Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q6ZT21 (TMPPE_HUMAN)

Entry version 118 (29 Sep 2021)
Sequence version 2 (26 Feb 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Transmembrane protein with metallophosphoesterase domain

Gene

TMPPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi214Divalent metal cation 1By similarity1
Metal bindingi216Divalent metal cation 1By similarity1
Metal bindingi246Divalent metal cation 1By similarity1
Metal bindingi246Divalent metal cation 2By similarity1
Metal bindingi277Divalent metal cation 2By similarity1
Metal bindingi391Divalent metal cation 2By similarity1
Metal bindingi393Divalent metal cation 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZT21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein with metallophosphoesterase domain (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMPPE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33865, TMPPE

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZT21

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188167

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		643853

Open Targets

More...OpenTargetsi		ENSG00000188167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164726564

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZT21, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMPPE

Domain mapping of disease mutations (DMDM)

More...DMDMi		190359341

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003221161 – 453Transmembrane protein with metallophosphoesterase domainAdd BLAST453

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZT21

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZT21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZT21

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZT21

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZT21

PeptideAtlas

More...PeptideAtlasi		Q6ZT21

PRoteomics IDEntifications database

More...PRIDEi		Q6ZT21

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68256 [Q6ZT21-1]
68257 [Q6ZT21-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZT21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZT21

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6ZT21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188167, Expressed in pancreas and 114 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188167, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		569104, 65 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZT21, 58 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343398

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZT21, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the metallophosphoesterase superfamily. LOC643853 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRHG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010260

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025443_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZT21

Identification of Orthologs from Complete Genome Data

More...OMAi		YIWRSTV

Database of Orthologous Groups

More...OrthoDBi		1154756at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZT21

TreeFam database of animal gene trees

More...TreeFami		TF315106

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.21.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00149, Metallophos, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56300, SSF56300, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZT21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL 
        60         70         80         90        100
FVNSLLLIGS LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF 
       110        120        130        140        150
FTMFFLVAEE PYLFSLAAYS CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG 
       160        170        180        190        200
RVVGSLEKTR KLVLRPALAV GVTAVLSVAG ILNAAQPPAV KTVEVPIHQL 
       210        220        230        240        250
PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI TVIVGDLSDS 
       260        270        280        290        300
EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL 
       310        320        330        340        350
HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD 
       360        370        380        390        400
LDKALEGCSP DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL 
       410        420        430        440        450
NVAAYLLNPF FAGLYQVAQA TFVYVSPGTA YYGIPMRLGS RAEITELILQ 

RSP
Length:453
Mass (Da):49,453
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5455B6801793D68
GO
Isoform 2 (identifier: Q6ZT21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Show »
Length:316
Mass (Da):34,078
Checksum:i1226BF591D3C3E44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209I → V in BAC86774 (PubMed:14702039).Curated1
Sequence conflicti266H → R in BAC86774 (PubMed:14702039).Curated1
Sequence conflicti347H → R in BAC87349 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0318581 – 137Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126979 mRNA Translation: BAC86774.1
AK128242 mRNA Translation: BAC87349.1
BC136872 mRNA Translation: AAI36873.1
BC136873 mRNA Translation: AAI36874.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33732.1 [Q6ZT21-1]
CCDS46786.1 [Q6ZT21-2]

NCBI Reference Sequences

More...RefSeqi		NP_001034859.2, NM_001039770.2 [Q6ZT21-1]
NP_001129710.1, NM_001136238.1 [Q6ZT21-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342462; ENSP00000343398; ENSG00000188167 [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167 [Q6ZT21-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		643853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:643853

UCSC genome browser

More...UCSCi		uc003cfk.3, human [Q6ZT21-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126979 mRNA Translation: BAC86774.1
AK128242 mRNA Translation: BAC87349.1
BC136872 mRNA Translation: AAI36873.1
BC136873 mRNA Translation: AAI36874.1
CCDSiCCDS33732.1 [Q6ZT21-1]
CCDS46786.1 [Q6ZT21-2]
RefSeqiNP_001034859.2, NM_001039770.2 [Q6ZT21-1]
NP_001129710.1, NM_001136238.1 [Q6ZT21-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi569104, 65 interactors
IntActiQ6ZT21, 58 interactors
STRINGi9606.ENSP00000343398

PTM databases

iPTMnetiQ6ZT21
PhosphoSitePlusiQ6ZT21
SwissPalmiQ6ZT21

Genetic variation databases

BioMutaiTMPPE
DMDMi190359341

Proteomic databases

EPDiQ6ZT21
jPOSTiQ6ZT21
MassIVEiQ6ZT21
MaxQBiQ6ZT21
PaxDbiQ6ZT21
PeptideAtlasiQ6ZT21
PRIDEiQ6ZT21
ProteomicsDBi68256 [Q6ZT21-1]
68257 [Q6ZT21-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11672, 73 antibodies

The DNASU plasmid repository

More...DNASUi		643853

Genome annotation databases

EnsembliENST00000342462; ENSP00000343398; ENSG00000188167 [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167 [Q6ZT21-2]
GeneIDi643853
KEGGihsa:643853
UCSCiuc003cfk.3, human [Q6ZT21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		643853
DisGeNETi643853

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMPPE
HGNCiHGNC:33865, TMPPE
HPAiENSG00000188167, Low tissue specificity
neXtProtiNX_Q6ZT21
OpenTargetsiENSG00000188167
PharmGKBiPA164726564
VEuPathDBiHostDB:ENSG00000188167

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRHG, Eukaryota
GeneTreeiENSGT00390000010260
HOGENOMiCLU_025443_6_0_1
InParanoidiQ6ZT21
OMAiYIWRSTV
OrthoDBi1154756at2759
PhylomeDBiQ6ZT21
TreeFamiTF315106

Enzyme and pathway databases

PathwayCommonsiQ6ZT21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		643853, 3 hits in 1010 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		643853
PharosiQ6ZT21, Tdark

Protein Ontology

More...PROi		PR:Q6ZT21
RNActiQ6ZT21, protein

Gene expression databases

BgeeiENSG00000188167, Expressed in pancreas and 114 other tissues

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149, Metallophos, 1 hit
SUPFAMiSSF56300, SSF56300, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMPPE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZT21
Secondary accession number(s): B2RNG5, Q6ZRG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again