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Entry version 127 (18 Sep 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Phosphoinositide 3-kinase adapter protein 1

Gene

PIK3AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SIGNOR Signaling Network Open Resource

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SIGNORi
Q6ZUJ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide 3-kinase adapter protein 1
Alternative name(s):
B-cell adapter for phosphoinositide 3-kinase
B-cell phosphoinositide 3-kinase adapter protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3AP1
Synonyms:BCAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30034 PIK3AP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607942 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZUJ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
118788

Open Targets

More...
OpenTargetsi
ENSG00000155629

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134979629

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZUJ8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIK3AP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205830907

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003412731 – 805Phosphoinositide 3-kinase adapter protein 1Add BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphotyrosineBy similarity1
Modified residuei419Phosphotyrosine; by SYKBy similarity1
Modified residuei444Phosphotyrosine; by SYKBy similarity1
Modified residuei459Phosphotyrosine; by SYKBy similarity1
Modified residuei513Phosphotyrosine; by ABL11 Publication1
Modified residuei553Phosphotyrosine; by ABL11 Publication1
Modified residuei570Phosphotyrosine; by ABL11 Publication1
Modified residuei594Phosphotyrosine; by ABL11 Publication1
Modified residuei642PhosphoserineCombined sources1
Modified residuei694Phosphotyrosine; by ABL11 Publication1
Modified residuei718PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity). Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity). Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6ZUJ8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ZUJ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZUJ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZUJ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZUJ8

PeptideAtlas

More...
PeptideAtlasi
Q6ZUJ8

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZUJ8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68334 [Q6ZUJ8-1]
68335 [Q6ZUJ8-2]
68336 [Q6ZUJ8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6ZUJ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZUJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in natural killer (NK) cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000155629 Expressed in 163 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6ZUJ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026136
HPA038452

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (By similarity).

Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase.

Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P629933EBI-2654168,EBI-401755

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125621, 17 interactors

Protein interaction database and analysis system

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IntActi
Q6ZUJ8, 8 interactors

Molecular INTeraction database

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MINTi
Q6ZUJ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339826

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1805
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6ZUJ8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 317DBBPROSITE-ProRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 144Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs; may mediate interaction with MYD88 and TIRAPBy similarityAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili645 – 667Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi760 – 802Pro-richAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DBB domain is required for dimerization.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKKC Eukaryota
ENOG4110NCP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000095183

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZUJ8

KEGG Orthology (KO)

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KOi
K12230

Identification of Orthologs from Complete Genome Data

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OMAi
YVETADM

Database of Orthologous Groups

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OrthoDBi
280243at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6ZUJ8

TreeFam database of animal gene trees

More...
TreeFami
TF328570

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017893 DBB_domain
IPR041340 PIK3AP1_TIR
IPR035897 Toll_tir_struct_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14545 DBB, 1 hit
PF18567 TIR_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01282 DBB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51376 DBB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZUJ8-1) [UniParc]FASTAAdd to basket
Also known as: BCAP-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASGVPRGC DILIVYSPDA EEWCQYLQTL FLSSRQVRSQ KILTHRLGPE
60 70 80 90 100
ASFSAEDLSL FLSTRCVVVL LSAELVQHFH KPALLPLLQR AFHPPHRVVR
110 120 130 140 150
LLCGVRDSEE FLDFFPDWAH WQELTCDDEP ETYVAAVKKA ISEDSGCDSV
160 170 180 190 200
TDTEPEDEKV VSYSKQQNLP TVTSPGNLMV VQPDRIRCGA ETTVYVIVRC
210 220 230 240 250
KLDDRVATEA EFSPEDSPSV RMEAKVENEY TISVKAPNLS SGNVSLKIYS
260 270 280 290 300
GDLVVCETVI SYYTDMEEIG NLLSNAANPV EFMCQAFKIV PYNTETLDKL
310 320 330 340 350
LTESLKNNIP ASGLHLFGIN QLEEEDMMTN QRDEELPTLL HFAAKYGLKN
360 370 380 390 400
LTALLLTCPG ALQAYSVANK HGHYPNTIAE KHGFRDLRQF IDEYVETVDM
410 420 430 440 450
LKSHIKEELM HGEEADAVYE SMAHLSTDLL MKCSLNPGCD EDLYESMAAF
460 470 480 490 500
VPAATEDLYV EMLQASTSNP IPGDGFSRAT KDSMIRKFLE GNSMGMTNLE
510 520 530 540 550
RDQCHLGQEE DVYHTVDDDE AFSVDLASRP PVPVPRPETT APGAHQLPDN
560 570 580 590 600
EPYIFKVFAE KSQERPGNFY VSSESIRKGP PVRPWRDRPQ SSIYDPFAGM
610 620 630 640 650
KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL
660 670 680 690 700
KRLRDSITRR QREKQKSGKQ TDLEITVPIR HSQHLPAKVE FGVYESGPRK
710 720 730 740 750
SVIPPRTELR RGDWKTDSTS STASSTSNRS STRSLLSVSS GMEGDNEDNE
760 770 780 790 800
VPEVTRSRSP GPPQVDGTPT MSLERPPRVP PRAASQRPPT RETFHPPPPV

PPRGR
Length:805
Mass (Da):90,398
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF1025A37905AEA7
GO
Isoform 2 (identifier: Q6ZUJ8-2) [UniParc]FASTAAdd to basket
Also known as: BCAP-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:627
Mass (Da):70,412
Checksum:iA2D7C2496537C129
GO
Isoform 3 (identifier: Q6ZUJ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MAASGVPRGC...GPEASFSAED → MRFFTSVACY...TGAKHVPGSS
     58-458: Missing.

