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UniProtKB - Q6ZUT9 (DEN5B_HUMAN)

Entry version 120 (31 Jul 2019)
Sequence version 2 (08 Apr 2008)
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Protein

DENN domain-containing protein 5B

Gene

DENND5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 5B
Alternative name(s):
Rab6IP1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28338 DENND5B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617279 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZUT9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei916 – 936HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000170456

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164718788

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DENND5B

Domain mapping of disease mutations (DMDM)

More...DMDMi		182676608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003265312 – 1274DENN domain-containing protein 5BAdd BLAST1273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei178PhosphoserineBy similarity1
Modified residuei822PhosphoserineCombined sources1
Modified residuei1062PhosphothreonineBy similarity1
Modified residuei1068PhosphoserineBy similarity1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1079PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZUT9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZUT9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZUT9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZUT9

PeptideAtlas

More...PeptideAtlasi		Q6ZUT9

PRoteomics IDEntifications database

More...PRIDEi		Q6ZUT9

ProteomicsDB human proteome resource

More...ProteomicsDBi		68365 [Q6ZUT9-1]
68366 [Q6ZUT9-2]
68367 [Q6ZUT9-3]
68368 [Q6ZUT9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZUT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZUT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170456 Expressed in 206 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZUT9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZUT9 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA038865

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127761, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZUT9, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373734

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZUT9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 244uDENNPROSITE-ProRule annotationAdd BLAST206
Domaini263 – 399cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini401 – 581dDENNPROSITE-ProRule annotationAdd BLAST181
Domaini772 – 932RUN 1PROSITE-ProRule annotationAdd BLAST161
Domaini936 – 1044PLATPROSITE-ProRule annotationAdd BLAST109
Domaini1118 – 1267RUN 2PROSITE-ProRule annotationAdd BLAST150

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RAB6IP1 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2080 Eukaryota
ENOG410XNYP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153678

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZUT9

KEGG Orthology (KO)

More...KOi		K20164

Database of Orthologous Groups

More...OrthoDBi		53600at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZUT9

TreeFam database of animal gene trees

More...TreeFami		TF313237

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF01477 PLAT, 1 hit
PF02759 RUN, 2 hits
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00593 RUN, 2 hits
SM00800 uDENN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF140741 SSF140741, 2 hits
SSF49723 SSF49723, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211 DENN, 1 hit
PS50095 PLAT, 1 hit
PS50826 RUN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZUT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSCAAPGP GSGSSPAACR FAHYFVLCGI DADSGLEPDE LAGENFDQSP 
        60         70         80         90        100
LRRTFKSKVL AHYPQNIEWN PFDQDAVNML CMPKGLSFRT QTDNKDPQFH 
       110        120        130        140        150
SFIITREDGS RTYGFVLTFY EEVTSKQICT AMQTLYQMHN AEHYSSVYAS 
       160        170        180        190        200
SSCSMDSLAS SLDEGDTTSL LKLQRYNSYD ISRDTLYVSK SICLITPLPF 
       210        220        230        240        250
MQACKKFLIQ LYKAVTSQQP PPLPLESYIH NILYEVPLPP PGRSLKFYGV 
       260        270        280        290        300
YEPVICQRPG PSELPLSDYP LREAFELLGL ENLVQVFTCV LLEMQILLYS 
       310        320        330        340        350
QDYQRLMTVA EGITTLLFPF QWQHVYVPIL PASLLHFLDA PVPYLMGLQS 
       360        370        380        390        400
KEGTDRSKLE LPQEANLCFV DIDNHFIELP EEFPQFPNKV DFIQELSEVL 
       410        420        430        440        450
VQFGIPPEGS LHCSESTSKL KNMVLKDLVN DKKNGNVCTN NISMYELLKG 
       460        470        480        490        500
NETIARLQAL AKRTGVAVEK MDLSASLGEK DKDLKLHCEE AELRDYQLNV 
       510        520        530        540        550
QLREVFANRF TQMFADYEAF VIQTAQDMES WLTNREQMQN FDKASFLSDQ 
       560        570        580        590        600
PEPYLPFLSR FIETQMFATF IDNKIMSQWE EKDPLLRVFD TRIDKIRLYN 
       610        620        630        640        650
VRAPTLRTSI YQKCSTLKEA AQSIEQRLMK MDHTAIHPHL LDMKIGQGKY 
       660        670        680        690        700
EQGFFPKLQS DVLATGPTSN NRWVSRSATA QRRKERLRQH SEHVGLDNDL 
       710        720        730        740        750
REKYMQEARS LGKNLRQPKL SDLSPAVIAQ TNCKFVEGLL KECRMKTKRM 
       760        770        780        790        800
LVEKMGHEAV ELGHGEANIT GLEENTLIAS LCDLLERIWS HGLQVKQGKS 
       810        820        830        840        850
ALWSHLIQFQ DREEKQEHLA ESPVALGPER RKSDSGVMLP TLRVSLIQDM 
       860        870        880        890        900
RHIQNMSEIK TDVGRARAWI RLSLEKKLLS QHLKQLLSNQ PLTKKLYKRY 
       910        920        930        940        950
AFLRCEEERE QFLYHLLSLN AVDYFCFTSV FTTIMIPYRS VIIPIKKLSN 
       960        970        980        990       1000
AIITSNPWIC VSGELGDTGV MQIPKNLLEM TFECQNLGKL TTVQIGHDNS 
      1010       1020       1030       1040       1050
GLLAKWLVDC VMVRNEITGH TYRFPCGRWL GKGIDDGSLE RILIGELMTS 
      1060       1070       1080       1090       1100
ASDEDLVKQC RTPPQQKSPT TARRLSITSL TGKNNKPNAG QIQEGIGEAV 
      1110       1120       1130       1140       1150
NNIVKHFHKP EKERGSLTVL LCGENGLVAA LEQVFHHGFK SARIFHKNVF 
      1160       1170       1180       1190       1200
IWDFIEKVVA YFETTDQILD NEDDVLIQKS SCKTFCHYVN AINTAPRNIG 
      1210       1220       1230       1240       1250
KDGKFQILVC LGTRDRLLPQ WIPLLAECPA ITRMYEESAL LRDRMTVNSL 
      1260       1270 
IRILQTIQDF TIVLEGSLIK GVDV
Length:1,274
Mass (Da):145,020
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i712F41E50EEE910A
GO
Isoform 2 (identifier: Q6ZUT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: MSGSCAAPGP...DSGLEPDELA → MGTHHHAQLI...KSQGAANTTS

