Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 129 (31 Jul 2019)
Sequence version 3 (10 Aug 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Tripartite motif-containing protein 67

Gene

TRIM67

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri7 – 42RING-type; degenerateAdd BLAST36
Zinc fingeri206 – 253B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri298 – 340B box-type 2PROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 67
Alternative name(s):
TRIM9-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM67
Synonyms:TNL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31859 TRIM67

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610584 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZTA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
440730

Open Targets

More...
OpenTargetsi
ENSG00000119283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947738

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM67

Domain mapping of disease mutations (DMDM)

More...
DMDMi
302393802

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002568641 – 783Tripartite motif-containing protein 67Add BLAST783

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZTA4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZTA4

PeptideAtlas

More...
PeptideAtlasi
Q6ZTA4

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZTA4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68269 [Q6ZTA4-3]
68270 [Q6ZTA4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZTA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZTA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119283 Expressed in 35 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZTA4 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034776

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
136847, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6ZTA4, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355613

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZTA4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini448 – 506COSPROSITE-ProRule annotationAdd BLAST59
Domaini513 – 607Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini589 – 780B30.2/SPRYPROSITE-ProRule annotationAdd BLAST192

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili345 – 382Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 65Poly-Ala7
Compositional biasi74 – 96Gly-richAdd BLAST23
Compositional biasi139 – 142Poly-Ala4
Compositional biasi148 – 156Poly-Ser9
Compositional biasi201 – 206Poly-Ala6
Compositional biasi277 – 280Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 42RING-type; degenerateAdd BLAST36
Zinc fingeri206 – 253B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri298 – 340B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4367 Eukaryota
ENOG410XQMV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007387

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZTA4

KEGG Orthology (KO)

More...
KOi
K10649

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRSPVCY

Database of Orthologous Groups

More...
OrthoDBi
516512at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZTA4

TreeFam database of animal gene trees

More...
TreeFami
TF315216

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003649 Bbox_C
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF00097 zf-C3HC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 2 hits
PS00518 ZF_RING_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZTA4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL
60 70 80 90 100
LSRGSGLQAG AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD
110 120 130 140 150
KLSLYSETDS GYGSYTPSLK SPNGVRVLPM VPAPPGSSAA AARGAACSSL
160 170 180 190 200
SSSSSSITCP QCHRSASLDH RGLRGFQRNR LLEAIVQRYQ QGRGAVPGTS
210 220 230 240 250
AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP SRGPFAKHRL
260 270 280 290 300
VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF
310 320 330 340 350
PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ
360 370 380 390 400
LSQALNGVSD KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA
410 420 430 440 450
LTRQKAKLLT KVTKEREHKL KMVWDQINHC TLKLRQSTGL MEYCLEVIKE
460 470 480 490 500
NDPSGFLQIS DALIKRVQVS QEQWVKGALE PKVSAEFDLT LDSEPLLQAI
510 520 530 540 550
HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT HSPVDGYILE
560 570 580 590 600
LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV
610 620 630 640 650
VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV
660 670 680 690 700
HYWELHVDRY DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM
710 720 730 740 750
HCNSHTNRTE GGVCKGATVG VLLDLNKHTL TFFINGQQQG PTAFSHVDGV
760 770 780
FMPALSLNRN VQVTLHTGLE VPTNLGRPKL SGN
Note: Gene prediction based on EST data.
Length:783
Mass (Da):83,823
Last modified:August 10, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC07A0E0B576D821
GO
Isoform 2 (identifier: Q6ZTA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-81: Missing.
     251-272: Missing.

Show »
Length:721
Mass (Da):78,073
Checksum:iD999202C92BF23DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W8C1F8W8C1_HUMAN
Tripartite motif-containing protein...
TRIM67
781Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC86689 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22C → R in BAC86689 (PubMed:14702039).Curated1
Sequence conflicti679M → V in BAC86689 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02135942 – 81Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_021360251 – 272Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY253917 mRNA Translation: AAP69949.1
AL109810 Genomic DNA No translation available.
AK126782 mRNA Translation: BAC86689.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44333.1 [Q6ZTA4-3]
CCDS73048.1 [Q6ZTA4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001004342.3, NM_001004342.3 [Q6ZTA4-3]
NP_001287818.1, NM_001300889.1 [Q6ZTA4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366653; ENSP00000355613; ENSG00000119283 [Q6ZTA4-3]
ENST00000449018; ENSP00000400163; ENSG00000119283 [Q6ZTA4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
440730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:440730

UCSC genome browser

More...
UCSCi
uc009xfn.2 human [Q6ZTA4-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253917 mRNA Translation: AAP69949.1
AL109810 Genomic DNA No translation available.
AK126782 mRNA Translation: BAC86689.1 Sequence problems.
CCDSiCCDS44333.1 [Q6ZTA4-3]
CCDS73048.1 [Q6ZTA4-2]
RefSeqiNP_001004342.3, NM_001004342.3 [Q6ZTA4-3]
NP_001287818.1, NM_001300889.1 [Q6ZTA4-2]

3D structure databases

SMRiQ6ZTA4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi136847, 1 interactor
IntActiQ6ZTA4, 2 interactors
STRINGi9606.ENSP00000355613

PTM databases

iPTMnetiQ6ZTA4
PhosphoSitePlusiQ6ZTA4

Polymorphism and mutation databases

BioMutaiTRIM67
DMDMi302393802

Proteomic databases

jPOSTiQ6ZTA4
PaxDbiQ6ZTA4
PeptideAtlasiQ6ZTA4
PRIDEiQ6ZTA4
ProteomicsDBi68269 [Q6ZTA4-3]
68270 [Q6ZTA4-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
440730
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366653; ENSP00000355613; ENSG00000119283 [Q6ZTA4-3]
ENST00000449018; ENSP00000400163; ENSG00000119283 [Q6ZTA4-2]
GeneIDi440730
KEGGihsa:440730
UCSCiuc009xfn.2 human [Q6ZTA4-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440730
DisGeNETi440730

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM67
HGNCiHGNC:31859 TRIM67
HPAiHPA034776
MIMi610584 gene
neXtProtiNX_Q6ZTA4
OpenTargetsiENSG00000119283
PharmGKBiPA134947738

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4367 Eukaryota
ENOG410XQMV LUCA
GeneTreeiENSGT00940000154071
HOGENOMiHOG000007387
InParanoidiQ6ZTA4
KOiK10649
OMAiCRSPVCY
OrthoDBi516512at2759
PhylomeDBiQ6ZTA4
TreeFamiTF315216

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM67 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
440730

Protein Ontology

More...
PROi
PR:Q6ZTA4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119283 Expressed in 35 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ6ZTA4 baseline and differential

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003649 Bbox_C
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 2 hits
PS00518 ZF_RING_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI67_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZTA4
Secondary accession number(s): Q5TER7, Q5TER8, Q7Z4K7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 10, 2010
Last modified: July 31, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again