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Protein

Cadherin-related family member 3

Gene

CDHR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
(Microbial infection) Acts as a receptor for rhinovirus C.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processCell adhesion, Host-virus interaction
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-related family member 3
Alternative name(s):
Cadherin-like protein 28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDHR3
Synonyms:CDH28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128536.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26308 CDHR3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615610 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZTQ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 713ExtracellularSequence analysisAdd BLAST694
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei714 – 734HelicalSequence analysisAdd BLAST21
Topological domaini735 – 885CytoplasmicSequence analysisAdd BLAST151

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Asthma susceptibility may be associated with variations affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age.1 Publication

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNET

More...
DisGeNETi
222256

Open Targets

More...
OpenTargetsi
ENSG00000128536

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA165617747

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDHR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030590320 – 885Cadherin-related family member 3Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZTQ4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ZTQ4

PeptideAtlas

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PeptideAtlasi
Q6ZTQ4

PRoteomics IDEntifications database

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PRIDEi
Q6ZTQ4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68286
68287 [Q6ZTQ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6ZTQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZTQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bronchial epithelium from adults and in fetal lung tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000128536 Expressed in 122 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6ZTQ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6ZTQ4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011218

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Interacts with rhinovirus C capsid proteins.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6ZTQ4, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000325954

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6ZTQ4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZTQ4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST110
Domaini136 – 236Cadherin 2PROSITE-ProRule annotationAdd BLAST101
Domaini237 – 344Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini346 – 466Cadherin 4PROSITE-ProRule annotationAdd BLAST121
Domaini462 – 566Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini567 – 695Cadherin 6PROSITE-ProRule annotationAdd BLAST129

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161245

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000060182

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106392

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZTQ4

KEGG Orthology (KO)

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KOi
K16503

Identification of Orthologs from Complete Genome Data

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OMAi
VHKFSVN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02NJ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6ZTQ4

TreeFam database of animal gene trees

More...
TreeFami
TF336601

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313 SSF49313, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50268 CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZTQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQEAIILLAL LGAMSGGEAL HLILLPATGN VAENSPPGTS VHKFSVKLSA
60 70 80 90 100
SLSPVIPGFP QIVNSNPLTE AFRVNWLSGT YFEVVTTGME QLDFETGPNI
110 120 130 140 150
FDLQIYVKDE VGVTDLQVLT VQVTDVNEPP QFQGNLAEGL HLYIVERANP
160 170 180 190 200
GFIYQVEAFD PEDTSRNIPL SYFLISPPKS FRMSANGTLF STTELDFEAG
210 220 230 240 250
HRSFHLIVEV RDSGGLKAST ELQVNIVNLN DEVPRFTSPT RVYTVLEELS
260 270 280 290 300
PGTIVANITA EDPDDEGFPS HLLYSITTVS KYFMINQLTG TIQVAQRIDR
310 320 330 340 350
DAGELRQNPT ISLEVLVKDR PYGGQENRIQ ITFIVEDVND NPATCQKFTF
360 370 380 390 400
SIMVPERTAK GTLLLDLNKF CFDDDSEAPN NRFNFTMPSG VGSGSRFLQD
410 420 430 440 450
PAGSGKIVLI GDLDYENPSN LAAGNKYTVI IQVQDVAPPY YKNNVYVYIL
460 470 480 490 500
TSPENEFPLI FDRPSYVFDV SERRPARTRV GQVRATDKDL PQSSLLYSIS
510 520 530 540 550
TGGASLQYPN VFWINPKTGE LQLVTKVDCE TTPIYILRIQ ATNNEDTSSV
560 570 580 590 600
TVTVNILEEN DEKPICTPNS YFLALPVDLK VGTNIQNFKL TCTDLDSSPR
610 620 630 640 650
SFRYSIGPGN VNNHFTFSPN AGSNVTRLLL TSRFDYAGGF DKIWDYKLLV
660 670 680 690 700
YVTDDNLMSD RKKAEALVET GTVTLSIKVI PHPTTIITTT PRPRVTYQVL
710 720 730 740 750
RKNVYSPSAW YVPFVITLGS ILLLGLLVYL VVLLAKAIHR HCPCKTGKNK
760 770 780 790 800
EPLTKKGETK TAERDVVVET IQMNTIFDGE AIDPVTGETY EFNSKTGARK
810 820 830 840 850
WKDPLTQMPK WKESSHQGAA PRRVTAGEGM GSLRSANWEE DELSGKAWAE
860 870 880
DAGLGSRNEG GKLGNPKNRN PAFMNRAYPK PHPGK
Length:885
Mass (Da):97,977
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDF0EEAFA904E9BE
GO
Isoform 2 (identifier: Q6ZTQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     477-560: RTRVGQVRAT...TVTVNILEEN → QGHLSGPEEK...GGNYPDEHYL
     561-885: Missing.

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):31,260
Checksum:i5B89A2395D907721
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQG5E7EQG5_HUMAN
Cadherin-related family member 3
CDHR3
797Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEI5E9PEI5_HUMAN
Cadherin-related family member 3
CDHR3
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C555H7C555_HUMAN
Cadherin-related family member 3
CDHR3
318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C548H7C548_HUMAN
Cadherin-related family member 3
CDHR3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF00F8WF00_HUMAN
Cadherin-related family member 3
CDHR3
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03522855V → M. Corresponds to variant dbSNP:rs35008315Ensembl.1
Natural variantiVAR_03522961Q → H. Corresponds to variant dbSNP:rs34426483Ensembl.1
Natural variantiVAR_035230529C → Y Common polymorphism; increases cell surface expression. 1 PublicationCorresponds to variant dbSNP:rs6967330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0283521 – 283Missing in isoform 2. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_028353477 – 560RTRVG…ILEEN → QGHLSGPEEKRLLSICMVRA VCHHFGLHIASGSPRVPGRP IGQSRPQTLPLQDWEEQGTS DKERRNEDCRERRRGGNYPD EHYL in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_028354561 – 885Missing in isoform 2. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074414 mRNA Translation: BAB85073.1
AK126338 mRNA Translation: BAC86529.1
CH236947 Genomic DNA Translation: EAL24403.1
BC111696 mRNA Translation: AAI11697.1
BC111738 mRNA Translation: AAI11739.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47684.1 [Q6ZTQ4-1]

NCBI Reference Sequences

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RefSeqi
NP_001288090.1, NM_001301161.1
NP_689963.2, NM_152750.4 [Q6ZTQ4-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.150120

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317716; ENSP00000325954; ENSG00000128536 [Q6ZTQ4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
222256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:222256

UCSC genome browser

More...
UCSCi
uc003vdl.5 human [Q6ZTQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074414 mRNA Translation: BAB85073.1
AK126338 mRNA Translation: BAC86529.1
CH236947 Genomic DNA Translation: EAL24403.1
BC111696 mRNA Translation: AAI11697.1
BC111738 mRNA Translation: AAI11739.1
CCDSiCCDS47684.1 [Q6ZTQ4-1]
RefSeqiNP_001288090.1, NM_001301161.1
NP_689963.2, NM_152750.4 [Q6ZTQ4-1]
UniGeneiHs.150120

3D structure databases

ProteinModelPortaliQ6ZTQ4
SMRiQ6ZTQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZTQ4, 3 interactors
STRINGi9606.ENSP00000325954

PTM databases

iPTMnetiQ6ZTQ4
PhosphoSitePlusiQ6ZTQ4

Polymorphism and mutation databases

BioMutaiCDHR3
DMDMi74758833

Proteomic databases

EPDiQ6ZTQ4
PaxDbiQ6ZTQ4
PeptideAtlasiQ6ZTQ4
PRIDEiQ6ZTQ4
ProteomicsDBi68286
68287 [Q6ZTQ4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317716; ENSP00000325954; ENSG00000128536 [Q6ZTQ4-1]
GeneIDi222256
KEGGihsa:222256
UCSCiuc003vdl.5 human [Q6ZTQ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
222256
DisGeNETi222256
EuPathDBiHostDB:ENSG00000128536.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CDHR3
HGNCiHGNC:26308 CDHR3
HPAiHPA011218
MIMi615610 gene
neXtProtiNX_Q6ZTQ4
OpenTargetsiENSG00000128536
PharmGKBiPA165617747

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000161245
HOGENOMiHOG000060182
HOVERGENiHBG106392
InParanoidiQ6ZTQ4
KOiK16503
OMAiVHKFSVN
OrthoDBiEOG091G02NJ
PhylomeDBiQ6ZTQ4
TreeFamiTF336601

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDHR3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
222256

Protein Ontology

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PROi
PR:Q6ZTQ4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128536 Expressed in 122 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ6ZTQ4 baseline and differential
GenevisibleiQ6ZTQ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS50268 CADHERIN_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDHR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZTQ4
Secondary accession number(s): Q8TCI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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