Show »
Length:1,309
Mass (Da):149,335
Checksum:iCEA06EB33B0A186A
GO
Isoform 3 (identifier: Q6ZUT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     544-585: ASFLSDQPEP...MSQWEEKDPL → VKRTIVFLLW...PYIIDFVNLF
     586-1274: Missing.

Show »
Length:507
Mass (Da):58,284
Checksum:iF8F36E3737B55C1A
GO
Isoform 4 (identifier: Q6ZUT9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: A → AVLYQWLEADRHGKSQGAANTTS
     703-716: KYMQEARSLGKNLR → VCGLPSWGASQQAP
     717-1274: Missing.

Show »
Length:738
Mass (Da):84,001
Checksum:iD76AB5126C9520EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGE5H0YGE5_HUMAN
DENN domain-containing protein 5B
DENND5B
537Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1S3G3V1S3_HUMAN
DENN domain-containing protein 5B
DENND5B MGC24039, hCG_1810950
1,309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4A0F5H4A0_HUMAN
DENN domain-containing protein 5B
DENND5B
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04583 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti434N → D in AAH68580 (PubMed:15489334).Curated1
Sequence conflicti480K → R in BAC04583 (PubMed:14702039).Curated1
Sequence conflicti538M → T in BAC04583 (PubMed:14702039).Curated1
Sequence conflicti1144I → T in BAC04583 (PubMed:14702039).Curated1
Sequence conflicti1149V → A in BAC04583 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04007652R → K1 PublicationCorresponds to variant dbSNP:rs4930979Ensembl.1
Natural variantiVAR_040077487H → N2 PublicationsCorresponds to variant dbSNP:rs1056320Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0326721 – 78Missing in isoform 3. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_0326731 – 42MSGSC…PDELA → MGTHHHAQLIFVFLVEMRFH RVDQAGLELLTSGNSPASAS RSAEITVVSQHAQPGFLYQW LEADRHGKSQGAANTTS in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_03267442A → AVLYQWLEADRHGKSQGAAN TTS in isoform 4. 1 Publication1
Alternative sequenceiVSP_032675544 – 585ASFLS…EKDPL → VKRTIVFLLWLLVALLLILT FLNFLFFCAYAYPYIIDFVN LF in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_032676586 – 1274Missing in isoform 3. 1 PublicationAdd BLAST689
Alternative sequenceiVSP_032677703 – 716KYMQE…GKNLR → VCGLPSWGASQQAP in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_032678717 – 1274Missing in isoform 4. 1 PublicationAdd BLAST558

