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Entry version 138 (07 Apr 2021)
Sequence version 2 (30 Aug 2005)
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Protein

Tubulin polyglutamylase TTLL7

Gene

TTLL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei106Binds negatively charged residues of beta-tubulin C-terminal tails1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei201ATP1 Publication1
Binding sitei203ATP1 Publication1
Sitei352Binds negatively charged residues of beta-tubulin C-terminal tails1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi188 – 191ATP binding1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Ligase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZT98

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin polyglutamylase TTLL7Curated (EC:6.-.-.-1 Publication)
Alternative name(s):
Testis development protein NYD-SP301 Publication
Tubulin--tyrosine ligase-like protein 7Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26242, TTLL7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618813, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZT98

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137941.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106R → E: Nearly abolished polyglutamylase activity. 1 Publication1
Mutagenesisi143 – 146NYVK → EYVE: 70% decreased polyglutamylase activity. 1 Publication4
Mutagenesisi178K → E: Decreased polyglutamylase activity. 1 Publication1
Mutagenesisi205R → E: Nearly abolished polyglutamylase activity. 1 Publication1
Mutagenesisi227R → E: Nearly abolished polyglutamylase activity. 1 Publication1
Mutagenesisi271K → E: Nearly abolished polyglutamylase activity. 1 Publication1
Mutagenesisi349E → Q: Loss of polyglutamylase activity. 1 Publication1
Mutagenesisi352R → A or E: Nearly abolished polyglutamylase activity. 1 Publication1
Mutagenesisi385 – 393KRRNLAKQK → EEENLAEQE: 45% decreased binding to microtubules. Decreased polyglutamylase activity. 76% decreased binding to microtubules; when associated with 425-E--E-427. 1 Publication9
Mutagenesisi425 – 427RRK → EEE: 76% decreased binding to microtubules; when associated with 385-E--E-393. 1 Publication3
Mutagenesisi477 – 480FQTF → AQTA: 40% decreased polyglutamylase activity. 1 Publication4
Mutagenesisi490 – 500RELNNPLKRMK → DELNNPLDDMD: 69% decreased polyglutamylase activity. 1 PublicationAdd BLAST11

Organism-specific databases

DisGeNET

More...
DisGeNETi
79739

Open Targets

More...
OpenTargetsi
ENSG00000137941

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670678

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZT98, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73920151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124441 – 887Tubulin polyglutamylase TTLL7Add BLAST887

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZT98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZT98

PeptideAtlas

More...
PeptideAtlasi
Q6ZT98

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZT98

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68266 [Q6ZT98-1]
68267 [Q6ZT98-2]
68268 [Q6ZT98-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6ZT98-2 [Q6ZT98-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZT98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZT98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137941, Expressed in corpus callosum and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZT98, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZT98, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137941, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with both alpha- and beta-tubulin (via C-terminal tubulin tails).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122852, 10 interactors

Protein interaction database and analysis system

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IntActi
Q6ZT98, 10 interactors

Molecular INTeraction database

More...
MINTi
Q6ZT98

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260505

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZT98, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1887
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZT98

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 390TTLPROSITE-ProRule annotationAdd BLAST353

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni388 – 450c-MTBD region1 PublicationAdd BLAST63

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2158, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010131_7_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZT98

Identification of Orthologs from Complete Genome Data

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OMAi
DVSKFWN

Database of Orthologous Groups

More...
OrthoDBi
1251554at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZT98

