Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 153 (16 Oct 2019)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

PH domain leucine-rich repeat-containing protein phosphatase 2

Gene

PHLPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit. Mn2+ is inhibitory below pH 8 and activating above pH 8 (PubMed:24892992).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by AKT1, AKT2 and AKT3. Activated by oleic acid and arachidonic acid (PubMed:24892992).Curated1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.13 mM for p-nitrophenyl phosphate

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi820Manganese 1By similarity1
    Metal bindingi820Manganese 2By similarity1
    Metal bindingi821Manganese 1; via carbonyl oxygenBy similarity1
    Metal bindingi985Manganese 2By similarity1
    Metal bindingi1024Manganese 2By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protein phosphatase
    LigandManganese, Metal-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-199418 Negative regulation of the PI3K/AKT network

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q6ZVD8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    PH domain leucine-rich repeat-containing protein phosphatase 2 (EC:3.1.3.162 Publications)
    Alternative name(s):
    PH domain leucine-rich repeat-containing protein phosphatase-like
    Short name:
    PHLPP-like
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PHLPP2
    Synonyms:KIAA0931, PHLPPL
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:29149 PHLPP2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611066 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6ZVD8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi783F → V: Decreases activity. 1 Publication1
    Mutagenesisi806D → N: Decreases activity. 1 Publication1
    Mutagenesisi808F → V: Abolishes activity. 1 Publication1
    Mutagenesisi989E → Q: Decreases activity. 1 Publication1
    Mutagenesisi1024D → N: Decreases activity. 1 Publication1

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    23035

    Open Targets

    More...
    OpenTargetsi
    ENSG00000040199

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA165450496

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6ZVD8

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1275209

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PHLPP2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116242711

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577841 – 1323PH domain leucine-rich repeat-containing protein phosphatase 2Add BLAST1323

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1210PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6ZVD8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6ZVD8

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6ZVD8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6ZVD8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6ZVD8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6ZVD8

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    68409 [Q6ZVD8-1]
    68410 [Q6ZVD8-2]
    68411 [Q6ZVD8-3]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    Q6ZVD8

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6ZVD8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6ZVD8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000040199 Expressed in 198 organ(s), highest expression level in colonic mucosa

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6ZVD8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6ZVD8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA048598

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with AKT1, AKT3 and PRKCB isoform beta-II (PubMed:17386267, PubMed:18162466, PubMed:19732725).

    Interacts with STK4, RPS6KB1, RAF1 (PubMed:20513427, PubMed:21986499, PubMed:24530606).

    Interacts with FKBP5; FKBP5 acts as a scaffold for PHLPP2 and Akt (PubMed:19732725).

    Interacts with SLC9A3R1; SLC9A3R1 scaffolds a heterotrimeric complex with PTEN (PubMed:21804599).

    7 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    116674, 26 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q6ZVD8

    Database of interacting proteins

    More...
    DIPi
    DIP-53556N

    Protein interaction database and analysis system

    More...
    IntActi
    Q6ZVD8, 23 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q6ZVD8

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000457991

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q6ZVD8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini150 – 248PHAdd BLAST99
    <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati250 – 271LRR 1Add BLAST22
    Repeati273 – 296LRR 2Add BLAST24
    Repeati300 – 321LRR 3Add BLAST22
    Repeati323 – 344LRR 4Add BLAST22
    Repeati346 – 368LRR 5Add BLAST23
    Repeati369 – 390LRR 6Add BLAST22
    Repeati392 – 412LRR 7Add BLAST21
    Repeati416 – 439LRR 8Add BLAST24
    Repeati440 – 460LRR 9Add BLAST21
    Repeati461 – 480LRR 10Add BLAST20
    Repeati481 – 502LRR 11Add BLAST22
    Repeati503 – 524LRR 12Add BLAST22
    Repeati526 – 547LRR 13Add BLAST22
    Repeati549 – 570LRR 14Add BLAST22
    Repeati571 – 592LRR 15Add BLAST22
    Repeati595 – 616LRR 16Add BLAST22
    Repeati621 – 644LRR 17Add BLAST24
    Repeati645 – 666LRR 18Add BLAST22
    Repeati669 – 690LRR 19Add BLAST22
    Repeati692 – 713LRR 20Add BLAST22
    Repeati714 – 735LRR 21Add BLAST22
    Repeati737 – 758LRR 22Add BLAST22
    Domaini785 – 1033PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST249

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 49Poly-Thr10
    Compositional biasi50 – 60Poly-SerAdd BLAST11
    Compositional biasi1071 – 1074Poly-Ser4

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0618 Eukaryota
    KOG0619 Eukaryota
    COG0631 LUCA
    COG4886 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159841

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000115529

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6ZVD8

    KEGG Orthology (KO)

    More...
    KOi
    K16340

    Database of Orthologous Groups

    More...
    OrthoDBi
    172467at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6ZVD8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315993

