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Entry version 128 (16 Oct 2019)
Sequence version 2 (22 Nov 2005)
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Protein

Storkhead-box protein 1

Gene

STOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).By similarity1 Publication
Isoform A: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Storkhead-box protein 1
Alternative name(s):
Winged-helix domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STOX1
Synonyms:C10orf24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23508 STOX1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609397 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZVD7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pre-eclampsia/eclampsia 4 (PEE4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02378418R → P in PEE4. 1 PublicationCorresponds to variant dbSNP:rs556362193Ensembl.1
Natural variantiVAR_023787825N → I in PEE4. 1 PublicationCorresponds to variant dbSNP:rs41278532Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
219736

MalaCards human disease database

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MalaCardsi
STOX1
MIMi609404 phenotype

Open Targets

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OpenTargetsi
ENSG00000165730

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
275555 Preeclampsia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134883643

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q6ZVD7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STOX1

Domain mapping of disease mutations (DMDM)

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DMDMi
82592525

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722811 – 989Storkhead-box protein 1Add BLAST989

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ZVD7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6ZVD7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ZVD7

PeptideAtlas

More...
PeptideAtlasi
Q6ZVD7

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZVD7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68406 [Q6ZVD7-1]
68407 [Q6ZVD7-2]
68408 [Q6ZVD7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZVD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZVD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, including the invasive extravillus trophoblast cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165730 Expressed in 140 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZVD7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZVD7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037844
HPA037845

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H8Y83EBI-3923644,EBI-739467

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128569, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZVD7, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3897 Eukaryota
ENOG410ZJ97 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055589

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZVD7

Identification of Orthologs from Complete Genome Data

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OMAi
AKEPYAE

Database of Orthologous Groups

More...
OrthoDBi
494782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZVD7

TreeFam database of animal gene trees

More...
TreeFami
TF337253

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019391 Storkhead-box_winged-helix
IPR040126 STOX1/2

The PANTHER Classification System

More...
PANTHERi
PTHR22437 PTHR22437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10264 Stork_head, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q6ZVD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARPVQLAPG SLALVLCRLE AQKAAGAAEE PGGRAVFRAF RRANARCFWN
60 70 80 90 100
ARLARAASRL AFQGWLRRGV LLVRAPPACL QVLRDAWRRR ALRPPRGFRI
110 120 130 140 150
RAVGDVFPVQ MNPITQSQFV PLGEVLCCAI SDMNTAQIVV TQESLLERLM
160 170 180 190 200
KHYPGIAIPS EDILYTTLGT LIKERKIYHT GEGYFIVTPQ TYFITNTTTQ
210 220 230 240 250
ENKRMLPSDE SRLMPASMTY LVSMESCAES AQENAAPISH CQSCQCFRDM
260 270 280 290 300
HTQDVQEAPV AAEVTRKSHR GLGESVSWVQ NGAVSVSAEH HICESTKPLP
310 320 330 340 350
YTRDKEKGKK FGFSLLWRSL SRKEKPKTEH SSFSAQFPPE EWPVRDEDDL
360 370 380 390 400
DNIPRDVEHE IIKRINPILT VDNLIKHTVL MQKYEEQKKY NSQGTSTDML
410 420 430 440 450
TIGHKYPSKE GVKKRQGLSA KPQGQGHSRR DRHKARNQGS EFQPGSIRLE
460 470 480 490 500
KHPKLPATQP IPRIKSPNEM VGQKPLGEIT TVLGSHLIYK KRISNPFQGL
510 520 530 540 550
SHRGSTISKG HKIQKTSDLK PSQTGPKEKP FQKPRSLDSS RIFDGKAKEP
560 570 580 590 600
YAEQPNDKME AESIYINDPT VKPINDDFRG HLFSHPQQSM LQNDGKCCPF
610 620 630 640 650
MESMLRYEVY GGENEVIPEV LRKSHSHFDK LGETKQTPHS LPSRGASFSD
660 670 680 690 700
RTPSACRLVD NTIHQFQNLG LLDYPVGVNP LRQAARQDKD SEELLRKGFV
710 720 730 740 750
QDAETTSLEN EQLSNDDQAL YQNEVEDDDG ACSSLYLEED DISENDDLRQ
760 770 780 790 800
MLPGHSQYSF TGGSQGNHLG KQKVIERSLT EYNSTMERVE SQVLKRNECY
810 820 830 840 850
KPTGLHATPG ESQEPNLSAE SCGLNSGAQF GFNYEEEPSV AKCVQASAPA
860 870 880 890 900
DERIFDYYSA RKASFEAEVI QDTIGDTGKK PASWSQSPQN QEMRKHFPQK
910 920 930 940 950
FQLFNTSHMP VLAQDVQYEH SHLEGTENHS MAGDSGIDSP RTQSLGSNNS
960 970 980
VILDGLKRRQ NFLQNVEGTK SSQPLTSNSL LPLTPVINV
Length:989
Mass (Da):110,962
Last modified:November 22, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F1E70504F081AC7
GO
Isoform B (identifier: Q6ZVD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-227: VSMESC → DTESGI
     228-989: Missing.

