UniProtKB - Q6ZUS6 (CC149_HUMAN)
Protein
Coiled-coil domain-containing protein 149
Gene
CCDC149
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 149 |
Gene namesi | Name:CCDC149 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25405, CCDC149 |
neXtProti | NX_Q6ZUS6 |
VEuPathDBi | HostDB:ENSG00000181982.18 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 91050 |
OpenTargetsi | ENSG00000181982 |
PharmGKBi | PA162381560 |
Miscellaneous databases
Pharosi | Q6ZUS6, Tdark |
Genetic variation databases
BioMutai | CCDC149 |
DMDMi | 205371874 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000344209 | 1 – 474 | Coiled-coil domain-containing protein 149Add BLAST | 474 |
Proteomic databases
jPOSTi | Q6ZUS6 |
MassIVEi | Q6ZUS6 |
PaxDbi | Q6ZUS6 |
PeptideAtlasi | Q6ZUS6 |
PRIDEi | Q6ZUS6 |
ProteomicsDBi | 68349 [Q6ZUS6-1] 68350 [Q6ZUS6-2] 68351 [Q6ZUS6-3] 68352 [Q6ZUS6-4] 68353 [Q6ZUS6-5] 68354 [Q6ZUS6-6] |
PTM databases
iPTMneti | Q6ZUS6 |
PhosphoSitePlusi | Q6ZUS6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181982, Expressed in parotid gland and 186 other tissues |
ExpressionAtlasi | Q6ZUS6, baseline and differential |
Genevisiblei | Q6ZUS6, HS |
Organism-specific databases
HPAi | ENSG00000181982, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124790, 4 interactors |
IntActi | Q6ZUS6, 3 interactors |
STRINGi | 9606.ENSP00000425715 |
Miscellaneous databases
RNActi | Q6ZUS6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 199 | Sequence analysisAdd BLAST | 199 | |
Coiled coili | 259 – 286 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 385 – 414 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 205 – 208 | Poly-Ser | 4 |
Sequence similaritiesi
Belongs to the CCDC149 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4687, Eukaryota |
GeneTreei | ENSGT00390000015958 |
HOGENOMi | CLU_016190_2_0_1 |
InParanoidi | Q6ZUS6 |
OrthoDBi | 697466at2759 |
PhylomeDBi | Q6ZUS6 |
TreeFami | TF319794 |
Family and domain databases
InterProi | View protein in InterPro IPR019179, Coiled-coil_dom-contain_pr_149 |
PANTHERi | PTHR21682, PTHR21682, 1 hit |
Pfami | View protein in Pfam PF09789, DUF2353, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZUS6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANQLRERHQ SLKKKYRELI DGDPSLPPEK RKQANLAQLL RDSQDRNKHL
60 70 80 90 100
GEEIKELQQR LGEVQGDNKL LRMTIAKQRL GDEAIGVRHF AAHEREDLVQ
110 120 130 140 150
QLERAKEQIE SLEHDLQASV DELQDVKEER SSYQDKVERL NQELNHILSG
160 170 180 190 200
HENRIIDVDA LCMENRYLQE RLKQLHEEVN LLKSNIAKYK NALERRKNSK
210 220 230 240 250
GQGKSSSSAL TGVLSAKQVQ DLLSEDHGCS LPATPQSISD LKSLATALLE
260 270 280 290 300
TIHEKNMVIQ HQRQTNKILG NRVAELEKKL RTLEVSGLWS LPGGKDTILF
310 320 330 340 350
SDPTLPSGQR SRSPLLKFVE QPTENKADPK DGEAQKQEED ESCAAAEALT
360 370 380 390 400
APEDAGRPAV NSPANQSRGN QCKLFHPSLP QLPSEEEVNS LGREIIKLTK
410 420 430 440 450
EQAAAELEEV RRESPIEGQR SETGPAPPGL AIQGELPKSH LDSFEASRPA
460 470
AKASTPEDGK GIPEGGGMRS TVKT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RQD2 | A0A0U1RQD2_HUMAN | Coiled-coil domain-containing prote... | CCDC149 | 540 | Annotation score: |
Sequence cautioni
The sequence AAH57761 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH67735 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86142 differs from that shown. Reason: Frameshift.Curated
The sequence BAC86142 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | R → Q in BAG64075 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042500 | 1 – 72 | Missing in isoform 6. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_042498 | 1 | M → MEEEAMNGDRTESDWQGLVS EYLVCKRKLESKKEALLILS KELDTCQQERDQYKLM in isoform 2, isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_042499 | 1 | M → MVVIVVVIIIIIARAATWDS EYLVCKRKLESKKEALLILS KELDTCQQERDQYKLM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_034741 | 70 – 86 | LLRMT…DEAIG → GRLRSKKKMKVVPLLRR in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_034742 | 87 – 474 | Missing in isoform 3. 1 PublicationAdd BLAST | 388 | |
