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Entry version 147 (16 Oct 2019)
Sequence version 2 (15 Mar 2005)
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Protein

FYVE, RhoGEF and PH domain-containing protein 6

Gene

FGD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1222 – 1281FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 6
Alternative name(s):
Zinc finger FYVE domain-containing protein 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGD6
Synonyms:KIAA1362, ZFYVE24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21740 FGD6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613520 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZV73

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55785

Open Targets

More...
OpenTargetsi
ENSG00000180263

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134967436

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZV73

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FGD6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61213484

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809521 – 1430FYVE, RhoGEF and PH domain-containing protein 6Add BLAST1430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei605PhosphoserineBy similarity1
Modified residuei692PhosphoserineCombined sources1
Modified residuei721PhosphoserineCombined sources1
Modified residuei1197PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZV73

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZV73

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZV73

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZV73

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZV73

PeptideAtlas

More...
PeptideAtlasi
Q6ZV73

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZV73

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68397 [Q6ZV73-1]
68398 [Q6ZV73-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZV73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZV73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180263 Expressed in 167 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZV73 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZV73 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007974

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120899, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZV73, 21 interactors

Molecular INTeraction database

More...
MINTi
Q6ZV73

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344446

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZV73

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini871 – 1060DHPROSITE-ProRule annotationAdd BLAST190
Domaini1089 – 1183PH 1PROSITE-ProRule annotationAdd BLAST95
Domaini1333 – 1429PH 2PROSITE-ProRule annotationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi344 – 349Poly-Ser6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1222 – 1281FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUBB Eukaryota
ENOG410XRXV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156334

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112571

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZV73

KEGG Orthology (KO)

More...
KOi
K05724

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPCKDSQ

Database of Orthologous Groups

More...
OrthoDBi
652460at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZV73

TreeFam database of animal gene trees

More...
TreeFami
TF316247

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15793 PH1_FGD6, 1 hit
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR037743 FGD6_N_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZV73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSAAEIKKP PVAPKPKFVV ANNKPAPPPI APKPDIVISS VPQSTKKMKP
60 70 80 90 100
AIAPKPKVLK TSPVREIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGN
110 120 130 140 150
QSNDYISPMC SCSSECIHKL GHRENLCVKQ LVLEPLEMNE NLENSKIDET
160 170 180 190 200
LTIKTRSKCD LYGEKAKNQG GVVLKASVLE EELKDALIHQ MPPFISAQKH
210 220 230 240 250
RPTDSPEMNG GCNSNGQFRI EFADLSPSPS SFEKVPDHHS CHLQLPSDEC
260 270 280 290 300
EHFETCQDDS EKSNNCFQSS ELEALENGKR STLISSDGVS KKSEVKDLGP
310 320 330 340 350
LEIHLVPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC
360 370 380 390 400
LTENSLKINK ISVLHQNVLC KQEQVDKMKL GNKSELNMES NSDAQDLVNS
410 420 430 440 450
QKAMCNETTS FEKMAPSFDK DSNLSSDSTT VDGSSMSLAV DEGTGFIRCT
460 470 480 490 500
VSMSLPKQLK LTCNEHLQSG RNLGVSAPQM QKESVIKEEN SLRIVPKKPQ
510 520 530 540 550
RHSLPATGVL KKAASEELLE KSSYPSSEEK SSEKSLERNH LQHLCAQNRG
560 570 580 590 600
VSSSFDMPKR ASEKPVWKLP HPILPFSGNP EFLKSVTVSS NSEPSTALTK
610 620 630 640 650
PRAKSLSAMD VEKCTKPCKD STKKNSFKKL LSMKLSICFM KSDFQKFWSK
660 670 680 690 700
SSQLGDTTTG HLSSGEQKGI ESDWQGLLVG EEKRSKPIKA YSTENYSLES
710 720 730 740 750
QKKRKKSRGQ TSAANGLRAE SLDDQMLSRE SSSQAPYKSV TSLCAPEYEN
760 770 780 790 800
IRHYEEIPEY ENLPFIMAIR KTQELEWQNS SSMEDADANV YEVEEPYEAP
810 820 830 840 850
DGQLQLGPRH QHSSSGASQE EQNDLGLGDL PSDEEEIINS SDEDDVSSES
860 870 880 890 900
SKGEPDPLED KQDEDNGMKS KVHHIAKEIM SSEKVFVDVL KLLHIDFRDA
910 920 930 940 950
VAHASRQLGK PVIEDRILNQ ILYYLPQLYE LNRDLLKELE ERMLHWTEQQ
960 970 980 990 1000
RIADIFVKKG PYLKMYSTYI KEFDKNIALL DEQCKKNPGF AAVVREFEMS
1010 1020 1030 1040 1050
PRCANLALKH YLLKPVQRIP QYRLLLTDYL KNLIEDAGDY RDTQDALAVV
1060 1070 1080 1090 1100
IEVANHANDT MKQGDNFQKL MQIQYSLNGH HEIVQPGRVF LKEGILMKLS
1110 1120 1130 1140 1150
RKVMQPRMFF LFNDALLYTT PVQSGMYKLN NMLSLAGMKV RKPTQEAYQN
1160 1170 1180 1190 1200
ELKIESVERS FILSASSATE RDEWLEAISR AIEEYAKKRI TFCPSRSLDE
1210 1220 1230 1240 1250
ADSENKEEVS PLGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKI
1260 1270 1280 1290 1300
VCQACSSNKY GLDYLKNQPA RVCEHCFQEL QKLDHQHSPR IGSPGNHKSP
1310 1320 1330 1340 1350
SSALSSVLHS IPSGRKQKKI PAALKEVSAN TEDSSMSGYL YRSKGNKKPW
1360 1370 1380 1390 1400
KHFWFVIKNK VLYTYAASED VAALESQPLL GFTVIQVKDE NSESKVFQLL
1410 1420 1430
HKNMLFYVFK AEDAHSAQKW IEAFQEGTIL
Length:1,430
Mass (Da):160,816
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i705D1D4DFB50D8FF
GO
Isoform 2 (identifier: Q6ZV73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1370-1374: DVAAL → VRSEI
     1375-1430: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):154,465
Checksum:iFA017AC35B18B7D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VY01F8VY01_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD6
1,206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQX5F8VQX5_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD6
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI21H0YI21_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD6
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWT6F8VWT6_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD6
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92052 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92600 differs from that shown. Reason: Frameshift.Curated
The sequence BAC87464 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD98096 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti832S → P in CAD98096 (PubMed:17974005).Curated1
Sequence conflicti848S → F in CAD98096 (PubMed:17974005).Curated1
Sequence conflicti949Q → H in BAC85990 (PubMed:14702039).Curated1
Sequence conflicti966Y → D in AAH13319 (PubMed:15489334).Curated1
Sequence conflicti992A → T in AAH13319 (PubMed:15489334).Curated1
Sequence conflicti1002R → C in BAA92600 (PubMed:10718198).Curated1
Sequence conflicti1051I → V in AAH13319 (PubMed:15489334).Curated1
Sequence conflicti1115A → V in CAD98096 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024286257Q → R. Corresponds to variant dbSNP:rs10507047Ensembl.1
Natural variantiVAR_0519851393E → K. Corresponds to variant dbSNP:rs3794255Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0130911370 – 1374DVAAL → VRSEI in isoform 2. 1 Publication5
Alternative sequenceiVSP_0130921375 – 1430Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002045 mRNA Translation: BAA92052.1 Different initiation.
AK124904 mRNA Translation: BAC85990.1
AK128492 mRNA Translation: BAC87464.1 Different initiation.
BC013319 mRNA Translation: AAH13319.2
BX538322 mRNA Translation: CAD98096.1 Sequence problems.
AB037783 mRNA Translation: BAA92600.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31878.1 [Q6ZV73-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060821.3, NM_018351.3 [Q6ZV73-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343958; ENSP00000344446; ENSG00000180263 [Q6ZV73-1]
ENST00000546711; ENSP00000450342; ENSG00000180263 [Q6ZV73-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55785