TreeFam database of animal gene trees

More...
TreeFami
TF313087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR004344, TTL/TTLL_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133, TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221, TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZT98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSLPQEGVI QGPSPLDLNT ELPYQSTMKR KVRKKKKKGT ITANVAGTKF
60 70 80 90 100
EIVRLVIDEM GFMKTPDEDE TSNLIWCDSA VQQEKISELQ NYQRINHFPG
110 120 130 140 150
MGEICRKDFL ARNMTKMIKS RPLDYTFVPR TWIFPAEYTQ FQNYVKELKK
160 170 180 190 200
KRKQKTFIVK PANGAMGHGI SLIRNGDKLP SQDHLIVQEY IEKPFLMEGY
210 220 230 240 250
KFDLRIYILV TSCDPLKIFL YHDGLVRMGT EKYIPPNESN LTQLYMHLTN
260 270 280 290 300
YSVNKHNEHF ERDETENKGS KRSIKWFTEF LQANQHDVAK FWSDISELVV
310 320 330 340 350
KTLIVAEPHV LHAYRMCRPG QPPGSESVCF EVLGFDILLD RKLKPWLLEI
360 370 380 390 400
NRAPSFGTDQ KIDYDVKRGV LLNALKLLNI RTSDKRRNLA KQKAEAQRRL
410 420 430 440 450
YGQNSIKRLL PGSSDWEQQR HQLERRKEEL KERLAQVRKQ ISREEHENRH
460 470 480 490 500
MGNYRRIYPP EDKALLEKYE NLLAVAFQTF LSGRAASFQR ELNNPLKRMK
510 520 530 540 550
EEDILDLLEQ CEIDDEKLMG KTTKTRGPKP LCSMPESTEI MKRPKYCSSD
560 570 580 590 600
SSYDSSSSSS ESDENEKEEY QNKKREKQVT YNLKPSNHYK LIQQPSSIRR
610 620 630 640 650
SVSCPRSISA QSPSSGDTRP FSAQQMISVS RPTSASRSHS LNRASSYMRH
660 670 680 690 700
LPHSNDACST NSQVSESLRQ LKTKEQEDDL TSQTLFVLKD MKIRFPGKSD
710 720 730 740 750
AESELLIEDI IDNWKYHKTK VASYWLIKLD SVKQRKVLDI VKTSIRTVLP
760 770 780 790 800
RIWKVPDVEE VNLYRIFNRV FNRLLWSRGQ GLWNCFCDSG SSWESIFNKS
810 820 830 840 850
PEVVTPLQLQ CCQRLVELCK QCLLVVYKYA TDKRGSLSGI GPDWGNSRYL
860 870 880
LPGSTQFFLR TPTYNLKYNS PGMTRSNVLF TSRYGHL
Length:887
Mass (Da):102,999
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i881C46437FB385EA
GO
Isoform 2 (identifier: Q6ZT98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     665-669: SESLR → IILAQ
     670-887: Missing.

Show »
Length:669
Mass (Da):77,555
Checksum:iD7A4167627FA53EB
GO
Isoform 3 (identifier: Q6ZT98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     791-792: SS → YV
     793-887: Missing.

Show »
Length:792
Mass (Da):92,222
Checksum:i62CB99ABC6EB205F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2X2F2Z2X2_HUMAN
Tubulin polyglutamylase TTLL7
TTLL7
553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2J7F2Z2J7_HUMAN
Tubulin polyglutamylase TTLL7
TTLL7
477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X234A0A087X234_HUMAN
Tubulin polyglutamylase TTLL7
TTLL7
543Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13P → S in AAO37763 (Ref. 1) Curated1
Sequence conflicti48T → A in BAC86695 (PubMed:14702039).Curated1
Sequence conflicti298L → M in AAH60878 (PubMed:15489334).Curated1
Sequence conflicti489Q → R in AAH60878 (PubMed:15489334).Curated1
Sequence conflicti493N → D in AAH60878 (PubMed:15489334).Curated1
Sequence conflicti575R → G in AAH60878 (PubMed:15489334).Curated1
Sequence conflicti609S → F in BAB15526 (PubMed:14702039).Curated1
Sequence conflicti677E → G in AAH60878 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015199665 – 669SESLR → IILAQ in isoform 2. 1 Publication5
Alternative sequenceiVSP_015200670 – 887Missing in isoform 2. 1 PublicationAdd BLAST218
Alternative sequenceiVSP_015201791 – 792SS → YV in isoform 3. 1 Publication2
Alternative sequenceiVSP_015202793 – 887Missing in isoform 3. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY170843 mRNA Translation: AAO37763.1
AK026686 mRNA Translation: BAB15526.1
AK126792 mRNA Translation: BAC86695.1
AC104454 Genomic DNA No translation available.
AL138844 Genomic DNA No translation available.
BC060878 mRNA Translation: AAH60878.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS690.2 [Q6ZT98-1]

