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UniProtKB - Q6ZVM7 (TM1L2_HUMAN)
Protein
TOM1-like protein 2
Gene
TOM1L2
Organism
Homo sapiens (Human)
Status
Functioni
Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.
2 PublicationsGO - Molecular functioni
- clathrin binding Source: UniProtKB
- phosphatidylinositol binding Source: InterPro
- protein kinase binding Source: UniProtKB
- ubiquitin binding Source: InterPro
GO - Biological processi
- negative regulation of mitotic nuclear division Source: UniProtKB
- protein transport Source: UniProtKB-KW
- signal transduction Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q6ZVM7 |
SignaLinki | Q6ZVM7 |
Names & Taxonomyi
Protein namesi | Recommended name: TOM1-like protein 2Alternative name(s): Target of Myb-like protein 2 |
Gene namesi | Name:TOM1L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11984, TOM1L2 |
MIMi | 615519, gene |
neXtProti | NX_Q6ZVM7 |
VEuPathDBi | HostDB:ENSG00000175662 |
Subcellular locationi
Endosome
- endosome Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- membrane Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 146691 |
OpenTargetsi | ENSG00000175662 |
PharmGKBi | PA36668 |
Miscellaneous databases
Pharosi | Q6ZVM7, Tdark |
Genetic variation databases
BioMutai | TOM1L2 |
DMDMi | 74712301 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278790 | 1 – 507 | TOM1-like protein 2Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 160 | PhosphoserineCombined sources | 1 | |
Modified residuei | 164 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZVM7 |
jPOSTi | Q6ZVM7 |
MassIVEi | Q6ZVM7 |
MaxQBi | Q6ZVM7 |
PaxDbi | Q6ZVM7 |
PeptideAtlasi | Q6ZVM7 |
PRIDEi | Q6ZVM7 |
ProteomicsDBi | 6447 68426 [Q6ZVM7-1] 68427 [Q6ZVM7-2] 68428 [Q6ZVM7-3] 68429 [Q6ZVM7-4] |
PTM databases
GlyGeni | Q6ZVM7, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q6ZVM7 |
PhosphoSitePlusi | Q6ZVM7 |
Expressioni
Tissue specificityi
Ubiquitously expressed with higher expression in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000175662, Expressed in heart left ventricle and 222 other tissues |
ExpressionAtlasi | Q6ZVM7, baseline and differential |
Genevisiblei | Q6ZVM7, HS |
Organism-specific databases
HPAi | ENSG00000175662, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with clathrin, SRC and TOLLIP.
2 PublicationsBinary interactionsi
Isoform 2 [Q6ZVM7-2]
With | #Exp. | IntAct |
---|---|---|
FAM9B [Q8IZU0] | 5 | EBI-12147805,EBI-10175124 |
TOLLIP [Q9H0E2] | 7 | EBI-12147805,EBI-74615 |
GO - Molecular functioni
- clathrin binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- ubiquitin binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 127001, 50 interactors |
DIPi | DIP-61860N |
IntActi | Q6ZVM7, 14 interactors |
MINTi | Q6ZVM7 |
STRINGi | 9606.ENSP00000368818 |
Miscellaneous databases
RNActi | Q6ZVM7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 152 | VHSPROSITE-ProRule annotationAdd BLAST | 133 | |
Domaini | 219 – 307 | GATPROSITE-ProRule annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 210 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 467 – 507 | DisorderedSequence analysisAdd BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 329 – 334 | Clathrin-binding | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 177 – 195 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
The GAT domain mediates interaction with TOLLIP.
