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Protein

LHFPL tetraspan subfamily member 2 protein

Gene

LHFPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in female and male fertility. Involved in distal reproductive tract development.By similarity

GO - Biological processi

Keywordsi

Biological processFertilization

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 2 proteinImported
Alternative name(s):
Lipoma HMGIC fusion partner-like 2 proteinImported
Gene namesi
Name:LHFPL2Imported
Synonyms:KIAA0206
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145685.13
HGNCiHGNC:6588 LHFPL2
MIMi609718 gene
neXtProtiNX_Q6ZUX7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10184
OpenTargetsiENSG00000145685
PharmGKBiPA30360

Polymorphism and mutation databases

BioMutaiLHFPL2
DMDMi116242618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002447631 – 228LHFPL tetraspan subfamily member 2 proteinAdd BLAST228

Proteomic databases

EPDiQ6ZUX7
MaxQBiQ6ZUX7
PaxDbiQ6ZUX7
PeptideAtlasiQ6ZUX7
PRIDEiQ6ZUX7
ProteomicsDBi68376

PTM databases

iPTMnetiQ6ZUX7
PhosphoSitePlusiQ6ZUX7
SwissPalmiQ6ZUX7

Expressioni

Tissue specificityi

Expressed in all tissues and cell lines examined except brain and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000145685 Expressed in 227 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_LHFPL2
ExpressionAtlasiQ6ZUX7 baseline and differential
GenevisibleiQ6ZUX7 HS

Organism-specific databases

HPAiHPA042402

Interactioni

Protein-protein interaction databases

BioGridi115482, 11 interactors
IntActiQ6ZUX7, 8 interactors
STRINGi9606.ENSP00000369702

Structurei

3D structure databases

ProteinModelPortaliQ6ZUX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00550000074479
HOGENOMiHOG000285972
HOVERGENiHBG054430
InParanoidiQ6ZUX7
OMAiYPGEWKA
OrthoDBiEOG091G0J9C
PhylomeDBiQ6ZUX7
TreeFamiTF321143

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZUX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHVIVTCRS MLWTLLSIVV AFAELIAFMS ADWLIGKARS RGGVEPAGPG
60 70 80 90 100
GGSPEPYHPT LGIYARCIRN PGVQHFQRDT LCGPYAESFG EIASGFWQAT
110 120 130 140 150
AIFLAVGIFI LCMVALVSVF TMCVQSIMKK SIFNVCGLLQ GIAGLFLILG
160 170 180 190 200
LILYPAGWGC QKAIDYCGHY ASAYKPGDCS LGWAFYTAIG GTVLTFICAV
210 220
FSAQAEIATS SDKVQEEIEE GKNLICLL
Length:228
Mass (Da):24,486
Last modified:October 17, 2006 - v2
Checksum:iC8FD766FFD9D0D31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35I → T in BAC86089 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026913102I → V. Corresponds to variant dbSNP:rs2303654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125227 mRNA Translation: BAC86089.1
AY309920 mRNA Translation: AAP74733.1
CH471084 Genomic DNA Translation: EAW95818.1
BC136335 mRNA Translation: AAI36336.1
BC136336 mRNA Translation: AAI36337.1
D86961 mRNA Translation: BAA13197.1
CCDSiCCDS4042.1
RefSeqiNP_005770.1, NM_005779.2
XP_006714578.1, XM_006714515.1
UniGeneiHs.670094
Hs.79299

Genome annotation databases

EnsembliENST00000380345; ENSP00000369702; ENSG00000145685
ENST00000515007; ENSP00000425906; ENSG00000145685
GeneIDi10184
KEGGihsa:10184
UCSCiuc003kfo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125227 mRNA Translation: BAC86089.1
AY309920 mRNA Translation: AAP74733.1
CH471084 Genomic DNA Translation: EAW95818.1
BC136335 mRNA Translation: AAI36336.1
BC136336 mRNA Translation: AAI36337.1
D86961 mRNA Translation: BAA13197.1
CCDSiCCDS4042.1
RefSeqiNP_005770.1, NM_005779.2
XP_006714578.1, XM_006714515.1
UniGeneiHs.670094
Hs.79299

3D structure databases

ProteinModelPortaliQ6ZUX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115482, 11 interactors
IntActiQ6ZUX7, 8 interactors
STRINGi9606.ENSP00000369702

PTM databases

iPTMnetiQ6ZUX7
PhosphoSitePlusiQ6ZUX7
SwissPalmiQ6ZUX7

Polymorphism and mutation databases

BioMutaiLHFPL2
DMDMi116242618

Proteomic databases

EPDiQ6ZUX7
MaxQBiQ6ZUX7
PaxDbiQ6ZUX7
PeptideAtlasiQ6ZUX7
PRIDEiQ6ZUX7
ProteomicsDBi68376

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380345; ENSP00000369702; ENSG00000145685
ENST00000515007; ENSP00000425906; ENSG00000145685
GeneIDi10184
KEGGihsa:10184
UCSCiuc003kfo.4 human

Organism-specific databases

CTDi10184
DisGeNETi10184
EuPathDBiHostDB:ENSG00000145685.13
GeneCardsiLHFPL2
HGNCiHGNC:6588 LHFPL2
HPAiHPA042402
MIMi609718 gene
neXtProtiNX_Q6ZUX7
OpenTargetsiENSG00000145685
PharmGKBiPA30360
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00550000074479
HOGENOMiHOG000285972
HOVERGENiHBG054430
InParanoidiQ6ZUX7
OMAiYPGEWKA
OrthoDBiEOG091G0J9C
PhylomeDBiQ6ZUX7
TreeFamiTF321143

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiLHFPL2 human
GeneWikiiLHFPL2
GenomeRNAii10184
PROiPR:Q6ZUX7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145685 Expressed in 227 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_LHFPL2
ExpressionAtlasiQ6ZUX7 baseline and differential
GenevisibleiQ6ZUX7 HS

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUX7
Secondary accession number(s): B2RMQ6, Q7Z5P0, Q92605
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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