UniProtKB - Q6ZV73 (FGD6_HUMAN)
Protein
FYVE, RhoGEF and PH domain-containing protein 6
Gene
FGD6
Organism
Homo sapiens (Human)
Status
Functioni
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1222 – 1281 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- Rho guanyl-nucleotide exchange factor activity Source: GO_Central
- small GTPase binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- cytoskeleton organization Source: UniProtKB
- filopodium assembly Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6ZV73 |
Names & Taxonomyi
Protein namesi | Recommended name: FYVE, RhoGEF and PH domain-containing protein 6Alternative name(s): Zinc finger FYVE domain-containing protein 24 |
Gene namesi | Name:FGD6 Synonyms:KIAA1362, ZFYVE24 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180263.13 |
HGNCi | HGNC:21740, FGD6 |
MIMi | 613520, gene |
neXtProti | NX_Q6ZV73 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Other locations
- Cytoplasm Curated
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- lamellipodium Source: UniProtKB
- ruffle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 55785 |
OpenTargetsi | ENSG00000180263 |
PharmGKBi | PA134967436 |
Miscellaneous databases
Pharosi | Q6ZV73, Tdark |
Polymorphism and mutation databases
BioMutai | FGD6 |
DMDMi | 61213484 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080952 | 1 – 1430 | FYVE, RhoGEF and PH domain-containing protein 6Add BLAST | 1430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 231 | PhosphoserineCombined sources | 1 | |
Modified residuei | 515 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineCombined sources | 1 | |
Modified residuei | 605 | PhosphoserineBy similarity | 1 | |
Modified residuei | 692 | PhosphoserineCombined sources | 1 | |
Modified residuei | 721 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1197 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZV73 |
jPOSTi | Q6ZV73 |
MassIVEi | Q6ZV73 |
MaxQBi | Q6ZV73 |
PaxDbi | Q6ZV73 |
PeptideAtlasi | Q6ZV73 |
PRIDEi | Q6ZV73 |
ProteomicsDBi | 68397 [Q6ZV73-1] 68398 [Q6ZV73-2] |
PTM databases
iPTMneti | Q6ZV73 |
PhosphoSitePlusi | Q6ZV73 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180263, Expressed in heart and 182 other tissues |
ExpressionAtlasi | Q6ZV73, baseline and differential |
Genevisiblei | Q6ZV73, HS |
Organism-specific databases
HPAi | ENSG00000180263, Low tissue specificity |
Interactioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB
- Rho guanyl-nucleotide exchange factor activity Source: GO_Central
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120899, 26 interactors |
IntActi | Q6ZV73, 24 interactors |
MINTi | Q6ZV73 |
STRINGi | 9606.ENSP00000344446 |
Miscellaneous databases
RNActi | Q6ZV73, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 871 – 1060 | DHPROSITE-ProRule annotationAdd BLAST | 190 | |
Domaini | 1089 – 1183 | PH 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1333 – 1429 | PH 2PROSITE-ProRule annotationAdd BLAST | 97 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 344 – 349 | Poly-Ser | 6 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1222 – 1281 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 60 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1729, Eukaryota |
GeneTreei | ENSGT00940000156334 |
HOGENOMi | CLU_004959_0_0_1 |
InParanoidi | Q6ZV73 |
OMAi | KPCKDSQ |
OrthoDBi | 652460at2759 |
PhylomeDBi | Q6ZV73 |
TreeFami | TF316247 |
Family and domain databases
CDDi | cd15793, PH1_FGD6, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR037743, FGD6_N_PH IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit PF00169, PH, 2 hits PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit SM00233, PH, 2 hits SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 2 hits PS50178, ZF_FYVE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZV73-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSAAEIKKP PVAPKPKFVV ANNKPAPPPI APKPDIVISS VPQSTKKMKP
