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UniProtKB - Q6ZUM4 (RHG27_HUMAN)

Entry version 156 (10 Feb 2021)
Sequence version 3 (13 Jul 2010)
Previous versions | rss
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Protein

Rho GTPase-activating protein 27

Gene

ARHGAP27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).By similarity

Caution

According to HGNC, ARHGAP27 and SH3D20 are 2 separate genes, corresponding to isoform 2 and isoform 4, respectively. However, a rat transcript and paralog proteins with a similar domain structure suggest the existence of a single gene encoding for a protein of 889 residues as displayed here.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processEndocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZUM4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840, Rho GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6ZUM4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6ZUM4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 27
Alternative name(s):
CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
Rho-type GTPase-activating protein 27
SH3 domain-containing protein 20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP27
Synonyms:CAMGAP1, SH3D20
ORF Names:PP905
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:31813, ARHGAP27

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610591, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZUM4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000159314.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		201176

Open Targets

More...OpenTargetsi		ENSG00000159314

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134873327

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZUM4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARHGAP27

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003175781 – 889Rho GTPase-activating protein 27Add BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei156PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei456PhosphoserineBy similarity1
Modified residuei461PhosphothreonineBy similarity1
Modified residuei466PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZUM4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZUM4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZUM4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZUM4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZUM4

PeptideAtlas

More...PeptideAtlasi		Q6ZUM4

PRoteomics IDEntifications database

More...PRIDEi		Q6ZUM4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68341 [Q6ZUM4-1]
68342 [Q6ZUM4-2]
68343 [Q6ZUM4-3]
68344 [Q6ZUM4-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6ZUM4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZUM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZUM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000159314, Expressed in lower esophagus mucosa and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZUM4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZUM4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000159314, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SH3KBP1/CIN85.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128369, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZUM4, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000403323

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZUM4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1889
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZUM4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 69SH3PROSITE-ProRule annotationAdd BLAST64
Domaini246 – 280WW 1PROSITE-ProRule annotationAdd BLAST35
Domaini299 – 333WW 2PROSITE-ProRule annotationAdd BLAST35
Domaini411 – 444WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini496 – 612PHPROSITE-ProRule annotationAdd BLAST117
Domaini697 – 886Rho-GAPPROSITE-ProRule annotationAdd BLAST190

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1450, Eukaryota
KOG4269, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1140156_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZUM4

Identification of Orthologs from Complete Genome Data

More...OMAi		ETVWEDE

Database of Orthologous Groups

More...OrthoDBi		1300981at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZUM4

TreeFam database of animal gene trees

More...TreeFami		TF329345

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015767, ARHGAP27
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR011047, Quinoprotein_ADH-like_supfam
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR23176:SF104, PTHR23176:SF104, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
PF00397, WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SM00456, WW, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF50998, SSF50998, 1 hit
SSF51045, SSF51045, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit
PS50020, WW_DOMAIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZUM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR 
        60         70         80         90        100
EPGGRPFYLP AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA 
       110        120        130        140        150
AATAGPDGAP EESGGRASSL CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP 
       160        170        180        190        200
VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA CSVAGSWVCP RPLARSDSEN 
       210        220        230        240        250
VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP GAAAAPLPSP 
       260        270        280        290        300
VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS 
       310        320        330        340        350
LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS 
       360        370        380        390        400
PGDPRPPTPE TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV 
       410        420        430        440        450
SQDKQMLYTN HFTQEQWVRL EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR 
       460        470        480        490        500
SIHKSSQDGD TPAQASPPEE KVPAELDEVG SWEEVSPATA AVRTKTLDKA 
       510        520        530        540        550
GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT SAAGGLRQPS 
       560        570        580        590        600
KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII 
       610        620        630        640        650
STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA 
       660        670        680        690        700
AAPALGPVGL ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA 
       710        720        730        740        750
ALCERERSRV PRFVQQCIRA VEARGLDIDG LYRISGNLAT IQKLRYKVDH 
       760        770        780        790        800
DERLDLDDGR WEDVHVITGA LKLFFRELPE PLFPFSHFRQ FIAAIKLQDQ 
       810        820        830        840        850
ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR MSVQSVAIVF 
       860        870        880 
GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH
Length:889
Mass (Da):98,396
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE341CCC4D012DA4C
GO
Isoform 2 (identifier: Q6ZUM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.