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00143 PP2Cc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.60.40.10, 1 hit
    3.80.10.10, 3 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001611 Leu-rich_rpt
    IPR003591 Leu-rich_rpt_typical-subtyp
    IPR032675 LRR_dom_sf
    IPR036457 PPM-type_dom_sf
    IPR001932 PPM-type_phosphatase_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13855 LRR_8, 2 hits
    PF00481 PP2C, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00369 LRR_TYP, 13 hits
    SM00332 PP2Cc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF81606 SSF81606, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51450 LRR, 18 hits
    PS51746 PPM_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6ZVD8-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS
    60 70 80 90 100
    SSSSSSSSSS DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT
    110 120 130 140 150
    ERPLQIVYDY LSRLGFDDPV RIQEEATNPD LGCMIRFYGE KPCHMDRLDR
    160 170 180 190 200
    ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC LIVSSVKDCQ TGKMHILPLV
    210 220 230 240 250
    GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ RQASKVVSQR
    260 270 280 290 300
    ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ
    310 320 330 340 350
    LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL
    360 370 380 390 400
    CLDGNFLTTL PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG
    410 420 430 440 450
    NCLEVLNLGV LNRMNHIKHV DLRMNHLKTM VIENLEGNKH ITHVDLRDNR
    460 470 480 490 500
    LTDLDLSSLC SLEQLHCGRN QLRELTLSGF SLRTLYASSN RLTAVNVYPV
    510 520 530 540 550
    PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV PVRILSSLSL
    560 570 580 590 600
    RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN
    610 620 630 640 650
    ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHLHLRILH
    660 670 680 690 700
    LANNQLQTFP ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS
    710 720 730 740 750
    NNISIFPEIL QLPQIQFVDL SCNDLTEILI PEALPATLQD LDLTGNTNLV
    760 770 780 790 800
    LEHKTLDIFS HITTLKIDQK PLPTTDSTVT STFWSHGLAE MAGQRNKLCV
    810 820 830 840 850
    SALAMDSFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL EEVQQSTNDT
    860 870 880 890 900
    VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT
    910 920 930 940 950
    CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT
    960 970 980 990 1000
    RMLGCTYLYP WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV
    1010 1020 1030 1040 1050
    RHVQDPLAAA KKLCTLAQSY GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP
    1060 1070 1080 1090 1100
    GPVGFASTTT IKDAPKPATP SSSSGIASEF SSEMSTSEVS SEVGSTASDE
    1110 1120 1130 1140 1150
    HNAGGLDTAL LPRPERRCSL HPTPTSGLFQ RQPSSATFSS NQSDNGLDSD
    1160 1170 1180 1190 1200
    DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPPLIESSP TLCSEEHARG
    1210 1220 1230 1240 1250
    SCFGIRRQNS VNSGMLLPMS KDRMELQKSP STSCLYGKKL SNGSIVPLED
    1260 1270 1280 1290 1300
    SLNLIEVATE VPKRKTGYFA APTQMEPEDQ FVVPHDLEEE VKEQMKQHQD
    1310 1320
    SRLEPEPHEE DRTEPPEEFD TAL
    Length:1,323
    Mass (Da):146,751
    Last modified:October 17, 2006 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04FC8550C2E22A6D
    GO
    Isoform 2 (identifier: Q6ZVD8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         940-956: DNKVNGVTCCTRMLGCT → NWVLNQKHLQDFPGEDK
         957-1323: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:956
    Mass (Da):107,079
    Checksum:iD639027D022AFED9
    GO
    Isoform 3 (identifier: Q6ZVD8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         596-662: Missing.

    Show »
    Length:1,256
    Mass (Da):139,394
    Checksum:iDC706C3744570432
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H3BMS5H3BMS5_HUMAN
    PH domain leucine-rich repeat-conta...
    PHLPP2
    1,358Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BS75H3BS75_HUMAN
    PH domain leucine-rich repeat-conta...
    PHLPP2
    319Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L187I3L187_HUMAN
    PH domain leucine-rich repeat-conta...
    PHLPP2
    723Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA76775 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence BAA91943 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147R → C in BX647823 (PubMed:17974005).Curated1
    Sequence conflicti542V → L (PubMed:15616553).Curated1
    Sequence conflicti766K → E in BX647823 (PubMed:17974005).Curated1
    Sequence conflicti896A → G in BAA91943 (PubMed:14702039).Curated1
    Sequence conflicti978E → G in BX647823 (PubMed:17974005).Curated1
    Sequence conflicti1016L → S in BX647823 (PubMed:17974005).Curated1
    Sequence conflicti1312R → Q in AAI29928 (PubMed:15489334).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017265596 – 662Missing in isoform 3. 1 PublicationAdd BLAST67
    Alternative sequenceiVSP_014056940 – 956DNKVN…MLGCT → NWVLNQKHLQDFPGEDK in isoform 2. 1 PublicationAdd BLAST17
    Alternative sequenceiVSP_014057957 – 1323Missing in isoform 2. 1 PublicationAdd BLAST367