NCBI Reference Sequences

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RefSeqi
NP_078962.4, NM_024686.4 [Q6ZT98-1]
XP_016857836.1, XM_017002347.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260505; ENSP00000260505; ENSG00000137941 [Q6ZT98-1]
ENST00000480174; ENSP00000435334; ENSG00000137941 [Q6ZT98-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79739

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79739

UCSC genome browser

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UCSCi
uc001djc.4, human [Q6ZT98-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY170843 mRNA Translation: AAO37763.1
AK026686 mRNA Translation: BAB15526.1
AK126792 mRNA Translation: BAC86695.1
AC104454 Genomic DNA No translation available.
AL138844 Genomic DNA No translation available.
BC060878 mRNA Translation: AAH60878.1
CCDSiCCDS690.2 [Q6ZT98-1]
RefSeqiNP_078962.4, NM_024686.4 [Q6ZT98-1]
XP_016857836.1, XM_017002347.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YLRX-ray2.55A36-518[»]
4YLSX-ray2.60A36-518[»]
SMRiQ6ZT98
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122852, 10 interactors
IntActiQ6ZT98, 10 interactors
MINTiQ6ZT98
STRINGi9606.ENSP00000260505

PTM databases

iPTMnetiQ6ZT98
PhosphoSitePlusiQ6ZT98

Genetic variation databases

BioMutaiTTLL7
DMDMi73920151

Proteomic databases

MassIVEiQ6ZT98
PaxDbiQ6ZT98
PeptideAtlasiQ6ZT98
PRIDEiQ6ZT98
ProteomicsDBi68266 [Q6ZT98-1]
68267 [Q6ZT98-2]
68268 [Q6ZT98-3]
TopDownProteomicsiQ6ZT98-2 [Q6ZT98-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
53234, 33 antibodies

The DNASU plasmid repository

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DNASUi
79739

Genome annotation databases

EnsembliENST00000260505; ENSP00000260505; ENSG00000137941 [Q6ZT98-1]
ENST00000480174; ENSP00000435334; ENSG00000137941 [Q6ZT98-2]
GeneIDi79739
KEGGihsa:79739
UCSCiuc001djc.4, human [Q6ZT98-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79739
DisGeNETi79739

GeneCards: human genes, protein and diseases

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GeneCardsi
TTLL7
HGNCiHGNC:26242, TTLL7
HPAiENSG00000137941, Tissue enhanced (brain)
MIMi618813, gene
neXtProtiNX_Q6ZT98
OpenTargetsiENSG00000137941
PharmGKBiPA142670678
VEuPathDBiHostDB:ENSG00000137941.16

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2158, Eukaryota
GeneTreeiENSGT00940000159078
HOGENOMiCLU_010131_7_1_1
InParanoidiQ6ZT98
OMAiDVSKFWN
OrthoDBi1251554at2759
PhylomeDBiQ6ZT98
TreeFamiTF313087

Enzyme and pathway databases

PathwayCommonsiQ6ZT98
ReactomeiR-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79739, 3 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTLL7, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79739
PharosiQ6ZT98, Tbio

Protein Ontology

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PROi
PR:Q6ZT98
RNActiQ6ZT98, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137941, Expressed in corpus callosum and 188 other tissues
ExpressionAtlasiQ6ZT98, baseline and differential
GenevisibleiQ6ZT98, HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR004344, TTL/TTLL_fam
PfamiView protein in Pfam
PF03133, TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221, TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZT98
Secondary accession number(s): Q5TAX8
, Q5TAX9, Q6P990, Q86YS1, Q9H5U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 7, 2021
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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