60 70 80 90 100
AIAPKPKVLK TSPVREIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGN
110 120 130 140 150
QSNDYISPMC SCSSECIHKL GHRENLCVKQ LVLEPLEMNE NLENSKIDET
160 170 180 190 200
LTIKTRSKCD LYGEKAKNQG GVVLKASVLE EELKDALIHQ MPPFISAQKH
210 220 230 240 250
RPTDSPEMNG GCNSNGQFRI EFADLSPSPS SFEKVPDHHS CHLQLPSDEC
260 270 280 290 300
EHFETCQDDS EKSNNCFQSS ELEALENGKR STLISSDGVS KKSEVKDLGP
310 320 330 340 350
LEIHLVPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC
360 370 380 390 400
LTENSLKINK ISVLHQNVLC KQEQVDKMKL GNKSELNMES NSDAQDLVNS
410 420 430 440 450
QKAMCNETTS FEKMAPSFDK DSNLSSDSTT VDGSSMSLAV DEGTGFIRCT
460 470 480 490 500
VSMSLPKQLK LTCNEHLQSG RNLGVSAPQM QKESVIKEEN SLRIVPKKPQ
510 520 530 540 550
RHSLPATGVL KKAASEELLE KSSYPSSEEK SSEKSLERNH LQHLCAQNRG
560 570 580 590 600
VSSSFDMPKR ASEKPVWKLP HPILPFSGNP EFLKSVTVSS NSEPSTALTK
610 620 630 640 650
PRAKSLSAMD VEKCTKPCKD STKKNSFKKL LSMKLSICFM KSDFQKFWSK
660 670 680 690 700
SSQLGDTTTG HLSSGEQKGI ESDWQGLLVG EEKRSKPIKA YSTENYSLES
710 720 730 740 750
QKKRKKSRGQ TSAANGLRAE SLDDQMLSRE SSSQAPYKSV TSLCAPEYEN
760 770 780 790 800
IRHYEEIPEY ENLPFIMAIR KTQELEWQNS SSMEDADANV YEVEEPYEAP
810 820 830 840 850
DGQLQLGPRH QHSSSGASQE EQNDLGLGDL PSDEEEIINS SDEDDVSSES
860 870 880 890 900
SKGEPDPLED KQDEDNGMKS KVHHIAKEIM SSEKVFVDVL KLLHIDFRDA
910 920 930 940 950
VAHASRQLGK PVIEDRILNQ ILYYLPQLYE LNRDLLKELE ERMLHWTEQQ
960 970 980 990 1000
RIADIFVKKG PYLKMYSTYI KEFDKNIALL DEQCKKNPGF AAVVREFEMS
1010 1020 1030 1040 1050
PRCANLALKH YLLKPVQRIP QYRLLLTDYL KNLIEDAGDY RDTQDALAVV
1060 1070 1080 1090 1100
IEVANHANDT MKQGDNFQKL MQIQYSLNGH HEIVQPGRVF LKEGILMKLS
1110 1120 1130 1140 1150
RKVMQPRMFF LFNDALLYTT PVQSGMYKLN NMLSLAGMKV RKPTQEAYQN
1160 1170 1180 1190 1200
ELKIESVERS FILSASSATE RDEWLEAISR AIEEYAKKRI TFCPSRSLDE
1210 1220 1230 1240 1250
ADSENKEEVS PLGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKI
1260 1270 1280 1290 1300
VCQACSSNKY GLDYLKNQPA RVCEHCFQEL QKLDHQHSPR IGSPGNHKSP
1310 1320 1330 1340 1350
SSALSSVLHS IPSGRKQKKI PAALKEVSAN TEDSSMSGYL YRSKGNKKPW
1360 1370 1380 1390 1400
KHFWFVIKNK VLYTYAASED VAALESQPLL GFTVIQVKDE NSESKVFQLL
1410 1420 1430
HKNMLFYVFK AEDAHSAQKW IEAFQEGTIL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VQX5 | F8VQX5_HUMAN | FYVE, RhoGEF and PH domain-containi... | FGD6 | 279 | Annotation score: | ||
F8VY01 | F8VY01_HUMAN | FYVE, RhoGEF and PH domain-containi... | FGD6 | 1,206 | Annotation score: | ||
H0YI21 | H0YI21_HUMAN | FYVE, RhoGEF and PH domain-containi... | FGD6 | 133 | Annotation score: | ||
F8VWT6 | F8VWT6_HUMAN | FYVE, RhoGEF and PH domain-containi... | FGD6 | 59 | Annotation score: |
Sequence cautioni
The sequence BAA92052 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92600 differs from that shown. Reason: Frameshift.Curated
The sequence BAC87464 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD98096 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 832 | S → P in CAD98096 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 848 | S → F in CAD98096 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 949 | Q → H in BAC85990 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 966 | Y → D in AAH13319 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 992 | A → T in AAH13319 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1002 | R → C in BAA92600 (PubMed:10718198).Curated | 1 | |
Sequence conflicti | 1051 | I → V in AAH13319 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1115 | A → V in CAD98096 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024286 | 257 | Q → R. Corresponds to variant dbSNP:rs10507047Ensembl. | 1 | |