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55785

UCSC genome browser

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UCSCi
uc001tdp.4 human [Q6ZV73-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002045 mRNA Translation: BAA92052.1 Different initiation.
AK124904 mRNA Translation: BAC85990.1
AK128492 mRNA Translation: BAC87464.1 Different initiation.
BC013319 mRNA Translation: AAH13319.2
BX538322 mRNA Translation: CAD98096.1 Sequence problems.
AB037783 mRNA Translation: BAA92600.1 Frameshift.
CCDSiCCDS31878.1 [Q6ZV73-1]
RefSeqiNP_060821.3, NM_018351.3 [Q6ZV73-1]

3D structure databases

SMRiQ6ZV73
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120899, 25 interactors
IntActiQ6ZV73, 21 interactors
MINTiQ6ZV73
STRINGi9606.ENSP00000344446

PTM databases

iPTMnetiQ6ZV73
PhosphoSitePlusiQ6ZV73

Polymorphism and mutation databases

BioMutaiFGD6
DMDMi61213484

Proteomic databases

EPDiQ6ZV73
jPOSTiQ6ZV73
MassIVEiQ6ZV73
MaxQBiQ6ZV73
PaxDbiQ6ZV73
PeptideAtlasiQ6ZV73
PRIDEiQ6ZV73
ProteomicsDBi68397 [Q6ZV73-1]
68398 [Q6ZV73-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55785

Genome annotation databases

EnsembliENST00000343958; ENSP00000344446; ENSG00000180263 [Q6ZV73-1]
ENST00000546711; ENSP00000450342; ENSG00000180263 [Q6ZV73-2]
GeneIDi55785
KEGGihsa:55785
UCSCiuc001tdp.4 human [Q6ZV73-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55785
DisGeNETi55785

GeneCards: human genes, protein and diseases

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GeneCardsi
FGD6
HGNCiHGNC:21740 FGD6
HPAiHPA007974
MIMi613520 gene
neXtProtiNX_Q6ZV73
OpenTargetsiENSG00000180263
PharmGKBiPA134967436

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IUBB Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00940000156334
HOGENOMiHOG000112571
InParanoidiQ6ZV73
KOiK05724
OMAiKPCKDSQ
OrthoDBi652460at2759
PhylomeDBiQ6ZV73
TreeFamiTF316247

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FGD6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55785
PharosiQ6ZV73

Protein Ontology

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PROi
PR:Q6ZV73

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000180263 Expressed in 167 organ(s), highest expression level in heart
ExpressionAtlasiQ6ZV73 baseline and differential
GenevisibleiQ6ZV73 HS

Family and domain databases

CDDicd15793 PH1_FGD6, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR037743 FGD6_N_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGD6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZV73
Secondary accession number(s): Q6ZR53
, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 16, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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