Alternative sequenceiVSP_034743 | 268 – 474 | Missing in isoform 2. 1 PublicationAdd BLAST | 207 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK125353 mRNA Translation: BAC86142.1 Sequence problems. AK296454 mRNA Translation: BAG59102.1 AK302905 mRNA Translation: BAG64075.1 AL834257 mRNA Translation: CAD38932.1 AC006390 Genomic DNA No translation available. AC113614 Genomic DNA No translation available. AC116422 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW92824.1 CH471069 Genomic DNA Translation: EAW92825.1 BC067735 mRNA Translation: AAH67735.1 Different initiation. BC057761 mRNA Translation: AAH57761.1 Different initiation. |
CCDSi | CCDS33967.2 [Q6ZUS6-5] CCDS47036.1 [Q6ZUS6-4] |
RefSeqi | NP_001124198.1, NM_001130726.3 [Q6ZUS6-4] NP_001317572.1, NM_001330643.1 NP_001317573.1, NM_001330644.1 [Q6ZUS6-1] NP_775734.2, NM_173463.5 [Q6ZUS6-5] XP_016864316.1, XM_017008827.1 [Q6ZUS6-5] |
Genome annotation databases
Ensembli | ENST00000389609; ENSP00000374260; ENSG00000181982 [Q6ZUS6-5] ENST00000502801; ENSP00000427529; ENSG00000181982 [Q6ZUS6-3] ENST00000504487; ENSP00000425715; ENSG00000181982 [Q6ZUS6-4] |
GeneIDi | 91050 |
KEGGi | hsa:91050 |
UCSCi | uc003grc.4, human [Q6ZUS6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK125353 mRNA Translation: BAC86142.1 Sequence problems. AK296454 mRNA Translation: BAG59102.1 AK302905 mRNA Translation: BAG64075.1 AL834257 mRNA Translation: CAD38932.1 AC006390 Genomic DNA No translation available. AC113614 Genomic DNA No translation available. AC116422 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW92824.1 CH471069 Genomic DNA Translation: EAW92825.1 BC067735 mRNA Translation: AAH67735.1 Different initiation. BC057761 mRNA Translation: AAH57761.1 Different initiation. |
CCDSi | CCDS33967.2 [Q6ZUS6-5] CCDS47036.1 [Q6ZUS6-4] |
RefSeqi | NP_001124198.1, NM_001130726.3 [Q6ZUS6-4] NP_001317572.1, NM_001330643.1 NP_001317573.1, NM_001330644.1 [Q6ZUS6-1] NP_775734.2, NM_173463.5 [Q6ZUS6-5] XP_016864316.1, XM_017008827.1 [Q6ZUS6-5] |
3D structure databases
SMRi | Q6ZUS6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124790, 4 interactors |
IntActi | Q6ZUS6, 3 interactors |
STRINGi | 9606.ENSP00000425715 |
PTM databases
iPTMneti | Q6ZUS6 |
PhosphoSitePlusi | Q6ZUS6 |
Genetic variation databases
BioMutai | CCDC149 |
DMDMi | 205371874 |
Proteomic databases
jPOSTi | Q6ZUS6 |
MassIVEi | Q6ZUS6 |
PaxDbi | Q6ZUS6 |
PeptideAtlasi | Q6ZUS6 |
PRIDEi | Q6ZUS6 |
ProteomicsDBi | 68349 [Q6ZUS6-1] 68350 [Q6ZUS6-2] 68351 [Q6ZUS6-3] 68352 [Q6ZUS6-4] 68353 [Q6ZUS6-5] 68354 [Q6ZUS6-6] |
Protocols and materials databases
Antibodypediai | 65174, 29 antibodies |
Genome annotation databases
Ensembli | ENST00000389609; ENSP00000374260; ENSG00000181982 [Q6ZUS6-5] ENST00000502801; ENSP00000427529; ENSG00000181982 [Q6ZUS6-3] ENST00000504487; ENSP00000425715; ENSG00000181982 [Q6ZUS6-4] |
GeneIDi | 91050 |
KEGGi | hsa:91050 |
UCSCi | uc003grc.4, human [Q6ZUS6-1] |
Organism-specific databases
CTDi | 91050 |
DisGeNETi | 91050 |
GeneCardsi | CCDC149 |
HGNCi | HGNC:25405, CCDC149 |
HPAi | ENSG00000181982, Low tissue specificity |
neXtProti | NX_Q6ZUS6 |
OpenTargetsi | ENSG00000181982 |
PharmGKBi | PA162381560 |
VEuPathDBi | HostDB:ENSG00000181982.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4687, Eukaryota |
GeneTreei | ENSGT00390000015958 |
HOGENOMi | CLU_016190_2_0_1 |
InParanoidi | Q6ZUS6 |
OrthoDBi | 697466at2759 |
PhylomeDBi | Q6ZUS6 |
TreeFami | TF319794 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZUS6 |
Miscellaneous databases
BioGRID-ORCSi | 91050, 3 hits in 871 CRISPR screens |
ChiTaRSi | CCDC149, human |
GenomeRNAii | 91050 |
Pharosi | Q6ZUS6, Tdark |
PROi | PR:Q6ZUS6 |
RNActi | Q6ZUS6, protein |
Gene expression databases
Bgeei | ENSG00000181982, Expressed in parotid gland and 186 other tissues |
ExpressionAtlasi | Q6ZUS6, baseline and differential |
Genevisiblei | Q6ZUS6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019179, Coiled-coil_dom-contain_pr_149 |
PANTHERi | PTHR21682, PTHR21682, 1 hit |
Pfami | View protein in Pfam PF09789, DUF2353, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC149_HUMAN | |
Accessioni | Q6ZUS6Primary (citable) accession number: Q6ZUS6 Secondary accession number(s): A6NJE7 Q8N3K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 10, 2021 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM