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Protein

Refilin-A

Gene

RFLNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Refilin-A
Alternative name(s):
Regulator of filamin protein A
Short name:
RefilinA
Gene namesi
Name:RFLNAImported
Synonyms:FAM101A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000178882.14
HGNCiHGNC:27051 RFLNA
MIMi615927 gene
neXtProtiNX_Q6ZTI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178882
PharmGKBiPA143485462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743311 – 216Refilin-AAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ6ZTI6
PaxDbiQ6ZTI6
PeptideAtlasiQ6ZTI6
PRIDEiQ6ZTI6
ProteomicsDBi68275
68276 [Q6ZTI6-2]

PTM databases

PhosphoSitePlusiQ6ZTI6

Expressioni

Gene expression databases

BgeeiENSG00000178882
CleanExiHS_FAM101A
GenevisibleiQ6ZTI6 HS

Organism-specific databases

HPAiHPA058911
HPA078021

Interactioni

Subunit structurei

Interacts with FLNA and FLNB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP21333-23EBI-10200920,EBI-9641086

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126843, 1 interactor
IntActiQ6ZTI6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6ZTI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Refilin family.Curated

Phylogenomic databases

eggNOGiENOG410IVW8 Eukaryota
ENOG410ZX5R LUCA
GeneTreeiENSGT00390000016836
HOGENOMiHOG000112422
HOVERGENiHBG107859
InParanoidiQ6ZTI6
OMAiCTWRSYR
OrthoDBiEOG091G13B3
PhylomeDBiQ6ZTI6
TreeFamiTF332387

Family and domain databases

InterProiView protein in InterPro
IPR028215 Refilin
PfamiView protein in Pfam
PF15068 FAM101, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZTI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGHLHLQGM EDSLKEQGRE GLLDSPDSGL PPSPSPSPPF YSLAPGILDA
60 70 80 90 100
RAGGAGASSE PPGPSEARAP PSQLPNPPAS EMRPRMLPVF FGESIKVNPE
110 120 130 140 150
PTHEIRCNSE VKYASEKHFQ DKVFYAPVPT VTAYSETIVA APNCTWRNYR
160 170 180 190 200
SQLTLEPRPR ALRFRSTTII FPKHARSTFR TTLHCSLGRP SRWFTASVQL
210
QLCQDPAPSL LGPATL
Length:216
Mass (Da):23,610
Last modified:November 4, 2008 - v3
Checksum:i6679E5A4CB3485E8
GO
Isoform 2 (identifier: Q6ZTI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,464
Checksum:i6A9F4247F5D551B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98N → S in BAC86601 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0227131 – 81Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073916 Genomic DNA No translation available.
AK126577 mRNA Translation: BAC86601.1
BC141805 mRNA Translation: AAI41806.1
CCDSiCCDS9258.1 [Q6ZTI6-2]
RefSeqiNP_001191228.1, NM_001204299.2 [Q6ZTI6-2]
NP_001334831.1, NM_001347902.1 [Q6ZTI6-2]
NP_859060.3, NM_181709.4 [Q6ZTI6-2]
UniGeneiHs.432901
Hs.524828

Genome annotation databases

EnsembliENST00000324038; ENSP00000315626; ENSG00000178882 [Q6ZTI6-2]
ENST00000338359; ENSP00000345898; ENSG00000178882 [Q6ZTI6-2]
ENST00000389727; ENSP00000374377; ENSG00000178882 [Q6ZTI6-2]
ENST00000546355; ENSP00000444080; ENSG00000178882 [Q6ZTI6-1]
GeneIDi100533183
144347
KEGGihsa:100533183
hsa:144347
UCSCiuc001ugd.3 human [Q6ZTI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRFLA_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTI6
Secondary accession number(s): A5D8T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 4, 2008
Last modified: June 20, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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