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Entry version 95 (18 Sep 2019)
Sequence version 2 (03 Oct 2006)
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Protein

G protein-regulated inducer of neurite outgrowth 3

Gene

GPRIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neurite outgrowth.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 3
Short name:
GRIN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPRIN3
Synonyms:KIAA2027
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27733 GPRIN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611241 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZVF9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185477

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390203

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPRIN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115502242

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002519501 – 776G protein-regulated inducer of neurite outgrowth 3Add BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei332PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZVF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZVF9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZVF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZVF9

PeptideAtlas

More...
PeptideAtlasi
Q6ZVF9

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZVF9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68413

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZVF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZVF9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6ZVF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185477 Expressed in 163 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZVF9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043148
HPA057666
HPA059092

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130131, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000476603

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZVF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVMU Eukaryota
ENOG4111KRR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00570000079168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZVF9

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFQSMLQ

Database of Orthologous Groups

More...
OrthoDBi
612273at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZVF9

TreeFam database of animal gene trees

More...
TreeFami
TF337047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C

The PANTHER Classification System

More...
PANTHERi
PTHR15718 PTHR15718, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15235 GRIN_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZVF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVPDPLRS AKTSLIAASG KEDDLGEPQA ASPRHRPALL CKNANGFSGA
60 70 80 90 100
PAEPDLSPRA AAEALMQVCE HETTQPDMSS PGVFNEVQKA PATFNSPGNP
110 120 130 140 150
QLPGSSQPAA SAPSSAAGRD LIHTPLTMPA NQHTCQSIPG DQPNAITSSM
160 170 180 190 200
PEDSLMRSQR TSNREQPEKP SCPVGGVLSS SKDQVSCEFP SPETIQGTVQ
210 220 230 240 250
TPVTAARVVS HSSSPVGGPE GERQGAICDS EMRSCKPLTR ESGCSENKQP
260 270 280 290 300
SVTASGPQGT TSVTPQPTPL TSEPSACPPG PEKVPLPAQR QMSRFKEAST
310 320 330 340 350
MTNQAESEIK EVPSRAWQDA EVQAVASVES RSVSTSPSIL TAFLKESRAP
360 370 380 390 400
EHFEQEQLRV ICHSSGSHTL ELSDSTLAPQ ESSQCPGIMP QVHIQAAAAE
410 420 430 440 450
STAFQRENKL ASLPGGVLKT SSINLVSSNA QHTCKEDGRL AGMTPVREES
460 470 480 490 500
TAKKLAGTNS SSLKATAIDQ ISISACSQAE TSYGLGKFET RPSEFAEKTT
510 520 530 540 550
NGHKTDPDCK LSDSCGSISK ADHSGSLDPT NKGDAREKKP ASPQVVKEKE
560 570 580 590 600
STGTDTSDAK TLLLNPKSQE SGGTESAANP TPSPIRKNQE STLEENRQTK
610 620 630 640 650
TATSLSLPSD PMGDSSPGSG KKTPSRSVKA SPRRPSRVSE FLKEQKLNVT
660 670 680 690 700
AAAAQVGLTP GDKKKQLGAD SKLQLKQSKR VRDVVWDEQG MTWEVYGASL
710 720 730 740 750
DAESLGIAIQ NHLQRQIREH EKLIKTQNSQ TRRSISSDTS SNKKLRGRQH
760 770
SVFQSMLQNF RRPNCCVRPA PSSVLD
Length:776
Mass (Da):82,439
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54C7E7CF69F1CD1B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC23123 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti363H → R in BAC85902 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05101939L → V. Corresponds to variant dbSNP:rs11734353Ensembl.1
Natural variantiVAR_051020378A → V. Corresponds to variant dbSNP:rs6811370Ensembl.1
Natural variantiVAR_051021382S → P. Corresponds to variant dbSNP:rs28622301Ensembl.1
Natural variantiVAR_051022390P → S. Corresponds to variant dbSNP:rs11733183Ensembl.1
Natural variantiVAR_051023446V → A1 PublicationCorresponds to variant dbSNP:rs7653897Ensembl.1
Natural variantiVAR_051024746R → K. Corresponds to variant dbSNP:rs17015286Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB095947 mRNA Translation: BAC23123.2 Different initiation.
AK124616 mRNA Translation: BAC85902.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34030.1

NCBI Reference Sequences

More...
RefSeqi
NP_938022.2, NM_198281.2
XP_005262993.1, XM_005262936.3
XP_005262994.1, XM_005262937.4
XP_016863532.1, XM_017008043.1
XP_016863533.1, XM_017008044.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333209; ENSP00000328672; ENSG00000185477
ENST00000609438; ENSP00000476603; ENSG00000185477

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
285513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285513

UCSC genome browser

More...
UCSCi
uc003hsm.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095947 mRNA Translation: BAC23123.2 Different initiation.
AK124616 mRNA Translation: BAC85902.1
CCDSiCCDS34030.1
RefSeqiNP_938022.2, NM_198281.2
XP_005262993.1, XM_005262936.3
XP_005262994.1, XM_005262937.4
XP_016863532.1, XM_017008043.1
XP_016863533.1, XM_017008044.1

3D structure databases

SMRiQ6ZVF9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi130131, 5 interactors
STRINGi9606.ENSP00000476603

PTM databases

iPTMnetiQ6ZVF9
PhosphoSitePlusiQ6ZVF9
SwissPalmiQ6ZVF9

Polymorphism and mutation databases

BioMutaiGPRIN3
DMDMi115502242

Proteomic databases

jPOSTiQ6ZVF9
MassIVEiQ6ZVF9
MaxQBiQ6ZVF9
PaxDbiQ6ZVF9
PeptideAtlasiQ6ZVF9
PRIDEiQ6ZVF9
ProteomicsDBi68413

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
285513
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333209; ENSP00000328672; ENSG00000185477
ENST00000609438; ENSP00000476603; ENSG00000185477
GeneIDi285513
KEGGihsa:285513
UCSCiuc003hsm.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285513

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPRIN3
HGNCiHGNC:27733 GPRIN3
HPAiHPA043148
HPA057666
HPA059092
MIMi611241 gene
neXtProtiNX_Q6ZVF9
OpenTargetsiENSG00000185477
PharmGKBiPA162390203

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVMU Eukaryota
ENOG4111KRR LUCA
GeneTreeiENSGT00570000079168
HOGENOMiHOG000060135
InParanoidiQ6ZVF9
OMAiVFQSMLQ
OrthoDBi612273at2759
PhylomeDBiQ6ZVF9
TreeFamiTF337047

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
285513

Pharos

More...
Pharosi
Q6ZVF9

Protein Ontology

More...
PROi
PR:Q6ZVF9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185477 Expressed in 163 organ(s), highest expression level in heart
GenevisibleiQ6ZVF9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C
PANTHERiPTHR15718 PTHR15718, 1 hit
PfamiView protein in Pfam
PF15235 GRIN_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRIN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZVF9
Secondary accession number(s): Q8IVE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 18, 2019
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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