Show »
Length:404
Mass (Da):45,484
Checksum:iEDBB28E0023875E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti726T → P in BAC03996 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04403521E → K1 PublicationCorresponds to variant dbSNP:rs17112076Ensembl.1
Natural variantiVAR_04403683A → S1 PublicationCorresponds to variant dbSNP:rs3748229Ensembl.1
Natural variantiVAR_044037551E → K. Corresponds to variant dbSNP:rs3748233EnsemblClinVar.1
Natural variantiVAR_044038638K → R. Corresponds to variant dbSNP:rs12784975Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0342381 – 178Missing in isoform 2. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_0342391 – 57MAASG…FSAED → MRFFTSVACYGSCLFASELL IRCKDWLKGRPALFTALLAC VLYLCEWTGAKHVPGSS in isoform 3. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_03424058 – 458Missing in isoform 3. 1 PublicationAdd BLAST401

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK092883 mRNA Translation: BAC03996.1
AK125635 mRNA Translation: BAC86227.1
BX648550 mRNA No translation available.
AL358235 Genomic DNA No translation available.
AL591364 Genomic DNA No translation available.
AL138765 Genomic DNA No translation available.
BC029917 mRNA Translation: AAH29917.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31259.1 [Q6ZUJ8-1]

NCBI Reference Sequences

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RefSeqi
NP_689522.2, NM_152309.2 [Q6ZUJ8-1]
XP_005269555.1, XM_005269498.1 [Q6ZUJ8-2]
XP_005269556.1, XM_005269499.1 [Q6ZUJ8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339364; ENSP00000339826; ENSG00000155629 [Q6ZUJ8-1]
ENST00000371109; ENSP00000360150; ENSG00000155629 [Q6ZUJ8-3]
ENST00000371110; ENSP00000360151; ENSG00000155629 [Q6ZUJ8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
118788

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:118788

UCSC genome browser

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UCSCi
uc001kmo.4 human [Q6ZUJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092883 mRNA Translation: BAC03996.1
AK125635 mRNA Translation: BAC86227.1
BX648550 mRNA No translation available.
AL358235 Genomic DNA No translation available.
AL591364 Genomic DNA No translation available.
AL138765 Genomic DNA No translation available.
BC029917 mRNA Translation: AAH29917.1
CCDSiCCDS31259.1 [Q6ZUJ8-1]
RefSeqiNP_689522.2, NM_152309.2 [Q6ZUJ8-1]
XP_005269555.1, XM_005269498.1 [Q6ZUJ8-2]
XP_005269556.1, XM_005269499.1 [Q6ZUJ8-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FORX-ray2.50A7-142[»]
SMRiQ6ZUJ8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi125621, 17 interactors
IntActiQ6ZUJ8, 8 interactors
MINTiQ6ZUJ8
STRINGi9606.ENSP00000339826

PTM databases

iPTMnetiQ6ZUJ8
PhosphoSitePlusiQ6ZUJ8

Polymorphism and mutation databases

BioMutaiPIK3AP1
DMDMi205830907

Proteomic databases

EPDiQ6ZUJ8
jPOSTiQ6ZUJ8
MassIVEiQ6ZUJ8
MaxQBiQ6ZUJ8
PaxDbiQ6ZUJ8
PeptideAtlasiQ6ZUJ8
PRIDEiQ6ZUJ8
ProteomicsDBi68334 [Q6ZUJ8-1]
68335 [Q6ZUJ8-2]
68336 [Q6ZUJ8-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
118788

Genome annotation databases

EnsembliENST00000339364; ENSP00000339826; ENSG00000155629 [Q6ZUJ8-1]
ENST00000371109; ENSP00000360150; ENSG00000155629 [Q6ZUJ8-3]
ENST00000371110; ENSP00000360151; ENSG00000155629 [Q6ZUJ8-2]
GeneIDi118788
KEGGihsa:118788
UCSCiuc001kmo.4 human [Q6ZUJ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
118788
DisGeNETi118788

GeneCards: human genes, protein and diseases

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GeneCardsi
PIK3AP1
HGNCiHGNC:30034 PIK3AP1
HPAiCAB026136
HPA038452
MIMi607942 gene
neXtProtiNX_Q6ZUJ8
OpenTargetsiENSG00000155629
PharmGKBiPA134979629

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IKKC Eukaryota
ENOG4110NCP LUCA
GeneTreeiENSGT00390000008787
HOGENOMiHOG000095183
InParanoidiQ6ZUJ8
KOiK12230
OMAiYVETADM
OrthoDBi280243at2759
PhylomeDBiQ6ZUJ8
TreeFamiTF328570

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SIGNORiQ6ZUJ8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIK3AP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PIK3AP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
118788
PharosiQ6ZUJ8

Protein Ontology

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PROi
PR:Q6ZUJ8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155629 Expressed in 163 organ(s), highest expression level in blood
GenevisibleiQ6ZUJ8 HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR017893 DBB_domain
IPR041340 PIK3AP1_TIR
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF14545 DBB, 1 hit
PF18567 TIR_3, 1 hit
SMARTiView protein in SMART
SM01282 DBB, 1 hit
PROSITEiView protein in PROSITE
PS51376 DBB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZUJ8
Secondary accession number(s): Q5TB56
, Q5VXJ9, Q8N6J6, Q8NAC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 18, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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