Show »
Length:227
Mass (Da):25,421
Checksum:iDF3237D2ECA7649C
GO
Isoform C (identifier: Q6ZVD7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-169: IAIPSEDILYTTLG → HRVWDLIIQSFWMD
     170-989: Missing.

Show »
Length:169
Mass (Da):19,059
Checksum:iA0C1D44F90B50E7F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y5I4A0A2R8Y5I4_HUMAN
Storkhead-box protein 1
STOX1
1,101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH63627 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB71600 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB71607 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85925 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC87173 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02378418R → P in PEE4. 1 PublicationCorresponds to variant dbSNP:rs556362193Ensembl.1
Natural variantiVAR_023785153Y → H3 PublicationsCorresponds to variant dbSNP:rs1341667EnsemblClinVar.1
Natural variantiVAR_023786608E → D2 PublicationsCorresponds to variant dbSNP:rs10509305EnsemblClinVar.1
Natural variantiVAR_023787825N → I in PEE4. 1 PublicationCorresponds to variant dbSNP:rs41278532Ensembl.1
Natural variantiVAR_051388863A → T. Corresponds to variant dbSNP:rs7904300Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016226156 – 169IAIPS…YTTLG → HRVWDLIIQSFWMD in isoform C. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_016227170 – 989Missing in isoform C. 1 PublicationAdd BLAST820
Alternative sequenceiVSP_016228222 – 227VSMESC → DTESGI in isoform B. 2 Publications6
Alternative sequenceiVSP_016229228 – 989Missing in isoform B. 2 PublicationsAdd BLAST762

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY842014 mRNA Translation: AAW48524.1
AY842015 mRNA Translation: AAW48525.1
AY842016 mRNA Translation: AAW48526.1
AY842017 mRNA Translation: AAW48527.1
AL359844 Genomic DNA No translation available.
AL391539 Genomic DNA No translation available.
BC063627 mRNA Translation: AAH63627.1 Different initiation.
BC140011 mRNA Translation: AAI40012.1
DQ099680 Genomic DNA Translation: AAZ07992.1
AK057864 mRNA Translation: BAB71600.1 Different initiation.
AK057891 mRNA Translation: BAB71607.1 Different initiation.
AK124681 mRNA Translation: BAC85925.1 Different initiation.
AK127878 mRNA Translation: BAC87173.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41535.1 [Q6ZVD7-1]
CCDS44416.1 [Q6ZVD7-3]
CCDS44417.1 [Q6ZVD7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001123631.1, NM_001130159.2 [Q6ZVD7-2]
NP_001123632.1, NM_001130160.2 [Q6ZVD7-3]
NP_001123633.1, NM_001130161.2 [Q6ZVD7-1]
NP_689922.3, NM_152709.4 [Q6ZVD7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298596; ENSP00000298596; ENSG00000165730 [Q6ZVD7-1]
ENST00000399162; ENSP00000382115; ENSG00000165730 [Q6ZVD7-3]
ENST00000399165; ENSP00000382118; ENSG00000165730 [Q6ZVD7-2]
ENST00000399169; ENSP00000382121; ENSG00000165730 [Q6ZVD7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
219736