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK095598 mRNA Translation: BAC04583.1 Different initiation.
AK125323 mRNA Translation: BAC86129.1
AC022080 Genomic DNA No translation available.
AC068792 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88553.1
BC020855 mRNA Translation: AAH20855.1
BC068580 mRNA Translation: AAH68580.1
AB209341 mRNA Translation: BAD92578.1
BX537924 mRNA Translation: CAD97905.1
CR749639 mRNA Translation: CAH18433.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44857.1 [Q6ZUT9-1]
CCDS76542.1 [Q6ZUT9-2]

NCBI Reference Sequences

More...RefSeqi		NP_001295268.1, NM_001308339.1
NP_659410.3, NM_144973.3 [Q6ZUT9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354285; ENSP00000346238; ENSG00000170456 [Q6ZUT9-4]
ENST00000389082; ENSP00000373734; ENSG00000170456 [Q6ZUT9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		160518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:160518

UCSC genome browser

More...UCSCi		uc001rki.2 human [Q6ZUT9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095598 mRNA Translation: BAC04583.1 Different initiation.
AK125323 mRNA Translation: BAC86129.1
AC022080 Genomic DNA No translation available.
AC068792 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88553.1
BC020855 mRNA Translation: AAH20855.1
BC068580 mRNA Translation: AAH68580.1
AB209341 mRNA Translation: BAD92578.1
BX537924 mRNA Translation: CAD97905.1
CR749639 mRNA Translation: CAH18433.1
CCDSiCCDS44857.1 [Q6ZUT9-1]
CCDS76542.1 [Q6ZUT9-2]
RefSeqiNP_001295268.1, NM_001308339.1
NP_659410.3, NM_144973.3 [Q6ZUT9-1]

3D structure databases

SMRiQ6ZUT9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127761, 4 interactors
IntActiQ6ZUT9, 1 interactor
STRINGi9606.ENSP00000373734

PTM databases

iPTMnetiQ6ZUT9
PhosphoSitePlusiQ6ZUT9

Polymorphism and mutation databases

BioMutaiDENND5B
DMDMi182676608

Proteomic databases

EPDiQ6ZUT9
jPOSTiQ6ZUT9
MaxQBiQ6ZUT9
PaxDbiQ6ZUT9
PeptideAtlasiQ6ZUT9
PRIDEiQ6ZUT9
ProteomicsDBi68365 [Q6ZUT9-1]
68366 [Q6ZUT9-2]
68367 [Q6ZUT9-3]
68368 [Q6ZUT9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354285; ENSP00000346238; ENSG00000170456 [Q6ZUT9-4]
ENST00000389082; ENSP00000373734; ENSG00000170456 [Q6ZUT9-1]
GeneIDi160518
KEGGihsa:160518
UCSCiuc001rki.2 human [Q6ZUT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		160518

GeneCards: human genes, protein and diseases

More...GeneCardsi		DENND5B
HGNCiHGNC:28338 DENND5B
HPAiHPA038865
MIMi617279 gene
neXtProtiNX_Q6ZUT9
OpenTargetsiENSG00000170456
PharmGKBiPA164718788

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2080 Eukaryota
ENOG410XNYP LUCA
GeneTreeiENSGT00940000153678
InParanoidiQ6ZUT9
KOiK20164
OrthoDBi53600at2759
PhylomeDBiQ6ZUT9
TreeFamiTF313237

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DENND5B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		160518

Protein Ontology

More...PROi		PR:Q6ZUT9

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170456 Expressed in 206 organ(s), highest expression level in testis
ExpressionAtlasiQ6ZUT9 baseline and differential
GenevisibleiQ6ZUT9 HS

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF01477 PLAT, 1 hit
PF02759 RUN, 2 hits
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00593 RUN, 2 hits
SM00800 uDENN, 1 hit
SUPFAMiSSF140741 SSF140741, 2 hits
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS50095 PLAT, 1 hit
PS50826 RUN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN5B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZUT9
Secondary accession number(s): B5ME75
, Q59FW8, Q68CZ7, Q6NUJ0, Q7Z3F9, Q8N973, Q8WUC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 31, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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