Show »
Length:548
Mass (Da):61,733
Checksum:i4E0EE2190C9F20E8
GO
Isoform 3 (identifier: Q6ZUM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-442: Missing.

Show »
Length:862
Mass (Da):95,068
Checksum:iF207CD53BDAE7EAD
GO
Isoform 4 (identifier: Q6ZUM4-4) [UniParc]FASTAAdd to basket
Also known as: SH3D20

The sequence of this isoform differs from the canonical sequence as follows:
     221-263: DDPPEPVYAN...THTDAGTGRP → PPRALGRGGG...RRPPLSEDFG
     264-889: Missing.

Show »
Length:263
Mass (Da):28,192
Checksum:i5731E04A9F89B4D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGE6A0A0C4DGE6_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNY3A0A0G2JNY3_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
889Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRG8A0A0G2JRG8_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
867Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNX6E9PNX6_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIR1E9PIR1_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
867Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNT2E9PNT2_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
667Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JP16A0A0G2JP16_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK18E9PK18_HUMAN
Rho GTPase-activating protein 27
ARHGAP27
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI01389 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01390 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01391 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41S → N in AAG23796 (PubMed:15498874).Curated1
Sequence conflicti162C → R in BAF83339 (PubMed:14702039).Curated1
Sequence conflicti213P → R in AAH67345 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038551889H → Q1 PublicationCorresponds to variant dbSNP:rs117139057Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310531 – 341Missing in isoform 2. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_031054221 – 263DDPPE…GTGRP → PPRALGRGGGWRARDRARTE PGRKETRSAQRRARRPPLSE DFG in isoform 4. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_031055264 – 889Missing in isoform 4. 2 PublicationsAdd BLAST626
Alternative sequenceiVSP_031056416 – 442Missing in isoform 3. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF258593 mRNA Translation: AAG23796.1
AK125535 mRNA Translation: BAC86196.1
AK290650 mRNA Translation: BAF83339.1
AC003070 Genomic DNA No translation available.
AC091132 Genomic DNA No translation available.
BC067345 mRNA Translation: AAH67345.1
BC101388 mRNA Translation: AAI01389.1 Different initiation.
BC101389 mRNA Translation: AAI01390.1 Different initiation.
BC101390 mRNA Translation: AAI01391.1 Different initiation.
BC101391 mRNA Translation: AAI01392.3

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11498.1 [Q6ZUM4-2]
CCDS32670.1 [Q6ZUM4-4]
CCDS74082.1 [Q6ZUM4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001269219.1, NM_001282290.1 [Q6ZUM4-1]
NP_777579.2, NM_174919.3 [Q6ZUM4-4]
NP_954976.1, NM_199282.2 [Q6ZUM4-2]
XP_006721808.1, XM_006721745.2 [Q6ZUM4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000290470; ENSP00000290470; ENSG00000159314 [Q6ZUM4-4]
ENST00000376922; ENSP00000366121; ENSG00000159314 [Q6ZUM4-2]
ENST00000428638; ENSP00000403323; ENSG00000159314 [Q6ZUM4-1]
ENST00000528273; ENSP00000436137; ENSG00000159314 [Q6ZUM4-4]
ENST00000610792; ENSP00000477741; ENSG00000276907 [Q6ZUM4-1]
ENST00000611188; ENSP00000481302; ENSG00000276907 [Q6ZUM4-4]
ENST00000612916; ENSP00000480582; ENSG00000276836 [Q6ZUM4-2]
ENST00000616021; ENSP00000478738; ENSG00000276907 [Q6ZUM4-2]
ENST00000633003; ENSP00000487991; ENSG00000276907 [Q6ZUM4-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		201176

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:201176

UCSC genome browser

More...UCSCi		uc002iix.4, human [Q6ZUM4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258593 mRNA Translation: AAG23796.1
AK125535 mRNA Translation: BAC86196.1
AK290650 mRNA Translation: BAF83339.1
AC003070 Genomic DNA No translation available.
AC091132 Genomic DNA No translation available.
BC067345 mRNA Translation: AAH67345.1
BC101388 mRNA Translation: AAI01389.1 Different initiation.
BC101389 mRNA Translation: AAI01390.1 Different initiation.
BC101390 mRNA Translation: AAI01391.1 Different initiation.
BC101391 mRNA Translation: AAI01392.3
CCDSiCCDS11498.1 [Q6ZUM4-2]
CCDS32670.1 [Q6ZUM4-4]
CCDS74082.1 [Q6ZUM4-1]
RefSeqiNP_001269219.1, NM_001282290.1 [Q6ZUM4-1]
NP_777579.2, NM_174919.3 [Q6ZUM4-4]
NP_954976.1, NM_199282.2 [Q6ZUM4-2]
XP_006721808.1, XM_006721745.2 [Q6ZUM4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PP2X-ray1.42A/B491-613[»]
SMRiQ6ZUM4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128369, 5 interactors
IntActiQ6ZUM4, 2 interactors
STRINGi9606.ENSP00000403323

PTM databases

GlyGeniQ6ZUM4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ6ZUM4
PhosphoSitePlusiQ6ZUM4

Genetic variation databases

BioMutaiARHGAP27
DMDMi300669680

Proteomic databases

EPDiQ6ZUM4
jPOSTiQ6ZUM4
MassIVEiQ6ZUM4
MaxQBiQ6ZUM4
PaxDbiQ6ZUM4
PeptideAtlasiQ6ZUM4
PRIDEiQ6ZUM4
ProteomicsDBi68341 [Q6ZUM4-1]
68342 [Q6ZUM4-2]
68343 [Q6ZUM4-3]
68344 [Q6ZUM4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49843, 139 antibodies

Genome annotation databases

EnsembliENST00000290470; ENSP00000290470; ENSG00000159314 [Q6ZUM4-4]
ENST00000376922; ENSP00000366121; ENSG00000159314 [Q6ZUM4-2]
ENST00000428638; ENSP00000403323; ENSG00000159314 [Q6ZUM4-1]
ENST00000528273; ENSP00000436137; ENSG00000159314 [Q6ZUM4-4]
ENST00000610792; ENSP00000477741; ENSG00000276907 [Q6ZUM4-1]
ENST00000611188; ENSP00000481302; ENSG00000276907 [Q6ZUM4-4]
ENST00000612916; ENSP00000480582; ENSG00000276836 [Q6ZUM4-2]
ENST00000616021; ENSP00000478738; ENSG00000276907 [Q6ZUM4-2]
ENST00000633003; ENSP00000487991; ENSG00000276907 [Q6ZUM4-4]
GeneIDi201176
KEGGihsa:201176
UCSCiuc002iix.4, human [Q6ZUM4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		201176
DisGeNETi201176

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGAP27
HGNCiHGNC:31813, ARHGAP27
HPAiENSG00000159314, Tissue enhanced (intestine)
MIMi610591, gene
neXtProtiNX_Q6ZUM4
OpenTargetsiENSG00000159314
PharmGKBiPA134873327
VEuPathDBiHostDB:ENSG00000159314.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1450, Eukaryota
KOG4269, Eukaryota
GeneTreeiENSGT00950000182860
HOGENOMiCLU_1140156_0_0_1
InParanoidiQ6ZUM4
OMAiETVWEDE
OrthoDBi1300981at2759
PhylomeDBiQ6ZUM4
TreeFamiTF329345

Enzyme and pathway databases

PathwayCommonsiQ6ZUM4
ReactomeiR-HSA-194840, Rho GTPase cycle
SignaLinkiQ6ZUM4
SIGNORiQ6ZUM4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		201176, 11 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGAP27, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		201176
PharosiQ6ZUM4, Tdark

Protein Ontology

More...PROi		PR:Q6ZUM4
RNActiQ6ZUM4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000159314, Expressed in lower esophagus mucosa and 205 other tissues
ExpressionAtlasiQ6ZUM4, baseline and differential
GenevisibleiQ6ZUM4, HS

Family and domain databases

CDDicd00201, WW, 3 hits
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR015767, ARHGAP27
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR011047, Quinoprotein_ADH-like_supfam
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR23176:SF104, PTHR23176:SF104, 1 hit
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
PF00397, WW, 2 hits
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SM00456, WW, 3 hits
SUPFAMiSSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF50998, SSF50998, 1 hit
SSF51045, SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit
PS50020, WW_DOMAIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG27_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZUM4
Secondary accession number(s): A4FU35
, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q8WY58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 13, 2010
Last modified: February 10, 2021
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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