Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Septin-14

Gene

SEPT14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114GTP; via amide nitrogenBy similarity1
Binding sitei249GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei264GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66GTPBy similarity8
Nucleotide bindingi195 – 203GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-14
Gene namesi
Name:SEPT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000154997.8
HGNCiHGNC:33280 SEPT14
MIMi612140 gene
neXtProtiNX_Q6ZU15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi346288
MalaCardsiSEPT14
OpenTargetsiENSG00000154997
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
PharmGKBiPA162402917

Polymorphism and mutation databases

BioMutaiSEPT14
DMDMi152112291

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944251 – 432Septin-14Add BLAST432

Proteomic databases

EPDiQ6ZU15
MaxQBiQ6ZU15
PaxDbiQ6ZU15
PeptideAtlasiQ6ZU15
PRIDEiQ6ZU15
ProteomicsDBi68306

PTM databases

iPTMnetiQ6ZU15
PhosphoSitePlusiQ6ZU15

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000154997 Expressed in 18 organ(s), highest expression level in right testis
CleanExiHS_SEPT14

Organism-specific databases

HPAiHPA073255

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT9.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131376, 6 interactors
IntActiQ6ZU15, 12 interactors
STRINGi9606.ENSP00000373627

Structurei

3D structure databases

ProteinModelPortaliQ6ZU15
SMRiQ6ZU15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 315Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 66G1 motifPROSITE-ProRule annotation8
Regioni111 – 114G3 motifPROSITE-ProRule annotation4
Regioni194 – 197G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili332 – 412Sequence analysisAdd BLAST81

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ6ZU15
KOiK16941
OMAiECLPYQL
OrthoDBiEOG091G0IKM
PhylomeDBiQ6ZU15
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZU15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERTMAMPT QIPADGDTQK ENNIRCLTTI GHFGFECLPN QLVSRSIRQG
60 70 80 90 100
FTFNILCVGE TGIGKSTLID TLFNTNLKDN KSSHFYSNVG LQIQTYELQE
110 120 130 140 150
SNVQLKLTVV ETVGYGDQID KEASYQPIVD YIDAQFEAYL QEELKIKRSL
160 170 180 190 200
FEYHDSRVHV CLYFISPTGH SLKSLDLLTM KNLDSKVNII PLIAKADTIS
210 220 230 240 250
KNDLQTFKNK IMSELISNGI QIYQLPTDEE TAAQANSSVS GLLPFAVVGS
260 270 280 290 300
TDEVKVGKRM VRGRHYPWGV LQVENENHCD FVKLRDMLLC TNMENLKEKT
310 320 330 340 350
HTQHYECYRY QKLQKMGFTD VGPNNQPVSF QEIFEAKRQE FYDQCQREEE
360 370 380 390 400
ELKQRFMQRV KEKEATFKEA EKELQDKFEH LKMIQQEEIR KLEEEKKQLE
410 420 430
GEIIDFYKMK AASEALQTQL STDTKKDKHR KK
Length:432
Mass (Da):50,025
Last modified:July 10, 2007 - v2
Checksum:iAFFF9A953F1FC637
GO

Sequence cautioni

The sequence BAC86412 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126048 mRNA Translation: BAC86412.1 Different initiation.
AK301928 mRNA Translation: BAG63348.1
AC092647 Genomic DNA No translation available.
CCDSiCCDS5519.2
RefSeqiNP_997249.2, NM_207366.2
XP_011513675.1, XM_011515373.2
UniGeneiHs.453629

Genome annotation databases

EnsembliENST00000388975; ENSP00000373627; ENSG00000154997
GeneIDi346288
KEGGihsa:346288
UCSCiuc003tqz.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126048 mRNA Translation: BAC86412.1 Different initiation.
AK301928 mRNA Translation: BAG63348.1
AC092647 Genomic DNA No translation available.
CCDSiCCDS5519.2
RefSeqiNP_997249.2, NM_207366.2
XP_011513675.1, XM_011515373.2
UniGeneiHs.453629

3D structure databases

ProteinModelPortaliQ6ZU15
SMRiQ6ZU15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131376, 6 interactors
IntActiQ6ZU15, 12 interactors
STRINGi9606.ENSP00000373627

PTM databases

iPTMnetiQ6ZU15
PhosphoSitePlusiQ6ZU15

Polymorphism and mutation databases

BioMutaiSEPT14
DMDMi152112291

Proteomic databases

EPDiQ6ZU15
MaxQBiQ6ZU15
PaxDbiQ6ZU15
PeptideAtlasiQ6ZU15
PRIDEiQ6ZU15
ProteomicsDBi68306

Protocols and materials databases

DNASUi346288
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388975; ENSP00000373627; ENSG00000154997
GeneIDi346288
KEGGihsa:346288
UCSCiuc003tqz.2 human

Organism-specific databases

CTDi346288
DisGeNETi346288
EuPathDBiHostDB:ENSG00000154997.8
GeneCardsiSEPT14
H-InvDBiHIX0025388
HGNCiHGNC:33280 SEPT14
HPAiHPA073255
MalaCardsiSEPT14
MIMi612140 gene
neXtProtiNX_Q6ZU15
OpenTargetsiENSG00000154997
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
PharmGKBiPA162402917
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ6ZU15
KOiK16941
OMAiECLPYQL
OrthoDBiEOG091G0IKM
PhylomeDBiQ6ZU15
TreeFamiTF101080

Miscellaneous databases

GenomeRNAii346288
PROiPR:Q6ZU15
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154997 Expressed in 18 organ(s), highest expression level in right testis
CleanExiHS_SEPT14

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEP14_HUMAN
AccessioniPrimary (citable) accession number: Q6ZU15
Secondary accession number(s): A6NCC2, B4DXD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again