TOM1L2

Functionⁱ

Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.2 Publications

GO - Molecular functionⁱ

clathrin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16412388
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16479011

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular protein transport Source: InterPro
negative regulation of mitotic nuclear division
Source: UniProtKB
Inferred from direct assayⁱ
- 16479011
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 16479011

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TOM1-like protein 2 Alternative name(s): Target of Myb-like protein 2
Gene namesⁱ	Name:TOM1L2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175662.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11984 TOM1L2
MIMⁱ	615519 gene
neXtProtⁱ	NX_Q6ZVM7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	146691
Open Targets More...OpenTargetsⁱ	ENSG00000175662
PharmGKBⁱ	PA36668

Polymorphism and mutation databases

BioMutaⁱ	TOM1L2
DMDMⁱ	74712301

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278790	1 – 507	TOM1-like protein 2Add BLAST		507

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	160	PhosphoserineCombined sources		1
Modified residueⁱ	164	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6ZVM7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6ZVM7
PaxDbⁱ	Q6ZVM7
PeptideAtlas More...PeptideAtlasⁱ	Q6ZVM7
PRIDEⁱ	Q6ZVM7
ProteomicsDBⁱ	68426 68427 [Q6ZVM7-2] 68428 [Q6ZVM7-3] 68429 [Q6ZVM7-4]

PTM databases

iPTMnetⁱ	Q6ZVM7
PhosphoSitePlusⁱ	Q6ZVM7

Miscellaneous databases

PMAP-CutDBⁱ	Q6ZVM7

PMAP-CutDBⁱ

Q6ZVM7

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with higher expression in heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175662 Expressed in 205 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_TOM1L2
ExpressionAtlasⁱ	Q6ZVM7 baseline and differential
Genevisibleⁱ	Q6ZVM7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022541 HPA023304

HPAⁱ

HPA022541
HPA023304

Interactionⁱ

Subunit structureⁱ

Interacts with clathrin, SRC and TOLLIP.2 Publications

GO - Molecular functionⁱ

clathrin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16412388
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16479011

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127001, 30 interactors
Database of interacting proteins More...DIPⁱ	DIP-61860N
IntActⁱ	Q6ZVM7, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q6ZVM7
STRINGⁱ	9606.ENSP00000368818

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6ZVM7
SMRⁱ	Q6ZVM7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – 152	VHSPROSITE-ProRule annotationAdd BLAST		133
Domainⁱ	219 – 307	GATPROSITE-ProRule annotationAdd BLAST		89

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	329 – 334	Clathrin-binding		6

Domainⁱ

The GAT domain mediates interaction with TOLLIP.

Sequence similaritiesⁱ

Belongs to the TOM1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150885
HOGENOMⁱ	HOG000285970
HOVERGENⁱ	HBG025068
InParanoidⁱ	Q6ZVM7
OMAⁱ	QRKNVKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08M1
PhylomeDBⁱ	Q6ZVM7
TreeFamⁱ	TF314105

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008942 ENTH_VHS IPR004152 GAT_dom IPR038425 GAT_sf IPR014645 TOM1 IPR027429 TOM1L2 IPR002014 VHS_dom
PANTHERⁱ	PTHR13856:SF31 PTHR13856:SF31, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03127 GAT, 1 hit PF00790 VHS, 1 hit
PIRSFⁱ	PIRSF036948 TOM1, 1 hit
SMARTⁱ	View protein in SMART SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit
PROSITEⁱ	View protein in PROSITE PS50909 GAT, 1 hit PS50179 VHS, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6ZVM7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA 
        60         70         80         90        100
IRALKKRLNG NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV 
       110        120        130        140        150
KIISPKNNPP TIVQDKVLAL IQAWADAFRS SPDLTGVVHI YEELKRKGVE 
       160        170        180        190        200
FPMADLDALS PIHTPQRSVP EVDPAATMPR SQSQQRTSAG SYSSPPPAPY 
       210        220        230        240        250
SAPQAPALSV TGPITANSEQ IARLRSELDV VRGNTKVMSE MLTEMVPGQE 
       260        270        280        290        300
DSSDLELLQE LNRTCRAMQQ RIVELISRVS NEEVTEELLH VNDDLNNVFL 
       310        320        330        340        350
RYERFERYRS GRSVQNASNG VLNEVTEDNL IDLGPGSPAV VSPMVGNTAP 
       360        370        380        390        400
PSSLSSQLAG LDLGTESVSG TLSSLQQCNP RDGFDMFAQT RGNSLAEQRK 
       410        420        430        440        450
TVTYEDPQAV GGLASALDNR KQSSEGIPVA QPSVMDDIEV WLRTDLKGDD 
       460        470        480        490        500
LEEGVTSEEF DKFLEERAKA AEMVPDLPSP PMEAPAPASN PSGRKKPERS 

EDALFAL

Length:507

Mass (Da):55,556

Last modified:July 5, 2004 - v1

Checksum:ⁱ6CB4B4433076D8D0

GO

Isoform 2 (identifier: Q6ZVM7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
73-122: Missing.

« Hide

        10         20         30         40         50
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA 
        60         70         80         90        100
IRALKKRLNG NRNYREVMLA LTAWADAFRS SPDLTGVVHI YEELKRKGVE 
       110        120        130        140        150
FPMADLDALS PIHTPQRSVP EVDPAATMPR SQSQQRTSAG SYSSPPPAPY 
       160        170        180        190        200
SAPQAPALSV TGPITANSEQ IARLRSELDV VRGNTKVMSE MLTEMVPGQE 
       210        220        230        240        250
DSSDLELLQE LNRTCRAMQQ RIVELISRVS NEEVTEELLH VNDDLNNVFL 
       260        270        280        290        300
RYERFERYRS GRSVQNASNG VLNEVTEDNL IDLGPGSPAV VSPMVGNTAP 
       310        320        330        340        350
PSSLSSQLAG LDLGTESVSG TLSSLQQCNP RDGFDMFAQT RGNSLAEQRK 
       360        370        380        390        400
TVTYEDPQAV GGLASALDNR KQSSEGIPVA QPSVMDDIEV WLRTDLKGDD 
       410        420        430        440        450
LEEGVTSEEF DKFLEERAKA AEMVPDLPSP PMEAPAPASN PSGRKKPERS 

EDALFAL

Note: No experimental confirmation available.

Show »

Length:457

Mass (Da):49,964

Checksum:ⁱ92D76584C342D6C8

GO

Isoform 3 (identifier: Q6ZVM7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
123-167: Missing.

« Hide

        10         20         30         40         50
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA 
        60         70         80         90        100
IRALKKRLNG NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV 
       110        120        130        140        150
KIISPKNNPP TIVQDKVLAL IQSVPEVDPA ATMPRSQSQQ RTSAGSYSSP 
       160        170        180        190        200
PPAPYSAPQA PALSVTGPIT ANSEQIARLR SELDVVRGNT KVMSEMLTEM 
       210        220        230        240        250
VPGQEDSSDL ELLQELNRTC RAMQQRIVEL ISRVSNEEVT EELLHVNDDL 
       260        270        280        290        300
NNVFLRYERF ERYRSGRSVQ NASNGVLNEV TEDNLIDLGP GSPAVVSPMV 
       310        320        330        340        350
GNTAPPSSLS SQLAGLDLGT ESVSGTLSSL QQCNPRDGFD MFAQTRGNSL 
       360        370        380        390        400
AEQRKTVTYE DPQAVGGLAS ALDNRKQSSE GIPVAQPSVM DDIEVWLRTD 
       410        420        430        440        450
LKGDDLEEGV TSEEFDKFLE ERAKAAEMVP DLPSPPMEAP APASNPSGRK 
       460 
KPERSEDALF AL

Show »

Length:462

Mass (Da):50,509

Checksum:ⁱ0E8EE9521D76DAFB

GO

Isoform 4 (identifier: Q6ZVM7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-267: Missing.

« Hide

        10         20         30         40         50
MQQRIVELIS RVSNEEVTEE LLHVNDDLNN VFLRYERFER YRSGRSVQNA 
        60         70         80         90        100
SNGVLNEVTE DNLIDLGPGS PAVVSPMVGN TAPPSSLSSQ LAGLDLGTES 
       110        120        130        140        150
VSGTLSSLQQ CNPRDGFDMF AQTRGNSLAE QRKTVTYEDP QAVGGLASAL 
       160        170        180        190        200
DNRKQSSEGI PVAQPSVMDD IEVWLRTDLK GDDLEEGVTS EEFDKFLEER 
       210        220        230        240
AKAAEMVPDL PSPPMEAPAP ASNPSGRKKP ERSEDALFAL

Note: No experimental confirmation available.

Show »

Length:240

Mass (Da):26,136

Checksum:ⁱ82DE20A5B198F997

GO

Isoform 5 (identifier: Q6ZVM7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
168-220: Missing.
426-426: G → GTFLSSAQKRGRGGESDLEPIDSWLITQGM

« Hide

        10         20         30         40         50
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA 
        60         70         80         90        100
IRALKKRLNG NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV 
       110        120        130        140        150
KIISPKNNPP TIVQDKVLAL IQAWADAFRS SPDLTGVVHI YEELKRKGVE 
       160        170        180        190        200
FPMADLDALS PIHTPQRIAR LRSELDVVRG NTKVMSEMLT EMVPGQEDSS 
       210        220        230        240        250
DLELLQELNR TCRAMQQRIV ELISRVSNEE VTEELLHVND DLNNVFLRYE 
       260        270        280        290        300
RFERYRSGRS VQNASNGVLN EVTEDNLIDL GPGSPAVVSP MVGNTAPPSS 
       310        320        330        340        350
LSSQLAGLDL GTESVSGTLS SLQQCNPRDG FDMFAQTRGN SLAEQRKTVT 
       360        370        380        390        400
YEDPQAVGGL ASALDNRKQS SEGTFLSSAQ KRGRGGESDL EPIDSWLITQ 
       410        420        430        440        450
GMIPVAQPSV MDDIEVWLRT DLKGDDLEEG VTSEEFDKFL EERAKAAEMV 
       460        470        480 
PDLPSPPMEA PAPASNPSGR KKPERSEDAL FAL

Note: No experimental confirmation available.

Show »

Length:483

Mass (Da):53,368

Checksum:ⁱ6C226EFFDDC0DF24

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7Z2U2	B7Z2U2_HUMAN	TOM1-like protein 2 TOM1-like protein 2 (cDNA FLJ54050, highly similar to Homo sapiens target of myb1-like 2 (TOM1L2), transcript variant 2, mRNA)	TOM1L2	389	Annotation score:
F5H3S6	F5H3S6_HUMAN	TOM1-like protein 2 TOM1-like protein 2	TOM1L2	388	Annotation score:
K7ENB0	K7ENB0_HUMAN	TOM1-like protein 2 TOM1-like protein 2	TOM1L2	83	Annotation score:
K7EKL6	K7EKL6_HUMAN	TOM1-like protein 2 TOM1-like protein 2	TOM1L2	39	Annotation score:

Sequence cautionⁱ

The sequence AAL78338 differs from that shown. Reason: Frameshift at positions 101, 121 and 170.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	P → A in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	177	T → S in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	323	N → S in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	331	I → L in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	347	N → S in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	400	K → Q in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	466	E → V in AAL78338 (PubMed:11997338).Curated	1
Sequence conflictⁱ	475	P → H in AAL78338 (PubMed:11997338).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_023390	1 – 267	Missing in isoform 4. 1 PublicationAdd BLAST	267
Alternative sequenceⁱVSP_023391	73 – 122	Missing in isoform 2. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_023392	123 – 167	Missing in isoform 3. 2 PublicationsAdd BLAST	45
Alternative sequenceⁱVSP_057214	168 – 220	Missing in isoform 5. 1 PublicationAdd BLAST	53
Alternative sequenceⁱVSP_057215	426	G → GTFLSSAQKRGRGGESDLEP IDSWLITQGM in isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF467441 mRNA Translation: AAL78338.1 Sequence problems. AK057308 mRNA Translation: BAB71421.1 AK124331 mRNA Translation: BAC85834.1 AK294846 mRNA Translation: BAH11903.1 AK301944 mRNA Translation: BAH13590.1 AC087163 Genomic DNA No translation available. AC122129 Genomic DNA No translation available. KF456255 Genomic DNA No translation available. BC051650 mRNA Translation: AAH51650.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32584.1 [Q6ZVM7-2] CCDS42270.1 [Q6ZVM7-1] CCDS74002.1 [Q6ZVM7-3] CCDS74003.1 [Q6ZVM7-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_001028723.1, NM_001033551.2 [Q6ZVM7-2] NP_001076437.1, NM_001082968.1 [Q6ZVM7-1] NP_001275715.1, NM_001288786.1 [Q6ZVM7-5] NP_001275716.1, NM_001288787.1 [Q6ZVM7-3] NP_001275717.1, NM_001288788.1 NP_001275718.1, NM_001288789.1
UniGeneⁱ	Hs.462379