Sequence similaritiesi
Belongs to the TOM1 family.Curated
Phylogenomic databases
eggNOGi | KOG1087, Eukaryota |
GeneTreei | ENSGT00940000156940 |
HOGENOMi | CLU_932372_0_0_1 |
InParanoidi | Q6ZVM7 |
OMAi | MLALTXA |
OrthoDBi | 1213216at2759 |
PhylomeDBi | Q6ZVM7 |
TreeFami | TF314105 |
Family and domain databases
Gene3Di | 1.20.58.160, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR004152, GAT_dom IPR038425, GAT_sf IPR014645, TOM1 IPR027429, TOM1L2 IPR002014, VHS_dom |
PANTHERi | PTHR13856:SF31, PTHR13856:SF31, 1 hit |
Pfami | View protein in Pfam PF03127, GAT, 1 hit PF00790, VHS, 1 hit |
PIRSFi | PIRSF036948, TOM1, 1 hit |
SMARTi | View protein in SMART SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50909, GAT, 1 hit PS50179, VHS, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZVM7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA
60 70 80 90 100
IRALKKRLNG NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV
110 120 130 140 150
KIISPKNNPP TIVQDKVLAL IQAWADAFRS SPDLTGVVHI YEELKRKGVE
160 170 180 190 200
FPMADLDALS PIHTPQRSVP EVDPAATMPR SQSQQRTSAG SYSSPPPAPY
210 220 230 240 250
SAPQAPALSV TGPITANSEQ IARLRSELDV VRGNTKVMSE MLTEMVPGQE
260 270 280 290 300
DSSDLELLQE LNRTCRAMQQ RIVELISRVS NEEVTEELLH VNDDLNNVFL
310 320 330 340 350
RYERFERYRS GRSVQNASNG VLNEVTEDNL IDLGPGSPAV VSPMVGNTAP
360 370 380 390 400
PSSLSSQLAG LDLGTESVSG TLSSLQQCNP RDGFDMFAQT RGNSLAEQRK
410 420 430 440 450
TVTYEDPQAV GGLASALDNR KQSSEGIPVA QPSVMDDIEV WLRTDLKGDD
460 470 480 490 500
LEEGVTSEEF DKFLEERAKA AEMVPDLPSP PMEAPAPASN PSGRKKPERS
EDALFAL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z2U2 | B7Z2U2_HUMAN | TOM1-like protein 2 | TOM1L2 | 389 | Annotation score: | ||
F5H3S6 | F5H3S6_HUMAN | TOM1-like protein 2 | TOM1L2 | 388 | Annotation score: | ||
K7ENB0 | K7ENB0_HUMAN | TOM1-like protein 2 | TOM1L2 | 83 | Annotation score: | ||
K7EKL6 | K7EKL6_HUMAN | TOM1-like protein 2 | TOM1L2 | 39 | Annotation score: |
Sequence cautioni
The sequence AAL78338 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | P → A in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 177 | T → S in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 323 | N → S in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 331 | I → L in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 347 | N → S in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 400 | K → Q in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 466 | E → V in AAL78338 (PubMed:11997338).Curated | 1 | |
Sequence conflicti | 475 | P → H in AAL78338 (PubMed:11997338).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023390 | 1 – 267 | Missing in isoform 4. 1 PublicationAdd BLAST | 267 | |
Alternative sequenceiVSP_023391 | 73 – 122 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_023392 | 123 – 167 | Missing in isoform 3. 2 PublicationsAdd BLAST | 45 | |
Alternative sequenceiVSP_057214 | 168 – 220 | Missing in isoform 5. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_057215 | 426 | G → GTFLSSAQKRGRGGESDLEP IDSWLITQGM in isoform 5. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF467441 mRNA Translation: AAL78338.1 Sequence problems. AK057308 mRNA Translation: BAB71421.1 AK124331 mRNA Translation: BAC85834.1 AK294846 mRNA Translation: BAH11903.1 AK301944 mRNA Translation: BAH13590.1 AC087163 Genomic DNA No translation available. AC122129 Genomic DNA No translation available. KF456255 Genomic DNA No translation available. BC051650 mRNA Translation: AAH51650.1 |
CCDSi | CCDS32584.1 [Q6ZVM7-2] CCDS42270.1 [Q6ZVM7-1] CCDS74002.1 [Q6ZVM7-3] CCDS74003.1 [Q6ZVM7-5] |
RefSeqi | NP_001028723.1, NM_001033551.2 [Q6ZVM7-2] NP_001076437.1, NM_001082968.1 [Q6ZVM7-1] NP_001275715.1, NM_001288786.1 [Q6ZVM7-5] NP_001275716.1, NM_001288787.1 [Q6ZVM7-3] NP_001275717.1, NM_001288788.1 NP_001275718.1, NM_001288789.1 |
Genome annotation databases
Ensembli | ENST00000318094; ENSP00000312860; ENSG00000175662 [Q6ZVM7-3] ENST00000379504; ENSP00000368818; ENSG00000175662 ENST00000395739; ENSP00000379088; ENSG00000175662 [Q6ZVM7-3] ENST00000478943; ENSP00000463313; ENSG00000175662 [Q6ZVM7-4] ENST00000535933; ENSP00000438621; ENSG00000175662 [Q6ZVM7-5] ENST00000581396; ENSP00000464297; ENSG00000175662 [Q6ZVM7-2] |
