UniProtKB - Q6ZTW0 (TPGS1_HUMAN)
Protein
Tubulin polyglutamylase complex subunit 1
Gene
TPGS1
Organism
Homo sapiens (Human)
Status
Functioni
May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).By similarity
GO - Molecular functioni
- microtubule binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- protein polyglutamylation Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q6ZTW0 |
Reactomei | R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin polyglutamylase complex subunit 1Short name: PGs1 |
Gene namesi | Name:TPGS1 Synonyms:C19orf20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25058, TPGS1 |
neXtProti | NX_Q6ZTW0 |
VEuPathDBi | HostDB:ENSG00000141933.9 |
Subcellular locationi
Cytoskeleton
Other locations
Note: Associated with microtubules from neurites, centrosomes, basal bodies and axonemes.By similarity
Cytoskeleton
- centrosome Source: UniProtKB
- microtubule Source: UniProtKB-KW
Other locations
- axon Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-KW
- dendrite Source: UniProtKB-SubCell
- motile cilium Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, MicrotubulePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000141933 |
PharmGKBi | PA134901246 |
Miscellaneous databases
Pharosi | Q6ZTW0, Tdark |
Genetic variation databases
BioMutai | TPGS1 |
DMDMi | 114152292 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249316 | 1 – 290 | Tubulin polyglutamylase complex subunit 1Add BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Modified residuei | 266 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZTW0 |
jPOSTi | Q6ZTW0 |
MassIVEi | Q6ZTW0 |
MaxQBi | Q6ZTW0 |
PaxDbi | Q6ZTW0 |
PeptideAtlasi | Q6ZTW0 |
PRIDEi | Q6ZTW0 |
ProteomicsDBi | 68296 [Q6ZTW0-1] 68297 [Q6ZTW0-2] |
PTM databases
iPTMneti | Q6ZTW0 |
PhosphoSitePlusi | Q6ZTW0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141933, Expressed in tibial artery and 123 other tissues |
Genevisiblei | Q6ZTW0, HS |
Organism-specific databases
HPAi | ENSG00000141933, Low tissue specificity |
Interactioni
Subunit structurei
Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
By similarityGO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 124900, 29 interactors |
IntActi | Q6ZTW0, 22 interactors |
STRINGi | 9606.ENSP00000352265 |
Miscellaneous databases
RNActi | Q6ZTW0, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502S17Y, Eukaryota |
GeneTreei | ENSGT00500000045074 |
HOGENOMi | CLU_084094_0_0_1 |
InParanoidi | Q6ZTW0 |
OMAi | NMDAKEF |
OrthoDBi | 1306505at2759 |
PhylomeDBi | Q6ZTW0 |
TreeFami | TF329086 |
Family and domain databases
InterProi | View protein in InterPro IPR039235, TPGS1 |
PANTHERi | PTHR31932, PTHR31932, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6ZTW0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAVEKRRQA VPPPAGFTDS GRQSVSRAAG AAESEEDFLR QVGVTEMLRA
60 70 80 90 100
ALLKVLEARP EEPIAFLAHY FENMGLRSPV NGGAGEPPGQ LLLQQQRLGR
110 120 130 140 150
ALWHLRLAHH SQRAAFNNNV SVAYECLSAG GRRKRPGLDG RTYSELLRRI
160 170 180 190 200
CRDGQAPEEV VAPLLRKVQC RDHEAVPLSV FRAGTLTCFV LLEFVARAGA
210 220 230 240 250
LFQLLEDSAA AVADRRVGQA VLDTLEGALQ ASDAAAPARF LEAGSRLGPD
260 270 280 290
SLALALDRAV GGRRPSAPMT REEFLERAAA LFIAKVKPVG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020401 | 248 – 266 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126170 mRNA Translation: BAC86469.1 BC009520 mRNA Translation: AAH09520.1 |
CCDSi | CCDS42454.1 [Q6ZTW0-1] |
RefSeqi | NP_277048.2, NM_033513.2 [Q6ZTW0-1] |
Genome annotation databases
Ensembli | ENST00000359315; ENSP00000352265; ENSG00000141933 [Q6ZTW0-1] |
GeneIDi | 91978 |
KEGGi | hsa:91978 |
UCSCi | uc002lou.4, human [Q6ZTW0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126170 mRNA Translation: BAC86469.1 BC009520 mRNA Translation: AAH09520.1 |
CCDSi | CCDS42454.1 [Q6ZTW0-1] |
RefSeqi | NP_277048.2, NM_033513.2 [Q6ZTW0-1] |
3D structure databases
SMRi | Q6ZTW0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124900, 29 interactors |
IntActi | Q6ZTW0, 22 interactors |
STRINGi | 9606.ENSP00000352265 |
PTM databases
iPTMneti | Q6ZTW0 |
PhosphoSitePlusi | Q6ZTW0 |
Genetic variation databases
BioMutai | TPGS1 |
DMDMi | 114152292 |
Proteomic databases
EPDi | Q6ZTW0 |
jPOSTi | Q6ZTW0 |
MassIVEi | Q6ZTW0 |
MaxQBi | Q6ZTW0 |
PaxDbi | Q6ZTW0 |
PeptideAtlasi | Q6ZTW0 |
PRIDEi | Q6ZTW0 |
ProteomicsDBi | 68296 [Q6ZTW0-1] 68297 [Q6ZTW0-2] |
Protocols and materials databases
Antibodypediai | 53504, 19 antibodies |
DNASUi | 91978 |
Genome annotation databases
Ensembli | ENST00000359315; ENSP00000352265; ENSG00000141933 [Q6ZTW0-1] |
GeneIDi | 91978 |
KEGGi | hsa:91978 |
UCSCi | uc002lou.4, human [Q6ZTW0-1] |
Organism-specific databases
CTDi | 91978 |
GeneCardsi | TPGS1 |
HGNCi | HGNC:25058, TPGS1 |
HPAi | ENSG00000141933, Low tissue specificity |
neXtProti | NX_Q6ZTW0 |
OpenTargetsi | ENSG00000141933 |
PharmGKBi | PA134901246 |
VEuPathDBi | HostDB:ENSG00000141933.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S17Y, Eukaryota |
GeneTreei | ENSGT00500000045074 |
HOGENOMi | CLU_084094_0_0_1 |
InParanoidi | Q6ZTW0 |
OMAi | NMDAKEF |
OrthoDBi | 1306505at2759 |
PhylomeDBi | Q6ZTW0 |
TreeFami | TF329086 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZTW0 |
Reactomei | R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin |
Miscellaneous databases
BioGRID-ORCSi | 91978, 8 hits in 873 CRISPR screens |
ChiTaRSi | TPGS1, human |
GenomeRNAii | 91978 |
Pharosi | Q6ZTW0, Tdark |
PROi | PR:Q6ZTW0 |
RNActi | Q6ZTW0, protein |
Gene expression databases
Bgeei | ENSG00000141933, Expressed in tibial artery and 123 other tissues |
Genevisiblei | Q6ZTW0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039235, TPGS1 |
PANTHERi | PTHR31932, PTHR31932, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPGS1_HUMAN | |
Accessioni | Q6ZTW0Primary (citable) accession number: Q6ZTW0 Secondary accession number(s): Q96GE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 10, 2021 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM