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Protein

Transmembrane protein 26

Gene

TMEM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 26
Gene namesi
Name:TMEM26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000196932.11
HGNCiHGNC:28550 TMEM26
MIMi617803 gene
neXtProtiNX_Q6ZUK4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196932
PharmGKBiPA134887276

Polymorphism and mutation databases

BioMutaiTMEM26
DMDMi74749674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458651 – 368Transmembrane protein 26Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZUK4
PeptideAtlasiQ6ZUK4
PRIDEiQ6ZUK4
ProteomicsDBi68337
68338 [Q6ZUK4-2]

PTM databases

iPTMnetiQ6ZUK4
PhosphoSitePlusiQ6ZUK4

Expressioni

Gene expression databases

BgeeiENSG00000196932 Expressed in 80 organ(s), highest expression level in adrenal tissue
CleanExiHS_TMEM26
ExpressionAtlasiQ6ZUK4 baseline and differential
GenevisibleiQ6ZUK4 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382237

Structurei

3D structure databases

ProteinModelPortaliQ6ZUK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4610 Eukaryota
ENOG410XS6J LUCA
GeneTreeiENSGT00390000014794
HOGENOMiHOG000047342
HOVERGENiHBG060870
InParanoidiQ6ZUK4
OMAiVQHIGCK
OrthoDBiEOG091G0BYS
PhylomeDBiQ6ZUK4
TreeFamiTF314156

Family and domain databases

InterProiView protein in InterPro
IPR019169 Transmembrane_26
PANTHERiPTHR22168 PTHR22168, 1 hit
PfamiView protein in Pfam
PF09772 Tmem26, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZUK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGLVFLNAL ATRLLFLLHS LVGVWRVTEV KKEPRYWLLA LLNLLLFLET
60 70 80 90 100
ALTLKFKRGR GYKWFSPAIF LYLISIVPSL WLLELHHETQ YCSIQAEGTS
110 120 130 140 150
QNTSRKEDFN QTLTSNEQTS RADDLIETAK VFVNNLSTVC EKVWTLGLHQ
160 170 180 190 200
TFLLMLIIGR WLLPIGGGIT RDQLSQLLLM FVGTAADILE FTSETLEEQN
210 220 230 240 250
VRNSPALVYA ILVIWTWSML QFPLDLAVQN VVCPVSVTER GFPSLFFCQY
260 270 280 290 300
SADLWNIGIS VFIQDGPFLV VRLILMTYFK VINQMLVFFA AKNFLVVVLQ
310 320 330 340 350
LYRLVVLALA VRASLRSQSE GLKGEHGCRA QTSESGPSQR DWQNESKEGL
360
AIPLRGSPVT SDDSHHTP
Length:368
Mass (Da):41,672
Last modified:July 5, 2004 - v1
Checksum:i2B1F82FEF0C1CCED
GO
Isoform 2 (identifier: Q6ZUK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-223: NSPALVYAILVIWTWSMLQFP → LCWKNSTNRRHTNPKWQLVLF
     224-368: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:223
Mass (Da):25,784
Checksum:i7E34DC2FF33B4E3A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXI3H7BXI3_HUMAN
Transmembrane protein 26
TMEM26
169Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019806203 – 223NSPAL…MLQFP → LCWKNSTNRRHTNPKWQLVL F in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_019807224 – 368Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125611 mRNA Translation: BAC86218.1
CR749606 mRNA Translation: CAH18401.1
AC068892 Genomic DNA No translation available.
AL356952 Genomic DNA No translation available.
BC042872 mRNA Translation: AAH42872.1
CCDSiCCDS41530.1 [Q6ZUK4-1]
RefSeqiNP_848600.2, NM_178505.7 [Q6ZUK4-1]
XP_011537753.1, XM_011539451.1 [Q6ZUK4-2]
UniGeneiHs.623955

Genome annotation databases

EnsembliENST00000399298; ENSP00000382237; ENSG00000196932 [Q6ZUK4-1]
ENST00000488505; ENSP00000426071; ENSG00000196932 [Q6ZUK4-2]
ENST00000503886; ENSP00000425286; ENSG00000196932 [Q6ZUK4-1]
GeneIDi219623
KEGGihsa:219623
UCSCiuc001jlo.3 human [Q6ZUK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125611 mRNA Translation: BAC86218.1
CR749606 mRNA Translation: CAH18401.1
AC068892 Genomic DNA No translation available.
AL356952 Genomic DNA No translation available.
BC042872 mRNA Translation: AAH42872.1
CCDSiCCDS41530.1 [Q6ZUK4-1]
RefSeqiNP_848600.2, NM_178505.7 [Q6ZUK4-1]
XP_011537753.1, XM_011539451.1 [Q6ZUK4-2]
UniGeneiHs.623955

3D structure databases

ProteinModelPortaliQ6ZUK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000382237

PTM databases

iPTMnetiQ6ZUK4
PhosphoSitePlusiQ6ZUK4

Polymorphism and mutation databases

BioMutaiTMEM26
DMDMi74749674

Proteomic databases

PaxDbiQ6ZUK4
PeptideAtlasiQ6ZUK4
PRIDEiQ6ZUK4
ProteomicsDBi68337
68338 [Q6ZUK4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399298; ENSP00000382237; ENSG00000196932 [Q6ZUK4-1]
ENST00000488505; ENSP00000426071; ENSG00000196932 [Q6ZUK4-2]
ENST00000503886; ENSP00000425286; ENSG00000196932 [Q6ZUK4-1]
GeneIDi219623
KEGGihsa:219623
UCSCiuc001jlo.3 human [Q6ZUK4-1]

Organism-specific databases

CTDi219623
EuPathDBiHostDB:ENSG00000196932.11
GeneCardsiTMEM26
H-InvDBiHIX0025927
HIX0035606
HGNCiHGNC:28550 TMEM26
MIMi617803 gene
neXtProtiNX_Q6ZUK4
OpenTargetsiENSG00000196932
PharmGKBiPA134887276
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4610 Eukaryota
ENOG410XS6J LUCA
GeneTreeiENSGT00390000014794
HOGENOMiHOG000047342
HOVERGENiHBG060870
InParanoidiQ6ZUK4
OMAiVQHIGCK
OrthoDBiEOG091G0BYS
PhylomeDBiQ6ZUK4
TreeFamiTF314156

Miscellaneous databases

ChiTaRSiTMEM26 human
GenomeRNAii219623
PROiPR:Q6ZUK4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196932 Expressed in 80 organ(s), highest expression level in adrenal tissue
CleanExiHS_TMEM26
ExpressionAtlasiQ6ZUK4 baseline and differential
GenevisibleiQ6ZUK4 HS

Family and domain databases

InterProiView protein in InterPro
IPR019169 Transmembrane_26
PANTHERiPTHR22168 PTHR22168, 1 hit
PfamiView protein in Pfam
PF09772 Tmem26, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM26_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUK4
Secondary accession number(s): Q6ZVM0, Q8IVN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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