GeneIDi | 146691 |
KEGGi | hsa:146691 |
MANE-Selecti | ENST00000379504.8; ENSP00000368818.3; NM_001082968.2; NP_001076437.1 |
UCSCi | uc002gry.5, human [Q6ZVM7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF467441 mRNA Translation: AAL78338.1 Sequence problems. AK057308 mRNA Translation: BAB71421.1 AK124331 mRNA Translation: BAC85834.1 AK294846 mRNA Translation: BAH11903.1 AK301944 mRNA Translation: BAH13590.1 AC087163 Genomic DNA No translation available. AC122129 Genomic DNA No translation available. KF456255 Genomic DNA No translation available. BC051650 mRNA Translation: AAH51650.1 |
CCDSi | CCDS32584.1 [Q6ZVM7-2] CCDS42270.1 [Q6ZVM7-1] CCDS74002.1 [Q6ZVM7-3] CCDS74003.1 [Q6ZVM7-5] |
RefSeqi | NP_001028723.1, NM_001033551.2 [Q6ZVM7-2] NP_001076437.1, NM_001082968.1 [Q6ZVM7-1] NP_001275715.1, NM_001288786.1 [Q6ZVM7-5] NP_001275716.1, NM_001288787.1 [Q6ZVM7-3] NP_001275717.1, NM_001288788.1 NP_001275718.1, NM_001288789.1 |
3D structure databases
SMRi | Q6ZVM7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127001, 50 interactors |
DIPi | DIP-61860N |
IntActi | Q6ZVM7, 14 interactors |
MINTi | Q6ZVM7 |
STRINGi | 9606.ENSP00000368818 |
PTM databases
GlyGeni | Q6ZVM7, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q6ZVM7 |
PhosphoSitePlusi | Q6ZVM7 |
Genetic variation databases
BioMutai | TOM1L2 |
DMDMi | 74712301 |
Proteomic databases
EPDi | Q6ZVM7 |
jPOSTi | Q6ZVM7 |
MassIVEi | Q6ZVM7 |
MaxQBi | Q6ZVM7 |
PaxDbi | Q6ZVM7 |
PeptideAtlasi | Q6ZVM7 |
PRIDEi | Q6ZVM7 |
ProteomicsDBi | 6447 68426 [Q6ZVM7-1] 68427 [Q6ZVM7-2] 68428 [Q6ZVM7-3] 68429 [Q6ZVM7-4] |
Protocols and materials databases
Antibodypediai | 13414, 147 antibodies from 25 providers |
DNASUi | 146691 |
Genome annotation databases
Ensembli | ENST00000318094; ENSP00000312860; ENSG00000175662 [Q6ZVM7-3] ENST00000379504; ENSP00000368818; ENSG00000175662 ENST00000395739; ENSP00000379088; ENSG00000175662 [Q6ZVM7-3] ENST00000478943; ENSP00000463313; ENSG00000175662 [Q6ZVM7-4] ENST00000535933; ENSP00000438621; ENSG00000175662 [Q6ZVM7-5] ENST00000581396; ENSP00000464297; ENSG00000175662 [Q6ZVM7-2] |
GeneIDi | 146691 |
KEGGi | hsa:146691 |
MANE-Selecti | ENST00000379504.8; ENSP00000368818.3; NM_001082968.2; NP_001076437.1 |
UCSCi | uc002gry.5, human [Q6ZVM7-1] |
Organism-specific databases
CTDi | 146691 |
DisGeNETi | 146691 |
GeneCardsi | TOM1L2 |
HGNCi | HGNC:11984, TOM1L2 |
HPAi | ENSG00000175662, Low tissue specificity |
MIMi | 615519, gene |
neXtProti | NX_Q6ZVM7 |
OpenTargetsi | ENSG00000175662 |
PharmGKBi | PA36668 |
VEuPathDBi | HostDB:ENSG00000175662 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1087, Eukaryota |
GeneTreei | ENSGT00940000156940 |
HOGENOMi | CLU_932372_0_0_1 |
InParanoidi | Q6ZVM7 |
OMAi | MLALTXA |
OrthoDBi | 1213216at2759 |
PhylomeDBi | Q6ZVM7 |
TreeFami | TF314105 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZVM7 |
SignaLinki | Q6ZVM7 |
Miscellaneous databases
BioGRID-ORCSi | 146691, 11 hits in 1041 CRISPR screens |
ChiTaRSi | TOM1L2, human |
GeneWikii | TOM1L2 |
GenomeRNAii | 146691 |
Pharosi | Q6ZVM7, Tdark |
PROi | PR:Q6ZVM7 |
RNActi | Q6ZVM7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175662, Expressed in heart left ventricle and 222 other tissues |
ExpressionAtlasi | Q6ZVM7, baseline and differential |
Genevisiblei | Q6ZVM7, HS |
Family and domain databases
Gene3Di | 1.20.58.160, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR004152, GAT_dom IPR038425, GAT_sf IPR014645, TOM1 IPR027429, TOM1L2 IPR002014, VHS_dom |
PANTHERi | PTHR13856:SF31, PTHR13856:SF31, 1 hit |
Pfami | View protein in Pfam PF03127, GAT, 1 hit PF00790, VHS, 1 hit |
PIRSFi | PIRSF036948, TOM1, 1 hit |
SMARTi | View protein in SMART SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50909, GAT, 1 hit PS50179, VHS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM1L2_HUMAN | |
Accessioni | Q6ZVM7Primary (citable) accession number: Q6ZVM7 Secondary accession number(s): B7Z2L7 Q96M88 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families