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:219736

UCSC genome browser

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UCSCi
uc001joq.5 human [Q6ZVD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842014 mRNA Translation: AAW48524.1
AY842015 mRNA Translation: AAW48525.1
AY842016 mRNA Translation: AAW48526.1
AY842017 mRNA Translation: AAW48527.1
AL359844 Genomic DNA No translation available.
AL391539 Genomic DNA No translation available.
BC063627 mRNA Translation: AAH63627.1 Different initiation.
BC140011 mRNA Translation: AAI40012.1
DQ099680 Genomic DNA Translation: AAZ07992.1
AK057864 mRNA Translation: BAB71600.1 Different initiation.
AK057891 mRNA Translation: BAB71607.1 Different initiation.
AK124681 mRNA Translation: BAC85925.1 Different initiation.
AK127878 mRNA Translation: BAC87173.1 Different initiation.
CCDSiCCDS41535.1 [Q6ZVD7-1]
CCDS44416.1 [Q6ZVD7-3]
CCDS44417.1 [Q6ZVD7-2]
RefSeqiNP_001123631.1, NM_001130159.2 [Q6ZVD7-2]
NP_001123632.1, NM_001130160.2 [Q6ZVD7-3]
NP_001123633.1, NM_001130161.2 [Q6ZVD7-1]
NP_689922.3, NM_152709.4 [Q6ZVD7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi128569, 6 interactors
IntActiQ6ZVD7, 9 interactors
STRINGi9606.ENSP00000298596

PTM databases

iPTMnetiQ6ZVD7
PhosphoSitePlusiQ6ZVD7

Polymorphism and mutation databases

BioMutaiSTOX1
DMDMi82592525

Proteomic databases

jPOSTiQ6ZVD7
MassIVEiQ6ZVD7
PaxDbiQ6ZVD7
PeptideAtlasiQ6ZVD7
PRIDEiQ6ZVD7
ProteomicsDBi68406 [Q6ZVD7-1]
68407 [Q6ZVD7-2]
68408 [Q6ZVD7-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
219736

Genome annotation databases

EnsembliENST00000298596; ENSP00000298596; ENSG00000165730 [Q6ZVD7-1]
ENST00000399162; ENSP00000382115; ENSG00000165730 [Q6ZVD7-3]
ENST00000399165; ENSP00000382118; ENSG00000165730 [Q6ZVD7-2]
ENST00000399169; ENSP00000382121; ENSG00000165730 [Q6ZVD7-1]
GeneIDi219736
KEGGihsa:219736
UCSCiuc001joq.5 human [Q6ZVD7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
219736
DisGeNETi219736

GeneCards: human genes, protein and diseases

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GeneCardsi
STOX1
HGNCiHGNC:23508 STOX1
HPAiHPA037844
HPA037845
MalaCardsiSTOX1
MIMi609397 gene
609404 phenotype
neXtProtiNX_Q6ZVD7
OpenTargetsiENSG00000165730
Orphaneti275555 Preeclampsia
PharmGKBiPA134883643

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3897 Eukaryota
ENOG410ZJ97 LUCA
GeneTreeiENSGT00520000055589
InParanoidiQ6ZVD7
OMAiAKEPYAE
OrthoDBi494782at2759
PhylomeDBiQ6ZVD7
TreeFamiTF337253

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STOX1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
219736
PharosiQ6ZVD7

Protein Ontology

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PROi
PR:Q6ZVD7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165730 Expressed in 140 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ6ZVD7 baseline and differential
GenevisibleiQ6ZVD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR019391 Storkhead-box_winged-helix
IPR040126 STOX1/2
PANTHERiPTHR22437 PTHR22437, 1 hit
PfamiView protein in Pfam
PF10264 Stork_head, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTOX1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZVD7
Secondary accession number(s): A2A3Q9
, A5D6Y7, B0QZA4, B0QZA5, B0QZA6, Q4F8Q6, Q5I946, Q5I947, Q5I948, Q5VX38, Q5VX39, Q6ZRY3, Q96LR3, Q96LS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 22, 2005
Last modified: October 16, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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