Genome annotation databases

Ensemblⁱ	ENST00000318094; ENSP00000312860; ENSG00000175662 [Q6ZVM7-3] ENST00000379504; ENSP00000368818; ENSG00000175662 [Q6ZVM7-1] ENST00000395739; ENSP00000379088; ENSG00000175662 [Q6ZVM7-3] ENST00000478943; ENSP00000463313; ENSG00000175662 [Q6ZVM7-4] ENST00000535933; ENSP00000438621; ENSG00000175662 [Q6ZVM7-5] ENST00000581396; ENSP00000464297; ENSG00000175662 [Q6ZVM7-2]
GeneIDⁱ	146691
KEGGⁱ	hsa:146691
UCSC genome browser More...UCSCⁱ	uc002gry.5 human [Q6ZVM7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q6ZVM7	Uncharacterized protein		PANPA		507	UniRef100_Q6ZVM7
Target of myb1 like 2 membrane trafficking protein		GORGO		507
TOM1L2 isoform 10		PONAB		240
TOM1L2 isoform 2		PANTR		240
Isoform 4 of TOM1-like protein 2		HUMAN		240
Q6ZVM7-2	TOM1L2 isoform 3		PONAB		457	UniRef100_A0A2J8RIA0
Uncharacterized protein		PANPA		457
Target of myb1 like 2 membrane trafficking protein		GORGO		457
Q6ZVM7-3	TOM1L2 isoform 4		PANTR		462	UniRef100_A0A2J8J377
Uncharacterized protein		PANPA		462
Target of myb1 like 2 membrane trafficking protein		GORGO		462
Q6ZVM7-5	Uncharacterized protein		PANPA		483	UniRef100_A0A2R8ZRF4
Target of myb1 like 2 membrane trafficking protein		GORGO		483

Protein	Similar proteins		Species	Score	Length	Source
Q6ZVM7	TOM1-like protein 2		MOUSE		507	UniRef90_Q6ZVM7
Uncharacterized protein		PANPA		507
Target of myb1 like 2 membrane trafficking protein		GORGO		507
TOM1L2 isoform 10		PONAB		240
TOM1L2 isoform 2		PANTR		240
+116
Q6ZVM7-2	TOM1-like protein 2		MOUSE		462	UniRef90_Q5SXA4
Uncharacterized protein		FELCA		464
TOM1L2 isoform 4		PANTR		462
Uncharacterized protein		PANPA		462
Target of myb1 like 2 membrane trafficking protein		GORGO		462
+50
Q6ZVM7-3	TOM1-like protein 2		MOUSE		462	UniRef90_Q5SXA4
Uncharacterized protein		FELCA		464
TOM1L2 isoform 4		PANTR		462
Uncharacterized protein		PANPA		462
Target of myb1 like 2 membrane trafficking protein		GORGO		462
+50
Q6ZVM7-5	TOM1L2 isoform 7		PANTR		483	UniRef90_A0A2I3TTV2
Uncharacterized protein		FELCA		485
Target of myb1 like 2 membrane trafficking protein		CALJA		483
TOM1L2 isoform 2		PONAB		483
Uncharacterized protein		AOTNA		483
+19

Protein	Similar proteins		Species	Score	Length	Source
Q6ZVM7	TOM1-like protein 2		MOUSE		507	UniRef50_Q6ZVM7
Target of Myb protein 1		CHICK		515
Uncharacterized protein		PANPA		507
Target of myb1 like 2 membrane trafficking protein		GORGO		507
TOM1L2 isoform 10		PONAB		240
+1008
Q6ZVM7-2	Isoform 3 of Target of Myb protein 1		HUMAN		447	UniRef50_O60784-3
target of Myb protein 1 isoform X2		LIPVE		448
Uncharacterized protein		Cebus capucinus imitator		447
TOM1 isoform 5		PANTR		447
Uncharacterized protein		RHIRO		447
+196
Q6ZVM7-3	Isoform 3 of Target of Myb protein 1		HUMAN		447	UniRef50_O60784-3
target of Myb protein 1 isoform X2		LIPVE		448
Uncharacterized protein		Cebus capucinus imitator		447
TOM1 isoform 5		PANTR		447
Uncharacterized protein		RHIRO		447
+196
Q6ZVM7-5	Isoform 2 of TOM1-like protein 2		MOUSE		487	UniRef50_Q5SRX1-2
Uncharacterized protein		CAVPO		487
TOM1-like protein 2		CASCN		487
TOM1-like protein 2 isoform X5		MESAU		487
TOM1-like protein 2 isoform X2		TARSY		487
+188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF467441 mRNA Translation: AAL78338.1 Sequence problems. AK057308 mRNA Translation: BAB71421.1 AK124331 mRNA Translation: BAC85834.1 AK294846 mRNA Translation: BAH11903.1 AK301944 mRNA Translation: BAH13590.1 AC087163 Genomic DNA No translation available. AC122129 Genomic DNA No translation available. KF456255 Genomic DNA No translation available. BC051650 mRNA Translation: AAH51650.1
CCDSⁱ	CCDS32584.1 [Q6ZVM7-2] CCDS42270.1 [Q6ZVM7-1] CCDS74002.1 [Q6ZVM7-3] CCDS74003.1 [Q6ZVM7-5]
RefSeqⁱ	NP_001028723.1, NM_001033551.2 [Q6ZVM7-2] NP_001076437.1, NM_001082968.1 [Q6ZVM7-1] NP_001275715.1, NM_001288786.1 [Q6ZVM7-5] NP_001275716.1, NM_001288787.1 [Q6ZVM7-3] NP_001275717.1, NM_001288788.1 NP_001275718.1, NM_001288789.1
UniGeneⁱ	Hs.462379