Natural variantiVAR_051985 | 1393 | E → K. Corresponds to variant dbSNP:rs3794255Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013091 | 1370 – 1374 | DVAAL → VRSEI in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_013092 | 1375 – 1430 | Missing in isoform 2. 1 PublicationAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002045 mRNA Translation: BAA92052.1 Different initiation. AK124904 mRNA Translation: BAC85990.1 AK128492 mRNA Translation: BAC87464.1 Different initiation. BC013319 mRNA Translation: AAH13319.2 BX538322 mRNA Translation: CAD98096.1 Sequence problems. AB037783 mRNA Translation: BAA92600.1 Frameshift. |
CCDSi | CCDS31878.1 [Q6ZV73-1] |
RefSeqi | NP_060821.3, NM_018351.3 [Q6ZV73-1] |
Genome annotation databases
Ensembli | ENST00000343958; ENSP00000344446; ENSG00000180263 [Q6ZV73-1] ENST00000546711; ENSP00000450342; ENSG00000180263 [Q6ZV73-2] |
GeneIDi | 55785 |
KEGGi | hsa:55785 |
UCSCi | uc001tdp.4, human [Q6ZV73-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002045 mRNA Translation: BAA92052.1 Different initiation. AK124904 mRNA Translation: BAC85990.1 AK128492 mRNA Translation: BAC87464.1 Different initiation. BC013319 mRNA Translation: AAH13319.2 BX538322 mRNA Translation: CAD98096.1 Sequence problems. AB037783 mRNA Translation: BAA92600.1 Frameshift. |
CCDSi | CCDS31878.1 [Q6ZV73-1] |
RefSeqi | NP_060821.3, NM_018351.3 [Q6ZV73-1] |
3D structure databases
SMRi | Q6ZV73 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120899, 26 interactors |
IntActi | Q6ZV73, 24 interactors |
MINTi | Q6ZV73 |
STRINGi | 9606.ENSP00000344446 |
PTM databases
iPTMneti | Q6ZV73 |
PhosphoSitePlusi | Q6ZV73 |
Polymorphism and mutation databases
BioMutai | FGD6 |
DMDMi | 61213484 |
Proteomic databases
EPDi | Q6ZV73 |
jPOSTi | Q6ZV73 |
MassIVEi | Q6ZV73 |
MaxQBi | Q6ZV73 |
PaxDbi | Q6ZV73 |
PeptideAtlasi | Q6ZV73 |
PRIDEi | Q6ZV73 |
ProteomicsDBi | 68397 [Q6ZV73-1] 68398 [Q6ZV73-2] |
Protocols and materials databases
Antibodypediai | 1926, 100 antibodies |
DNASUi | 55785 |
Genome annotation databases
Ensembli | ENST00000343958; ENSP00000344446; ENSG00000180263 [Q6ZV73-1] ENST00000546711; ENSP00000450342; ENSG00000180263 [Q6ZV73-2] |
GeneIDi | 55785 |
KEGGi | hsa:55785 |
UCSCi | uc001tdp.4, human [Q6ZV73-1] |
Organism-specific databases
CTDi | 55785 |
DisGeNETi | 55785 |
EuPathDBi | HostDB:ENSG00000180263.13 |
GeneCardsi | FGD6 |
HGNCi | HGNC:21740, FGD6 |
HPAi | ENSG00000180263, Low tissue specificity |
MIMi | 613520, gene |
neXtProti | NX_Q6ZV73 |
OpenTargetsi | ENSG00000180263 |
PharmGKBi | PA134967436 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1729, Eukaryota |
GeneTreei | ENSGT00940000156334 |
HOGENOMi | CLU_004959_0_0_1 |
InParanoidi | Q6ZV73 |
OMAi | KPCKDSQ |
OrthoDBi | 652460at2759 |
PhylomeDBi | Q6ZV73 |
TreeFami | TF316247 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZV73 |
Miscellaneous databases
BioGRID-ORCSi | 55785, 3 hits in 842 CRISPR screens |
ChiTaRSi | FGD6, human |
GenomeRNAii | 55785 |
Pharosi | Q6ZV73, Tdark |
PROi | PR:Q6ZV73 |
RNActi | Q6ZV73, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180263, Expressed in heart and 182 other tissues |
ExpressionAtlasi | Q6ZV73, baseline and differential |
Genevisiblei | Q6ZV73, HS |
Family and domain databases
CDDi | cd15793, PH1_FGD6, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR037743, FGD6_N_PH IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit PF00169, PH, 2 hits PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit SM00233, PH, 2 hits SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 2 hits PS50178, ZF_FYVE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGD6_HUMAN | |
Accessioni | Q6ZV73Primary (citable) accession number: Q6ZV73 Secondary accession number(s): Q6ZR53 Q9P2I5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations