdd BLAST22
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 243CytoplasmicSequence analysisAdd BLAST17
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 301ExtracellularSequence analysisAdd BLAST37
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 343CytoplasmicSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 377ExtracellularSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi344838
OpenTargetsiENSG00000188582
PharmGKBiPA134880790

Polymorphism and mutation databases

BioMutaiPAQR9
DMDMi51701778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188521 – 377Membrane progestin receptor epsilonAdd BLAST377

Proteomic databases

PaxDbiQ6ZVX9
PeptideAtlasiQ6ZVX9
PRIDEiQ6ZVX9
ProteomicsDBi68448

PTM databases

iPTMnetiQ6ZVX9
PhosphoSitePlusiQ6ZVX9

Expressioni

Tissue specificityi

Expression levels vary widely in a range of tissues (PubMed:16044242). Expressed in the brain, at high level in the pituitary gland and also in hypothalamus, limbic system, caudate nucleus accumens, pons and olfactory bulb (PubMed:23161870).2 Publications

Gene expression databases

BgeeiENSG00000188582 Expressed in 77 organ(s), highest expression level in liver
CleanExiHS_PAQR9
ExpressionAtlasiQ6ZVX9 baseline and differential
GenevisibleiQ6ZVX9 HS

Organism-specific databases

HPAiHPA052798

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000341564

Structurei

3D structure databases

ProteinModelPortaliQ6ZVX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000115439
HOVERGENiHBG053506
InParanoidiQ6ZVX9
OMAiVMTPYVQ
OrthoDBiEOG091G0949
PhylomeDBiQ6ZVX9
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6ZVX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV
60 70 80 90 100
PDDFVECFIL SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK
110 120 130 140 150
FCRLFFLSGG DVPFHHPWLL PLWCYASGVL LTFAMSCTAH VFSCLSLRLR
160 170 180 190 200
AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL SLLDARVMTP YLQQRLGWHV
210 220 230 240 250
DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF ALRTFVFVMP
260 270 280 290 300
LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ
310 320 330 340 350
PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV
360 370
GYMLLLVVCL GLVIRKFLNS SEFCSKK
Length:377
Mass (Da):42,692
Last modified:July 5, 2004 - v1
Checksum:iC1708C12C5C5A7C5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4R3H7C4R3_HUMAN
Membrane progestin receptor epsilon
PAQR9
146Annotation score:
H7C5S8H7C5S8_HUMAN
Membrane progestin receptor epsilon
PAQR9
38Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424287 mRNA Translation: AAR08375.1
AK123932 mRNA Translation: BAC85729.1
BC118666 mRNA Translation: AAI18667.1
BC122527 mRNA Translation: AAI22528.1
CCDSiCCDS3128.1
RefSeqiNP_940906.1, NM_198504.2
UniGeneiHs.408385
Hs.656111

Genome annotation databases

EnsembliENST00000340634; ENSP00000341564; ENSG00000188582
GeneIDi344838
KEGGihsa:344838
UCSCiuc003evg.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424287 mRNA Translation: AAR08375.1
AK123932 mRNA Translation: BAC85729.1
BC118666 mRNA Translation: AAI18667.1
BC122527 mRNA Translation: AAI22528.1
CCDSiCCDS3128.1
RefSeqiNP_940906.1, NM_198504.2
UniGeneiHs.408385
Hs.656111

3D structure databases

ProteinModelPortaliQ6ZVX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341564

PTM databases

iPTMnetiQ6ZVX9
PhosphoSitePlusiQ6ZVX9

Polymorphism and mutation databases

BioMutaiPAQR9
DMDMi51701778

Proteomic databases

PaxDbiQ6ZVX9
PeptideAtlasiQ6ZVX9
PRIDEiQ6ZVX9
ProteomicsDBi68448

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340634; ENSP00000341564; ENSG00000188582
GeneIDi344838
KEGGihsa:344838
UCSCiuc003evg.5 human

Organism-specific databases

CTDi344838
DisGeNETi344838
EuPathDBiHostDB:ENSG00000188582.8
GeneCardsiPAQR9
HGNCiHGNC:30131 PAQR9
HPAiHPA052798
MIMi614580 gene
neXtProtiNX_Q6ZVX9
OpenTargetsiENSG00000188582
PharmGKBiPA134880790
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000115439
HOVERGENiHBG053506
InParanoidiQ6ZVX9
OMAiVMTPYVQ
OrthoDBiEOG091G0949
PhylomeDBiQ6ZVX9
TreeFamiTF319738

Miscellaneous databases

GenomeRNAii344838
PROiPR:Q6ZVX9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188582 Expressed in 77 organ(s), highest expression level in liver
CleanExiHS_PAQR9
ExpressionAtlasiQ6ZVX9 baseline and differential
GenevisibleiQ6ZVX9 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVX9
Secondary accession number(s): Q147T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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