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB023148 mRNA Translation: BAA76775.2 Different initiation.
    BX647823 mRNA No translation available.
    AC009097 Genomic DNA No translation available.
    BC129927 mRNA Translation: AAI29928.1
    AK001854 mRNA Translation: BAA91943.1 Different initiation.
    AK124678 mRNA Translation: BAC85924.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS32479.1 [Q6ZVD8-1]
    CCDS73910.1 [Q6ZVD8-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001275932.1, NM_001289003.1 [Q6ZVD8-3]
    NP_055835.2, NM_015020.3 [Q6ZVD8-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000393524; ENSP00000377159; ENSG00000040199 [Q6ZVD8-3]
    ENST00000568954; ENSP00000457991; ENSG00000040199 [Q6ZVD8-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    23035

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:23035

    UCSC genome browser

    More...
    UCSCi
    uc002fax.5 human [Q6ZVD8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB023148 mRNA Translation: BAA76775.2 Different initiation.
    BX647823 mRNA No translation available.
    AC009097 Genomic DNA No translation available.
    BC129927 mRNA Translation: AAI29928.1
    AK001854 mRNA Translation: BAA91943.1 Different initiation.
    AK124678 mRNA Translation: BAC85924.1
    CCDSiCCDS32479.1 [Q6ZVD8-1]
    CCDS73910.1 [Q6ZVD8-3]
    RefSeqiNP_001275932.1, NM_001289003.1 [Q6ZVD8-3]
    NP_055835.2, NM_015020.3 [Q6ZVD8-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi116674, 26 interactors
    CORUMiQ6ZVD8
    DIPiDIP-53556N
    IntActiQ6ZVD8, 23 interactors
    MINTiQ6ZVD8
    STRINGi9606.ENSP00000457991

    Chemistry databases

    BindingDBiQ6ZVD8
    ChEMBLiCHEMBL1275209

    PTM databases

    DEPODiQ6ZVD8
    iPTMnetiQ6ZVD8
    PhosphoSitePlusiQ6ZVD8

    Polymorphism and mutation databases

    BioMutaiPHLPP2
    DMDMi116242711

    Proteomic databases

    jPOSTiQ6ZVD8
    MassIVEiQ6ZVD8
    MaxQBiQ6ZVD8
    PaxDbiQ6ZVD8
    PeptideAtlasiQ6ZVD8
    PRIDEiQ6ZVD8
    ProteomicsDBi68409 [Q6ZVD8-1]
    68410 [Q6ZVD8-2]
    68411 [Q6ZVD8-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    23035

    Genome annotation databases

    EnsembliENST00000393524; ENSP00000377159; ENSG00000040199 [Q6ZVD8-3]
    ENST00000568954; ENSP00000457991; ENSG00000040199 [Q6ZVD8-1]
    GeneIDi23035
    KEGGihsa:23035
    UCSCiuc002fax.5 human [Q6ZVD8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    23035
    DisGeNETi23035

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PHLPP2
    HGNCiHGNC:29149 PHLPP2
    HPAiHPA048598
    MIMi611066 gene
    neXtProtiNX_Q6ZVD8
    OpenTargetsiENSG00000040199
    PharmGKBiPA165450496

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0618 Eukaryota
    KOG0619 Eukaryota
    COG0631 LUCA
    COG4886 LUCA
    GeneTreeiENSGT00940000159841
    HOGENOMiHOG000115529
    InParanoidiQ6ZVD8
    KOiK16340
    OrthoDBi172467at2759
    PhylomeDBiQ6ZVD8
    TreeFamiTF315993

    Enzyme and pathway databases

    ReactomeiR-HSA-199418 Negative regulation of the PI3K/AKT network
    SIGNORiQ6ZVD8

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PHLPP2 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PHLPPL

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    23035
    PharosiQ6ZVD8

    Protein Ontology

    More...
    PROi
    PR:Q6ZVD8

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000040199 Expressed in 198 organ(s), highest expression level in colonic mucosa
    ExpressionAtlasiQ6ZVD8 baseline and differential
    GenevisibleiQ6ZVD8 HS

    Family and domain databases

    CDDicd00143 PP2Cc, 1 hit
    Gene3Di3.60.40.10, 1 hit
    3.80.10.10, 3 hits
    InterProiView protein in InterPro
    IPR001611 Leu-rich_rpt
    IPR003591 Leu-rich_rpt_typical-subtyp
    IPR032675 LRR_dom_sf
    IPR036457 PPM-type_dom_sf
    IPR001932 PPM-type_phosphatase_dom
    PfamiView protein in Pfam
    PF13855 LRR_8, 2 hits
    PF00481 PP2C, 1 hit
    SMARTiView protein in SMART
    SM00369 LRR_TYP, 13 hits
    SM00332 PP2Cc, 1 hit
    SUPFAMiSSF81606 SSF81606, 1 hit
    PROSITEiView protein in PROSITE
    PS51450 LRR, 18 hits
    PS51746 PPM_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLP2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZVD8
    Secondary accession number(s): A1L374, Q9NV17, Q9Y2E3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 17, 2006
    Last modified: October 16, 2019
    This is version 153 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again