UniProtKB - Q6ZT21 (TMPPE_HUMAN)
Protein
Transmembrane protein with metallophosphoesterase domain
Gene
TMPPE
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 214 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 216 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 246 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 246 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 277 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 391 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 393 | Divalent metal cation 1By similarity | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6ZT21 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TMPPE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33865, TMPPE |
neXtProti | NX_Q6ZT21 |
VEuPathDBi | HostDB:ENSG00000188167.8 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 114 – 134 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 643853 |
OpenTargetsi | ENSG00000188167 |
PharmGKBi | PA164726564 |
Miscellaneous databases
Pharosi | Q6ZT21, Tdark |
Genetic variation databases
BioMutai | TMPPE |
DMDMi | 190359341 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000322116 | 1 – 453 | Transmembrane protein with metallophosphoesterase domainAdd BLAST | 453 |
Proteomic databases
EPDi | Q6ZT21 |
jPOSTi | Q6ZT21 |
MassIVEi | Q6ZT21 |
MaxQBi | Q6ZT21 |
PaxDbi | Q6ZT21 |
PeptideAtlasi | Q6ZT21 |
PRIDEi | Q6ZT21 |
ProteomicsDBi | 68256 [Q6ZT21-1] 68257 [Q6ZT21-2] |
PTM databases
iPTMneti | Q6ZT21 |
PhosphoSitePlusi | Q6ZT21 |
SwissPalmi | Q6ZT21 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188167, Expressed in pancreas and 113 other tissues |
Organism-specific databases
HPAi | ENSG00000188167, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6ZT21
Protein-protein interaction databases
BioGRIDi | 569104, 65 interactors |
IntActi | Q6ZT21, 58 interactors |
MINTi | Q6ZT21 |
STRINGi | 9606.ENSP00000343398 |
Miscellaneous databases
RNActi | Q6ZT21, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRHG, Eukaryota |
GeneTreei | ENSGT00390000010260 |
HOGENOMi | CLU_025443_6_0_1 |
InParanoidi | Q6ZT21 |
OMAi | YSGHGMD |
OrthoDBi | 1154756at2759 |
PhylomeDBi | Q6ZT21 |
TreeFami | TF315106 |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6ZT21-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL
60 70 80 90 100
FVNSLLLIGS LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF
110 120 130 140 150
FTMFFLVAEE PYLFSLAAYS CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG
160 170 180 190 200
RVVGSLEKTR KLVLRPALAV GVTAVLSVAG ILNAAQPPAV KTVEVPIHQL
210 220 230 240 250
PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI TVIVGDLSDS
260 270 280 290 300
EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL
310 320 330 340 350
HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD
360 370 380 390 400
LDKALEGCSP DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL
410 420 430 440 450
NVAAYLLNPF FAGLYQVAQA TFVYVSPGTA YYGIPMRLGS RAEITELILQ
RSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 209 | I → V in BAC86774 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 266 | H → R in BAC86774 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 347 | H → R in BAC87349 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031858 | 1 – 137 | Missing in isoform 2. 1 PublicationAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126979 mRNA Translation: BAC86774.1 AK128242 mRNA Translation: BAC87349.1 BC136872 mRNA Translation: AAI36873.1 BC136873 mRNA Translation: AAI36874.1 |
CCDSi | CCDS33732.1 [Q6ZT21-1] CCDS46786.1 [Q6ZT21-2] |
RefSeqi | NP_001034859.2, NM_001039770.2 [Q6ZT21-1] NP_001129710.1, NM_001136238.1 [Q6ZT21-2] |
Genome annotation databases
Ensembli | ENST00000342462; ENSP00000343398; ENSG00000188167 [Q6ZT21-1] ENST00000416695; ENSP00000400715; ENSG00000188167 [Q6ZT21-2] |
GeneIDi | 643853 |
KEGGi | hsa:643853 |
UCSCi | uc003cfk.3, human [Q6ZT21-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126979 mRNA Translation: BAC86774.1 AK128242 mRNA Translation: BAC87349.1 BC136872 mRNA Translation: AAI36873.1 BC136873 mRNA Translation: AAI36874.1 |
CCDSi | CCDS33732.1 [Q6ZT21-1] CCDS46786.1 [Q6ZT21-2] |
RefSeqi | NP_001034859.2, NM_001039770.2 [Q6ZT21-1] NP_001129710.1, NM_001136238.1 [Q6ZT21-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 569104, 65 interactors |
IntActi | Q6ZT21, 58 interactors |
MINTi | Q6ZT21 |
STRINGi | 9606.ENSP00000343398 |
PTM databases
iPTMneti | Q6ZT21 |
PhosphoSitePlusi | Q6ZT21 |
SwissPalmi | Q6ZT21 |
Genetic variation databases
BioMutai | TMPPE |
DMDMi | 190359341 |
Proteomic databases
EPDi | Q6ZT21 |
jPOSTi | Q6ZT21 |
MassIVEi | Q6ZT21 |
MaxQBi | Q6ZT21 |
PaxDbi | Q6ZT21 |
PeptideAtlasi | Q6ZT21 |
PRIDEi | Q6ZT21 |
ProteomicsDBi | 68256 [Q6ZT21-1] 68257 [Q6ZT21-2] |
Protocols and materials databases
Antibodypediai | 11672, 72 antibodies |
Genome annotation databases
Ensembli | ENST00000342462; ENSP00000343398; ENSG00000188167 [Q6ZT21-1] ENST00000416695; ENSP00000400715; ENSG00000188167 [Q6ZT21-2] |
GeneIDi | 643853 |
KEGGi | hsa:643853 |
UCSCi | uc003cfk.3, human [Q6ZT21-1] |
Organism-specific databases
CTDi | 643853 |
DisGeNETi | 643853 |
GeneCardsi | TMPPE |
HGNCi | HGNC:33865, TMPPE |
HPAi | ENSG00000188167, Low tissue specificity |
neXtProti | NX_Q6ZT21 |
OpenTargetsi | ENSG00000188167 |
PharmGKBi | PA164726564 |
VEuPathDBi | HostDB:ENSG00000188167.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRHG, Eukaryota |
GeneTreei | ENSGT00390000010260 |
HOGENOMi | CLU_025443_6_0_1 |
InParanoidi | Q6ZT21 |
OMAi | YSGHGMD |
OrthoDBi | 1154756at2759 |
PhylomeDBi | Q6ZT21 |
TreeFami | TF315106 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZT21 |
Miscellaneous databases
BioGRID-ORCSi | 643853, 1 hit in 873 CRISPR screens |
GenomeRNAii | 643853 |
Pharosi | Q6ZT21, Tdark |
PROi | PR:Q6ZT21 |
RNActi | Q6ZT21, protein |
Gene expression databases
Bgeei | ENSG00000188167, Expressed in pancreas and 113 other tissues |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMPPE_HUMAN | |
Accessioni | Q6ZT21Primary (citable) accession number: Q6ZT21 Secondary accession number(s): B2RNG5, Q6ZRG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families