Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 102 (12 Aug 2020)
Sequence version 2 (18 Mar 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Putative interleukin-17 receptor E-like

Gene

IL17REL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZVW7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative interleukin-17 receptor E-like
Short name:
IL-17 receptor E-like
Short name:
IL-17RE-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL17REL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188263.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33808, IL17REL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613414, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZVW7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
400935

Open Targets

More...
OpenTargetsi
ENSG00000188263

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391970

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZVW7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL17REL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046175

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003259581 – 336Putative interleukin-17 receptor E-likeAdd BLAST336

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZVW7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZVW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZVW7

PeptideAtlas

More...
PeptideAtlasi
Q6ZVW7

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZVW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68446

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZVW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZVW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188263, Expressed in mucosa of stomach and 36 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188263, Tissue enhanced (lymphoid tissue, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
134822, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374633

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZVW7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTUV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162605

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039632_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZVW7

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSWGSWV

Database of Orthologous Groups

More...
OrthoDBi
441889at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZVW7

TreeFam database of animal gene trees

More...
TreeFami
TF335690

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N

The PANTHER Classification System

More...
PANTHERi
PTHR15583, PTHR15583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15037, IL17_R_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZVW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSVLEALT SSTAMQCVPS DGCAMLLRVR ASITLHERLR GLEACAMSLD
60 70 80 90 100
TQETQCQSVW VARASHRQQG GQQLQVHFGC FAVSVAQHLY VTLRTIPHFC
110 120 130 140 150
GVQLDQRHLV EAGKLSYWVD RRRKAILVQV PRASGSPDYY LRLCLKRFTC
160 170 180 190 200
EDAGAPVRVT ANSVSQAVFL PYSQELPCLC LEGWSATPDA VRIQICPFEN
210 220 230 240 250
DTEALEVLWD TVYYHPESQT LSWEPACPVS GHVSLCWRPG PGAGCRKLQQ
260 270 280 290 300
SSQLVHRRVQ YPLVDTQPQL CLKFSTSWGS WVRCPFEQRR FPTPPTSRCT
310 320 330
CVTGGSHSSL PANAHSRPAR SLQPQVTWQP PLLLPS
Length:336
Mass (Da):37,514
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i971639DC7A96B7E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70 – 72GGQ → RGR in BAC85743 (PubMed:14702039).Curated3
Sequence conflicti165S → P in BAC85743 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06118770G → R. Corresponds to variant dbSNP:rs9617090Ensembl.1
Natural variantiVAR_039957333L → P. Corresponds to variant dbSNP:rs5771069Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK123987 mRNA Translation: BAC85743.1
AL022327 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33679.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001694.2, NM_001001694.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341280; ENSP00000342520; ENSG00000188263
ENST00000389983; ENSP00000374633; ENSG00000188263

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
400935

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:400935

UCSC genome browser

More...
UCSCi
uc003bje.2, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123987 mRNA Translation: BAC85743.1
AL022327 Genomic DNA No translation available.
CCDSiCCDS33679.1
RefSeqiNP_001001694.2, NM_001001694.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi134822, 1 interactor
STRINGi9606.ENSP00000374633

PTM databases

iPTMnetiQ6ZVW7
PhosphoSitePlusiQ6ZVW7

Polymorphism and mutation databases

BioMutaiIL17REL
DMDMi172046175

Proteomic databases

jPOSTiQ6ZVW7
MassIVEiQ6ZVW7
PaxDbiQ6ZVW7
PeptideAtlasiQ6ZVW7
PRIDEiQ6ZVW7
ProteomicsDBi68446

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52494, 13 antibodies

Genome annotation databases

EnsembliENST00000341280; ENSP00000342520; ENSG00000188263
ENST00000389983; ENSP00000374633; ENSG00000188263
GeneIDi400935
KEGGihsa:400935
UCSCiuc003bje.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
400935
DisGeNETi400935
EuPathDBiHostDB:ENSG00000188263.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL17REL
HGNCiHGNC:33808, IL17REL
HPAiENSG00000188263, Tissue enhanced (lymphoid tissue, stomach)
MIMi613414, gene
neXtProtiNX_Q6ZVW7
OpenTargetsiENSG00000188263
PharmGKBiPA162391970

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTUV, Eukaryota
GeneTreeiENSGT00940000162605
HOGENOMiCLU_039632_0_0_1
InParanoidiQ6ZVW7
OMAiTSWGSWV
OrthoDBi441889at2759
PhylomeDBiQ6ZVW7
TreeFamiTF335690

Enzyme and pathway databases

PathwayCommonsiQ6ZVW7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
400935, 3 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL17REL, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
400935
PharosiQ6ZVW7, Tdark

Protein Ontology

More...
PROi
PR:Q6ZVW7
RNActiQ6ZVW7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188263, Expressed in mucosa of stomach and 36 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
PANTHERiPTHR15583, PTHR15583, 1 hit
PfamiView protein in Pfam
PF15037, IL17_R_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI17EL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZVW7
Secondary accession number(s): A6NCN4, A6PVC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: August 12, 2020
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again