3D structure databases

ProteinModelPortalⁱ	Q6ZVM7
SMRⁱ	Q6ZVM7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127001, 30 interactors
DIPⁱ	DIP-61860N
IntActⁱ	Q6ZVM7, 7 interactors
MINTⁱ	Q6ZVM7
STRINGⁱ	9606.ENSP00000368818

PTM databases

iPTMnetⁱ	Q6ZVM7
PhosphoSitePlusⁱ	Q6ZVM7

Polymorphism and mutation databases

BioMutaⁱ	TOM1L2
DMDMⁱ	74712301

Proteomic databases

EPDⁱ	Q6ZVM7
MaxQBⁱ	Q6ZVM7
PaxDbⁱ	Q6ZVM7
PeptideAtlasⁱ	Q6ZVM7
PRIDEⁱ	Q6ZVM7
ProteomicsDBⁱ	68426 68427 [Q6ZVM7-2] 68428 [Q6ZVM7-3] 68429 [Q6ZVM7-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000318094; ENSP00000312860; ENSG00000175662 [Q6ZVM7-3] ENST00000379504; ENSP00000368818; ENSG00000175662 [Q6ZVM7-1] ENST00000395739; ENSP00000379088; ENSG00000175662 [Q6ZVM7-3] ENST00000478943; ENSP00000463313; ENSG00000175662 [Q6ZVM7-4] ENST00000535933; ENSP00000438621; ENSG00000175662 [Q6ZVM7-5] ENST00000581396; ENSP00000464297; ENSG00000175662 [Q6ZVM7-2]
GeneIDⁱ	146691
KEGGⁱ	hsa:146691
UCSCⁱ	uc002gry.5 human [Q6ZVM7-1]

Organism-specific databases

CTDⁱ	146691
DisGeNETⁱ	146691
EuPathDBⁱ	HostDB:ENSG00000175662.17
GeneCardsⁱ	TOM1L2
HGNCⁱ	HGNC:11984 TOM1L2
HPAⁱ	HPA022541 HPA023304
MIMⁱ	615519 gene
neXtProtⁱ	NX_Q6ZVM7
OpenTargetsⁱ	ENSG00000175662
PharmGKBⁱ	PA36668
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
GeneTreeⁱ	ENSGT00930000150885
HOGENOMⁱ	HOG000285970
HOVERGENⁱ	HBG025068
InParanoidⁱ	Q6ZVM7
OMAⁱ	QRKNVKY
OrthoDBⁱ	EOG091G08M1
PhylomeDBⁱ	Q6ZVM7
TreeFamⁱ	TF314105

Miscellaneous databases

ChiTaRSⁱ	TOM1L2 human
GeneWikiⁱ	TOM1L2
GenomeRNAiⁱ	146691
PMAP-CutDBⁱ	Q6ZVM7
Protein Ontology More...PROⁱ	PR:Q6ZVM7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175662 Expressed in 205 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_TOM1L2
ExpressionAtlasⁱ	Q6ZVM7 baseline and differential
Genevisibleⁱ	Q6ZVM7 HS

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008942 ENTH_VHS IPR004152 GAT_dom IPR038425 GAT_sf IPR014645 TOM1 IPR027429 TOM1L2 IPR002014 VHS_dom
PANTHERⁱ	PTHR13856:SF31 PTHR13856:SF31, 1 hit
Pfamⁱ	View protein in Pfam PF03127 GAT, 1 hit PF00790 VHS, 1 hit
PIRSFⁱ	PIRSF036948 TOM1, 1 hit
SMARTⁱ	View protein in SMART SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit
PROSITEⁱ	View protein in PROSITE PS50909 GAT, 1 hit PS50179 VHS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM1L2_HUMAN
Accessionⁱ	Q6ZVM7Primary (citable) accession number: Q6ZVM7 Secondary accession number(s): B7Z2L7 , B7Z7F4, Q86V61, Q8TDE7, Q96M88
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q6ZVM7 (TM1L2_HUMAN)

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TOM1-like protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

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Keywords - PTMⁱ

Expressionⁱ

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Keywords - Coding sequence diversityⁱ

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